iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098594

UUCD1 version

UUC-PoA-01062

Ensembl Protein ID

ENSPPYP00000016505.1

UniProt Accession

Q5RBQ4; Q5RBN2; UBP46_PONAB

Genbank Protein ID

CAH90806.1; CAH90828.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46

Genbank Nucleotide ID

CR858584; CR858606

Gene Name

USP46

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000014777.1	ENSPPYT00000017179.1	ENSPPYP00000016505.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-98	330.5	24	353

Active Site

Position(s)	Description	Evidence
44	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
313	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +Gl N+gNtCY+NSvLQ+L++++++re++l  +k +      +++k++ll++l++lf+++   k+k +++ p+++++ l+ke+  f++y
   Q: 24   FGLVNFGNTCYCNSVLQALYFCRPFRENVLA-YKAQ------QKKKENLLTCLADLFHSIAtqKKKVGVIPPKKFISRLRKENDLFDNY 105
           6******************************.3333......567899************976777779******************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +qqDa+Efl++ll+++ + l   ++++k+e+++ + ++ +++++ +++k + ++++++Fqg+l+++++cl+c++vss++e+fldls++v
   Q: 106  MQQDAHEFLNYLLNTIADIL---QEEKKQEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDV 191
           ********************...34555555555556666677788888888************************************* PP
   S: 177  pgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
           ++++     s+++cL++f+++e+l++e+kyyce+c++kqea+k++++kklP +L lhLkRf++ e+ ++ +k++ +v fpleL l  f+
   Q: 192  EQNT-----SITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELRL--FN 273
           ****.....9**********************************************************************66555..77 PP
   S: 266  tspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg.........staYvlfYkr 337
           ts++  ++ ++ Y+L+avvvH G +++ GHY+++vk+ +g WllfdD+ V++++ + ++e+ g         +++Y+lfY++
   Q: 274  TSSDA-VNLDRMYDLVAVVVHCGsGPNRGHYITIVKS-HGFWLLFDDDIVEKIDAQAIEEFYGltsdisknsESGYILFYQS 353
           77554.4459***************************.888*******************999*****************97 PP

Organism

Pongo abelii

Functional Description
(View)

Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity).

Protein Sequence
(Fasta)

MGTNASALEK DIGPEQFPIN EHYFGLVNFG NTCYCNSVLQ ALYFCRPFRE NVLAYKAQQK 60
KKENLLTCLA DLFHSIATQK KKVGVIPPKK FISRLRKEND LFDNYMQQDA HEFLNYLLNT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGCCAGGG CCAAAAGTTG AAAAATCCGG AGACCCCCAA GGGCTGCTGA CGATTGCCCG 60
CCCCGGCCTC CCCGCCCAGC GCGCCACCAT GGGGCAGTGC CGGGTTTCCC CCTGTAAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0085--Behavior
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007610--P:behavior
GO:0016579--P:protein deubiquitination
GO:0032228--P:regulation of synaptic transmission, GABAergic
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

pon:100174399; pon:100189895

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000193	Aegilops tauschii	60.00	1.00e-125	442.00
IUUC-Aml-002353	Ailuropoda melanoleuca	100.00	0.00e+00	701.00
IUUC-Atr-002650	Amborella trichopoda	59.56	7.00e-126	443.00
IUUC-Apl-003380	Anas platyrhynchos	98.31	0.00e+00	687.00
IUUC-Aca-005031	Anolis carolinensis	97.18	0.00e+00	728.00
IUUC-Aly-005830	Arabidopsis lyrata	58.92	1.00e-123	436.00
IUUC-Ath-006663	Arabidopsis thaliana	59.07	2.00e-126	445.00
IUUC-Ago-007871	Ashbya gossypii	38.57	6.00e-49	189.00
IUUC-Ame-010862	Astyanax mexicanus	94.69	0.00e+00	702.00
IUUC-Bta-013023	Bos taurus	100.00	0.00e+00	700.00
IUUC-Bdi-014008	Brachypodium distachyon	60.55	3.00e-125	441.00
IUUC-Bol-015138	Brassica oleracea	58.60	9.00e-125	439.00
IUUC-Bra-017483	Brassica rapa	60.34	3.00e-126	444.00
IUUC-Cel-018379	Caenorhabditis elegans	62.41	6.00e-145	506.00
IUUC-Cja-018956	Callithrix jacchus	100.00	0.00e+00	698.00
IUUC-Cfa-021064	Canis familiaris	99.44	0.00e+00	690.00
IUUC-Cpo-022443	Cavia porcellus	99.72	0.00e+00	697.00
IUUC-Cre-022711	Chlamydomonas reinhardtii	53.65	8.00e-100	356.00
IUUC-Csa-023841	Chlorocebus sabaeus	100.00	0.00e+00	702.00
IUUC-Csv-025828	Ciona savignyi	73.89	3.00e-88	318.00
IUUC-Cne-026900	Cryptococcus neoformans	41.91	4.00e-60	226.00
IUUC-Dre-028230	Danio rerio	94.17	0.00e+00	700.00
IUUC-Dno-029209	Dasypus novemcinctus	100.00	0.00e+00	697.00
IUUC-Dme-032038	Drosophila melanogaster	81.28	5.00e-100	357.00
IUUC-Eca-033721	Equus caballus	99.72	0.00e+00	695.00
IUUC-Eeu-034916	Erinaceus europaeus	98.64	3.00e-162	563.00
IUUC-Fca-036299	Felis catus	100.00	0.00e+00	698.00
IUUC-Fox-037682	Fusarium oxysporum	42.32	4.00e-74	272.00
IUUC-Fso-038299	Fusarium solani	37.07	9.00e-75	274.00
IUUC-Gmo-038611	Gadus morhua	94.63	0.00e+00	693.00
IUUC-Ggr-039806	Gaeumannomyces graminis	42.24	2.00e-75	276.00
IUUC-Gga-041157	Gallus gallus	98.59	0.00e+00	690.00
IUUC-Gac-041764	Gasterosteus aculeatus	95.48	0.00e+00	697.00
IUUC-Gma-042927	Glycine max	60.66	9.00e-128	449.00
IUUC-Ggo-044659	Gorilla gorilla	100.00	0.00e+00	697.00
IUUC-Hsa-046156	Homo sapiens	100.00	0.00e+00	702.00
IUUC-Hvu-047692	Hordeum vulgare	58.86	1.00e-123	435.00
IUUC-Itr-048157	Ictidomys tridecemlineatus	100.00	0.00e+00	702.00
IUUC-Kpa-049250	Komagataella pastoris	44.83	2.00e-69	256.00
IUUC-Lch-049969	Latimeria chalumnae	96.62	0.00e+00	662.00
IUUC-Lpe-051368	Leersia perrieri	58.70	1.00e-122	432.00
IUUC-Loc-052479	Lepisosteus oculatus	90.99	0.00e+00	671.00
IUUC-Laf-054085	Loxodonta africana	100.00	0.00e+00	702.00
IUUC-Mcc-055566	Macaca mulatta	100.00	0.00e+00	699.00
IUUC-Mor-057072	Magnaporthe oryzae	43.65	8.00e-76	278.00
IUUC-Mpo-057424	Magnaporthe poae	42.86	2.00e-75	276.00
IUUC-Mtr-057715	Medicago truncatula	60.33	5.00e-128	450.00
IUUC-Mla-059142	Melampsora laricipopulina	54.45	5.00e-95	342.00
IUUC-Mga-059575	Meleagris gallopavo	98.59	0.00e+00	686.00
IUUC-Mvi-060357	Microbotryum violaceum	53.96	2.00e-77	284.00
IUUC-Mdo-062579	Monodelphis domestica	99.72	0.00e+00	700.00
IUUC-Mmu-063611	Mus musculus	100.00	0.00e+00	702.00
IUUC-Mac-065323	Musa acuminata	60.11	4.00e-124	437.00
IUUC-Mpu-066038	Mustela putorius furo	100.00	0.00e+00	699.00
IUUC-Mlu-068183	Myotis lucifugus	99.72	0.00e+00	697.00
IUUC-Nle-069330	Nomascus leucogenys	100.00	0.00e+00	702.00
IUUC-Opr-070980	Ochotona princeps	99.72	0.00e+00	697.00
IUUC-Ont-072134	Oreochromis niloticus	94.97	0.00e+00	706.00
IUUC-Oan-073583	Ornithorhynchus anatinus	93.52	0.00e+00	685.00
IUUC-Ocu-074923	Oryctolagus cuniculus	99.72	0.00e+00	696.00
IUUC-Oba-075220	Oryza barthii	59.73	7.00e-123	433.00
IUUC-Obr-076208	Oryza brachyantha	57.65	8.00e-120	423.00
IUUC-Ogl-077216	Oryza glaberrima	59.73	7.00e-123	433.00
IUUC-Ogu-078836	Oryza glumaepatula	59.73	7.00e-123	433.00
IUUC-Oin-079522	Oryza indica	59.73	7.00e-123	433.00
IUUC-Olo-080882	Oryza longistaminata	59.73	7.00e-123	433.00
IUUC-Ome-081549	Oryza meridionalis	59.73	7.00e-123	433.00
IUUC-Oni-082982	Oryza nivara	59.73	7.00e-123	433.00
IUUC-Opu-083532	Oryza punctata	59.73	5.00e-123	434.00
IUUC-Oru-084568	Oryza rufipogon	59.73	7.00e-123	433.00
IUUC-Osa-085299	Oryza sativa	59.73	7.00e-123	433.00
IUUC-Ola-086546	Oryzias latipes	95.24	0.00e+00	704.00
IUUC-Olu-087809	Ostreococcus lucimarinus	48.44	1.00e-81	296.00
IUUC-Oga-088073	Otolemur garnettii	99.72	0.00e+00	695.00
IUUC-Oar-089248	Ovis aries	100.00	0.00e+00	698.00
IUUC-Ptr-090814	Pan troglodytes	100.00	0.00e+00	702.00
IUUC-Pan-091753	Papio anubis	100.00	0.00e+00	702.00
IUUC-Psi-094012	Pelodiscus sinensis	99.15	0.00e+00	689.00
IUUC-Ppa-095415	Physcomitrella patens	59.03	1.00e-127	449.00
IUUC-Pfo-097369	Poecilia formosa	94.97	0.00e+00	706.00
IUUC-Pop-099798	Populus trichocarpa	60.38	8.00e-127	446.00
IUUC-Pca-100913	Procavia capensis	83.66	9.00e-160	555.00
IUUC-Ppe-101474	Prunus persica	59.84	6.00e-127	447.00
IUUC-Pva-102892	Pteropus vampyrus	100.00	0.00e+00	698.00
IUUC-Pgr-103306	Puccinia graminis	52.63	2.00e-94	340.00
IUUC-Rno-104909	Rattus norvegicus	99.72	0.00e+00	700.00
IUUC-Sce-106367	Saccharomyces cerevisiae	37.63	1.00e-55	211.00
IUUC-Sha-107400	Sarcophilus harrisii	99.72	0.00e+00	696.00
IUUC-Smo-109064	Selaginella moellendorffii	60.33	6.00e-121	427.00
IUUC-Sit-110819	Setaria italica	59.73	2.00e-123	435.00
IUUC-Sly-111210	Solanum lycopersicum	59.73	1.00e-126	445.00
IUUC-Stu-112398	Solanum tuberosum	60.16	6.00e-127	447.00
IUUC-Sbi-114562	Sorghum bicolor	58.90	1.00e-123	436.00
IUUC-Sre-115197	Sporisorium reilianum	49.11	4.00e-80	293.00
IUUC-Ssc-115550	Sus scrofa	100.00	0.00e+00	698.00
IUUC-Tgu-116800	Taeniopygia guttata	98.59	0.00e+00	690.00
IUUC-Tru-118212	Takifugu rubripes	94.97	0.00e+00	707.00
IUUC-Tni-120071	Tetraodon nigroviridis	94.97	0.00e+00	707.00
IUUC-Tca-121329	Theobroma cacao	60.11	3.00e-127	448.00
IUUC-Tae-125280	Triticum aestivum	60.27	1.00e-126	446.00
IUUC-Tur-126563	Triticum urartu	60.00	4.00e-126	444.00
IUUC-Uma-129409	Ustilago maydis	49.13	5.00e-81	296.00
IUUC-Vpa-130590	Vicugna pacos	94.93	0.00e+00	652.00
IUUC-Vvi-131371	Vitis vinifera	59.84	8.00e-127	446.00
IUUC-Xma-133111	Xiphophorus maculatus	94.97	0.00e+00	706.00
IUUC-Yli-134632	Yarrowia lipolytica	45.21	7.00e-79	288.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence