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Tag Content
iUUCD ID IUUC-Dre-027685
UUCD1 version UUC-DaR-01321
Ensembl Protein ID ENSDARP00000002609.7
UniProt Accession Q803I4; Q6PUR9; Q9PTH4; RING2_DANRE
Genbank Protein ID AAS92634.1; AAH44472.1; AAF17506.1
Protein Name E3 ubiquitin-protein ligase RING2; RING finger protein 1B; RING finger protein 2; RING-type E3 ubiquitin transferase RING2
Genbank Nucleotide ID AY576996; BC044472; AF196346
Gene Name rnf2; ring1b
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000010381.9 ENSDART00000017034.7 ENSDARP00000002609.7
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 24040141
Classification
Family E-value Score Start End
E3 activity/RING/RING 3.30e-07 31.6 53 93
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+++k+   +  C H f+adC+  ++       s++  CP+Cr
   Q: 53   CPICLDMLKNTMTTKECLHRFCADCIiTAL------RSGNKECPTCR 93
           **********555555*********98888......**********8 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (By similarity).
 E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (By similarity).
Protein Sequence
(Fasta)
MKMTQTVQTN GVQPLSKTWE LSLYELQRTP QEAITDGLEI AVSPRSLHSE LMCPICLDML 60
KNTMTTKECL HRFCADCIIT ALRSGNKECP TCRKKLVSKR SLRPDPNFDA LISKIYPSRD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-027685|E3,RING|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAACGCGCT GGCAGGAGAG AGAGTGTTCA CAACATTGAG ATGTAAGTAT GTAAACAGCT 60
GCGTTTTTAC TAAAATATAT GCTTATTGCT TGTCGACGTT AACGGCTTAA TTAGCACGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-027685|E3,RING|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF16207--RAWUL
SMART

SM00184--RING
Gene Ontology

GO:0071339--C:MLL1 complex
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0036353--P:histone H2A-K119 monoubiquitination
GO:1902254--P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0033339--P:pectoral fin development
GO:0032330--P:regulation of chondrocyte differentiation
GO:0060042--P:retina morphogenesis in camera-type eye
GO:0006351--P:transcription, DNA-templated
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000516 Aegilops tauschii 57.81 7.00e-19 88.60
IUUC-Aml-001250 Ailuropoda melanoleuca 88.89 0.00e+00 626.00
IUUC-Apl-003587 Anas platyrhynchos 88.99 0.00e+00 632.00
IUUC-Aca-004928 Anolis carolinensis 88.99 0.00e+00 631.00
IUUC-Aly-005911 Arabidopsis lyrata 50.00 1.00e-22 101.00
IUUC-Ath-006899 Arabidopsis thaliana 48.81 2.00e-22 100.00
IUUC-Ame-010622 Astyanax mexicanus 97.92 0.00e+00 696.00
IUUC-Bta-013553 Bos taurus 89.29 0.00e+00 634.00
IUUC-Bdi-014202 Brachypodium distachyon 54.22 8.00e-24 105.00
IUUC-Bol-015993 Brassica oleracea 52.50 1.00e-23 104.00
IUUC-Bra-017150 Brassica rapa 52.50 1.00e-23 104.00
IUUC-Cel-018573 Caenorhabditis elegans 50.00 4.00e-15 78.60
IUUC-Cja-019093 Callithrix jacchus 89.29 0.00e+00 633.00
IUUC-Cfa-020681 Canis familiaris 89.02 0.00e+00 630.00
IUUC-Cpo-021402 Cavia porcellus 75.89 8.00e-144 503.00
IUUC-Cre-022709 Chlamydomonas reinhardtii 35.48 5.00e-07 49.70
IUUC-Csa-024231 Chlorocebus sabaeus 89.29 0.00e+00 634.00
IUUC-Cho-024843 Choloepus hoffmanni 75.30 9.00e-145 506.00
IUUC-Csv-026314 Ciona savignyi 47.28 4.00e-84 304.00
IUUC-Dno-029993 Dasypus novemcinctus 89.29 0.00e+00 634.00
IUUC-Dor-030986 Dipodomys ordii 64.88 1.00e-118 419.00
IUUC-Dme-031721 Drosophila melanogaster 78.91 1.00e-67 250.00
IUUC-Ete-032564 Echinops telfairi 73.51 5.00e-143 500.00
IUUC-Eca-033251 Equus caballus 89.29 0.00e+00 634.00
IUUC-Eeu-034951 Erinaceus europaeus 89.29 0.00e+00 634.00
IUUC-Fca-036240 Felis catus 88.99 0.00e+00 628.00
IUUC-Fal-037376 Ficedula albicollis 89.29 0.00e+00 632.00
IUUC-Gmo-038879 Gadus morhua 92.33 2.00e-180 624.00
IUUC-Gga-041134 Gallus gallus 88.99 0.00e+00 630.00
IUUC-Gac-042589 Gasterosteus aculeatus 92.35 0.00e+00 630.00
IUUC-Gma-044107 Glycine max 48.94 5.00e-23 102.00
IUUC-Ggo-044529 Gorilla gorilla 89.29 0.00e+00 634.00
IUUC-Hsa-046100 Homo sapiens 89.29 0.00e+00 634.00
IUUC-Hvu-047152 Hordeum vulgare 54.22 1.00e-23 104.00
IUUC-Itr-047891 Ictidomys tridecemlineatus 89.29 0.00e+00 634.00
IUUC-Lch-049494 Latimeria chalumnae 89.58 2.00e-178 617.00
IUUC-Lpe-050923 Leersia perrieri 43.48 3.00e-24 106.00
IUUC-Loc-052544 Lepisosteus oculatus 94.46 0.00e+00 679.00
IUUC-Laf-053675 Loxodonta africana 88.64 2.00e-164 571.00
IUUC-Mcc-055685 Macaca mulatta 89.29 0.00e+00 632.00
IUUC-Meu-056000 Macropus eugenii 83.33 5.00e-76 278.00
IUUC-Mtr-058234 Medicago truncatula 51.81 4.00e-24 105.00
IUUC-Mga-059354 Meleagris gallopavo 89.29 0.00e+00 632.00
IUUC-Mmr-060809 Microcebus murinus 89.29 0.00e+00 633.00
IUUC-Mdo-062206 Monodelphis domestica 89.29 0.00e+00 634.00
IUUC-Mmu-063715 Mus musculus 89.29 0.00e+00 633.00
IUUC-Mac-064893 Musa acuminata 46.94 1.00e-23 104.00
IUUC-Mpu-066460 Mustela putorius furo 89.29 0.00e+00 634.00
IUUC-Mlu-067743 Myotis lucifugus 89.29 0.00e+00 634.00
IUUC-Nle-069512 Nomascus leucogenys 89.29 0.00e+00 634.00
IUUC-Opr-070807 Ochotona princeps 82.87 1.00e-87 317.00
IUUC-Ont-072541 Oreochromis niloticus 92.69 0.00e+00 636.00
IUUC-Oan-073454 Ornithorhynchus anatinus 89.29 0.00e+00 634.00
IUUC-Ocu-073981 Oryctolagus cuniculus 89.58 0.00e+00 635.00
IUUC-Oba-075605 Oryza barthii 53.01 2.00e-23 103.00
IUUC-Obr-076282 Oryza brachyantha 43.48 2.00e-24 107.00
IUUC-Ogl-077288 Oryza glaberrima 43.48 4.00e-24 106.00
IUUC-Ogu-078992 Oryza glumaepatula 53.01 3.00e-23 103.00
IUUC-Oin-079939 Oryza indica 43.48 3.00e-24 106.00
IUUC-Olo-080262 Oryza longistaminata 44.35 1.00e-24 108.00
IUUC-Ome-081418 Oryza meridionalis 43.48 2.00e-24 107.00
IUUC-Oni-083103 Oryza nivara 43.48 4.00e-24 106.00
IUUC-Opu-083314 Oryza punctata 43.48 3.00e-24 107.00
IUUC-Oru-084356 Oryza rufipogon 55.26 5.00e-23 103.00
IUUC-Osa-085727 Oryza sativa 43.48 3.00e-24 106.00
IUUC-Ola-086937 Oryzias latipes 92.58 0.00e+00 629.00
IUUC-Oga-088881 Otolemur garnettii 86.49 1.00e-75 276.00
IUUC-Oar-089823 Ovis aries 89.29 0.00e+00 633.00
IUUC-Ptr-090557 Pan troglodytes 89.29 0.00e+00 634.00
IUUC-Pan-091950 Papio anubis 89.29 0.00e+00 634.00
IUUC-Psi-093349 Pelodiscus sinensis 88.69 0.00e+00 631.00
IUUC-Ppa-095164 Physcomitrella patens 58.21 8.00e-22 98.20
IUUC-Pfo-096803 Poecilia formosa 92.40 0.00e+00 632.00
IUUC-Pab-098392 Pongo abelii 88.39 0.00e+00 628.00
IUUC-Pop-100011 Populus trichocarpa 49.48 2.00e-24 107.00
IUUC-Pca-100946 Procavia capensis 86.96 6.00e-132 462.00
IUUC-Ppe-101894 Prunus persica 61.82 2.00e-17 83.20
IUUC-Pva-102498 Pteropus vampyrus 95.52 6.00e-75 274.00
IUUC-Pte-104165 Pyrenophora teres 39.29 1.00e-05 44.70
IUUC-Rno-105492 Rattus norvegicus 89.29 0.00e+00 633.00
IUUC-Sha-107645 Sarcophilus harrisii 89.58 0.00e+00 633.00
IUUC-Smo-108741 Selaginella moellendorffii 51.95 8.00e-21 91.30
IUUC-Sit-109707 Setaria italica 46.30 3.00e-25 109.00
IUUC-Sly-111537 Solanum lycopersicum 54.41 5.00e-19 89.40
IUUC-Stu-112805 Solanum tuberosum 51.28 2.00e-20 93.60
IUUC-Sar-113064 Sorex araneus 97.62 9.00e-72 263.00
IUUC-Sbi-114798 Sorghum bicolor 45.37 3.00e-24 106.00
IUUC-Ssc-115830 Sus scrofa 88.99 0.00e+00 631.00
IUUC-Tgu-116694 Taeniopygia guttata 88.99 0.00e+00 632.00
IUUC-Tru-117837 Takifugu rubripes 92.40 0.00e+00 634.00
IUUC-Tsy-119174 Tarsius syrichta 88.10 4.00e-179 620.00
IUUC-Tni-120389 Tetraodon nigroviridis 91.55 0.00e+00 626.00
IUUC-Tca-121428 Theobroma cacao 34.97 1.00e-24 107.00
IUUC-Tae-125498 Triticum aestivum 54.22 1.00e-23 104.00
IUUC-Tur-126796 Triticum urartu 54.22 1.00e-23 104.00
IUUC-Tbe-127428 Tupaia belangeri 82.87 9.00e-88 315.00
IUUC-Ttr-128796 Tursiops truncatus 89.29 0.00e+00 634.00
IUUC-Uma-129563 Ustilago maydis 31.37 7.00e-08 52.40
IUUC-Vpa-130691 Vicugna pacos 89.29 0.00e+00 634.00
IUUC-Vvi-131143 Vitis vinifera 42.42 1.00e-24 107.00
IUUC-Xtr-132022 Xenopus tropicalis 88.39 1.00e-180 625.00
IUUC-Xma-133424 Xiphophorus maculatus 92.11 0.00e+00 632.00
Created Date 25-Jun-2017

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