iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059456

Ensembl Protein ID

ENSMGAP00000014145.2

UniProt Accession

G1NKZ9; G1NKZ9_MELGA

Protein Name

Tyrosine-protein kinase

Gene Name

FRK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000013388.2	ENSMGAT00000015068.2	ENSMGAP00000014145.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.00e-12	44.9	60	123

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk........elegkrGlfPenFvekle 63
           + +l++yea ++d+L++++Gd+++v+  +   egW++++           ++ +G +P+n+++ ++
   Q: 60   FVALFNYEARTEDDLSFQAGDKLEVL--DASHEGWWYAKLllpegsvcPGRKLQGYIPANYIAAVQ 123
           679***********************..88899*****889**99988888999********9987 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MGNFCQKYCS CLEPYVPCLF SGKEDEREED VGQVFANPAV VRIGSQAGEK DKHLVSTCNF 60
VALFNYEART EDDLSFQAGD KLEVLDASHE GWWYAKLLLP EGSVCPGRKL QGYIPANYIA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAAACT TCTGTCAGAA GTACTGCAGC TGTTTGGAGC CCTATGTTCC TTGCTTATTC 60
TCAGGGAAAG AAGATGAGCG GGAAGAGGAT GTTGGACAGG TTTTTGCCAA CCCTGCTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	31.15	5.00e-23	102.00
IUUC-Apl-003394	Anas platyrhynchos	79.53	0.00e+00	851.00
IUUC-Aca-004553	Anolis carolinensis	67.74	0.00e+00	735.00
IUUC-Bdi-014122	Brachypodium distachyon	30.35	4.00e-22	99.80
IUUC-Bol-015649	Brassica oleracea	32.16	4.00e-20	92.80
IUUC-Bra-017825	Brassica rapa	32.16	1.00e-20	94.70
IUUC-Cja-019885	Callithrix jacchus	69.29	0.00e+00	748.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	30.21	2.00e-22	99.40
IUUC-Dre-028274	Danio rerio	57.72	1.00e-170	592.00
IUUC-Dno-029689	Dasypus novemcinctus	70.06	0.00e+00	733.00
IUUC-Dme-031976	Drosophila melanogaster	60.25	4.00e-171	593.00
IUUC-Eeu-034770	Erinaceus europaeus	56.46	7.00e-146	509.00
IUUC-Fal-036892	Ficedula albicollis	77.25	0.00e+00	840.00
IUUC-Gga-041072	Gallus gallus	93.25	0.00e+00	1001.00
IUUC-Hvu-047855	Hordeum vulgare	31.54	4.00e-23	102.00
IUUC-Loc-052913	Lepisosteus oculatus	60.47	2.00e-178	617.00
IUUC-Mmr-061480	Microcebus murinus	67.72	0.00e+00	711.00
IUUC-Mac-065247	Musa acuminata	29.82	4.00e-23	102.00
IUUC-Mlu-067167	Myotis lucifugus	67.63	0.00e+00	715.00
IUUC-Nle-069786	Nomascus leucogenys	68.52	0.00e+00	740.00
IUUC-Ont-072417	Oreochromis niloticus	57.58	4.00e-176	610.00
IUUC-Obr-076765	Oryza brachyantha	28.79	4.00e-21	96.30
IUUC-Oni-082868	Oryza nivara	30.00	3.00e-21	97.10
IUUC-Opu-083800	Oryza punctata	30.00	4.00e-21	97.40
IUUC-Ola-086419	Oryzias latipes	63.46	8.00e-172	596.00
IUUC-Pan-092732	Papio anubis	68.40	0.00e+00	738.00
IUUC-Psi-093899	Pelodiscus sinensis	73.60	0.00e+00	787.00
IUUC-Pma-094230	Petromyzon marinus	58.32	2.00e-163	568.00
IUUC-Pfo-096035	Poecilia formosa	62.42	3.00e-171	594.00
IUUC-Pop-099946	Populus trichocarpa	28.96	3.00e-21	96.70
IUUC-Rno-105269	Rattus norvegicus	68.15	0.00e+00	721.00
IUUC-Sit-109712	Setaria italica	30.59	9.00e-21	95.50
IUUC-Sbi-113999	Sorghum bicolor	31.37	4.00e-19	89.70
IUUC-Tgu-116491	Taeniopygia guttata	80.83	0.00e+00	813.00
IUUC-Tru-117795	Takifugu rubripes	57.51	1.00e-156	546.00
IUUC-Tni-120512	Tetraodon nigroviridis	64.18	1.00e-177	615.00
IUUC-Tae-123192	Triticum aestivum	31.15	3.00e-23	103.00
IUUC-Tur-126022	Triticum urartu	30.74	2.00e-22	100.00
IUUC-Ttr-128817	Tursiops truncatus	68.49	0.00e+00	724.00
IUUC-Vpa-130389	Vicugna pacos	64.97	0.00e+00	670.00
IUUC-Vvi-131372	Vitis vinifera	28.33	1.00e-20	94.70
IUUC-Xtr-132360	Xenopus tropicalis	59.03	0.00e+00	651.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence