iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036320

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AANG02136510

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000013716.3	ENSFCAT00000013719.3	ENSFCAP00000012721.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.90e-91	304.7	194	823

Active Site

Position(s)	Description	Evidence
203	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
759	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp............kepkgellkslqklfeelwkskkka 67
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         p             ep g+l+ ++ ++++e++++kk+ 
   Q: 194  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEvkmsgtivkiE---------PpdlaltepleinLEPPGPLTLAMSQFLNEMQETKKGI 273
           5******************************86555555540.........24555555555658899********************* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlk 151
           v+p+el+++++k+a++f+gy+qqD+qE+l++lld+++ e +++ +k + +++++++++l++e     ++++kkk+ +s+++++F+g+l+
   Q: 274  VTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEQQRVSKGILKAFGNSTEKLDEElknkvKDYEKKKSVPSFVDRIFGGELT 362
           *************************************************************99999999******************** PP
   S: 152  sqikclecdnvssreepfldlslpvpgkeetkke....................................................... 185
           s+i+c ec++vs  +e+fldlslpv ++++ kk+                                                       
   Q: 363  STIMCDECRTVSLVHESFLDLSLPVLDDQSGKKSindknlkktmededkdseeekdndsymkerndipsgtskhlqkkakkqakkqakn 451
           *****************************99999******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 452  qrrqqkiqgkvlhlndictidhpednecevemslqgevdvksnhiseeeithkeycvnqkdlngqekmienktdnqksteevdmrnvnm 540
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 541  dndleglassptecprklngayltegssgevdissgfknlnlnaalrpdeinieilneshspgtkvyevvnedpetafctlanreafht 629
           ***************************************************************************************** PP
   S: 186  ...slqdcLesftkeeelegenkyycekckkkqe.................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
              s+q+cL +ft++e+l+++nk+ ce c+++q                  a+k++ ++  P+vL+lhLkRf  ++++ + +k+nk+++
   Q: 630  decSIQHCLYQFTRNEKLRDANKLLCEVCTRRQYsgpkanvkgerkhvytnAKKQMLISLAPPVLTLHLKRF--QQAGFNLRKVNKHIK 716
           ******************************777788888888888888888*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn........................ekgkWllfdDskVte 316
           fp+ Ldl+pfct ++++++e   ++ Y+L++vv HsG+++sGHY+ay+k                         +kg+W++++D++V++
   Q: 717  FPEILDLAPFCTLKCKNVAEentRVLYSLYGVVEHSGTMRSGHYTAYAKAraanshlsnlvlhgdipqdfemqsTKGQWFHISDTHVQA 805
           *************9999887777999************************9999999999999999999999888999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+ ++vl+   s+aY+lfY+r
   Q: 806  VPTTKVLN---SQAYLLFYER 823
           ********...********98 PP

Organism

Felis catus

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRTKGKT VPIDDSSESL EPTCRHIRKG LEQGNLKRAL LNVEWNICQD CKTDNKVKDK 60
SEEETEENPS VWLCLKCGHQ GCGRDSQEQH ALKHYMTPRS EPHCLVLSLD NWSVWCYLCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACGCCACTA TCTTAACCTA CTTTTATCTG CTCACTAATA TGGATGAGCA TTTCTTCGTA 60
TCTTTTAAGA CCAATTGTCC TTTTATCGTG AATTACCTGT TTATATCCCT CGCCTATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	30.14	3.00e-29	124.00
IUUC-Aml-001931	Ailuropoda melanoleuca	95.16	0.00e+00	1481.00
IUUC-Atr-003015	Amborella trichopoda	32.53	9.00e-36	145.00
IUUC-Apl-004145	Anas platyrhynchos	61.68	0.00e+00	896.00
IUUC-Aca-004314	Anolis carolinensis	59.57	0.00e+00	898.00
IUUC-Aly-006422	Arabidopsis lyrata	28.62	2.00e-29	124.00
IUUC-Ath-006732	Arabidopsis thaliana	34.45	4.00e-33	137.00
IUUC-Ame-011659	Astyanax mexicanus	49.55	4.00e-111	395.00
IUUC-Bta-013362	Bos taurus	91.16	0.00e+00	1436.00
IUUC-Bdi-014465	Brachypodium distachyon	31.29	3.00e-29	124.00
IUUC-Bol-015941	Brassica oleracea	29.54	9.00e-32	132.00
IUUC-Bra-016751	Brassica rapa	28.88	3.00e-29	124.00
IUUC-Cja-019177	Callithrix jacchus	90.57	0.00e+00	1471.00
IUUC-Cfa-020051	Canis familiaris	96.00	0.00e+00	1503.00
IUUC-Cpo-021886	Cavia porcellus	82.05	0.00e+00	1303.00
IUUC-Csa-024103	Chlorocebus sabaeus	90.81	0.00e+00	1484.00
IUUC-Cho-024315	Choloepus hoffmanni	78.12	1.00e-130	460.00
IUUC-Cin-025775	Ciona intestinalis	49.65	5.00e-40	155.00
IUUC-Csv-026075	Ciona savignyi	50.48	4.00e-58	219.00
IUUC-Cme-027348	Cyanidioschyzon merolae	39.19	3.00e-20	93.60
IUUC-Dre-028388	Danio rerio	46.48	0.00e+00	655.00
IUUC-Dno-029409	Dasypus novemcinctus	88.01	0.00e+00	1422.00
IUUC-Dor-030443	Dipodomys ordii	78.16	0.00e+00	660.00
IUUC-Ete-032807	Echinops telfairi	85.65	0.00e+00	693.00
IUUC-Eca-033479	Equus caballus	91.66	0.00e+00	1484.00
IUUC-Eeu-034835	Erinaceus europaeus	85.25	0.00e+00	682.00
IUUC-Fal-037029	Ficedula albicollis	60.14	0.00e+00	857.00
IUUC-Gmo-039480	Gadus morhua	52.23	7.00e-115	407.00
IUUC-Gga-040527	Gallus gallus	63.14	0.00e+00	910.00
IUUC-Gac-042343	Gasterosteus aculeatus	51.03	2.00e-114	406.00
IUUC-Gma-044402	Glycine max	28.90	4.00e-32	133.00
IUUC-Ggo-045598	Gorilla gorilla	90.45	0.00e+00	1474.00
IUUC-Hsa-046598	Homo sapiens	90.21	0.00e+00	1464.00
IUUC-Hvu-047146	Hordeum vulgare	29.23	2.00e-28	121.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	89.48	0.00e+00	1458.00
IUUC-Lch-050536	Latimeria chalumnae	52.50	0.00e+00	759.00
IUUC-Lpe-050703	Leersia perrieri	30.43	2.00e-29	124.00
IUUC-Loc-051814	Lepisosteus oculatus	57.25	1.00e-128	454.00
IUUC-Laf-053732	Loxodonta africana	87.94	0.00e+00	1431.00
IUUC-Mcc-054661	Macaca mulatta	91.17	0.00e+00	1485.00
IUUC-Meu-055967	Macropus eugenii	74.26	1.00e-157	550.00
IUUC-Mtr-057945	Medicago truncatula	31.25	1.00e-33	139.00
IUUC-Mga-059551	Meleagris gallopavo	62.62	0.00e+00	922.00
IUUC-Mvi-060391	Microbotryum violaceum	33.16	1.00e-19	91.70
IUUC-Mmr-061747	Microcebus murinus	90.83	0.00e+00	1440.00
IUUC-Mdo-062220	Monodelphis domestica	69.41	0.00e+00	1049.00
IUUC-Mmu-063582	Mus musculus	81.54	0.00e+00	1263.00
IUUC-Mac-064941	Musa acuminata	32.74	1.00e-37	151.00
IUUC-Mpu-066339	Mustela putorius furo	94.67	0.00e+00	1521.00
IUUC-Mlu-067511	Myotis lucifugus	85.73	0.00e+00	1359.00
IUUC-Nle-069252	Nomascus leucogenys	90.93	0.00e+00	1485.00
IUUC-Opr-070969	Ochotona princeps	84.84	0.00e+00	1322.00
IUUC-Ont-071786	Oreochromis niloticus	50.95	4.00e-117	415.00
IUUC-Ocu-074704	Oryctolagus cuniculus	90.73	0.00e+00	1419.00
IUUC-Oba-075094	Oryza barthii	30.06	2.00e-31	131.00
IUUC-Obr-076743	Oryza brachyantha	31.68	1.00e-31	132.00
IUUC-Ogl-077739	Oryza glaberrima	30.06	1.00e-31	131.00
IUUC-Ogu-078851	Oryza glumaepatula	30.06	2.00e-31	131.00
IUUC-Oin-079402	Oryza indica	30.06	2.00e-31	131.00
IUUC-Olo-080431	Oryza longistaminata	30.06	2.00e-31	131.00
IUUC-Ome-081580	Oryza meridionalis	30.06	2.00e-31	131.00
IUUC-Oni-082644	Oryza nivara	30.06	2.00e-31	131.00
IUUC-Opu-083452	Oryza punctata	29.81	2.00e-31	131.00
IUUC-Oru-084546	Oryza rufipogon	30.06	2.00e-31	131.00
IUUC-Osa-085858	Oryza sativa	30.06	2.00e-31	131.00
IUUC-Oga-088713	Otolemur garnettii	89.84	0.00e+00	1452.00
IUUC-Oar-089887	Ovis aries	90.81	0.00e+00	1453.00
IUUC-Ptr-091670	Pan troglodytes	90.45	0.00e+00	1477.00
IUUC-Pan-092293	Papio anubis	91.17	0.00e+00	1485.00
IUUC-Psi-093101	Pelodiscus sinensis	65.16	0.00e+00	939.00
IUUC-Ppa-095622	Physcomitrella patens	31.50	2.00e-33	138.00
IUUC-Pab-098773	Pongo abelii	92.40	0.00e+00	1150.00
IUUC-Pop-099136	Populus trichocarpa	30.21	1.00e-38	154.00
IUUC-Pca-101069	Procavia capensis	71.71	0.00e+00	878.00
IUUC-Ppe-101794	Prunus persica	30.00	2.00e-34	141.00
IUUC-Pva-103092	Pteropus vampyrus	88.00	0.00e+00	697.00
IUUC-Rno-105237	Rattus norvegicus	82.25	0.00e+00	1283.00
IUUC-Sha-106889	Sarcophilus harrisii	73.76	0.00e+00	1126.00
IUUC-Sit-110283	Setaria italica	33.14	5.00e-31	129.00
IUUC-Sly-111487	Solanum lycopersicum	30.61	2.00e-39	157.00
IUUC-Stu-112820	Solanum tuberosum	29.77	6.00e-37	149.00
IUUC-Sar-113530	Sorex araneus	83.57	0.00e+00	1340.00
IUUC-Sbi-113785	Sorghum bicolor	40.00	2.00e-25	111.00
IUUC-Ssc-116091	Sus scrofa	89.65	0.00e+00	1427.00
IUUC-Tgu-117478	Taeniopygia guttata	59.69	0.00e+00	873.00
IUUC-Tsy-119042	Tarsius syrichta	76.76	0.00e+00	927.00
IUUC-Tni-120015	Tetraodon nigroviridis	45.62	3.00e-178	619.00
IUUC-Tca-121701	Theobroma cacao	28.46	7.00e-37	149.00
IUUC-Tae-125351	Triticum aestivum	30.46	2.00e-27	118.00
IUUC-Tur-126788	Triticum urartu	29.23	6.00e-27	116.00
IUUC-Tbe-127309	Tupaia belangeri	75.93	0.00e+00	1139.00
IUUC-Ttr-128271	Tursiops truncatus	91.54	0.00e+00	1469.00
IUUC-Vpa-130674	Vicugna pacos	90.22	0.00e+00	1356.00
IUUC-Xtr-131869	Xenopus tropicalis	51.77	0.00e+00	791.00
IUUC-Xma-134195	Xiphophorus maculatus	53.10	4.00e-117	415.00
IUUC-Zma-135157	Zea mays	32.20	5.00e-28	120.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence