iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089904

Ensembl Protein ID

ENSOARP00000011400.1

UniProt Accession

W5PLS7; W5PLS7_SHEEP

Genbank Protein ID

ENSOARP00000011400

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01019346

Gene Name

GRB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000010626.1	ENSOART00000011560.1	ENSOARP00000011400.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.90e-28	97.4	4	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           ++ yd++a+ ddeL++k+Gd+++v+ +ee d++W k+  el+gk G++P+n++e
   Q: 4    IAKYDFKATADDELSFKRGDILKVL-NEECDQNWYKA--ELNGKDGFIPKNYIE 54
           578**********************.999******99..9************97 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAAGCCA TCGCCAAATA TGACTTCAAA GCCACCGCAG ACGACGAGCT GAGCTTCAAA 60
AGGGGGGACA TCCTCAAGGT AAGTACTTAT GCCCAGCTCT CGGTGAGACG GCCTCTCCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0070436--C:Grb2-EGFR complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0012506--C:vesicle membrane
GO:0003723--F:RNA binding
GO:0048646--P:anatomical structure formation involved in morphogenesis
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0030154--P:cell differentiation
GO:0071479--P:cellular response to ionizing radiation
GO:0008286--P:insulin receptor signaling pathway
GO:0030838--P:positive regulation of actin filament polymerization
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0009967--P:positive regulation of signal transduction
GO:0031623--P:receptor internalization
GO:0043408--P:regulation of MAPK cascade
GO:0042770--P:signal transduction in response to DNA damage

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001345	Ailuropoda melanoleuca	91.19	5.00e-103	366.00
IUUC-Apl-003322	Anas platyrhynchos	89.58	4.00e-101	359.00
IUUC-Aca-005193	Anolis carolinensis	90.37	1.00e-116	411.00
IUUC-Ame-010929	Astyanax mexicanus	84.86	5.00e-110	389.00
IUUC-Bta-012932	Bos taurus	92.66	2.00e-118	417.00
IUUC-Cel-018665	Caenorhabditis elegans	53.46	8.00e-63	233.00
IUUC-Cja-019225	Callithrix jacchus	92.66	2.00e-118	417.00
IUUC-Cfa-020887	Canis familiaris	92.66	2.00e-118	417.00
IUUC-Cpo-022488	Cavia porcellus	92.66	2.00e-118	417.00
IUUC-Csa-023326	Chlorocebus sabaeus	92.66	2.00e-118	417.00
IUUC-Cho-024953	Choloepus hoffmanni	74.77	2.00e-86	311.00
IUUC-Cin-025144	Ciona intestinalis	58.96	3.00e-67	248.00
IUUC-Csv-026210	Ciona savignyi	55.61	3.00e-64	238.00
IUUC-Dre-028403	Danio rerio	88.07	2.00e-113	401.00
IUUC-Dno-029187	Dasypus novemcinctus	91.28	4.00e-117	413.00
IUUC-Dor-030763	Dipodomys ordii	92.66	2.00e-118	417.00
IUUC-Dme-031741	Drosophila melanogaster	60.85	2.00e-70	258.00
IUUC-Ete-032354	Echinops telfairi	62.67	7.00e-71	259.00
IUUC-Eca-033222	Equus caballus	92.66	2.00e-118	417.00
IUUC-Eeu-034513	Erinaceus europaeus	66.51	1.00e-76	278.00
IUUC-Fca-036294	Felis catus	92.66	2.00e-118	417.00
IUUC-Fal-037130	Ficedula albicollis	89.91	3.00e-115	407.00
IUUC-Gmo-039546	Gadus morhua	87.16	3.00e-112	397.00
IUUC-Gga-041139	Gallus gallus	90.83	9.00e-117	412.00
IUUC-Gac-041968	Gasterosteus aculeatus	88.07	2.00e-113	400.00
IUUC-Ggo-044562	Gorilla gorilla	92.66	2.00e-118	417.00
IUUC-Hsa-046730	Homo sapiens	92.66	2.00e-118	417.00
IUUC-Itr-049025	Ictidomys tridecemlineatus	92.66	2.00e-118	417.00
IUUC-Lch-050230	Latimeria chalumnae	96.24	1.00e-73	269.00
IUUC-Loc-052723	Lepisosteus oculatus	88.99	2.00e-114	404.00
IUUC-Laf-053774	Loxodonta africana	91.28	5.00e-117	412.00
IUUC-Mcc-054603	Macaca mulatta	92.66	2.00e-118	417.00
IUUC-Meu-056173	Macropus eugenii	73.39	5.00e-89	320.00
IUUC-Mga-059950	Meleagris gallopavo	90.83	9.00e-117	412.00
IUUC-Mmr-060878	Microcebus murinus	92.66	2.00e-118	417.00
IUUC-Mdo-062454	Monodelphis domestica	90.37	3.00e-116	410.00
IUUC-Mmu-063913	Mus musculus	92.20	5.00e-118	416.00
IUUC-Mpu-066125	Mustela putorius furo	92.66	2.00e-118	417.00
IUUC-Mlu-068007	Myotis lucifugus	92.66	2.00e-118	417.00
IUUC-Nle-069101	Nomascus leucogenys	92.66	2.00e-118	417.00
IUUC-Opr-071075	Ochotona princeps	92.66	2.00e-118	417.00
IUUC-Ont-072253	Oreochromis niloticus	84.86	3.00e-110	390.00
IUUC-Ocu-074583	Oryctolagus cuniculus	92.66	2.00e-118	417.00
IUUC-Ola-086586	Oryzias latipes	93.17	3.00e-86	311.00
IUUC-Oga-089047	Otolemur garnettii	92.66	2.00e-118	417.00
IUUC-Ptr-090678	Pan troglodytes	92.66	2.00e-118	417.00
IUUC-Pan-092090	Papio anubis	92.66	2.00e-118	417.00
IUUC-Psi-093765	Pelodiscus sinensis	90.37	3.00e-116	410.00
IUUC-Pma-094650	Petromyzon marinus	78.80	1.00e-102	365.00
IUUC-Pfo-096131	Poecilia formosa	87.61	4.00e-113	400.00
IUUC-Pab-098709	Pongo abelii	92.66	2.00e-118	417.00
IUUC-Pca-100581	Procavia capensis	90.62	5.00e-102	362.00
IUUC-Pva-103066	Pteropus vampyrus	92.66	2.00e-118	417.00
IUUC-Pgr-103396	Puccinia graminis	45.45	2.00e-08	55.50
IUUC-Rno-105224	Rattus norvegicus	92.66	2.00e-118	417.00
IUUC-Sha-107247	Sarcophilus harrisii	89.58	4.00e-101	359.00
IUUC-Sar-113277	Sorex araneus	77.06	2.00e-92	331.00
IUUC-Ssc-115478	Sus scrofa	92.66	2.00e-118	417.00
IUUC-Tgu-117479	Taeniopygia guttata	89.45	7.00e-115	405.00
IUUC-Tru-118451	Takifugu rubripes	78.17	2.00e-99	354.00
IUUC-Tsy-119029	Tarsius syrichta	93.12	3.00e-83	300.00
IUUC-Tbe-128097	Tupaia belangeri	92.20	2.00e-117	414.00
IUUC-Ttr-128871	Tursiops truncatus	100.00	1.00e-90	324.00
IUUC-Vpa-130754	Vicugna pacos	92.66	2.00e-118	417.00
IUUC-Xtr-132275	Xenopus tropicalis	84.78	4.00e-112	396.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence