iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066304

Ensembl Protein ID

ENSMPUP00000010634.1

UniProt Accession

M3YH27; M3YH27_MUSPF

Genbank Protein ID

ENSMPUP00000010634

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01074640

Gene Name

USP25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000010719.1	ENSMPUT00000010810.1	ENSMPUP00000010634.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.00e-65	219.9	173	658

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 173  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 260
           6******************************99988889999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           +++qqD++Ef++ lld le+++++                  + +ee +++k k+++++lF g++    + +  +++ + +e f +++l
   Q: 261  ESQQQDVSEFTHKLLDWLEDAFQM------------------KAEEETDEEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 329
           **********************33..................123456788999************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    ++++++klP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 330  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSGKS---GQEHWFTKLPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 407
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 408  YMHRnreitrikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspiddidassppsgstaqtlpstteq 496
           ****8888888888888888888888888888888888888888888888888777777777777777777777777777777655555 PP
   S: 268  ...peekqke............................................................................... 274
              p     +                                                                               
   Q: 497  qgaP-----Sselpstsptsiaaisarsvihkpftqsrippdlpmhpaprhiteeelsvlesclhrwrteiendtrdlqesisrihrti 580
           5550.....05555555555666666666666666666666666666666666666666777777777777777777778888888888 PP
   S: 275  ..........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                     ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 581  elmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHRENrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 658
           8888888888**************************965556***************99997779************6 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MKTEKQKMLR WKEIWSINEH QQTFLNQLRE ITGINDAQIL QQALKDSNGN LELAVAFLTA 60
KNAKTPQQEE TTYYQTALPG NDRYISVGSQ ADTNVIDLTG DDKDDLQRAI ALSLAESNRA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAAGATGCC CTAACTTGCA ATCTAGCACC CCATGCTGAA TTCTGTTCAG TCCTCTTATT 60
ACTGAAAACA CCCATCCTCA GATGCCCCAA ATAATGTCAG GTGGGACAAT GATTTGAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	95.31	0.00e+00	2071.00
IUUC-Apl-004030	Anas platyrhynchos	82.99	0.00e+00	1886.00
IUUC-Aca-004753	Anolis carolinensis	65.10	0.00e+00	1053.00
IUUC-Ani-009503	Aspergillus nidulans	32.82	5.00e-12	67.00
IUUC-Ame-010624	Astyanax mexicanus	71.31	0.00e+00	1149.00
IUUC-Bta-013166	Bos taurus	96.87	0.00e+00	1439.00
IUUC-Cel-018346	Caenorhabditis elegans	27.69	1.00e-29	125.00
IUUC-Cja-019150	Callithrix jacchus	96.76	0.00e+00	2099.00
IUUC-Cfa-020649	Canis familiaris	98.56	0.00e+00	2162.00
IUUC-Cpo-021807	Cavia porcellus	92.43	0.00e+00	2106.00
IUUC-Csa-023388	Chlorocebus sabaeus	96.85	0.00e+00	2128.00
IUUC-Cho-024343	Choloepus hoffmanni	98.19	7.00e-156	544.00
IUUC-Cin-025302	Ciona intestinalis	37.23	1.00e-96	347.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	55.32	1.00e-10	62.40
IUUC-Dre-028016	Danio rerio	75.26	0.00e+00	1681.00
IUUC-Dno-029495	Dasypus novemcinctus	93.94	0.00e+00	2106.00
IUUC-Dor-030948	Dipodomys ordii	80.83	0.00e+00	1494.00
IUUC-Fca-035876	Felis catus	98.43	0.00e+00	1495.00
IUUC-Fal-036762	Ficedula albicollis	83.77	0.00e+00	1115.00
IUUC-Gmo-039490	Gadus morhua	72.16	0.00e+00	1583.00
IUUC-Gga-040817	Gallus gallus	85.14	0.00e+00	1950.00
IUUC-Gac-042473	Gasterosteus aculeatus	72.13	0.00e+00	1609.00
IUUC-Ggo-044939	Gorilla gorilla	92.26	0.00e+00	1971.00
IUUC-Hsa-046204	Homo sapiens	97.39	0.00e+00	1436.00
IUUC-Kpa-049349	Komagataella pastoris	27.75	6.00e-10	60.50
IUUC-Lch-049572	Latimeria chalumnae	79.01	0.00e+00	1764.00
IUUC-Loc-052070	Lepisosteus oculatus	77.72	0.00e+00	1715.00
IUUC-Lma-053078	Leptosphaeria maculans	30.56	4.00e-12	67.40
IUUC-Laf-054426	Loxodonta africana	96.52	0.00e+00	1320.00
IUUC-Mcc-055858	Macaca mulatta	96.85	0.00e+00	2131.00
IUUC-Mga-059808	Meleagris gallopavo	85.31	0.00e+00	1351.00
IUUC-Mmr-060987	Microcebus murinus	96.49	0.00e+00	2088.00
IUUC-Mmu-064245	Mus musculus	91.93	0.00e+00	1431.00
IUUC-Mlu-067139	Myotis lucifugus	96.07	0.00e+00	1489.00
IUUC-Nfi-068458	Neosartorya fischeri	23.37	5.00e-17	84.00
IUUC-Nle-069075	Nomascus leucogenys	97.65	0.00e+00	1438.00
IUUC-Ont-072150	Oreochromis niloticus	73.60	0.00e+00	1682.00
IUUC-Oan-073054	Ornithorhynchus anatinus	79.64	0.00e+00	1745.00
IUUC-Ocu-074102	Oryctolagus cuniculus	94.38	0.00e+00	2111.00
IUUC-Ola-086529	Oryzias latipes	69.38	0.00e+00	1540.00
IUUC-Oga-088939	Otolemur garnettii	95.82	0.00e+00	1449.00
IUUC-Oar-090266	Ovis aries	95.78	0.00e+00	2111.00
IUUC-Ptr-090546	Pan troglodytes	97.25	0.00e+00	1432.00
IUUC-Pan-092311	Papio anubis	96.76	0.00e+00	2130.00
IUUC-Psi-093459	Pelodiscus sinensis	91.03	0.00e+00	1184.00
IUUC-Pfo-096726	Poecilia formosa	73.74	0.00e+00	1672.00
IUUC-Pab-097608	Pongo abelii	93.87	0.00e+00	2010.00
IUUC-Pca-100718	Procavia capensis	81.91	0.00e+00	1439.00
IUUC-Pva-103150	Pteropus vampyrus	91.20	0.00e+00	1528.00
IUUC-Rno-105727	Rattus norvegicus	93.46	0.00e+00	1394.00
IUUC-Sha-107051	Sarcophilus harrisii	89.24	0.00e+00	1369.00
IUUC-Sar-113097	Sorex araneus	84.94	0.00e+00	1860.00
IUUC-Ssc-115877	Sus scrofa	94.22	0.00e+00	1427.00
IUUC-Tgu-117473	Taeniopygia guttata	76.50	0.00e+00	1697.00
IUUC-Tru-118135	Takifugu rubripes	66.01	0.00e+00	1402.00
IUUC-Tsy-119471	Tarsius syrichta	88.72	0.00e+00	1851.00
IUUC-Tni-120139	Tetraodon nigroviridis	71.99	0.00e+00	1000.00
IUUC-Tbe-127549	Tupaia belangeri	87.74	0.00e+00	1889.00
IUUC-Ttr-128896	Tursiops truncatus	90.00	0.00e+00	1949.00
IUUC-Uma-129338	Ustilago maydis	24.44	4.00e-13	71.20
IUUC-Vda-129742	Verticillium dahliae	24.19	2.00e-12	68.60
IUUC-Vpa-130500	Vicugna pacos	92.32	0.00e+00	1330.00
IUUC-Xtr-132896	Xenopus tropicalis	80.91	0.00e+00	1274.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence