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Tag Content
UUCD2 ID IUUC-Ocu-074160
UUCD1 version UUC-OrC-00531
Ensembl Protein ID ENSOCUP00000012456.2
UniProt Accession G1T7I0; G1T7I0_RABIT
Genbank Protein ID ENSOCUP00000012456
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAGW02050536
Gene Name NEDD4L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOCUG00000014471.2 ENSOCUT00000014484.2 ENSOCUP00000012456.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 3.20e-135 450.9 607 938
Active Site
Position(s) Description Evidence
908 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 607  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 695
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 696  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 779
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 780  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 868
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 869  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 938
           *********************************************************************8 PP
   
Organism Oryctolagus cuniculus
Protein Sequence
(Fasta)
QGESRILRVK VVSGIDLAKK DIFGASDPYV KLSLYVADEN RELALVQTKT IKKTLNPKWN 60
EEFYFRVNPS NHRLLFEVFD ENRLTRDDFL GQVDVPLSHL PTEDPTMERP YTFKDFLLRP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ocu-074160|E3,HECT|Oryctolagus cuniculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGGGAGAGT CCCGTATCCT CAGAGTCAAA GTCGTTTCTG GAATCGATCT CGCCAAAAAG 60
GACATCTTCG GAGCCAGGTA CACGCGCTTG TTTTCTCTGG GTTTCTGAAG AGCGTAGCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ocu-074160|E3,HECT|Oryctolagus cuniculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
PRINTS

PR00360--C2DOMAIN
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001314 Ailuropoda melanoleuca 97.29 0.00e+00 1702.00
IUUC-Apl-003893 Anas platyrhynchos 91.94 0.00e+00 1658.00
IUUC-Aca-004744 Anolis carolinensis 88.74 0.00e+00 1613.00
IUUC-Acl-008273 Aspergillus clavatus 49.17 4.00e-164 571.00
IUUC-Afl-008713 Aspergillus flavus 48.76 3.00e-161 562.00
IUUC-Afu-009103 Aspergillus fumigatus 49.25 2.00e-163 569.00
IUUC-Ani-009259 Aspergillus nidulans 48.37 3.00e-162 565.00
IUUC-Ang-009738 Aspergillus niger 49.25 2.00e-162 566.00
IUUC-Aor-010053 Aspergillus oryzae 58.05 2.00e-101 362.00
IUUC-Ate-010529 Aspergillus terreus 49.34 1.00e-164 573.00
IUUC-Ame-010810 Astyanax mexicanus 86.91 0.00e+00 1030.00
IUUC-Bgr-012148 Blumeria graminis 47.91 4.00e-155 541.00
IUUC-Bta-012679 Bos taurus 95.45 0.00e+00 1578.00
IUUC-Cel-018564 Caenorhabditis elegans 52.61 0.00e+00 634.00
IUUC-Cja-018732 Callithrix jacchus 95.74 0.00e+00 1785.00
IUUC-Cfa-021226 Canis familiaris 95.42 0.00e+00 1746.00
IUUC-Cpo-021671 Cavia porcellus 98.09 0.00e+00 1761.00
IUUC-Csa-023344 Chlorocebus sabaeus 93.97 0.00e+00 1763.00
IUUC-Cho-024832 Choloepus hoffmanni 100.00 0.00e+00 743.00
IUUC-Csv-026098 Ciona savignyi 59.19 0.00e+00 655.00
IUUC-Cgl-026642 Colletotrichum gloeosporioides 47.33 2.00e-155 543.00
IUUC-Cne-026849 Cryptococcus neoformans 48.66 7.00e-159 554.00
IUUC-Dre-027770 Danio rerio 77.60 0.00e+00 1410.00
IUUC-Dno-029466 Dasypus novemcinctus 95.63 0.00e+00 1781.00
IUUC-Dor-030138 Dipodomys ordii 94.86 0.00e+00 1647.00
IUUC-Dse-031241 Dothistroma septosporum 47.78 6.00e-160 557.00
IUUC-Dme-032166 Drosophila melanogaster 67.09 0.00e+00 712.00
IUUC-Ete-033145 Echinops telfairi 91.08 0.00e+00 1293.00
IUUC-Eca-033445 Equus caballus 95.55 0.00e+00 1566.00
IUUC-Eeu-035247 Erinaceus europaeus 90.31 0.00e+00 1504.00
IUUC-Fca-035489 Felis catus 91.86 0.00e+00 1511.00
IUUC-Fal-037604 Ficedula albicollis 90.08 0.00e+00 1670.00
IUUC-Fox-037774 Fusarium oxysporum 48.51 3.00e-158 551.00
IUUC-Gmo-039674 Gadus morhua 76.06 0.00e+00 1358.00
IUUC-Ggr-040107 Gaeumannomyces graminis 47.17 4.00e-156 545.00
IUUC-Gga-040703 Gallus gallus 91.45 0.00e+00 1692.00
IUUC-Gac-042020 Gasterosteus aculeatus 77.53 0.00e+00 1390.00
IUUC-Ggo-045332 Gorilla gorilla 97.93 0.00e+00 1738.00
IUUC-Hsa-045968 Homo sapiens 95.94 0.00e+00 1777.00
IUUC-Lch-050443 Latimeria chalumnae 84.41 0.00e+00 1424.00
IUUC-Loc-052662 Lepisosteus oculatus 80.00 0.00e+00 1406.00
IUUC-Laf-053850 Loxodonta africana 98.09 0.00e+00 1791.00
IUUC-Mcc-055821 Macaca mulatta 95.72 0.00e+00 1770.00
IUUC-Meu-056712 Macropus eugenii 82.94 0.00e+00 777.00
IUUC-Mor-057097 Magnaporthe oryzae 47.60 7.00e-157 547.00
IUUC-Mla-058996 Melampsora laricipopulina 53.94 1.00e-149 523.00
IUUC-Mmr-060798 Microcebus murinus 92.11 0.00e+00 1654.00
IUUC-Mdo-062173 Monodelphis domestica 92.55 0.00e+00 1744.00
IUUC-Mmu-064136 Mus musculus 94.80 0.00e+00 1743.00
IUUC-Mpu-066765 Mustela putorius furo 95.42 0.00e+00 1751.00
IUUC-Mlu-067565 Myotis lucifugus 92.84 0.00e+00 1546.00
IUUC-Nfi-068427 Neosartorya fischeri 49.17 1.00e-163 570.00
IUUC-Ncr-068918 Neurospora crassa 47.16 4.00e-157 548.00
IUUC-Nle-069070 Nomascus leucogenys 92.20 0.00e+00 1683.00
IUUC-Opr-071044 Ochotona princeps 99.04 0.00e+00 1207.00
IUUC-Ont-072044 Oreochromis niloticus 75.62 0.00e+00 1428.00
IUUC-Oan-073032 Ornithorhynchus anatinus 90.27 0.00e+00 1390.00
IUUC-Ola-087467 Oryzias latipes 76.77 0.00e+00 1415.00
IUUC-Oga-088460 Otolemur garnettii 90.55 0.00e+00 1541.00
IUUC-Oar-090198 Ovis aries 95.53 0.00e+00 1739.00
IUUC-Ptr-090939 Pan troglodytes 95.94 0.00e+00 1777.00
IUUC-Pan-092284 Papio anubis 95.73 0.00e+00 1774.00
IUUC-Psi-093645 Pelodiscus sinensis 91.99 0.00e+00 1692.00
IUUC-Pma-094364 Petromyzon marinus 82.44 0.00e+00 861.00
IUUC-Pfo-096768 Poecilia formosa 72.14 0.00e+00 1220.00
IUUC-Pab-098088 Pongo abelii 96.05 0.00e+00 1777.00
IUUC-Pca-100714 Procavia capensis 76.78 0.00e+00 1319.00
IUUC-Pva-102354 Pteropus vampyrus 97.70 0.00e+00 1697.00
IUUC-Pgr-103620 Puccinia graminis 53.53 6.00e-148 518.00
IUUC-Ptt-103806 Puccinia triticina 53.38 9.00e-123 434.00
IUUC-Pte-104016 Pyrenophora teres 48.84 8.00e-163 567.00
IUUC-Pyt-104550 Pyrenophora triticirepentis 48.84 8.00e-163 567.00
IUUC-Rno-105318 Rattus norvegicus 94.18 0.00e+00 1725.00
IUUC-Sce-106289 Saccharomyces cerevisiae 49.17 6.00e-164 571.00
IUUC-Sha-107482 Sarcophilus harrisii 93.54 0.00e+00 1581.00
IUUC-Ssc-115950 Sus scrofa 69.90 0.00e+00 1168.00
IUUC-Tgu-117130 Taeniopygia guttata 92.30 0.00e+00 1699.00
IUUC-Tru-118610 Takifugu rubripes 78.99 0.00e+00 1439.00
IUUC-Tsy-119492 Tarsius syrichta 93.51 0.00e+00 1650.00
IUUC-Tni-120113 Tetraodon nigroviridis 73.67 0.00e+00 1330.00
IUUC-Tre-122203 Trichoderma reesei 47.37 4.00e-152 531.00
IUUC-Tvi-122595 Trichoderma virens 47.19 2.00e-154 539.00
IUUC-Tbe-127441 Tupaia belangeri 93.23 0.00e+00 794.00
IUUC-Ttr-128235 Tursiops truncatus 91.07 0.00e+00 1556.00
IUUC-Vda-129753 Verticillium dahliae 47.60 1.00e-156 546.00
IUUC-Vpa-130544 Vicugna pacos 78.76 0.00e+00 915.00
IUUC-Xtr-132859 Xenopus tropicalis 88.60 0.00e+00 1622.00
IUUC-Xma-133797 Xiphophorus maculatus 79.57 0.00e+00 1419.00
IUUC-Yli-134668 Yarrowia lipolytica 46.19 6.00e-162 564.00
Created Date 25-Jun-2017

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