iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.40e-07	31.2	406	465

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..........kdgpl........vlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+e++                       + +CgH++h  Cl ++ + + ++ ++ +CP+C+
   Q: 406  CTICMERLtapsgykgpqP---TvkpdlvgkLSRCGHIYHIYCLVAM-YNNGNKDGSLQCPTCK 465
           9*******55555444320...222333333577**********555.56677**********6 PP

Organism

Mus musculus

Functional Description
(View)

Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4 (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations.

Protein Sequence
(Fasta)

MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD SRLAPYIIDL 60
QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG SWTPYDMEVG ITIQYAYEKQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGAGAGAG AGAGAGAGAG AGAGAGAGAG AGAGAGAGAG AGAGAGAGAA TGCGTATGCA 60
TGCACGAGCT GTAGGGAGAT GCGAGCCTCT GAGCTCACGC CGCGGACACG GCCGGTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50918--WWE
PS50089--ZF_RING_2

Pfam

PF02825--WWE
PF00097--zf-C3HC4

SMART

SM00184--RING
SM00678--WWE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0016567--P:protein ubiquitination

KEGG

mmu:207521

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001420	Ailuropoda melanoleuca	88.91	0.00e+00	919.00
IUUC-Apl-004196	Anas platyrhynchos	65.40	0.00e+00	666.00
IUUC-Aca-004282	Anolis carolinensis	82.31	0.00e+00	971.00
IUUC-Aly-006456	Arabidopsis lyrata	35.38	1.00e-06	47.40
IUUC-Bta-013541	Bos taurus	89.88	1.00e-167	583.00
IUUC-Cja-019164	Callithrix jacchus	93.05	0.00e+00	1005.00
IUUC-Cfa-020475	Canis familiaris	90.14	0.00e+00	946.00
IUUC-Cpo-021358	Cavia porcellus	91.09	0.00e+00	1041.00
IUUC-Csa-023895	Chlorocebus sabaeus	94.35	0.00e+00	1085.00
IUUC-Cho-024781	Choloepus hoffmanni	98.05	1.00e-170	592.00
IUUC-Cin-025512	Ciona intestinalis	52.73	4.00e-65	242.00
IUUC-Csv-026089	Ciona savignyi	52.04	3.00e-63	236.00
IUUC-Dre-028695	Danio rerio	82.07	3.00e-164	572.00
IUUC-Dno-029115	Dasypus novemcinctus	92.41	0.00e+00	1048.00
IUUC-Dor-030701	Dipodomys ordii	87.70	0.00e+00	769.00
IUUC-Dme-031724	Drosophila melanogaster	41.63	8.00e-49	188.00
IUUC-Eca-033784	Equus caballus	96.04	0.00e+00	681.00
IUUC-Eeu-035106	Erinaceus europaeus	74.88	0.00e+00	753.00
IUUC-Fca-035528	Felis catus	92.02	0.00e+00	1038.00
IUUC-Fal-037476	Ficedula albicollis	90.88	4.00e-174	604.00
IUUC-Gmo-039590	Gadus morhua	82.86	2.00e-145	509.00
IUUC-Gga-040618	Gallus gallus	80.94	0.00e+00	931.00
IUUC-Gac-041759	Gasterosteus aculeatus	67.90	0.00e+00	802.00
IUUC-Ggo-044787	Gorilla gorilla	94.18	0.00e+00	1083.00
IUUC-Hsa-045998	Homo sapiens	93.86	0.00e+00	1088.00
IUUC-Itr-048056	Ictidomys tridecemlineatus	94.27	0.00e+00	1049.00
IUUC-Lch-049663	Latimeria chalumnae	61.40	0.00e+00	677.00
IUUC-Laf-054482	Loxodonta africana	91.76	0.00e+00	1061.00
IUUC-Mcc-055090	Macaca mulatta	93.36	0.00e+00	957.00
IUUC-Meu-056882	Macropus eugenii	83.91	5.00e-168	584.00
IUUC-Mga-060182	Meleagris gallopavo	71.32	0.00e+00	691.00
IUUC-Mdo-062755	Monodelphis domestica	84.67	0.00e+00	800.00
IUUC-Mac-064552	Musa acuminata	30.65	3.00e-04	40.00
IUUC-Mpu-066276	Mustela putorius furo	93.70	0.00e+00	1063.00
IUUC-Mlu-067664	Myotis lucifugus	87.90	0.00e+00	647.00
IUUC-Nle-069360	Nomascus leucogenys	94.18	0.00e+00	1064.00
IUUC-Opr-070345	Ochotona princeps	84.24	0.00e+00	737.00
IUUC-Ont-072400	Oreochromis niloticus	62.18	0.00e+00	772.00
IUUC-Oan-073373	Ornithorhynchus anatinus	92.57	7.00e-169	586.00
IUUC-Ocu-074185	Oryctolagus cuniculus	92.40	0.00e+00	834.00
IUUC-Ola-086644	Oryzias latipes	80.90	2.00e-154	539.00
IUUC-Oga-088147	Otolemur garnettii	94.66	0.00e+00	1034.00
IUUC-Oar-090311	Ovis aries	95.55	0.00e+00	639.00
IUUC-Ptr-091535	Pan troglodytes	93.86	0.00e+00	1086.00
IUUC-Pan-092233	Papio anubis	94.02	0.00e+00	1084.00
IUUC-Psi-093689	Pelodiscus sinensis	81.21	0.00e+00	852.00
IUUC-Pfo-096557	Poecilia formosa	66.40	0.00e+00	773.00
IUUC-Pab-098027	Pongo abelii	94.67	0.00e+00	1090.00
IUUC-Pca-100457	Procavia capensis	99.13	8.00e-125	440.00
IUUC-Pva-102381	Pteropus vampyrus	81.09	0.00e+00	691.00
IUUC-Rno-105599	Rattus norvegicus	96.88	0.00e+00	904.00
IUUC-Ssc-116338	Sus scrofa	92.10	0.00e+00	1060.00
IUUC-Tgu-116484	Taeniopygia guttata	90.55	3.00e-162	564.00
IUUC-Tru-118590	Takifugu rubripes	82.87	2.00e-156	545.00
IUUC-Tsy-119110	Tarsius syrichta	92.59	0.00e+00	780.00
IUUC-Tni-120695	Tetraodon nigroviridis	68.25	0.00e+00	783.00
IUUC-Tbe-127393	Tupaia belangeri	85.22	0.00e+00	839.00
IUUC-Ttr-128524	Tursiops truncatus	78.88	0.00e+00	699.00
IUUC-Vpa-130723	Vicugna pacos	97.20	2.00e-60	226.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence