iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fox-037756

Ensembl Protein ID

FOXG_00950P0

UniProt Accession

A0A0D2XAN4; A0A0D2XAN4_FUSO4

Genbank Protein ID

KNA95337.1

Protein Name

E3 ubiquitin-protein ligase HUWE1

Genbank Nucleotide ID

DS231696

Gene Name

FOXG_00950

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FOXG_00950	FOXG_00950T0	FOXG_00950P0

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.90e-119	397.7	3663	3990

Active Site

Position(s)	Description	Evidence
3959	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklll 101
            +l+++f gEeg+d+gGvtre+++ ls+++++p++ lf+  ++d++t++pn+ sg+ n ehl +F+f+Gr++gkal++gr+ld+ +s+++yk++l
   Q: 3663 GKLNIRFHGEEGVDAGGVTREWFQVLSRQMFDPNYVLFTPVSSDRTTFHPNKLSGI-NDEHLMFFKFIGRIIGKALYEGRVLDCYFSRAVYKRIL 3756
           4899***************************************************9.56************************************ PP
   S: 102  gkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreG 196
           gk++s++d+e++dp++yksl ++++n   di+++ ++ tfsv+++++g t++++L+p+G++i Vt+eNk++Yv+lvve++l +++keq+++f +G
   Q: 3757 GKSVSVKDMESFDPDYYKSLCWMLDN---DITDI-ITETFSVENDEFGATTVVDLIPNGREIAVTEENKHDYVRLVVEHKLLSSVKEQMAHFLQG 3847
           ************************99...99999.999********************************************************* PP
   S: 197  fneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlf 287
           f+++ip el+s+F+e+elelli+G ++id++d+k++t+y++ yt++s++iqwFw++l++f++eer+++LqFvTg+s++Pl+Gf+el+     ++f
   Q: 3848 FHDIIPAELISIFNEQELELLISGLPDIDIDDWKSNTEYHN-YTPSSQQIQWFWRALRSFDKEERAKLLQFVTGTSKVPLNGFKELEgmngVNRF 3941
           ***************************************66.*********************************************99996667 PP
   S: 288  virk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFe 334
            i++ ++++drlPss+TCfn+L+LPeY+s++ l+++++ Ai+ + + F+
   Q: 3942 NIHRdYGNKDRLPSSHTCFNQLDLPEYESYDHLRSQIMKAITAGsEYFG 3990
           777768999*********************************9977776 PP

Organism

Fusarium oxysporum

Protein Sequence
(Fasta)

MGKITKPMQP KHKDTLSPWL KSYVETTSTT PLPLLPQKLE SFPSRWPFGR GDLYHWIPLL 60
NRFDSILEHF CATYKLNEGP QTRDFGCDVL LNQDQESTFG SERRWSTEEL AGLGFSSNGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGAAGA TCACTAAGCC CATGCAACCA AAGCATAAGG ATACTTTGGT TAGTGACAAA 60
ATGAAACAGC CGGAAGATGC ATTGCTAACA TAATATTGTA GTCTCCTTGG CTCAAGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	30.85	2.00e-124	440.00
IUUC-Aml-001684	Ailuropoda melanoleuca	53.53	7.00e-137	482.00
IUUC-Atr-002582	Amborella trichopoda	46.91	2.00e-135	477.00
IUUC-Apl-003729	Anas platyrhynchos	52.69	4.00e-102	362.00
IUUC-Aca-005263	Anolis carolinensis	53.76	5.00e-138	485.00
IUUC-Aly-006157	Arabidopsis lyrata	33.33	9.00e-152	531.00
IUUC-Ath-007160	Arabidopsis thaliana	43.13	2.00e-138	487.00
IUUC-Ago-008005	Ashbya gossypii	56.11	0.00e+00	730.00
IUUC-Acl-008254	Aspergillus clavatus	34.85	0.00e+00	1245.00
IUUC-Afl-008712	Aspergillus flavus	57.82	0.00e+00	1228.00
IUUC-Afu-009022	Aspergillus fumigatus	36.36	0.00e+00	1245.00
IUUC-Ani-009412	Aspergillus nidulans	35.75	0.00e+00	1278.00
IUUC-Ang-009771	Aspergillus niger	35.60	0.00e+00	1267.00
IUUC-Aor-010186	Aspergillus oryzae	56.61	0.00e+00	1202.00
IUUC-Ate-010253	Aspergillus terreus	58.39	0.00e+00	1254.00
IUUC-Ame-011067	Astyanax mexicanus	53.41	1.00e-136	481.00
IUUC-Bgr-012043	Blumeria graminis	40.39	0.00e+00	1540.00
IUUC-Bta-012813	Bos taurus	53.53	5.00e-137	482.00
IUUC-Bci-013995	Botrytis cinerea	61.98	0.00e+00	1321.00
IUUC-Bdi-014884	Brachypodium distachyon	35.46	2.00e-139	490.00
IUUC-Bol-016533	Brassica oleracea	56.00	3.00e-95	339.00
IUUC-Bra-016726	Brassica rapa	32.87	2.00e-156	546.00
IUUC-Cel-018179	Caenorhabditis elegans	52.55	4.00e-131	462.00
IUUC-Cja-018741	Callithrix jacchus	53.53	1.00e-136	481.00
IUUC-Cfa-020083	Canis familiaris	53.53	5.00e-137	482.00
IUUC-Cpo-021923	Cavia porcellus	43.90	6.00e-98	352.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	50.47	1.00e-133	467.00
IUUC-Csa-023853	Chlorocebus sabaeus	53.53	5.00e-137	482.00
IUUC-Cho-024718	Choloepus hoffmanni	57.94	4.00e-126	446.00
IUUC-Cin-025627	Ciona intestinalis	52.24	9.00e-132	464.00
IUUC-Csv-025872	Ciona savignyi	52.00	2.00e-128	450.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	55.31	0.00e+00	2388.00
IUUC-Cne-027095	Cryptococcus neoformans	36.79	0.00e+00	644.00
IUUC-Cme-027267	Cyanidioschyzon merolae	49.53	4.00e-120	424.00
IUUC-Dre-028525	Danio rerio	52.10	1.00e-122	434.00
IUUC-Dno-029680	Dasypus novemcinctus	53.53	5.00e-137	482.00
IUUC-Dor-030902	Dipodomys ordii	48.29	2.00e-115	410.00
IUUC-Dse-031197	Dothistroma septosporum	54.64	0.00e+00	1144.00
IUUC-Dme-032122	Drosophila melanogaster	55.29	2.00e-136	481.00
IUUC-Eca-033915	Equus caballus	52.51	1.00e-134	474.00
IUUC-Eeu-034963	Erinaceus europaeus	53.18	6.00e-135	475.00
IUUC-Fca-035824	Felis catus	53.53	4.00e-137	482.00
IUUC-Fso-038464	Fusarium solani	75.86	0.00e+00	3838.00
IUUC-Gmo-039073	Gadus morhua	53.08	9.00e-137	481.00
IUUC-Ggr-039946	Gaeumannomyces graminis	47.82	0.00e+00	2004.00
IUUC-Gga-040309	Gallus gallus	58.63	3.00e-108	382.00
IUUC-Gac-042430	Gasterosteus aculeatus	53.08	9.00e-137	481.00
IUUC-Gma-044216	Glycine max	39.50	3.00e-138	486.00
IUUC-Hsa-046879	Homo sapiens	53.53	7.00e-137	481.00
IUUC-Hvu-047697	Hordeum vulgare	33.00	6.00e-145	508.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	53.53	3.00e-137	481.00
IUUC-Kpa-049228	Komagataella pastoris	57.03	0.00e+00	749.00
IUUC-Lch-050252	Latimeria chalumnae	53.64	3.00e-137	483.00
IUUC-Lpe-051550	Leersia perrieri	33.55	1.00e-148	521.00
IUUC-Loc-052472	Lepisosteus oculatus	53.92	1.00e-137	484.00
IUUC-Lma-053159	Leptosphaeria maculans	55.57	0.00e+00	1197.00
IUUC-Laf-054154	Loxodonta africana	53.53	3.00e-137	483.00
IUUC-Mcc-055085	Macaca mulatta	53.53	6.00e-137	482.00
IUUC-Mor-057201	Magnaporthe oryzae	46.01	0.00e+00	1961.00
IUUC-Mpo-057597	Magnaporthe poae	48.83	0.00e+00	1469.00
IUUC-Mtr-057633	Medicago truncatula	39.82	3.00e-140	493.00
IUUC-Mla-058888	Melampsora laricipopulina	57.21	2.00e-145	506.00
IUUC-Mvi-060320	Microbotryum violaceum	43.46	0.00e+00	724.00
IUUC-Mmr-060820	Microcebus murinus	53.53	3.00e-137	483.00
IUUC-Mdo-062930	Monodelphis domestica	53.76	1.00e-137	484.00
IUUC-Mmu-063601	Mus musculus	53.53	5.00e-137	482.00
IUUC-Mac-065557	Musa acuminata	32.70	3.00e-141	496.00
IUUC-Mpu-066653	Mustela putorius furo	53.53	5.00e-137	482.00
IUUC-Mlu-067418	Myotis lucifugus	45.28	6.00e-138	485.00
IUUC-Nfi-068278	Neosartorya fischeri	57.20	0.00e+00	1233.00
IUUC-Ncr-068813	Neurospora crassa	45.93	0.00e+00	1900.00
IUUC-Nle-069418	Nomascus leucogenys	53.53	7.00e-137	481.00
IUUC-Ont-071300	Oreochromis niloticus	53.08	1.00e-136	481.00
IUUC-Oan-073046	Ornithorhynchus anatinus	53.74	7.00e-137	481.00
IUUC-Ocu-074178	Oryctolagus cuniculus	53.53	3.00e-137	483.00
IUUC-Oba-075757	Oryza barthii	32.97	4.00e-152	532.00
IUUC-Obr-076553	Oryza brachyantha	33.00	1.00e-150	527.00
IUUC-Ogl-077520	Oryza glaberrima	32.97	1.00e-151	530.00
IUUC-Ogu-077981	Oryza glumaepatula	47.51	6.00e-130	458.00
IUUC-Oin-079767	Oryza indica	33.00	2.00e-152	533.00
IUUC-Olo-080326	Oryza longistaminata	47.30	1.00e-128	454.00
IUUC-Ome-081925	Oryza meridionalis	32.87	2.00e-149	523.00
IUUC-Oni-082619	Oryza nivara	33.22	4.00e-152	532.00
IUUC-Opu-083428	Oryza punctata	47.73	2.00e-131	463.00
IUUC-Oru-084501	Oryza rufipogon	33.06	1.00e-152	533.00
IUUC-Osa-086200	Oryza sativa	32.29	6.00e-135	473.00
IUUC-Olu-087813	Ostreococcus lucimarinus	46.96	4.00e-115	406.00
IUUC-Oga-088903	Otolemur garnettii	53.53	5.00e-137	482.00
IUUC-Oar-090210	Ovis aries	53.53	4.00e-137	482.00
IUUC-Pan-092368	Papio anubis	53.09	3.00e-124	439.00
IUUC-Pno-094871	Phaeosphaeria nodorum	56.21	0.00e+00	1173.00
IUUC-Ppa-095834	Physcomitrella patens	39.37	7.00e-140	491.00
IUUC-Pfo-096232	Poecilia formosa	53.08	7.00e-137	481.00
IUUC-Pab-098583	Pongo abelii	53.53	5.00e-137	482.00
IUUC-Pop-099468	Populus trichocarpa	32.68	3.00e-161	562.00
IUUC-Pca-100310	Procavia capensis	61.69	3.00e-90	327.00
IUUC-Ppe-101641	Prunus persica	32.70	5.00e-157	548.00
IUUC-Pva-102116	Pteropus vampyrus	50.11	3.00e-123	436.00
IUUC-Pgr-103465	Puccinia graminis	40.35	0.00e+00	770.00
IUUC-Ptt-103813	Puccinia triticina	39.38	0.00e+00	734.00
IUUC-Pte-104018	Pyrenophora teres	36.52	0.00e+00	1279.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	35.76	0.00e+00	1243.00
IUUC-Sce-106449	Saccharomyces cerevisiae	41.27	0.00e+00	773.00
IUUC-Sha-106961	Sarcophilus harrisii	53.76	1.00e-137	484.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	43.41	0.00e+00	852.00
IUUC-Spo-108024	Schizosaccharomyces pombe	44.31	0.00e+00	857.00
IUUC-Smo-109428	Selaginella moellendorffii	40.62	1.00e-140	493.00
IUUC-Sit-110598	Setaria italica	37.25	9.00e-143	501.00
IUUC-Sly-111706	Solanum lycopersicum	39.97	7.00e-141	494.00
IUUC-Stu-112582	Solanum tuberosum	34.56	1.00e-57	216.00
IUUC-Sar-113291	Sorex araneus	54.55	2.00e-132	467.00
IUUC-Sbi-114042	Sorghum bicolor	33.08	8.00e-149	521.00
IUUC-Sre-114958	Sporisorium reilianum	55.89	4.00e-177	612.00
IUUC-Ssc-115754	Sus scrofa	53.53	5.00e-137	482.00
IUUC-Tru-118570	Takifugu rubripes	53.08	7.00e-137	481.00
IUUC-Tni-120836	Tetraodon nigroviridis	51.94	3.00e-132	466.00
IUUC-Tca-121479	Theobroma cacao	32.65	7.00e-154	538.00
IUUC-Tre-121909	Trichoderma reesei	63.12	0.00e+00	3212.00
IUUC-Tvi-122370	Trichoderma virens	64.81	0.00e+00	2939.00
IUUC-Tae-125214	Triticum aestivum	31.72	1.00e-143	503.00
IUUC-Tme-127172	Tuber melanosporum	34.08	0.00e+00	1118.00
IUUC-Ttr-129253	Tursiops truncatus	53.53	7.00e-137	481.00
IUUC-Uma-129355	Ustilago maydis	56.92	8.00e-178	614.00
IUUC-Vda-129886	Verticillium dahliae	51.26	0.00e+00	2254.00
IUUC-Vpa-130708	Vicugna pacos	53.53	2.00e-136	480.00
IUUC-Vvi-131170	Vitis vinifera	43.34	9.00e-140	489.00
IUUC-Xtr-132123	Xenopus tropicalis	52.00	2.00e-129	457.00
IUUC-Xma-133869	Xiphophorus maculatus	53.08	8.00e-137	481.00
IUUC-Yli-134657	Yarrowia lipolytica	45.51	0.00e+00	890.00
IUUC-Zma-135570	Zea mays	32.75	1.00e-149	523.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence