iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040460

Ensembl Protein ID

ENSGALP00000043553.1

UniProt Accession

A0A1D5NTA0; A0A1D5NTA0_CHICK

Protein Name

Ubiquitin thioesterase

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000038229.1	ENSGALT00000067358.1	ENSGALP00000043553.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.40e-45	154.2	80	270

Active Site

Position(s)	Description	Evidence
87	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
90	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
264		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA++++                                                          ll+ f++ s+sd
   Q: 80   YIRKTRPDGNCFYRAFGFAhlealledsqelqrfkeisarskdelvaqgfteftiedfhntfmeliervergvplpeLLAAFNEPSTSD 168
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts  lq+++ ff++f+e+++ +kefcq++vep++k +++ihi+aLa +L++p+ v+++d++e   gg+++p++fpe + +
   Q: 169  YLVVYLRLLTSGCLQRHRRFFEQFLEGGRSIKEFCQQEVEPMCKeSDHIHIIALARALQVPVLVEYMDRGE---GGATNPHVFPEGS-Q 253
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 254  PRVCLLYRPGHYDILYK 270
           ***************96 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MAAEVPQQQP EPLGPDADGV NCLAYDEAIM AQQDRIQQEI AVQNPLVSER LELAVLYKEY 60
AQDDHIYQQK IKDLLQKYSY IRKTRPDGNC FYRAFGFAHL EALLEDSQEL QRFKEISARS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGGGCGGG GCAGCGGCGG AAGATGGCGG CGGAGGTCCC TCAGCAGCAG CCGGAGCCGC 60
TCGGCCCCGA CGCGGACGGT AACGGCGCAG CCCCGAGCCC GGCCCTGAGC CCCGCGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

KEGG

gga:777320

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	79.27	4.00e-129	453.00
IUUC-Apl-003233	Anas platyrhynchos	87.69	2.00e-28	116.00
IUUC-Aca-004648	Anolis carolinensis	77.94	1.00e-125	442.00
IUUC-Aly-005710	Arabidopsis lyrata	38.28	4.00e-47	181.00
IUUC-Ath-007112	Arabidopsis thaliana	38.14	5.00e-46	177.00
IUUC-Afl-008439	Aspergillus flavus	35.42	7.00e-09	53.90
IUUC-Ame-010662	Astyanax mexicanus	73.68	4.00e-116	410.00
IUUC-Bta-013533	Bos taurus	82.56	1.00e-130	458.00
IUUC-Bol-016100	Brassica oleracea	36.55	7.00e-45	173.00
IUUC-Bra-017705	Brassica rapa	33.88	2.00e-39	156.00
IUUC-Cel-018295	Caenorhabditis elegans	34.91	6.00e-39	154.00
IUUC-Cja-019190	Callithrix jacchus	81.78	5.00e-129	453.00
IUUC-Cfa-020430	Canis familiaris	82.54	5.00e-127	446.00
IUUC-Cpo-022355	Cavia porcellus	82.17	3.00e-130	457.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	37.29	2.00e-44	172.00
IUUC-Csa-023286	Chlorocebus sabaeus	79.03	2.00e-127	447.00
IUUC-Cho-024411	Choloepus hoffmanni	40.30	9.00e-25	106.00
IUUC-Cin-025507	Ciona intestinalis	42.78	5.00e-44	170.00
IUUC-Csv-026273	Ciona savignyi	47.35	6.00e-64	236.00
IUUC-Dre-028315	Danio rerio	76.98	3.00e-113	400.00
IUUC-Dno-029165	Dasypus novemcinctus	78.50	6.00e-97	345.00
IUUC-Dor-030943	Dipodomys ordii	82.17	3.00e-130	457.00
IUUC-Dme-031922	Drosophila melanogaster	54.40	1.00e-73	269.00
IUUC-Ete-032296	Echinops telfairi	77.36	2.00e-72	265.00
IUUC-Eca-033695	Equus caballus	82.54	1.00e-126	445.00
IUUC-Eeu-034775	Erinaceus europaeus	42.86	1.00e-51	196.00
IUUC-Fca-036441	Felis catus	81.23	4.00e-127	446.00
IUUC-Gmo-038908	Gadus morhua	71.75	2.00e-114	404.00
IUUC-Ggr-040020	Gaeumannomyces graminis	32.49	2.00e-30	127.00
IUUC-Gac-042417	Gasterosteus aculeatus	74.80	5.00e-111	393.00
IUUC-Gma-043712	Glycine max	38.65	9.00e-49	186.00
IUUC-Ggo-044552	Gorilla gorilla	77.36	2.00e-73	268.00
IUUC-Hsa-046766	Homo sapiens	81.78	6.00e-130	456.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	82.17	3.00e-130	457.00
IUUC-Lch-050602	Latimeria chalumnae	74.21	6.00e-108	382.00
IUUC-Loc-052003	Lepisosteus oculatus	44.00	1.00e-50	192.00
IUUC-Lma-052964	Leptosphaeria maculans	47.06	1.10e+00	28.50
IUUC-Laf-053705	Loxodonta africana	82.17	3.00e-130	457.00
IUUC-Mcc-055745	Macaca mulatta	76.45	7.00e-126	442.00
IUUC-Meu-056569	Macropus eugenii	72.32	6.00e-114	402.00
IUUC-Mtr-057712	Medicago truncatula	38.29	4.00e-43	168.00
IUUC-Mvi-060358	Microbotryum violaceum	30.54	5.00e-11	61.20
IUUC-Mmr-061123	Microcebus murinus	81.19	1.00e-106	379.00
IUUC-Mdo-062613	Monodelphis domestica	75.65	1.00e-108	385.00
IUUC-Mmu-063658	Mus musculus	82.17	3.00e-130	457.00
IUUC-Mac-065274	Musa acuminata	37.60	3.00e-38	152.00
IUUC-Mpu-066172	Mustela putorius furo	81.78	6.00e-130	456.00
IUUC-Mlu-066966	Myotis lucifugus	82.17	1.00e-129	455.00
IUUC-Nle-069519	Nomascus leucogenys	68.82	8.00e-74	270.00
IUUC-Opr-070761	Ochotona princeps	34.59	1.00e-24	105.00
IUUC-Ont-071901	Oreochromis niloticus	74.50	3.00e-112	397.00
IUUC-Oan-072922	Ornithorhynchus anatinus	43.75	1.00e-54	205.00
IUUC-Ocu-074643	Oryctolagus cuniculus	43.75	1.00e-52	199.00
IUUC-Oni-082026	Oryza nivara	32.97	1.00e-16	80.50
IUUC-Oru-084761	Oryza rufipogon	32.97	1.00e-16	80.50
IUUC-Ola-087331	Oryzias latipes	71.58	1.00e-77	282.00
IUUC-Oga-088064	Otolemur garnettii	81.78	6.00e-130	456.00
IUUC-Oar-089251	Ovis aries	83.27	2.00e-126	444.00
IUUC-Ptr-091430	Pan troglodytes	81.78	5.00e-129	453.00
IUUC-Pan-091969	Papio anubis	43.30	2.00e-52	198.00
IUUC-Psi-093823	Pelodiscus sinensis	82.75	4.00e-125	440.00
IUUC-Pma-094366	Petromyzon marinus	65.06	2.00e-93	334.00
IUUC-Pfo-096734	Poecilia formosa	74.90	1.00e-104	372.00
IUUC-Pab-097919	Pongo abelii	81.19	2.00e-105	374.00
IUUC-Pop-099401	Populus trichocarpa	38.69	2.00e-45	175.00
IUUC-Pca-100252	Procavia capensis	41.05	2.00e-18	85.10
IUUC-Ppe-101977	Prunus persica	39.78	7.00e-48	184.00
IUUC-Pva-102499	Pteropus vampyrus	82.47	8.00e-127	445.00
IUUC-Rno-105233	Rattus norvegicus	82.17	3.00e-130	457.00
IUUC-Sha-107081	Sarcophilus harrisii	83.73	2.00e-127	447.00
IUUC-Sly-111640	Solanum lycopersicum	40.52	3.00e-49	187.00
IUUC-Sar-113295	Sorex araneus	43.75	1.00e-51	195.00
IUUC-Ssc-116202	Sus scrofa	81.78	6.00e-130	456.00
IUUC-Tru-117664	Takifugu rubripes	69.85	4.00e-111	393.00
IUUC-Tni-120440	Tetraodon nigroviridis	34.38	4.00e-30	124.00
IUUC-Tca-121467	Theobroma cacao	39.71	1.00e-47	183.00
IUUC-Tbe-128116	Tupaia belangeri	77.36	2.00e-74	272.00
IUUC-Ttr-128622	Tursiops truncatus	81.01	3.00e-127	447.00
IUUC-Uma-129443	Ustilago maydis	32.37	1.00e-24	106.00
IUUC-Vvi-131389	Vitis vinifera	40.81	1.00e-49	189.00
IUUC-Xtr-131951	Xenopus tropicalis	42.67	7.00e-52	196.00
IUUC-Xma-134191	Xiphophorus maculatus	74.50	4.00e-105	373.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence