iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-097657

Ensembl Protein ID

ENSPPYP00000023558.1

UniProt Accession

H2PXR4; H2PXR4_PONAB

Genbank Protein ID

ENSPPYP00000023558

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01387901

Gene Name

LOC100439484

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000025934.1	ENSPPYT00000029413.1	ENSPPYP00000023558.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-42	146.4	388	696

Active Site

Position(s)	Description	Evidence
666	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + +ev +v E+   g +++G+++efl+ll+++l+n++  lf  + + +++l+ n+++      +++l++ +G++l+++l++g + + ++
   Q: 388  YAIEVAYVIENdnfGSEHPGSKQEFLSLLMQHLENSS--LF--EGSLSKNLSLNSQAL-----KENLYYEAGKMLAISLVHGGPSPGFF 467
           56788898887777***********************..45..677788888888885.....689*********************** PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           sk+++++l+  +   e+++ + +++ ++ + +i  +   ++ ++ +dl++      ++e++++  + g+ +   t ++k++ vk+++ y
   Q: 468  SKTLFNCLVYGP---ENTQPILDDVSDFdVAQIIIRI--NTATTVADLKSI-----INECYNYLELIGCLRLITTLSDKYMLVKDILVY 546
           ***********8...*************988888774..555555788765.....88999**99************************ PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq.. 266
           ++ ++++  +e+f++G++++  le+++++ e  +++l+++ e+++++ l++   ++ ++ +d +a+  Fw+ + +++++ + ++ ++  
   Q: 547  HVIQRVHAPFESFKQGLKTLGVLEKIQAYPEAFCSILCHKPESLSAKILSE--LFTVHTLPDVKAL-GFWNSYlQAVEDGKSTTTMEdi 632
           ***************************************************..888899******8.8998765788777777666666 PP
   S: 267  ..FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
             F+Tg+s++P++Gf++ + ++ +++      ++P  n+C n+L +P  +++++++e++ ++i++t +++
   Q: 633  liFATGCSSIPPAGFKPTP-SIECLHV-----DFPVGNKCNNCLAIPITNTYKEFQENMDFTIRNTLRLG 696
           66****************9.99****9.....********************************987665 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MNESKPGDSQ NLACVFCRKN DDCPNKYGEK KTKEKWNLTV HYYCLLMSSG IWQRGKEEEG 60
VYGFLIEDIR KEVNRASKLK CCVCKKNGAS IGCVAPRCKR SYHFPCGLQR ECIFQFTGNF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATGAAA GTAAACCTGG TGACTCACAG AACCTTGCTT GTGTTTTCTG TCGAAAAAAT 60
GATGACTGTC CTAATAAATA TGGAGAAAAG AAAACTAAGG AGAAATGGAA TCTCACTGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

pon:100439484

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011288	Astyanax mexicanus	40.00	7.00e-162	564.00
IUUC-Cin-025325	Ciona intestinalis	40.88	1.00e-65	243.00
IUUC-Dre-027829	Danio rerio	40.48	5.00e-154	538.00
IUUC-Dme-031692	Drosophila melanogaster	34.83	6.00e-42	165.00
IUUC-Gmo-039715	Gadus morhua	38.73	6.00e-77	281.00
IUUC-Gac-041444	Gasterosteus aculeatus	39.00	2.00e-143	503.00
IUUC-Loc-052839	Lepisosteus oculatus	57.58	1.00e-31	128.00
IUUC-Meu-056753	Macropus eugenii	49.49	1.00e-129	457.00
IUUC-Mdo-063022	Monodelphis domestica	66.47	0.00e+00	913.00
IUUC-Ont-072174	Oreochromis niloticus	37.87	1.00e-139	490.00
IUUC-Pma-094295	Petromyzon marinus	53.97	3.00e-74	271.00
IUUC-Pfo-096351	Poecilia formosa	37.52	3.00e-144	505.00
IUUC-Tru-117690	Takifugu rubripes	38.26	1.00e-153	536.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence