iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048470

Ensembl Protein ID

ENSSTOP00000022456.1

UniProt Accession

I3NDK9; I3NDK9_ICTTR

Genbank Protein ID

ENSSTOP00000022456

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01087979

Gene Name

ZNRF3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000021823.1	ENSSTOT00000029408.1	ENSSTOP00000022456.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	9.30e-06	26.1	193	234

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCle +   ++++v pC H fh++C+  w        ++ +CP Cr
   Q: 193  CAICLEKYidGEELRVIPCTHRFHRKCVDPW------LLQHHTCPHCR 234
           ********66334******************......9999******8 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MHPLGLCNNN DEEDLYEYGW VGVVKLEQPE LDPKPCLTVL GKAKRAVQRG ATAVIFDVSE 60
NPEAIDQLNQ GSEDPLKRPV VYVKGADALK LMNIVNKQKV ARARIQHRPP RQPTEYFDMG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGCACCCA CTGGGCCTGT GTAATAACAA TGATGAAGAG GACTTGTACG AGTATGGCTG 60
GGTAGGAGTG GTGAAGCTGG AACAGCCAGA ATTGGACCCC AAACCATGCC TCACTGTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:2000051--P:negative regulation of non-canonical Wnt signaling pathway
GO:0072089--P:stem cell proliferation
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0038018--P:Wnt receptor catabolic process
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001916	Ailuropoda melanoleuca	84.17	0.00e+00	1172.00
IUUC-Apl-004188	Anas platyrhynchos	71.72	0.00e+00	1014.00
IUUC-Aly-005850	Arabidopsis lyrata	42.68	4.00e-15	73.60
IUUC-Ath-007372	Arabidopsis thaliana	42.68	1.00e-14	71.60
IUUC-Ame-011764	Astyanax mexicanus	61.55	0.00e+00	729.00
IUUC-Bta-012478	Bos taurus	63.22	0.00e+00	648.00
IUUC-Bol-016217	Brassica oleracea	56.25	3.00e-14	70.50
IUUC-Bra-017407	Brassica rapa	56.25	3.00e-14	70.90
IUUC-Cja-019504	Callithrix jacchus	88.96	0.00e+00	1320.00
IUUC-Cfa-020048	Canis familiaris	87.17	0.00e+00	1273.00
IUUC-Cpo-021725	Cavia porcellus	83.17	0.00e+00	1214.00
IUUC-Csa-023586	Chlorocebus sabaeus	88.54	0.00e+00	1254.00
IUUC-Cho-024867	Choloepus hoffmanni	92.23	0.00e+00	690.00
IUUC-Cin-025569	Ciona intestinalis	47.11	1.00e-55	211.00
IUUC-Csv-025869	Ciona savignyi	44.53	3.00e-49	189.00
IUUC-Dre-027553	Danio rerio	61.94	0.00e+00	783.00
IUUC-Dno-029370	Dasypus novemcinctus	82.73	0.00e+00	1157.00
IUUC-Dor-030816	Dipodomys ordii	81.29	0.00e+00	1149.00
IUUC-Ete-033060	Echinops telfairi	74.30	0.00e+00	838.00
IUUC-Eca-034044	Equus caballus	87.91	0.00e+00	1291.00
IUUC-Eeu-034591	Erinaceus europaeus	65.59	2.00e-134	472.00
IUUC-Fca-036000	Felis catus	87.91	0.00e+00	1280.00
IUUC-Fal-037147	Ficedula albicollis	71.12	0.00e+00	1017.00
IUUC-Gmo-039099	Gadus morhua	49.07	6.00e-118	417.00
IUUC-Gga-041243	Gallus gallus	67.92	0.00e+00	792.00
IUUC-Gac-041340	Gasterosteus aculeatus	47.80	7.00e-113	400.00
IUUC-Gma-044387	Glycine max	48.28	4.00e-15	73.90
IUUC-Ggo-044953	Gorilla gorilla	88.86	0.00e+00	1293.00
IUUC-Hsa-046484	Homo sapiens	89.57	0.00e+00	1306.00
IUUC-Lch-050004	Latimeria chalumnae	58.77	0.00e+00	667.00
IUUC-Loc-051830	Lepisosteus oculatus	64.21	0.00e+00	788.00
IUUC-Laf-053975	Loxodonta africana	89.05	0.00e+00	1009.00
IUUC-Mcc-055302	Macaca mulatta	87.80	0.00e+00	1239.00
IUUC-Meu-056263	Macropus eugenii	77.05	0.00e+00	788.00
IUUC-Mtr-058744	Medicago truncatula	54.17	2.00e-13	68.60
IUUC-Mga-059706	Meleagris gallopavo	71.84	0.00e+00	1030.00
IUUC-Mmr-061372	Microcebus murinus	86.80	0.00e+00	1209.00
IUUC-Mdo-062651	Monodelphis domestica	74.88	0.00e+00	790.00
IUUC-Mmu-064339	Mus musculus	84.72	0.00e+00	1232.00
IUUC-Mac-064877	Musa acuminata	56.60	5.00e-13	68.20
IUUC-Mpu-066211	Mustela putorius furo	82.69	0.00e+00	1197.00
IUUC-Mlu-067058	Myotis lucifugus	86.13	0.00e+00	1182.00
IUUC-Nle-069886	Nomascus leucogenys	88.71	0.00e+00	1274.00
IUUC-Opr-070218	Ochotona princeps	80.38	0.00e+00	1069.00
IUUC-Ont-072483	Oreochromis niloticus	59.87	0.00e+00	760.00
IUUC-Oan-073718	Ornithorhynchus anatinus	70.64	0.00e+00	905.00
IUUC-Ocu-073847	Oryctolagus cuniculus	79.35	0.00e+00	1034.00
IUUC-Opu-083306	Oryza punctata	67.44	5.00e-13	67.40
IUUC-Ola-087358	Oryzias latipes	61.69	0.00e+00	761.00
IUUC-Oga-088362	Otolemur garnettii	86.68	0.00e+00	1295.00
IUUC-Oar-090197	Ovis aries	98.98	1.00e-96	347.00
IUUC-Ptr-091350	Pan troglodytes	89.20	0.00e+00	1304.00
IUUC-Pan-091700	Papio anubis	87.68	0.00e+00	1232.00
IUUC-Psi-093301	Pelodiscus sinensis	71.04	0.00e+00	961.00
IUUC-Pfo-096917	Poecilia formosa	62.68	0.00e+00	754.00
IUUC-Pab-097932	Pongo abelii	88.14	0.00e+00	1317.00
IUUC-Pop-099512	Populus trichocarpa	50.00	1.00e-14	72.00
IUUC-Pca-101054	Procavia capensis	91.88	0.00e+00	955.00
IUUC-Pva-102879	Pteropus vampyrus	87.79	0.00e+00	1267.00
IUUC-Sha-106507	Sarcophilus harrisii	54.10	4.00e-164	571.00
IUUC-Sit-110656	Setaria italica	67.44	5.00e-13	67.40
IUUC-Stu-112289	Solanum tuberosum	40.26	1.00e-13	69.30
IUUC-Sar-113182	Sorex araneus	87.11	2.00e-110	393.00
IUUC-Ssc-115966	Sus scrofa	79.69	0.00e+00	1058.00
IUUC-Tgu-116864	Taeniopygia guttata	64.94	0.00e+00	653.00
IUUC-Tru-118502	Takifugu rubripes	60.10	0.00e+00	725.00
IUUC-Tsy-119210	Tarsius syrichta	86.26	0.00e+00	1217.00
IUUC-Tni-120344	Tetraodon nigroviridis	50.34	8.00e-121	427.00
IUUC-Tca-120966	Theobroma cacao	46.88	7.00e-13	68.20
IUUC-Tbe-127735	Tupaia belangeri	86.59	2.00e-137	482.00
IUUC-Ttr-128714	Tursiops truncatus	75.72	0.00e+00	977.00
IUUC-Vvi-131280	Vitis vinifera	31.50	2.00e-13	69.70
IUUC-Xtr-132280	Xenopus tropicalis	58.23	0.00e+00	688.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence