iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089736

Ensembl Protein ID

ENSOARP00000016840.1

UniProt Accession

W5Q2A2; W5Q2A2_SHEEP

Genbank Protein ID

ENSOARP00000016840

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AMGL01100931

Gene Name

WHSC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000015690.1	ENSOART00000017079.1	ENSOARP00000016840.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.40e-16	59.8	794	834

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl++     +p+ + w+C++Cr
   Q: 794  WCFVCSKGGS----LLCCESCPAAFHPDCLSID----MPDGS-WFCNDCR 834
           8*********....*******************....9***8.******8 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MEFSVRKSPL SAPKVAKCMK MKQAPEVLGS ANGKTPSCDV SRECSVFLSK AQLSAGLQDG 60
VVQKFNGHDA LPFIPAERLK DLTSRVFNGE PGAHDAKLRF ESQEVKGLGT PPHTTPVKNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCCCCCCC CCGGGGCCCC GGGGGCGCGC GCGATGGAGC GGCCGCGGCC GCCCGGCAGG 60
CTCTGCCCCG CTCGCCAGAG GGCAGTTTAA GAAAAATCTC GGCATTGGAG ACACGCGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002181	Ailuropoda melanoleuca	80.79	0.00e+00	1996.00
IUUC-Apl-003677	Anas platyrhynchos	71.27	0.00e+00	1783.00
IUUC-Aca-004278	Anolis carolinensis	72.06	0.00e+00	1219.00
IUUC-Bta-012522	Bos taurus	87.69	0.00e+00	2088.00
IUUC-Cja-018908	Callithrix jacchus	80.08	0.00e+00	1968.00
IUUC-Cfa-020894	Canis familiaris	80.36	0.00e+00	2024.00
IUUC-Cpo-021982	Cavia porcellus	78.63	0.00e+00	1960.00
IUUC-Csa-023807	Chlorocebus sabaeus	80.97	0.00e+00	1990.00
IUUC-Cho-024405	Choloepus hoffmanni	60.64	6.00e-167	581.00
IUUC-Dre-027492	Danio rerio	72.94	0.00e+00	951.00
IUUC-Dno-030020	Dasypus novemcinctus	78.29	0.00e+00	1797.00
IUUC-Dor-031103	Dipodomys ordii	73.79	0.00e+00	1759.00
IUUC-Ete-032488	Echinops telfairi	73.57	0.00e+00	1827.00
IUUC-Eca-034066	Equus caballus	81.20	0.00e+00	2044.00
IUUC-Eeu-035199	Erinaceus europaeus	62.90	0.00e+00	650.00
IUUC-Fca-035434	Felis catus	77.87	0.00e+00	1617.00
IUUC-Fal-037113	Ficedula albicollis	70.66	0.00e+00	1801.00
IUUC-Gmo-039686	Gadus morhua	69.51	0.00e+00	910.00
IUUC-Gga-040273	Gallus gallus	70.15	0.00e+00	1776.00
IUUC-Gac-042123	Gasterosteus aculeatus	48.14	0.00e+00	1097.00
IUUC-Ggo-044643	Gorilla gorilla	80.83	0.00e+00	2003.00
IUUC-Hsa-046380	Homo sapiens	80.97	0.00e+00	1987.00
IUUC-Itr-048658	Ictidomys tridecemlineatus	86.80	0.00e+00	1216.00
IUUC-Lch-050217	Latimeria chalumnae	62.02	0.00e+00	1525.00
IUUC-Lpe-051661	Leersia perrieri	29.21	5.00e-12	67.00
IUUC-Laf-053780	Loxodonta africana	79.12	0.00e+00	1991.00
IUUC-Mcc-054928	Macaca mulatta	80.97	0.00e+00	2009.00
IUUC-Meu-056184	Macropus eugenii	66.55	0.00e+00	699.00
IUUC-Mga-059576	Meleagris gallopavo	70.73	0.00e+00	1775.00
IUUC-Mmr-061045	Microcebus murinus	79.49	0.00e+00	1981.00
IUUC-Mdo-062576	Monodelphis domestica	73.81	0.00e+00	1847.00
IUUC-Mmu-063640	Mus musculus	79.11	0.00e+00	1961.00
IUUC-Mac-065303	Musa acuminata	29.22	6.00e-11	62.80
IUUC-Mpu-066512	Mustela putorius furo	80.82	0.00e+00	1983.00
IUUC-Mlu-067280	Myotis lucifugus	76.21	0.00e+00	925.00
IUUC-Nle-069896	Nomascus leucogenys	80.87	0.00e+00	2008.00
IUUC-Ont-072197	Oreochromis niloticus	73.31	0.00e+00	924.00
IUUC-Oan-072724	Ornithorhynchus anatinus	69.79	0.00e+00	1177.00
IUUC-Ocu-074758	Oryctolagus cuniculus	77.86	0.00e+00	1896.00
IUUC-Olo-080702	Oryza longistaminata	42.66	1.00e-44	174.00
IUUC-Opu-083371	Oryza punctata	41.88	2.00e-46	181.00
IUUC-Oga-088702	Otolemur garnettii	78.49	0.00e+00	1794.00
IUUC-Ptr-091055	Pan troglodytes	80.97	0.00e+00	1984.00
IUUC-Pan-092752	Papio anubis	88.46	0.00e+00	1217.00
IUUC-Psi-093620	Pelodiscus sinensis	72.34	0.00e+00	1808.00
IUUC-Pfo-097464	Poecilia formosa	49.96	0.00e+00	1096.00
IUUC-Pab-098051	Pongo abelii	80.89	0.00e+00	2001.00
IUUC-Pop-099927	Populus trichocarpa	30.46	1.00e-12	68.60
IUUC-Pca-100273	Procavia capensis	79.26	0.00e+00	1945.00
IUUC-Pva-102473	Pteropus vampyrus	74.94	0.00e+00	1792.00
IUUC-Rno-105056	Rattus norvegicus	79.26	0.00e+00	1961.00
IUUC-Sha-107494	Sarcophilus harrisii	74.71	0.00e+00	1836.00
IUUC-Sar-113310	Sorex araneus	80.02	0.00e+00	1624.00
IUUC-Ssc-116344	Sus scrofa	80.60	0.00e+00	1952.00
IUUC-Tgu-116786	Taeniopygia guttata	71.58	0.00e+00	1798.00
IUUC-Tru-117638	Takifugu rubripes	48.68	0.00e+00	1090.00
IUUC-Tsy-118937	Tarsius syrichta	86.28	0.00e+00	1282.00
IUUC-Tbe-127291	Tupaia belangeri	78.33	0.00e+00	1254.00
IUUC-Ttr-129017	Tursiops truncatus	76.11	0.00e+00	1574.00
IUUC-Xtr-132673	Xenopus tropicalis	62.49	0.00e+00	1547.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence