iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000041180.13	ENSMUST00000139215.7	ENSMUSP00000117273.1
ENSMUSG00000041180.13	ENSMUST00000169036.8	ENSMUSP00000128387.2
ENSMUSG00000041180.13	ENSMUST00000047247.11	ENSMUSP00000042646.5
ENSMUSG00000041180.13	ENSMUST00000155594.8	ENSMUSP00000120791.2
ENSMUSG00000041180.13	ENSMUST00000177381.7	ENSMUSP00000134964.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Post-translational Modifications (PTMs)
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.70e-103	346.0	437	775

Active Site

Position(s)	Description	Evidence
743	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+v+fvgE+gld+gG+t+e++ ll++++++pd+g+f+y+++++++++ + +      ++ + F+++G+l+g+a++++  ld+
   Q: 437  RADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKC-----DNYSEFRLVGILMGLAVYNSITLDI 520
           589***************************************************87766.....789********************** PP
   S: 91   plsksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           ++++++yk+ll+               +++++dl +v+pel++ lke++++ e ++ee  +  tf+v +e++g +k+++LkpgG++ipV
   Q: 521  RFPPCCYKKLLSPpvvpsdqstpvgicSVTIDDLCQVMPELAHGLKELLSY-EGNVEED-FYSTFQVFQEEFGVIKSYNLKPGGDKIPV 607
           ************9666666666666555**********************9.6788885.***************************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevle 254
           tn+N++eYv+l++++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++e+d+++l++ t+y+g y +++ +i++Fw+v+ 
   Q: 608  TNQNRREYVQLYTDFLLNKSIYKQFAAFYCGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRSTQYDG-YAKTDLTIRYFWDVVL 695
           **********************************************************************76.**************** PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +f  e +k++L+F+Tgs+r+P+gG+a+l+   f i+k ++s+++lP ++TCfn+L+LP+Y+sk+ lk+kL++ i++++gF+l+
   Q: 696  GFPLELQKKLLHFTTGSDRVPVGGMADLN---FKISKnETSTNWLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 775
           *****************************...9999967777**************************************985 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MSEAARDLSP GAPPAVAAAA PEERKGKEPE REKLPPIVTA GAAAGLDRGS KGQISTFSSF 60
VSTVTQKKEA AENRSSPTHL ALPNIRNVRD LPPICLDVRQ KQRMSVEALP SEVKVPPLPE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCGGGGGC GGGGGCGGCG CGGCGGCGGC GGTTGGAAGG AGCCCTCTCG CGGCCGCGGC 60
AGCAGCAGCA GCGCCCGCCC CGGCTGCAGT CCGGCCGCCG CTGCCGCCGC CGCCACCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	91.84	0.00e+00	1387.00
IUUC-Apl-003589	Anas platyrhynchos	83.74	0.00e+00	1244.00
IUUC-Aca-004350	Anolis carolinensis	80.93	0.00e+00	1191.00
IUUC-Ago-007908	Ashbya gossypii	35.26	4.00e-81	296.00
IUUC-Acl-008288	Aspergillus clavatus	35.63	1.00e-97	351.00
IUUC-Afl-008402	Aspergillus flavus	34.44	8.00e-91	328.00
IUUC-Afu-008762	Aspergillus fumigatus	35.08	5.00e-95	342.00
IUUC-Ani-009176	Aspergillus nidulans	35.82	9.00e-93	335.00
IUUC-Ang-009791	Aspergillus niger	36.30	3.00e-93	336.00
IUUC-Aor-009921	Aspergillus oryzae	34.27	5.00e-90	325.00
IUUC-Ate-010295	Aspergillus terreus	36.48	1.00e-100	361.00
IUUC-Ame-010660	Astyanax mexicanus	82.94	7.00e-154	536.00
IUUC-Bgr-011981	Blumeria graminis	33.99	7.00e-92	332.00
IUUC-Bta-012945	Bos taurus	90.82	0.00e+00	1351.00
IUUC-Bci-013697	Botrytis cinerea	34.82	6.00e-82	299.00
IUUC-Cja-019263	Callithrix jacchus	89.59	0.00e+00	1335.00
IUUC-Cfa-020486	Canis familiaris	93.19	0.00e+00	1258.00
IUUC-Cpo-021755	Cavia porcellus	90.17	0.00e+00	1361.00
IUUC-Csa-023814	Chlorocebus sabaeus	90.24	0.00e+00	1268.00
IUUC-Cho-024980	Choloepus hoffmanni	73.64	0.00e+00	1059.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	41.52	9.00e-96	345.00
IUUC-Dre-028551	Danio rerio	73.73	0.00e+00	1122.00
IUUC-Dno-029497	Dasypus novemcinctus	89.00	0.00e+00	1210.00
IUUC-Dor-030867	Dipodomys ordii	79.18	0.00e+00	1144.00
IUUC-Dse-031239	Dothistroma septosporum	32.59	1.00e-87	318.00
IUUC-Ete-032902	Echinops telfairi	77.72	0.00e+00	1139.00
IUUC-Eca-033678	Equus caballus	90.97	0.00e+00	1369.00
IUUC-Eeu-035262	Erinaceus europaeus	76.13	0.00e+00	1009.00
IUUC-Fca-035590	Felis catus	92.48	0.00e+00	1390.00
IUUC-Fal-037123	Ficedula albicollis	79.63	0.00e+00	1199.00
IUUC-Fox-037941	Fusarium oxysporum	41.20	1.00e-101	365.00
IUUC-Fso-038388	Fusarium solani	41.78	2.00e-104	374.00
IUUC-Gmo-039553	Gadus morhua	65.26	0.00e+00	842.00
IUUC-Ggr-040110	Gaeumannomyces graminis	40.99	4.00e-99	356.00
IUUC-Gga-040406	Gallus gallus	83.33	0.00e+00	1283.00
IUUC-Gac-042141	Gasterosteus aculeatus	74.82	0.00e+00	1079.00
IUUC-Ggo-045504	Gorilla gorilla	89.17	0.00e+00	1341.00
IUUC-Hsa-045786	Homo sapiens	89.92	0.00e+00	1347.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	86.77	0.00e+00	1187.00
IUUC-Kpa-049152	Komagataella pastoris	34.36	4.00e-76	279.00
IUUC-Lch-049824	Latimeria chalumnae	79.05	0.00e+00	1077.00
IUUC-Loc-052173	Lepisosteus oculatus	76.42	0.00e+00	1179.00
IUUC-Laf-054017	Loxodonta africana	91.72	0.00e+00	1282.00
IUUC-Mcc-055713	Macaca mulatta	90.14	0.00e+00	1319.00
IUUC-Meu-056212	Macropus eugenii	68.83	4.00e-115	408.00
IUUC-Mor-057045	Magnaporthe oryzae	37.08	7.00e-91	329.00
IUUC-Mla-059187	Melampsora laricipopulina	43.43	7.00e-87	314.00
IUUC-Mga-059884	Meleagris gallopavo	77.87	0.00e+00	1136.00
IUUC-Mmr-061344	Microcebus murinus	90.14	0.00e+00	1340.00
IUUC-Mdo-062653	Monodelphis domestica	84.27	0.00e+00	1276.00
IUUC-Mpu-066069	Mustela putorius furo	93.38	0.00e+00	1269.00
IUUC-Mlu-067925	Myotis lucifugus	91.52	0.00e+00	1338.00
IUUC-Nfi-068439	Neosartorya fischeri	34.92	2.00e-94	340.00
IUUC-Ncr-068903	Neurospora crassa	38.20	4.00e-93	337.00
IUUC-Nle-070046	Nomascus leucogenys	89.84	0.00e+00	1353.00
IUUC-Opr-071085	Ochotona princeps	78.86	5.00e-137	481.00
IUUC-Ont-072126	Oreochromis niloticus	71.75	0.00e+00	1139.00
IUUC-Oan-072933	Ornithorhynchus anatinus	86.73	0.00e+00	1154.00
IUUC-Ocu-073800	Oryctolagus cuniculus	92.77	0.00e+00	1234.00
IUUC-Ola-086988	Oryzias latipes	74.71	0.00e+00	1081.00
IUUC-Oga-088117	Otolemur garnettii	94.32	0.00e+00	1111.00
IUUC-Oar-089371	Ovis aries	91.11	0.00e+00	1323.00
IUUC-Ptr-090551	Pan troglodytes	88.09	0.00e+00	1294.00
IUUC-Pan-092067	Papio anubis	90.62	0.00e+00	1326.00
IUUC-Psi-092963	Pelodiscus sinensis	83.87	0.00e+00	1242.00
IUUC-Pfo-096562	Poecilia formosa	69.80	0.00e+00	1100.00
IUUC-Pab-098680	Pongo abelii	90.32	0.00e+00	1353.00
IUUC-Pca-100986	Procavia capensis	73.04	0.00e+00	862.00
IUUC-Pva-102219	Pteropus vampyrus	76.58	0.00e+00	1033.00
IUUC-Pgr-103315	Puccinia graminis	36.96	8.00e-98	352.00
IUUC-Ptt-103736	Puccinia triticina	42.25	5.00e-95	342.00
IUUC-Rno-105270	Rattus norvegicus	96.17	0.00e+00	1368.00
IUUC-Sce-106306	Saccharomyces cerevisiae	34.84	9.00e-70	258.00
IUUC-Sha-106819	Sarcophilus harrisii	87.67	0.00e+00	1328.00
IUUC-Spo-108271	Schizosaccharomyces pombe	34.05	1.00e-84	308.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	34.65	3.00e-85	310.00
IUUC-Sar-113134	Sorex araneus	81.67	0.00e+00	1186.00
IUUC-Ssc-115441	Sus scrofa	92.05	0.00e+00	1366.00
IUUC-Tgu-117166	Taeniopygia guttata	82.80	0.00e+00	1236.00
IUUC-Tsy-118898	Tarsius syrichta	78.88	0.00e+00	1060.00
IUUC-Tre-122108	Trichoderma reesei	39.72	4.00e-90	326.00
IUUC-Tvi-122644	Trichoderma virens	39.64	6.00e-96	346.00
IUUC-Tme-127004	Tuber melanosporum	37.03	3.00e-102	367.00
IUUC-Tbe-127292	Tupaia belangeri	75.24	0.00e+00	1011.00
IUUC-Ttr-128352	Tursiops truncatus	88.51	0.00e+00	1281.00
IUUC-Vda-129969	Verticillium dahliae	41.23	1.00e-93	338.00
IUUC-Vpa-130218	Vicugna pacos	89.26	0.00e+00	975.00
IUUC-Xtr-132594	Xenopus tropicalis	76.43	0.00e+00	1140.00
IUUC-Xma-134157	Xiphophorus maculatus	73.81	0.00e+00	1009.00
IUUC-Yli-134470	Yarrowia lipolytica	35.56	1.00e-76	281.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence