iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021448

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02015929

Gene Name

UBR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000009629.3	ENSCPOT00000009716.2	ENSCPOP00000008643.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/N-recognin/N-domain	1.90e-40	136.8	202	278
E3 activity/RING/RING	1.60e-08	34.9	1072	1177
E3 activity/N-recognin/UBR-box	2.90e-31	107.8	73	143

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy+vLfNDE+Hsy++viyslq+Al++e++ea++++t+idkeGRravkaG+ya+c+eak++i+++se+++q+pL+Vev
   Q: 202  YYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGTYAACQEAKEDIKSHSENVSQHPLHVEV 278
           9**************************************************************************97 PP

E3 activity/RING/RING

   S: 1    CaiCledf............kd...................................gplvlpCgHvfhadClqkw........... 29
           C++C+e+              +                                   g+++++CgHv+ha C+qk+           
   Q: 1072 CILCQEEQevkiennamvlaACvqkstaltqhrgkpvelsgepetldplfmdpdlayGTYTGSCGHVMHAVCWQKYfeavqlssqqr 1158
           7788554433333333222200222233333333333333333333333333333337999************************** PP
   S: 30   ..pglknssskefrCPlCr 46
             ++l +++s+e +CPlC+
   Q: 1159 vhVDLFDLESGEYLCPLCK 1177
           ******************7 PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCg+vfk+get+y+Cr+C++d+t+vlC++Cf+++vHk+H+yk+++s+gggfCdCGdteAw++g++C +++
   Q: 73   QLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQNSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCINHE 143
           68******************************************************************996 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

PALWWDQQVD FYTAFLHHLA QLVPEIYFAE MDPDLEKQEE NVQLSIFTPL EWYLFGEDPD 60
ICLEKLKQSA AFQLCGKVFK SGETTYSCRD CAIDPTCVLC MDCFQNSVHK NHRYKMHTST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGCTTTTT GTATTGGTAA AGGACAAAAT ATATTGTAAA TGACAAACTA TATTATAAAT 60
CTTCTTGAAA ATACAAAATT ATCTTTTATT TGTACCTCTG GATTGTAAAG AGGGGAACTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000502--C:proteasome complex
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0032007--P:negative regulation of TOR signaling
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001354	Ailuropoda melanoleuca	91.68	0.00e+00	3219.00
IUUC-Apl-004160	Anas platyrhynchos	76.75	0.00e+00	2690.00
IUUC-Aca-004982	Anolis carolinensis	73.64	0.00e+00	2600.00
IUUC-Ago-007752	Ashbya gossypii	28.85	3.00e-26	115.00
IUUC-Acl-008055	Aspergillus clavatus	23.10	3.00e-46	181.00
IUUC-Ani-009334	Aspergillus nidulans	24.07	3.00e-51	198.00
IUUC-Ate-010550	Aspergillus terreus	23.75	5.00e-48	187.00
IUUC-Ame-011231	Astyanax mexicanus	56.30	0.00e+00	1856.00
IUUC-Bgr-011999	Blumeria graminis	23.55	3.00e-46	181.00
IUUC-Bta-012347	Bos taurus	91.43	0.00e+00	3193.00
IUUC-Cja-018911	Callithrix jacchus	87.89	0.00e+00	3070.00
IUUC-Cfa-020991	Canis familiaris	92.43	0.00e+00	3239.00
IUUC-Cre-022930	Chlamydomonas reinhardtii	42.31	3.20e-02	30.40
IUUC-Csa-024255	Chlorocebus sabaeus	92.26	0.00e+00	2656.00
IUUC-Cho-024550	Choloepus hoffmanni	70.17	0.00e+00	2332.00
IUUC-Dno-029427	Dasypus novemcinctus	89.65	0.00e+00	3102.00
IUUC-Dor-031073	Dipodomys ordii	77.27	0.00e+00	1353.00
IUUC-Ete-032318	Echinops telfairi	74.76	0.00e+00	1227.00
IUUC-Eca-033348	Equus caballus	91.44	0.00e+00	3011.00
IUUC-Eeu-034664	Erinaceus europaeus	82.64	0.00e+00	2867.00
IUUC-Fca-035604	Felis catus	87.62	0.00e+00	1513.00
IUUC-Fal-037333	Ficedula albicollis	76.49	0.00e+00	2655.00
IUUC-Fox-037984	Fusarium oxysporum	28.05	1.00e-39	159.00
IUUC-Fso-038463	Fusarium solani	25.59	5.00e-42	167.00
IUUC-Gmo-039363	Gadus morhua	55.29	0.00e+00	1617.00
IUUC-Gga-040486	Gallus gallus	75.59	0.00e+00	2598.00
IUUC-Gac-041985	Gasterosteus aculeatus	55.76	0.00e+00	1694.00
IUUC-Ggo-044704	Gorilla gorilla	85.10	0.00e+00	2511.00
IUUC-Hsa-046753	Homo sapiens	92.25	0.00e+00	3236.00
IUUC-Itr-048410	Ictidomys tridecemlineatus	91.29	0.00e+00	3197.00
IUUC-Lch-049904	Latimeria chalumnae	60.39	0.00e+00	2088.00
IUUC-Loc-052624	Lepisosteus oculatus	60.03	0.00e+00	2019.00
IUUC-Laf-053857	Loxodonta africana	88.74	0.00e+00	3139.00
IUUC-Mcc-054873	Macaca mulatta	92.02	0.00e+00	3183.00
IUUC-Meu-056858	Macropus eugenii	71.35	0.00e+00	1003.00
IUUC-Mga-059917	Meleagris gallopavo	76.40	0.00e+00	2704.00
IUUC-Mmr-061128	Microcebus murinus	88.61	0.00e+00	3048.00
IUUC-Mdo-062306	Monodelphis domestica	79.03	0.00e+00	2778.00
IUUC-Mmu-063389	Mus musculus	90.20	0.00e+00	3184.00
IUUC-Mpu-065983	Mustela putorius furo	91.73	0.00e+00	3244.00
IUUC-Mlu-068013	Myotis lucifugus	89.03	0.00e+00	3110.00
IUUC-Nfi-068403	Neosartorya fischeri	23.37	2.00e-53	205.00
IUUC-Nle-070031	Nomascus leucogenys	92.48	0.00e+00	3241.00
IUUC-Opr-070551	Ochotona princeps	69.53	0.00e+00	1325.00
IUUC-Ont-072035	Oreochromis niloticus	56.77	0.00e+00	1939.00
IUUC-Ocu-074930	Oryctolagus cuniculus	87.84	0.00e+00	3060.00
IUUC-Osa-086106	Oryza sativa	36.76	8.00e-14	72.40
IUUC-Ola-086683	Oryzias latipes	56.40	0.00e+00	1881.00
IUUC-Oga-088017	Otolemur garnettii	88.19	0.00e+00	3077.00
IUUC-Oar-089557	Ovis aries	90.80	0.00e+00	3178.00
IUUC-Ptr-091366	Pan troglodytes	91.04	0.00e+00	3205.00
IUUC-Pan-092184	Papio anubis	92.02	0.00e+00	3182.00
IUUC-Psi-093720	Pelodiscus sinensis	77.80	0.00e+00	2654.00
IUUC-Ppa-095780	Physcomitrella patens	22.25	1.00e-24	109.00
IUUC-Pfo-097124	Poecilia formosa	57.11	0.00e+00	1909.00
IUUC-Pab-098586	Pongo abelii	92.49	0.00e+00	3239.00
IUUC-Pop-099184	Populus trichocarpa	45.26	5.00e-14	72.00
IUUC-Pca-100673	Procavia capensis	83.09	0.00e+00	1671.00
IUUC-Pva-102724	Pteropus vampyrus	92.08	0.00e+00	2334.00
IUUC-Pgr-103372	Puccinia graminis	22.32	4.00e-52	201.00
IUUC-Pte-104174	Pyrenophora teres	23.91	1.00e-45	179.00
IUUC-Pyt-104431	Pyrenophora triticirepentis	23.55	7.00e-45	177.00
IUUC-Rno-105474	Rattus norvegicus	86.11	0.00e+00	2267.00
IUUC-Sha-106993	Sarcophilus harrisii	79.66	0.00e+00	2853.00
IUUC-Sar-113447	Sorex araneus	86.26	0.00e+00	2090.00
IUUC-Ssc-115768	Sus scrofa	86.91	0.00e+00	2872.00
IUUC-Tgu-116949	Taeniopygia guttata	72.08	0.00e+00	2457.00
IUUC-Tru-117782	Takifugu rubripes	56.03	0.00e+00	1908.00
IUUC-Tsy-119177	Tarsius syrichta	80.07	0.00e+00	2159.00
IUUC-Tni-120884	Tetraodon nigroviridis	52.44	0.00e+00	1728.00
IUUC-Tre-122137	Trichoderma reesei	25.69	2.00e-60	229.00
IUUC-Tvi-122272	Trichoderma virens	24.62	3.00e-52	201.00
IUUC-Tbe-128088	Tupaia belangeri	79.92	0.00e+00	1236.00
IUUC-Ttr-129062	Tursiops truncatus	86.37	0.00e+00	3005.00
IUUC-Uma-129344	Ustilago maydis	23.63	2.00e-54	208.00
IUUC-Vpa-130578	Vicugna pacos	83.47	0.00e+00	2864.00
IUUC-Xtr-132244	Xenopus tropicalis	61.05	0.00e+00	2104.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence