iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	miRNAMap
Protein-protein Interaction
iRefIndex	HINT
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.50e-14	52.9	82	139

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++++++W+++  ++++ +G +P+n+++ ++
   Q: 82   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 139
           68899************************.***********..79999**********997 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MGQQPGKVLG DQRRPSLPAL HFIKGAGKRD SSRHGGPHCN VFVEHEALQR PVASDFEPQG 60
LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS ITKGEKLRVL GYNHNGEWCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATCCATCAT GGCGGCCTCG GGGGTTGGTG TCTATCCCTG AGAGGCGCCG GAGCTGGAAC 60
CGGGTGTCGG GTCCTGCGGC TGAGGAACCC TTCCGCGGCA CACACCACCA CTGGCTGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR033221--ABL1
IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030426--C:growth cone
GO:0005739--C:mitochondrion
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0001726--C:ruffle
GO:0045202--C:synapse
GO:0005524--F:ATP binding
GO:0070097--F:delta-catenin binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004672--F:protein kinase activity
GO:0019901--F:protein kinase binding
GO:0005102--F:receptor binding
GO:0030041--P:actin filament polymerization
GO:0008306--P:associative learning
GO:0030154--P:cell differentiation
GO:0034599--P:cellular response to oxidative stress
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:1903210--P:glomerular visceral epithelial cell apoptotic process
GO:0045087--P:innate immune response
GO:0007611--P:learning or memory
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:1900006--P:positive regulation of dendrite development
GO:1903055--P:positive regulation of extracellular matrix organization
GO:0048146--P:positive regulation of fibroblast proliferation
GO:1901300--P:positive regulation of hydrogen peroxide-mediated programmed cell death
GO:0043525--P:positive regulation of neuron apoptotic process
GO:1901216--P:positive regulation of neuron death
GO:0045907--P:positive regulation of vasoconstriction
GO:0046777--P:protein autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0042493--P:response to drug
GO:0034976--P:response to endoplasmic reticulum stress
GO:0071871--P:response to epinephrine
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

rno:311860

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001550	Ailuropoda melanoleuca	85.69	0.00e+00	1790.00
IUUC-Ame-011903	Astyanax mexicanus	72.81	0.00e+00	1147.00
IUUC-Cja-019491	Callithrix jacchus	86.64	0.00e+00	1866.00
IUUC-Cfa-021256	Canis familiaris	86.28	0.00e+00	1852.00
IUUC-Cpo-022046	Cavia porcellus	86.83	0.00e+00	1577.00
IUUC-Dre-028190	Danio rerio	67.35	0.00e+00	1278.00
IUUC-Dno-029853	Dasypus novemcinctus	85.42	0.00e+00	1813.00
IUUC-Dor-030635	Dipodomys ordii	80.23	0.00e+00	1663.00
IUUC-Dme-032098	Drosophila melanogaster	75.11	0.00e+00	780.00
IUUC-Eeu-035173	Erinaceus europaeus	84.50	0.00e+00	1421.00
IUUC-Fca-035967	Felis catus	85.85	0.00e+00	1792.00
IUUC-Gmo-039550	Gadus morhua	75.79	0.00e+00	1148.00
IUUC-Gac-041643	Gasterosteus aculeatus	66.27	0.00e+00	1333.00
IUUC-Ggo-045299	Gorilla gorilla	86.21	0.00e+00	1880.00
IUUC-Itr-047935	Ictidomys tridecemlineatus	87.26	0.00e+00	1732.00
IUUC-Lch-050530	Latimeria chalumnae	75.32	0.00e+00	1573.00
IUUC-Loc-052430	Lepisosteus oculatus	85.57	0.00e+00	1040.00
IUUC-Laf-053609	Loxodonta africana	85.16	0.00e+00	1774.00
IUUC-Mcc-055654	Macaca mulatta	87.44	0.00e+00	1909.00
IUUC-Meu-056488	Macropus eugenii	75.63	0.00e+00	1576.00
IUUC-Mga-059270	Meleagris gallopavo	79.37	0.00e+00	1616.00
IUUC-Mmr-060593	Microcebus murinus	85.71	0.00e+00	1753.00
IUUC-Mdo-062227	Monodelphis domestica	89.77	0.00e+00	1347.00
IUUC-Mmu-064002	Mus musculus	96.15	0.00e+00	2065.00
IUUC-Mpu-066197	Mustela putorius furo	84.04	0.00e+00	1798.00
IUUC-Nle-069977	Nomascus leucogenys	85.21	0.00e+00	1361.00
IUUC-Ont-072307	Oreochromis niloticus	63.87	0.00e+00	1304.00
IUUC-Ola-087389	Oryzias latipes	68.25	0.00e+00	1129.00
IUUC-Ptr-090800	Pan troglodytes	86.73	0.00e+00	1885.00
IUUC-Pfo-096979	Poecilia formosa	71.30	0.00e+00	1118.00
IUUC-Pca-100874	Procavia capensis	98.68	0.00e+00	771.00
IUUC-Pva-102415	Pteropus vampyrus	85.68	0.00e+00	1791.00
IUUC-Ssc-115472	Sus scrofa	85.14	0.00e+00	1784.00
IUUC-Tgu-117037	Taeniopygia guttata	80.24	0.00e+00	1726.00
IUUC-Tru-118324	Takifugu rubripes	67.53	0.00e+00	1123.00
IUUC-Tsy-119216	Tarsius syrichta	94.91	0.00e+00	1158.00
IUUC-Tni-119950	Tetraodon nigroviridis	59.16	0.00e+00	1117.00
IUUC-Ttr-128209	Tursiops truncatus	86.43	0.00e+00	1872.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence