iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007793

Ensembl Protein ID

AAS52150

UniProt Accession

Q75A03; DIA2_ASHGO

Genbank Protein ID

AAS52150.2

Protein Name

Protein DIA2

Genbank Nucleotide ID

AE016817

Gene Name

DIA2; ADR230W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_ADR230W	AAS52150	AAS52150

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	26.41	9.00e-45	176.00	IUUC-Sce-106400
E3 adaptor/Cullin RING/SCF/F-box	23.08	4.00e-09	57.80	IUUC-Spo-108112

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ashbya gossypii

Functional Description
(View)

F-box protein component of a SCF ubiquitin ligase complex involved in ubiquitin-dependent protein degradation. The SCF-DIA2 complex is specifically involved in the pheromone induced degradation of phosphorylated TEC1. Involved in DNA replication, genome stability, and the control of cell cycle, probably through its association to replication origins to facilitate the ubiquitination of another origin-binding protein (By similarity).

Protein Sequence
(Fasta)

MSEDIIDRSL ELGIQCFQGE DYKGAAELFS KSLQLARSYT DRSLEGIREK VGLPKRCLHD 60
PSRVYHPRYL VLLDNRAATW EKLNKLDRAL ADAAYMITVD AYNLKGYIRR GKVLQKLGRY 120

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Nucleotide Sequence
(Fasta)

ATGTCCGAAG ATATTATAGA TAGGTCATTG GAGCTTGGAA TCCAATGTTT CCAAGGCGAG 60
GACTACAAGG GGGCTGCAGA GTTATTCAGC AAGTCACTGC AGCTTGCACG ATCATATACG 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat

PROSITE

PS50181--FBOX
PS50005--TPR
PS50293--TPR_REGION

Pfam

PF12937--F-box-like

SMART

SM00028--TPR

Gene Ontology

GO:0005634--C:nucleus
GO:0007049--P:cell cycle

KEGG

ago:AGOS_ADR230W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000136	Aegilops tauschii	30.53	5.00e-06	43.10
IUUC-Ath-006998	Arabidopsis thaliana	29.87	7.60e-02	30.80
IUUC-Acl-008351	Aspergillus clavatus	46.27	5.00e-10	57.40
IUUC-Afl-008600	Aspergillus flavus	55.00	9.00e-07	46.20
IUUC-Ani-009209	Aspergillus nidulans	24.26	1.00e-10	59.30
IUUC-Ang-009799	Aspergillus niger	36.08	8.00e-09	53.10
IUUC-Ate-010543	Aspergillus terreus	27.49	6.00e-11	60.10
IUUC-Bgr-012086	Blumeria graminis	34.38	5.00e-13	67.00
IUUC-Bci-013665	Botrytis cinerea	26.12	1.00e-12	65.90
IUUC-Bol-015260	Brassica oleracea	35.71	5.10e-02	31.20
IUUC-Bra-017514	Brassica rapa	39.39	8.00e-03	32.70
IUUC-Cja-019100	Callithrix jacchus	32.26	2.40e-02	33.50
IUUC-Cho-024526	Choloepus hoffmanni	25.53	2.00e-03	34.30
IUUC-Cgl-026584	Colletotrichum gloeosporioides	23.79	3.00e-09	54.70
IUUC-Cne-026948	Cryptococcus neoformans	42.11	4.00e-04	36.60
IUUC-Dse-031168	Dothistroma septosporum	40.32	8.00e-06	43.10
IUUC-Eeu-035160	Erinaceus europaeus	38.46	2.00e-03	34.30
IUUC-Fso-038167	Fusarium solani	24.86	7.00e-10	57.00
IUUC-Gmo-038877	Gadus morhua	37.50	1.00e-05	42.00
IUUC-Gma-043760	Glycine max	30.19	2.00e-03	34.70
IUUC-Hvu-047581	Hordeum vulgare	37.93	5.10e-02	29.30
IUUC-Itr-048696	Ictidomys tridecemlineatus	23.40	4.00e-03	33.50
IUUC-Kpa-049108	Komagataella pastoris	23.05	1.00e-12	65.90
IUUC-Lma-053184	Leptosphaeria maculans	25.00	1.00e-11	62.40
IUUC-Mla-058833	Melampsora laricipopulina	23.53	5.00e-09	53.90
IUUC-Mmr-061349	Microcebus murinus	25.53	2.00e-03	35.00
IUUC-Mac-064570	Musa acuminata	33.93	8.00e-04	36.20
IUUC-Nfi-068490	Neosartorya fischeri	44.29	1.00e-09	55.80
IUUC-Ogu-078889	Oryza glumaepatula	31.31	1.00e-06	46.20
IUUC-Osa-085303	Oryza sativa	32.32	2.00e-07	48.50
IUUC-Oga-087924	Otolemur garnettii	23.40	4.00e-03	33.50
IUUC-Pno-095042	Phaeosphaeria nodorum	22.67	1.00e-13	68.90
IUUC-Pop-100065	Populus trichocarpa	40.00	1.00e-02	32.00
IUUC-Ppe-101741	Prunus persica	43.33	1.00e-03	35.40
IUUC-Pgr-103647	Puccinia graminis	25.20	1.00e-08	49.70
IUUC-Pte-104379	Pyrenophora teres	26.00	2.00e-11	62.00
IUUC-Pyt-104626	Pyrenophora triticirepentis	26.34	1.00e-12	65.50
IUUC-Sce-106400	Saccharomyces cerevisiae	26.44	1.00e-46	179.00
IUUC-Sja-107999	Schizosaccharomyces japonicus	27.48	4.00e-10	57.40
IUUC-Spo-108112	Schizosaccharomyces pombe	24.66	5.00e-11	60.50
IUUC-Ssl-108627	Sclerotinia sclerotiorum	25.42	1.00e-12	65.50
IUUC-Stu-112162	Solanum tuberosum	34.09	5.00e-03	33.10
IUUC-Sre-114931	Sporisorium reilianum	22.40	7.00e-04	37.00
IUUC-Tni-120506	Tetraodon nigroviridis	30.50	9.00e-07	44.70
IUUC-Tae-125096	Triticum aestivum	30.53	5.00e-06	43.10
IUUC-Tur-126053	Triticum urartu	37.31	3.00e-05	40.40
IUUC-Tme-126968	Tuber melanosporum	43.08	2.00e-08	51.20
IUUC-Tbe-127382	Tupaia belangeri	31.25	1.30e-02	32.00
IUUC-Vpa-130065	Vicugna pacos	23.91	1.00e-03	35.80
IUUC-Vvi-130912	Vitis vinifera	21.71	3.00e-03	33.90
IUUC-Yli-134623	Yarrowia lipolytica	25.29	1.00e-11	62.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence