iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.70e-11	45.2	26	114

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees......................ksklmveikdvqpevfrallkFlYtgklde 67
           +Dv++ v+g+ ++ah+++Laa+S +F++ f +  + +                       + + + ++ v +evf  ll+FlY+g++++
   Q: 26   SDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPQpvtgidptqhgsvpasptrgstAPAGIIPVNSVGYEVFLLLLQFLYSGQVSI 114
           6*****************************777665579*******************97799999********************975 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts redundantly with BOP2. BOP1/2 promote leaf and floral meristem fate and determinacy in a pathway targeting AP1 and AGL24. BOP1/2 act as transcriptional co-regulators through direct interaction with TGA factors, including PAN, a direct regulator of AP1. Controls lateral organ fate through positive regulation of adaxial-abaxial polarity genes ATHB-14/PHB, YAB1/FIL and YAB3, and through positive regulation of LOB domain-containing genes LOB, LBD6/AS2 and LBD36. Promotes and maintains a developmentally determinate state in leaf cells through the negative regulation of JAG, JGL and class I KNOX genes. Is also involved in nectary development, formation of normal abscission zones and suppression of bract formation.

Protein Sequence
(Fasta)

MSNLEESLRS LSLDFLNLLI NGQAFSDVTF SVEGRLVHAH RCILAARSLF FRKFFCGTDS 60
PQPVTGIDPT QHGSVPASPT RGSTAPAGII PVNSVGYEVF LLLLQFLYSG QVSIVPQKHE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACACTGAA ACAGTTATAA TTTTTTTTTA ACCATCTTAG TTTAAATATC TGAGCCGCCC 60
GGTTCATCCA TTCAAATCTC TCTCTCACTT ACCAAACCCA AACAAATATC TAACACCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000210--BTB/POZ_dom
IPR024228--NPR_central_dom
IPR011333--SKP1/BTB/POZ

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50097--BTB

Pfam

PF12796--Ank_2
PF00651--BTB
PF11900--DUF3420

SMART

SM00248--ANK
SM00225--BTB

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0010434--P:bract formation
GO:0010582--P:floral meristem determinacy
GO:0010227--P:floral organ abscission
GO:0048439--P:flower morphogenesis
GO:0009864--P:induced systemic resistance, jasmonic acid mediated signaling pathway
GO:0010254--P:nectary development
GO:0009944--P:polarity specification of adaxial/abaxial axis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0009954--P:proximal/distal pattern formation
GO:0030162--P:regulation of proteolysis

KEGG

ath:AT2G41370

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000810	Aegilops tauschii	68.57	5.00e-168	583.00
IUUC-Atr-002962	Amborella trichopoda	65.52	3.00e-130	457.00
IUUC-Aly-006361	Arabidopsis lyrata	98.92	0.00e+00	849.00
IUUC-Bdi-014484	Brachypodium distachyon	68.05	3.00e-164	570.00
IUUC-Bol-015455	Brassica oleracea	93.83	0.00e+00	819.00
IUUC-Bra-016669	Brassica rapa	92.78	0.00e+00	798.00
IUUC-Gma-043636	Glycine max	77.41	0.00e+00	660.00
IUUC-Hvu-047540	Hordeum vulgare	67.83	8.00e-171	592.00
IUUC-Lpe-051262	Leersia perrieri	71.82	2.00e-170	591.00
IUUC-Mtr-057696	Medicago truncatula	77.09	0.00e+00	642.00
IUUC-Mla-059110	Melampsora laricipopulina	26.19	8.00e-04	38.90
IUUC-Mac-065209	Musa acuminata	75.49	5.00e-167	580.00
IUUC-Oba-075319	Oryza barthii	62.50	1.00e-94	339.00
IUUC-Ogl-077085	Oryza glaberrima	69.14	2.00e-168	584.00
IUUC-Ogu-078533	Oryza glumaepatula	68.92	9.00e-169	585.00
IUUC-Oin-079134	Oryza indica	69.28	2.00e-168	585.00
IUUC-Ome-081679	Oryza meridionalis	68.99	3.00e-168	584.00
IUUC-Oni-082646	Oryza nivara	69.28	4.00e-169	587.00
IUUC-Opu-083258	Oryza punctata	70.77	3.00e-170	590.00
IUUC-Oru-084680	Oryza rufipogon	69.42	2.00e-168	585.00
IUUC-Osa-085677	Oryza sativa	66.17	3.00e-140	491.00
IUUC-Ppa-095240	Physcomitrella patens	50.53	8.00e-94	337.00
IUUC-Pop-099689	Populus trichocarpa	79.92	0.00e+00	671.00
IUUC-Ppe-101402	Prunus persica	81.76	0.00e+00	646.00
IUUC-Smo-109071	Selaginella moellendorffii	55.19	5.00e-108	384.00
IUUC-Sit-109779	Setaria italica	70.25	8.00e-170	589.00
IUUC-Sly-111738	Solanum lycopersicum	79.35	0.00e+00	657.00
IUUC-Stu-112278	Solanum tuberosum	76.89	0.00e+00	645.00
IUUC-Sbi-114575	Sorghum bicolor	68.45	9.00e-141	492.00
IUUC-Tca-120934	Theobroma cacao	80.85	0.00e+00	711.00
IUUC-Tae-124843	Triticum aestivum	69.85	2.00e-170	591.00
IUUC-Vvi-131425	Vitis vinifera	79.36	0.00e+00	657.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence