iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000056753.1	ENSRNOT00000083002.1	ENSRNOP00000068974.1
ENSRNOG00000056753.1	ENSRNOT00000086991.1	ENSRNOP00000070631.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.30e-103	345.6	474	812

Active Site

Position(s)	Description	Evidence
780	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+v+fvgE+gld+gG+t+e++ ll++++++pd+g+f+y+++++++++ + +      ++ + F+++G+l+g+a++++  ld+
   Q: 474  RADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKC-----DNYSEFRLVGILMGLAVYNSITLDI 557
           589***************************************************87766.....789********************** PP
   S: 91   plsksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           ++++++yk+ll+               +++++dl +++pel++ lke++++ e ++ee  +  tf+v +e++g +k+++LkpgG++ipV
   Q: 558  RFPPCCYKKLLSPpvvpsdqstpvgicSVTIDDLCQIMPELAHGLKELLSY-EGNVEED-FYSTFQVFQEEFGVIKSYNLKPGGDKIPV 644
           ************9666666666666555**********************9.6788885.***************************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevle 254
           tn+N++eYv+l++++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++e+d+++l++ t+y+g y +++ +i++Fw+v+ 
   Q: 645  TNQNRREYVQLYTDFLLNKSIYKQFAAFYCGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRSTQYDG-YAKTDLTIRYFWDVVL 732
           **********************************************************************76.**************** PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +f  e +k++L+F+Tgs+r+P+gG+a+l+   f i+k ++s+++lP ++TCfn+L+LP+Y+sk+ lk+kL++ i++++gF+l+
   Q: 733  GFPLELQKKLLHFTTGSDRVPVGGMADLN---FKISKnETSTNWLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 812
           *****************************...9999967777**************************************985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MVPHCPLPTP SSSPVGRGYD RTHGEWANLK GAQGSSLPGT GGPAGNGRSR GRRDPEEFKG 60
QGPPVGSEVP GSSATTGEGK ARGLDRGSKG QISTFSSFVS SVTQKKEAAE NRSSPTHLAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCGTTGGGT GGTGGAGGTG GCGATATTTT AACATCTCGG CTTAAAGTAA TTCAGTTTTA 60
ACGTTCTTAC CCAGAATTTA TTACGAGCTT TATTACGGAT TACTCAGCAT TTTGGATATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	91.96	0.00e+00	1405.00
IUUC-Apl-003589	Anas platyrhynchos	83.86	0.00e+00	1261.00
IUUC-Aca-004350	Anolis carolinensis	80.55	0.00e+00	1212.00
IUUC-Ago-007908	Ashbya gossypii	35.06	5.00e-83	302.00
IUUC-Acl-008288	Aspergillus clavatus	35.69	1.00e-101	365.00
IUUC-Afl-008402	Aspergillus flavus	34.66	1.00e-94	340.00
IUUC-Afu-008762	Aspergillus fumigatus	35.14	6.00e-99	355.00
IUUC-Ani-009176	Aspergillus nidulans	35.88	1.00e-96	348.00
IUUC-Ang-009791	Aspergillus niger	36.36	3.00e-97	350.00
IUUC-Aor-009921	Aspergillus oryzae	34.49	8.00e-94	338.00
IUUC-Ate-010295	Aspergillus terreus	36.30	8.00e-105	375.00
IUUC-Ame-010660	Astyanax mexicanus	83.28	3.00e-153	534.00
IUUC-Bgr-011981	Blumeria graminis	34.21	4.00e-96	346.00
IUUC-Bta-012945	Bos taurus	90.93	0.00e+00	1373.00
IUUC-Bci-013697	Botrytis cinerea	34.55	9.00e-85	308.00
IUUC-Cja-019263	Callithrix jacchus	89.64	0.00e+00	1357.00
IUUC-Cfa-020486	Canis familiaris	93.64	0.00e+00	1282.00
IUUC-Cpo-021755	Cavia porcellus	89.07	0.00e+00	1394.00
IUUC-Csa-023814	Chlorocebus sabaeus	90.29	0.00e+00	1293.00
IUUC-Cho-024980	Choloepus hoffmanni	73.88	0.00e+00	1080.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	41.61	5.00e-99	356.00
IUUC-Dre-028551	Danio rerio	75.00	0.00e+00	1121.00
IUUC-Dno-029497	Dasypus novemcinctus	89.86	0.00e+00	1249.00
IUUC-Dor-030867	Dipodomys ordii	79.56	0.00e+00	1147.00
IUUC-Dse-031239	Dothistroma septosporum	32.65	3.00e-91	330.00
IUUC-Ete-032902	Echinops telfairi	77.40	0.00e+00	1158.00
IUUC-Eca-033678	Equus caballus	91.64	0.00e+00	1377.00
IUUC-Eeu-035262	Erinaceus europaeus	76.68	0.00e+00	1055.00
IUUC-Fca-035590	Felis catus	92.60	0.00e+00	1412.00
IUUC-Fal-037123	Ficedula albicollis	80.08	0.00e+00	1201.00
IUUC-Fox-037941	Fusarium oxysporum	41.08	3.00e-105	376.00
IUUC-Fso-038388	Fusarium solani	41.87	5.00e-108	385.00
IUUC-Gmo-039553	Gadus morhua	65.68	0.00e+00	851.00
IUUC-Ggr-040110	Gaeumannomyces graminis	41.07	4.00e-103	369.00
IUUC-Gga-040406	Gallus gallus	83.20	0.00e+00	1295.00
IUUC-Gac-042141	Gasterosteus aculeatus	75.36	0.00e+00	1106.00
IUUC-Ggo-045504	Gorilla gorilla	89.50	0.00e+00	1358.00
IUUC-Hsa-045786	Homo sapiens	90.26	0.00e+00	1363.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	87.06	0.00e+00	1214.00
IUUC-Kpa-049152	Komagataella pastoris	34.36	6.00e-79	289.00
IUUC-Lch-049824	Latimeria chalumnae	78.87	0.00e+00	1085.00
IUUC-Loc-052173	Lepisosteus oculatus	77.84	0.00e+00	1169.00
IUUC-Laf-054017	Loxodonta africana	91.85	0.00e+00	1315.00
IUUC-Mcc-055713	Macaca mulatta	90.17	0.00e+00	1362.00
IUUC-Meu-056212	Macropus eugenii	68.81	1.00e-114	407.00
IUUC-Mor-057045	Magnaporthe oryzae	38.20	4.00e-95	343.00
IUUC-Mla-059187	Melampsora laricipopulina	43.31	2.00e-89	322.00
IUUC-Mga-059884	Meleagris gallopavo	78.01	0.00e+00	1144.00
IUUC-Mmr-061344	Microcebus murinus	90.95	0.00e+00	1385.00
IUUC-Mdo-062653	Monodelphis domestica	84.37	0.00e+00	1303.00
IUUC-Mmu-063775	Mus musculus	98.23	0.00e+00	1378.00
IUUC-Mpu-066069	Mustela putorius furo	93.05	0.00e+00	1307.00
IUUC-Mlu-067925	Myotis lucifugus	91.92	0.00e+00	1369.00
IUUC-Nfi-068439	Neosartorya fischeri	34.98	3.00e-98	353.00
IUUC-Ncr-068903	Neurospora crassa	38.28	8.00e-97	348.00
IUUC-Nle-070046	Nomascus leucogenys	90.04	0.00e+00	1386.00
IUUC-Opr-071085	Ochotona princeps	79.19	8.00e-137	481.00
IUUC-Ont-072126	Oreochromis niloticus	75.87	0.00e+00	1134.00
IUUC-Oan-072933	Ornithorhynchus anatinus	87.17	0.00e+00	1176.00
IUUC-Ocu-073800	Oryctolagus cuniculus	92.60	0.00e+00	1273.00
IUUC-Ola-086988	Oryzias latipes	74.96	0.00e+00	1106.00
IUUC-Oga-088117	Otolemur garnettii	94.48	0.00e+00	1129.00
IUUC-Oar-089371	Ovis aries	91.78	0.00e+00	1350.00
IUUC-Ptr-090551	Pan troglodytes	90.87	0.00e+00	1332.00
IUUC-Pan-092067	Papio anubis	90.66	0.00e+00	1367.00
IUUC-Psi-092963	Pelodiscus sinensis	83.88	0.00e+00	1259.00
IUUC-Pfo-096562	Poecilia formosa	73.84	0.00e+00	1106.00
IUUC-Pab-098680	Pongo abelii	90.66	0.00e+00	1367.00
IUUC-Pca-100986	Procavia capensis	73.50	0.00e+00	887.00
IUUC-Pva-102219	Pteropus vampyrus	76.11	0.00e+00	1051.00
IUUC-Pgr-103315	Puccinia graminis	37.58	6.00e-100	358.00
IUUC-Ptt-103736	Puccinia triticina	42.13	4.00e-97	349.00
IUUC-Sce-106306	Saccharomyces cerevisiae	34.84	2.00e-71	264.00
IUUC-Sha-106819	Sarcophilus harrisii	88.08	0.00e+00	1337.00
IUUC-Spo-108271	Schizosaccharomyces pombe	34.11	1.00e-87	318.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	34.55	5.00e-89	323.00
IUUC-Sar-113134	Sorex araneus	82.47	0.00e+00	1194.00
IUUC-Ssc-115441	Sus scrofa	92.05	0.00e+00	1357.00
IUUC-Tgu-117166	Taeniopygia guttata	81.60	0.00e+00	1231.00
IUUC-Tsy-118898	Tarsius syrichta	79.40	0.00e+00	1108.00
IUUC-Tre-122108	Trichoderma reesei	39.60	3.00e-94	340.00
IUUC-Tvi-122644	Trichoderma virens	39.72	2.00e-99	357.00
IUUC-Tme-127004	Tuber melanosporum	36.92	9.00e-106	379.00
IUUC-Tbe-127292	Tupaia belangeri	75.34	0.00e+00	1055.00
IUUC-Ttr-128352	Tursiops truncatus	88.90	0.00e+00	1310.00
IUUC-Vda-129969	Verticillium dahliae	41.10	6.00e-97	349.00
IUUC-Vpa-130218	Vicugna pacos	89.42	0.00e+00	976.00
IUUC-Xtr-132594	Xenopus tropicalis	75.36	0.00e+00	1142.00
IUUC-Xma-134157	Xiphophorus maculatus	73.92	0.00e+00	1035.00
IUUC-Yli-134470	Yarrowia lipolytica	35.35	4.00e-80	293.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence