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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046286
Ensembl Protein ID ENSP00000360798.3
UniProt Accession P42566; B2R8J7; D3DPJ2; Q5SRH4; EPS15_HUMAN
Genbank Protein ID AAA52101.1; CAA82305.1; BAG36194.1; ABD34786.1; CAI13030.1; CAI13030.1; EAX06823.1
Protein Name Epidermal growth factor receptor substrate 15; Protein AF-1p
Genbank Nucleotide ID U07707; Z29064; AK313396; DQ367924; BX647676; AC104170; CH471059
Gene Name EPS15; AF1P
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000085832.16 ENST00000371730.6 ENSP00000360795.2
ENSG00000085832.16 ENST00000371733.7 ENSP00000360798.3
ENSG00000085832.16 ENST00000465467.1 ENSP00000474739.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 16159959; 24768539
UBD/Alpha-Helix/DUIM DUIM 16462748
Classification
Family E-value Score Start End
UBD/Alpha-Helix/DUIM 0.37 12.7 877 893
UBD/Alpha-Helix/UIM 0.021 7.3 851 870
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/DUIM
   S: 1    dEdeeLqlAlalSlqEe 17
           +E+e+L+lA+alS++E 
   Q: 877  QEQEDLELAIALSKSEI 893
           699************96 PP
   

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEeees 20
           +E++++++A ++S  Eee++
   Q: 851  SEEDMIEWAKRESEREEEQR 870
           79****************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
 Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Protein Sequence
(Fasta)
MAAAAQLSLT QLSSGNPVYE KYYRQVDTGN TGRVLASDAA AFLKKSGLPD LILGKIWDLA 60
DTDGKGILNK QEFFVALRLV ACAQNGLEVS LSSLNLAVPP PRFHDTSSPL LISGTSAAEL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046286|UBD,UIM;UBD,DUIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCCCGGCCT CGCCTGCGGC CGCTCCCTCC GCCTCCTCCC CGCCCCGAGC CCCAGTCAGC 60
CCGTCTTCCT TCCCCTCCCT TGCATGATGG AAACACCATG GCTGCGGCGG CCCAGCTCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046286|UBD,UIM;UBD,DUIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0106--Calcium
KW-1003--Cell membrane
KW-0160--Chromosomal rearrangement
KW-0168--Coated pit
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0967--Endosome
KW-0945--Host-virus interaction
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0729--SH3-binding
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR000261--EH_dom
IPR003903--UIM_dom
PROSITE

PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50031--EH
PS50330--UIM
Pfam

PF12763--EF-hand_4
SMART

SM00054--EFh
SM00027--EH
SM00726--UIM
Gene Ontology

GO:0016235--C:aggresome
GO:0030122--C:AP-2 adaptor complex
GO:0016324--C:apical plasma membrane
GO:0009925--C:basal plasma membrane
GO:0060170--C:ciliary membrane
GO:0005905--C:clathrin-coated pit
GO:0005829--C:cytosol
GO:0031901--C:early endosome membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0045296--F:cadherin binding
GO:0005509--F:calcium ion binding
GO:0031593--F:polyubiquitin binding
GO:0008283--P:cell proliferation
GO:0048268--P:clathrin coat assembly
GO:0032456--P:endocytic recycling
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0006895--P:Golgi to endosome transport
GO:0061024--P:membrane organization
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0001921--P:positive regulation of receptor recycling
GO:0015031--P:protein transport
GO:0019065--P:receptor-mediated endocytosis of virus by host cell
GO:0042127--P:regulation of cell proliferation
GO:0016050--P:vesicle organization
GO:0046718--P:viral entry into host cell
KEGG hsa:2060
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001596 Ailuropoda melanoleuca 92.51 0.00e+00 1419.00
IUUC-Apl-003288 Anas platyrhynchos 75.25 0.00e+00 1099.00
IUUC-Aca-005333 Anolis carolinensis 70.82 0.00e+00 1102.00
IUUC-Ago-007867 Ashbya gossypii 27.38 4.00e-31 130.00
IUUC-Bta-013028 Bos taurus 91.63 0.00e+00 1464.00
IUUC-Bol-015187 Brassica oleracea 38.04 8.00e-14 72.40
IUUC-Bra-017706 Brassica rapa 38.04 3.00e-13 71.20
IUUC-Cja-019821 Callithrix jacchus 95.32 0.00e+00 1614.00
IUUC-Cfa-021233 Canis familiaris 92.13 0.00e+00 1143.00
IUUC-Cpo-022339 Cavia porcellus 90.21 0.00e+00 1469.00
IUUC-Csa-024072 Chlorocebus sabaeus 97.73 0.00e+00 1528.00
IUUC-Cho-025000 Choloepus hoffmanni 74.44 0.00e+00 1129.00
IUUC-Dre-027504 Danio rerio 61.29 6.00e-172 598.00
IUUC-Dno-029498 Dasypus novemcinctus 87.09 0.00e+00 1392.00
IUUC-Dor-030630 Dipodomys ordii 88.63 0.00e+00 1418.00
IUUC-Ete-032737 Echinops telfairi 75.47 0.00e+00 1115.00
IUUC-Eca-033328 Equus caballus 93.47 0.00e+00 1462.00
IUUC-Eeu-035267 Erinaceus europaeus 82.60 0.00e+00 926.00
IUUC-Fca-035511 Felis catus 93.46 0.00e+00 1491.00
IUUC-Fal-036796 Ficedula albicollis 73.38 0.00e+00 1092.00
IUUC-Gmo-038971 Gadus morhua 59.79 1.00e-168 587.00
IUUC-Gga-040315 Gallus gallus 73.31 0.00e+00 1130.00
IUUC-Gac-042011 Gasterosteus aculeatus 52.84 0.00e+00 707.00
IUUC-Ggo-045493 Gorilla gorilla 93.16 0.00e+00 1505.00
IUUC-Loc-052749 Lepisosteus oculatus 52.74 1.00e-162 566.00
IUUC-Laf-054158 Loxodonta africana 90.46 0.00e+00 1434.00
IUUC-Mcc-055325 Macaca mulatta 98.19 0.00e+00 1579.00
IUUC-Mtr-058311 Medicago truncatula 34.09 1.00e-14 75.90
IUUC-Mga-060058 Meleagris gallopavo 72.45 0.00e+00 1155.00
IUUC-Mmr-061060 Microcebus murinus 94.36 0.00e+00 1506.00
IUUC-Mmu-064091 Mus musculus 88.93 0.00e+00 1270.00
IUUC-Mpu-065932 Mustela putorius furo 92.45 0.00e+00 1456.00
IUUC-Mlu-067488 Myotis lucifugus 90.47 0.00e+00 1453.00
IUUC-Nle-068996 Nomascus leucogenys 99.09 0.00e+00 1587.00
IUUC-Opr-070750 Ochotona princeps 82.84 4.00e-139 489.00
IUUC-Ont-071424 Oreochromis niloticus 65.76 2.00e-159 556.00
IUUC-Oan-073457 Ornithorhynchus anatinus 66.84 0.00e+00 745.00
IUUC-Ocu-074535 Oryctolagus cuniculus 93.91 0.00e+00 1475.00
IUUC-Oba-075548 Oryza barthii 30.56 2.00e-13 71.60
IUUC-Ogl-077317 Oryza glaberrima 30.56 2.00e-13 71.60
IUUC-Ogu-078266 Oryza glumaepatula 30.56 2.00e-13 71.60
IUUC-Oin-079539 Oryza indica 30.56 2.00e-13 71.60
IUUC-Ome-081550 Oryza meridionalis 30.56 2.00e-13 72.00
IUUC-Oni-082418 Oryza nivara 30.56 2.00e-13 71.60
IUUC-Opu-084149 Oryza punctata 39.73 6.00e-13 70.50
IUUC-Oru-084223 Oryza rufipogon 35.64 3.00e-13 71.20
IUUC-Osa-085387 Oryza sativa 35.64 3.00e-13 71.20
IUUC-Ola-087107 Oryzias latipes 49.64 0.00e+00 640.00
IUUC-Oga-088532 Otolemur garnettii 90.32 0.00e+00 1457.00
IUUC-Oar-089833 Ovis aries 91.50 0.00e+00 1487.00
IUUC-Ptr-090733 Pan troglodytes 99.55 0.00e+00 1618.00
IUUC-Pan-092491 Papio anubis 93.43 0.00e+00 1445.00
IUUC-Psi-094063 Pelodiscus sinensis 75.67 0.00e+00 1166.00
IUUC-Pma-094451 Petromyzon marinus 56.05 9.00e-101 360.00
IUUC-Ppa-095176 Physcomitrella patens 35.79 3.00e-14 74.70
IUUC-Pab-098749 Pongo abelii 99.00 0.00e+00 1613.00
IUUC-Pop-099501 Populus trichocarpa 32.74 9.00e-13 69.30
IUUC-Pca-100378 Procavia capensis 77.14 0.00e+00 888.00
IUUC-Ppe-102036 Prunus persica 35.16 1.00e-12 69.30
IUUC-Pva-102739 Pteropus vampyrus 93.16 0.00e+00 1324.00
IUUC-Rno-105042 Rattus norvegicus 87.90 0.00e+00 1368.00
IUUC-Sce-106303 Saccharomyces cerevisiae 28.32 8.00e-35 143.00
IUUC-Spo-108370 Schizosaccharomyces pombe 27.11 1.00e-33 139.00
IUUC-Smo-109013 Selaginella moellendorffii 41.30 3.00e-16 76.30
IUUC-Sit-110002 Setaria italica 23.19 2.00e-13 72.40
IUUC-Sly-111403 Solanum lycopersicum 32.52 5.00e-12 67.40
IUUC-Stu-112258 Solanum tuberosum 35.80 6.00e-10 59.30
IUUC-Sar-113358 Sorex araneus 74.67 0.00e+00 962.00
IUUC-Ssc-115746 Sus scrofa 90.97 0.00e+00 1437.00
IUUC-Tgu-117351 Taeniopygia guttata 73.28 0.00e+00 1092.00
IUUC-Tru-117870 Takifugu rubripes 56.47 0.00e+00 731.00
IUUC-Tsy-118873 Tarsius syrichta 84.26 0.00e+00 939.00
IUUC-Tni-120351 Tetraodon nigroviridis 57.08 0.00e+00 735.00
IUUC-Tca-121631 Theobroma cacao 45.45 2.00e-12 68.60
IUUC-Tbe-127307 Tupaia belangeri 91.00 0.00e+00 1384.00
IUUC-Ttr-128775 Tursiops truncatus 89.34 0.00e+00 1353.00
IUUC-Vpa-130684 Vicugna pacos 86.87 0.00e+00 1397.00
IUUC-Xtr-132716 Xenopus tropicalis 58.87 0.00e+00 939.00
IUUC-Xma-133907 Xiphophorus maculatus 52.94 0.00e+00 670.00
IUUC-Yli-134577 Yarrowia lipolytica 28.70 3.00e-38 154.00
Created Date 25-Jun-2017

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