iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059362

UUCD1 version

UUC-MeG-00286

Ensembl Protein ID

ENSMGAP00000005847.2

UniProt Accession

G1N2I2; G1N2I2_MELGA

Protein Name

Uncharacterized protein

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000005780.2	ENSMGAT00000006591.2	ENSMGAP00000005847.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.80e-134	446.2	634	963

Active Site

Position(s)	Description	Evidence
933	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld+++
   Q: 634  FLKARLWIEFDGEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAFF 722
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d   ++ldl+f v+ee++g+t+++eLk+gG++i Vtn+Nk++Y++lv+++r
   Q: 723  IRPFYKMMLQKPITLHDMESVDSEYYNSLRWILEN---DP--AELDLRFIVDEELFGQTHQHELKSGGSEIVVTNKNKRDYIHLVIQWR 806
           *********************************99...44..558******************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + +++++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv d+k +tkyk+gy+ ++++iqwFw+++ +++se+r ++LqFvTg
   Q: 807  FVSRVQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVADWKLHTKYKNGYSVNHQVIQWFWKAVLMMDSEKRIRLLQFVTG 895
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p+lf++++++++++lP+++TCfn+L+LP+Y+s e l +kLl+Aie+t+gF+
   Q: 896  TSRVPMNGFAELYgsngPQLFTVEQWGTPEKLPRAHTCFNRLDLPPYDSFEDLWDKLLLAIENTQGFD 963
           *******************************************************************8 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

KEGCWEQLYY NADNAWKEES TRIVRVKVIA GIGLAKKDIL GASDPYVKVT VYDPVNGVLS 60
SVQTKTIRKS LNPKWNEELL FRVNPQKHRL LFEVFDENRL TRDDFLGQVD IPLYQLPTEH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGAGGGCT GCTGGGAACA GCTATATGTG AGATTAGCCA TCATGTTCTG TAGCAGTAAG 60
CACCCTAACT CAGCAGAATT CTACTTGAGA ATGCTGAGAA CCCAGATAAA TTAATAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	75.89	0.00e+00	1303.00
IUUC-Apl-003886	Anas platyrhynchos	90.23	0.00e+00	1618.00
IUUC-Aca-004744	Anolis carolinensis	62.25	0.00e+00	1092.00
IUUC-Acl-008273	Aspergillus clavatus	48.74	4.00e-157	548.00
IUUC-Afl-008713	Aspergillus flavus	48.24	2.00e-154	539.00
IUUC-Afu-009103	Aspergillus fumigatus	48.58	4.00e-158	551.00
IUUC-Ani-009259	Aspergillus nidulans	48.91	2.00e-155	542.00
IUUC-Aor-010053	Aspergillus oryzae	56.71	6.00e-98	350.00
IUUC-Ate-010529	Aspergillus terreus	48.57	3.00e-157	548.00
IUUC-Ame-011138	Astyanax mexicanus	84.34	0.00e+00	846.00
IUUC-Bgr-012148	Blumeria graminis	46.80	1.00e-151	530.00
IUUC-Bta-012453	Bos taurus	74.68	0.00e+00	1253.00
IUUC-Bci-013785	Botrytis cinerea	46.08	4.00e-153	535.00
IUUC-Cel-018564	Caenorhabditis elegans	52.99	0.00e+00	626.00
IUUC-Cja-019034	Callithrix jacchus	75.09	0.00e+00	1190.00
IUUC-Cfa-020258	Canis familiaris	76.47	0.00e+00	1284.00
IUUC-Cpo-021648	Cavia porcellus	74.18	0.00e+00	1391.00
IUUC-Csa-023334	Chlorocebus sabaeus	77.26	0.00e+00	1420.00
IUUC-Cho-024832	Choloepus hoffmanni	83.52	0.00e+00	628.00
IUUC-Cin-025157	Ciona intestinalis	50.45	0.00e+00	867.00
IUUC-Csv-026098	Ciona savignyi	61.09	0.00e+00	670.00
IUUC-Dno-029466	Dasypus novemcinctus	63.25	0.00e+00	1151.00
IUUC-Dor-030138	Dipodomys ordii	59.77	0.00e+00	1043.00
IUUC-Dme-032166	Drosophila melanogaster	67.35	0.00e+00	713.00
IUUC-Ete-032409	Echinops telfairi	69.81	0.00e+00	1036.00
IUUC-Eca-033441	Equus caballus	76.84	0.00e+00	1398.00
IUUC-Fca-036384	Felis catus	76.75	0.00e+00	1309.00
IUUC-Fal-037547	Ficedula albicollis	87.34	0.00e+00	1570.00
IUUC-Fox-037774	Fusarium oxysporum	47.66	6.00e-155	540.00
IUUC-Gmo-039674	Gadus morhua	62.20	0.00e+00	1098.00
IUUC-Gga-040524	Gallus gallus	92.84	0.00e+00	1640.00
IUUC-Gac-042607	Gasterosteus aculeatus	64.75	0.00e+00	1190.00
IUUC-Ggo-045332	Gorilla gorilla	62.81	0.00e+00	1110.00
IUUC-Hsa-046479	Homo sapiens	76.12	0.00e+00	1295.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	71.25	0.00e+00	907.00
IUUC-Lch-050445	Latimeria chalumnae	67.16	0.00e+00	1144.00
IUUC-Loc-052645	Lepisosteus oculatus	69.14	0.00e+00	1291.00
IUUC-Laf-053638	Loxodonta africana	72.76	0.00e+00	1218.00
IUUC-Mcc-055585	Macaca mulatta	76.36	0.00e+00	1288.00
IUUC-Meu-056897	Macropus eugenii	93.03	6.00e-166	577.00
IUUC-Mvi-060395	Microbotryum violaceum	53.72	3.00e-148	518.00
IUUC-Mmr-061061	Microcebus murinus	76.93	0.00e+00	1345.00
IUUC-Mdo-062173	Monodelphis domestica	62.30	0.00e+00	1137.00
IUUC-Mmu-063318	Mus musculus	87.16	0.00e+00	895.00
IUUC-Mpu-066567	Mustela putorius furo	77.65	0.00e+00	1454.00
IUUC-Mlu-068148	Myotis lucifugus	76.47	0.00e+00	1303.00
IUUC-Nfi-068427	Neosartorya fischeri	48.82	5.00e-158	551.00
IUUC-Ncr-068918	Neurospora crassa	47.55	3.00e-154	538.00
IUUC-Nle-069225	Nomascus leucogenys	75.55	0.00e+00	1288.00
IUUC-Opr-071044	Ochotona princeps	71.27	0.00e+00	871.00
IUUC-Ont-071664	Oreochromis niloticus	68.31	0.00e+00	1193.00
IUUC-Oan-073019	Ornithorhynchus anatinus	78.38	0.00e+00	1376.00
IUUC-Ocu-074409	Oryctolagus cuniculus	75.32	0.00e+00	1293.00
IUUC-Ola-087467	Oryzias latipes	63.45	0.00e+00	1128.00
IUUC-Oga-088241	Otolemur garnettii	68.85	0.00e+00	1135.00
IUUC-Oar-089797	Ovis aries	76.45	0.00e+00	1373.00
IUUC-Ptr-091629	Pan troglodytes	75.60	0.00e+00	1184.00
IUUC-Pan-092284	Papio anubis	63.38	0.00e+00	1150.00
IUUC-Psi-093618	Pelodiscus sinensis	84.41	0.00e+00	1380.00
IUUC-Pma-094364	Petromyzon marinus	81.29	0.00e+00	814.00
IUUC-Pno-095118	Phaeosphaeria nodorum	43.61	4.00e-161	561.00
IUUC-Pfo-097145	Poecilia formosa	67.05	0.00e+00	1172.00
IUUC-Pab-098394	Pongo abelii	76.50	0.00e+00	1419.00
IUUC-Pca-100568	Procavia capensis	65.74	0.00e+00	1015.00
IUUC-Pva-102354	Pteropus vampyrus	62.58	0.00e+00	1090.00
IUUC-Ptt-103806	Puccinia triticina	52.54	7.00e-119	421.00
IUUC-Pte-104016	Pyrenophora teres	48.98	2.00e-160	559.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	48.98	2.00e-160	559.00
IUUC-Rno-106095	Rattus norvegicus	66.77	0.00e+00	1245.00
IUUC-Sha-107370	Sarcophilus harrisii	72.29	0.00e+00	1241.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	46.48	7.00e-154	537.00
IUUC-Sit-110149	Setaria italica	44.53	3.00e-92	334.00
IUUC-Stu-112582	Solanum tuberosum	34.99	2.00e-51	197.00
IUUC-Sbi-113794	Sorghum bicolor	44.00	5.00e-92	334.00
IUUC-Sre-114929	Sporisorium reilianum	48.47	2.00e-156	546.00
IUUC-Ssc-115950	Sus scrofa	56.12	0.00e+00	895.00
IUUC-Tgu-117474	Taeniopygia guttata	87.47	0.00e+00	1581.00
IUUC-Tru-117675	Takifugu rubripes	64.57	0.00e+00	1172.00
IUUC-Tni-119993	Tetraodon nigroviridis	64.72	0.00e+00	1149.00
IUUC-Tre-122203	Trichoderma reesei	47.55	1.00e-154	539.00
IUUC-Tvi-122595	Trichoderma virens	46.97	7.00e-154	537.00
IUUC-Tbe-127408	Tupaia belangeri	70.67	0.00e+00	1001.00
IUUC-Ttr-128437	Tursiops truncatus	68.59	0.00e+00	1016.00
IUUC-Uma-129332	Ustilago maydis	48.31	3.00e-148	518.00
IUUC-Vpa-130503	Vicugna pacos	80.16	0.00e+00	995.00
IUUC-Xtr-132431	Xenopus tropicalis	72.37	0.00e+00	1362.00
IUUC-Xma-133797	Xiphophorus maculatus	64.04	0.00e+00	1150.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence