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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046982
Ensembl Protein ID ENSP00000296137.2
UniProt Accession Q9BQS8; B7ZKT7; Q3MJE6; Q86T41; Q86TB1; Q8TEF9; Q96IV5; Q9H8P9; FYCO1_HUMAN
Genbank Protein ID CAC33883.1; CAD89924.1; CAD91151.1; AAH07218.1; AAI01469.1; AAI01471.1; AAI43369.1; BAB14559.1; BAB84991.1
Protein Name FYVE and coiled-coil domain-containing protein 1; Zinc finger FYVE domain-containing protein 7
Genbank Nucleotide ID AJ292348; AL833308; AL832358; AC099782; BC101468; BC101470; BC143368; AK023397; AK074165
Gene Name FYCO1; ZFYVE7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163820.14 ENST00000433878.5 ENSP00000388136.1
ENSG00000163820.14 ENST00000296137.6 ENSP00000296137.2
ENSG00000163820.14 ENST00000535325.5 ENSP00000441178.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 60.47 3.00e-11 66.60 IUUC-Sce-106309
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May mediate microtubule plus end-directed vesicle transport.
 May mediate microtubule plus end-directed vesicle transport.
Protein Sequence
(Fasta)
MASTNAESQL QRIIRDLQDA VTELSKEFQE AGEPITDDST SLHKFSYKLE YLLQFDQKEK 60
ATLLGNKKDY WDYFCACLAK VKGANDGIRF VKSISELRTS LGKGRAFIRY SLVHQRLADT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046982|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCCTCTTGG TGTGCGCGTC ATGGCCGTCA GCACCGCGTT CCCGTCCTCT TCCGCTTGGC 60
CCCAGAAAGT TTCGGTTCTG CCCGGCGGTG GACCCACGAG CGCGTAAGTG CCGCGGAAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046982|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0898--Cataract
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0225--Disease mutation
KW-0967--Endosome
KW-0458--Lysosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR009038--GOLD_dom
IPR004012--Run_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50866--GOLD
PS50826--RUN
PS50178--ZF_FYVE
Pfam

PF01363--FYVE
PF02759--RUN
SMART

SM00064--FYVE
Gene Ontology

GO:0005776--C:autophagosome
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0016020--C:membrane
GO:0046872--F:metal ion binding
GO:0044183--F:protein binding involved in protein folding
GO:0051082--F:unfolded protein binding
GO:0006458--P:'de novo' protein folding
GO:0061077--P:chaperone-mediated protein folding
GO:0072383--P:plus-end-directed vesicle transport along microtubule
GO:1901098--P:positive regulation of autophagosome maturation
KEGG hsa:79443
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001622 Ailuropoda melanoleuca 77.80 0.00e+00 1967.00
IUUC-Apl-004173 Anas platyrhynchos 40.70 3.00e-170 592.00
IUUC-Ame-010798 Astyanax mexicanus 50.83 5.00e-115 407.00
IUUC-Bta-012394 Bos taurus 78.52 0.00e+00 1961.00
IUUC-Cja-019711 Callithrix jacchus 93.10 0.00e+00 2404.00
IUUC-Cfa-020392 Canis familiaris 79.04 0.00e+00 2008.00
IUUC-Cpo-021456 Cavia porcellus 74.92 0.00e+00 1891.00
IUUC-Csa-023192 Chlorocebus sabaeus 95.47 0.00e+00 2443.00
IUUC-Dre-027779 Danio rerio 40.31 4.00e-161 563.00
IUUC-Dno-029277 Dasypus novemcinctus 75.80 0.00e+00 1435.00
IUUC-Eca-033806 Equus caballus 85.04 0.00e+00 2217.00
IUUC-Fca-035563 Felis catus 74.76 0.00e+00 1149.00
IUUC-Fal-036657 Ficedula albicollis 50.91 0.00e+00 1373.00
IUUC-Gmo-038911 Gadus morhua 38.12 0.00e+00 634.00
IUUC-Gga-041069 Gallus gallus 52.15 0.00e+00 1429.00
IUUC-Gac-042183 Gasterosteus aculeatus 40.31 0.00e+00 897.00
IUUC-Ggo-045276 Gorilla gorilla 98.51 0.00e+00 2498.00
IUUC-Itr-048929 Ictidomys tridecemlineatus 82.18 0.00e+00 2056.00
IUUC-Lch-049451 Latimeria chalumnae 43.63 0.00e+00 978.00
IUUC-Loc-052441 Lepisosteus oculatus 43.48 0.00e+00 1080.00
IUUC-Lma-053072 Leptosphaeria maculans 48.65 6.00e-09 56.20
IUUC-Laf-053370 Loxodonta africana 80.05 0.00e+00 1719.00
IUUC-Mcc-054975 Macaca mulatta 95.81 0.00e+00 2518.00
IUUC-Meu-056668 Macropus eugenii 58.52 0.00e+00 681.00
IUUC-Mor-056945 Magnaporthe oryzae 32.43 4.00e-09 57.00
IUUC-Mmr-061339 Microcebus murinus 87.42 0.00e+00 2259.00
IUUC-Mdo-063054 Monodelphis domestica 60.00 0.00e+00 1529.00
IUUC-Mlu-067157 Myotis lucifugus 79.32 0.00e+00 1982.00
IUUC-Nle-069695 Nomascus leucogenys 96.21 0.00e+00 2400.00
IUUC-Ont-072336 Oreochromis niloticus 38.15 1.00e-163 571.00
IUUC-Oan-073536 Ornithorhynchus anatinus 61.93 0.00e+00 1751.00
IUUC-Ola-086470 Oryzias latipes 38.43 0.00e+00 802.00
IUUC-Oga-088658 Otolemur garnettii 85.13 0.00e+00 2287.00
IUUC-Oar-089316 Ovis aries 82.99 0.00e+00 958.00
IUUC-Ptr-091653 Pan troglodytes 99.26 0.00e+00 2504.00
IUUC-Pan-092033 Papio anubis 94.39 0.00e+00 2396.00
IUUC-Psi-093520 Pelodiscus sinensis 62.86 0.00e+00 669.00
IUUC-Pfo-096903 Poecilia formosa 39.36 0.00e+00 866.00
IUUC-Pab-098777 Pongo abelii 97.23 0.00e+00 2485.00
IUUC-Pva-102241 Pteropus vampyrus 81.86 0.00e+00 2041.00
IUUC-Pte-104063 Pyrenophora teres 48.65 2.00e-08 54.70
IUUC-Rno-104949 Rattus norvegicus 77.12 0.00e+00 1973.00
IUUC-Sce-106309 Saccharomyces cerevisiae 44.00 2.00e-12 66.20
IUUC-Sha-106591 Sarcophilus harrisii 62.42 0.00e+00 1575.00
IUUC-Spo-108288 Schizosaccharomyces pombe 51.22 5.00e-11 61.60
IUUC-Ssc-115324 Sus scrofa 80.15 0.00e+00 1765.00
IUUC-Tgu-116887 Taeniopygia guttata 67.15 2.00e-144 508.00
IUUC-Tru-118394 Takifugu rubripes 33.66 7.00e-89 322.00
IUUC-Tsy-119577 Tarsius syrichta 83.42 0.00e+00 2098.00
IUUC-Tni-119998 Tetraodon nigroviridis 40.31 2.00e-163 570.00
IUUC-Tvi-122664 Trichoderma virens 42.55 2.00e-09 57.40
IUUC-Tbe-127875 Tupaia belangeri 34.65 1.00e-14 76.60
IUUC-Ttr-128386 Tursiops truncatus 83.08 0.00e+00 927.00
IUUC-Vpa-130696 Vicugna pacos 34.65 1.00e-14 76.30
Created Date 25-Jun-2017

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