iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000269897.5	ENST00000475460.6	ENSP00000473382.1
ENSG00000269897.5	ENST00000602390.5	ENSP00000473391.1
ENSG00000269897.5	ENST00000489125.2	ENSP00000473495.1
ENSG00000269897.5	ENST00000417470.1	ENSP00000398759.2

Annotation

Cancer Mutation
ICGC
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	TCGA	ICGC	THPA
HPM
DNA & RNA Element
circBase	CircNet	miRTarBase	TargetScan
SomamiR	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19956605
ULD/UDP/UFD/RAWUL	RAWUL	9009205; 9121482; 18588675; 22325352; 23523425

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.30e-05	27.3	161	200
ULD/UDP/UFD/RAWUL	5.00e-30	105.5	274	369

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C   f d + +  C H f+++C+ ++        ++ +CP+C+
   Q: 161  CVLCGGYFIDATTIIECLHSFCKTCIVRY------LETSKYCPICD 200
           ********99999****************......**********5 PP

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk..........lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwkkegpLv 82
           isls+e++++n+ +++ +          ++k+ylrc+a++tV+hl+kfl++k+++++++++d+++e+e+L+d++tL++i+yi++w+++gpL+
   Q: 274  ISLSIEFFDQNRLDRKVNkdkekskeevNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPLP 365
           7899999999998887768888899999**************************************************************** PP
   S: 83   LqYr 86
           L+Yr
   Q: 366  LKYR 369
           ***9 PP

Organism

Homo sapiens

Functional Description
(View)

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Protein Sequence
(Fasta)

MELSESVQKG FQMLADPRSF DSNAFTLLLR AAFQSLLDAQ ADEAVLDHPD LKHIDPVVLK 60
HCHAAAATYI LEAGKHRADK STLSTYLEDC KFDRERIELF CTEYQNNKNS LEILLGRTLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGCGTGTCG AAGGTCACGG CGCGCTCACA ATGGAGCTCT CGGAGTCTGT GCAGAAAGGC 60
TTCCAGATGC TGGCGGATCC CCGCTCCTTC GACTCCAACG CCTTCACGCT TCTCCTCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0000151--C:ubiquitin ligase complex
GO:1990841--F:promoter-specific chromatin binding
GO:0071535--F:RING-like zinc finger domain binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030097--P:hemopoiesis
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0010468--P:regulation of gene expression
GO:0007379--P:segment specification
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:100532731; hsa:648

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000603	Aegilops tauschii	40.85	5.00e-12	65.90
IUUC-Aml-001498	Ailuropoda melanoleuca	98.77	2.00e-170	591.00
IUUC-Apl-004208	Anas platyrhynchos	95.14	7.00e-136	476.00
IUUC-Aca-004661	Anolis carolinensis	83.44	5.00e-140	490.00
IUUC-Ath-007649	Arabidopsis thaliana	42.50	3.00e-12	67.00
IUUC-Ame-010610	Astyanax mexicanus	72.21	1.00e-138	486.00
IUUC-Bta-012606	Bos taurus	99.08	2.00e-171	595.00
IUUC-Bol-015090	Brassica oleracea	36.63	9.00e-14	71.60
IUUC-Cja-019482	Callithrix jacchus	99.68	0.00e+00	629.00
IUUC-Cfa-020482	Canis familiaris	98.77	2.00e-170	591.00
IUUC-Cpo-022061	Cavia porcellus	99.68	0.00e+00	629.00
IUUC-Csa-024102	Chlorocebus sabaeus	95.19	0.00e+00	868.00
IUUC-Cho-025081	Choloepus hoffmanni	81.93	9.00e-113	399.00
IUUC-Cin-025612	Ciona intestinalis	49.07	3.00e-52	199.00
IUUC-Dre-027929	Danio rerio	79.75	2.00e-142	498.00
IUUC-Dno-029797	Dasypus novemcinctus	98.09	0.00e+00	648.00
IUUC-Dor-030256	Dipodomys ordii	96.50	4.00e-169	587.00
IUUC-Dme-031904	Drosophila melanogaster	45.02	1.00e-52	202.00
IUUC-Ete-033148	Echinops telfairi	64.71	3.00e-83	301.00
IUUC-Eca-033318	Equus caballus	99.39	6.00e-172	596.00
IUUC-Eeu-034547	Erinaceus europaeus	86.31	2.00e-150	525.00
IUUC-Fca-035866	Felis catus	99.39	2.00e-171	594.00
IUUC-Fal-036660	Ficedula albicollis	96.01	3.00e-161	560.00
IUUC-Gmo-039341	Gadus morhua	82.31	7.00e-126	443.00
IUUC-Gga-040611	Gallus gallus	95.54	2.00e-166	578.00
IUUC-Gac-041888	Gasterosteus aculeatus	72.49	4.00e-129	454.00
IUUC-Gma-042798	Glycine max	39.51	5.00e-12	65.50
IUUC-Ggo-045027	Gorilla gorilla	100.00	0.00e+00	630.00
IUUC-Itr-049045	Ictidomys tridecemlineatus	99.36	1.00e-179	621.00
IUUC-Lch-049714	Latimeria chalumnae	86.24	1.00e-164	572.00
IUUC-Loc-052161	Lepisosteus oculatus	81.35	5.00e-144	503.00
IUUC-Laf-054108	Loxodonta africana	97.80	2.00e-179	621.00
IUUC-Mcc-055562	Macaca mulatta	99.56	0.00e+00	923.00
IUUC-Meu-056709	Macropus eugenii	97.85	2.00e-174	604.00
IUUC-Mtr-058158	Medicago truncatula	43.42	4.00e-10	57.00
IUUC-Mga-060104	Meleagris gallopavo	92.77	2.00e-120	424.00
IUUC-Mmr-061191	Microcebus murinus	97.23	0.00e+00	903.00
IUUC-Mdo-062711	Monodelphis domestica	93.17	4.00e-154	537.00
IUUC-Mmu-064255	Mus musculus	95.22	3.00e-167	580.00
IUUC-Mpu-066466	Mustela putorius furo	98.47	1.00e-170	592.00
IUUC-Mlu-067622	Myotis lucifugus	99.36	0.00e+00	627.00
IUUC-Nle-069253	Nomascus leucogenys	93.00	0.00e+00	847.00
IUUC-Opr-070511	Ochotona princeps	99.04	5.00e-180	623.00
IUUC-Ont-072177	Oreochromis niloticus	84.23	6.00e-130	456.00
IUUC-Oan-073336	Ornithorhynchus anatinus	97.55	7.00e-172	596.00
IUUC-Ocu-074113	Oryctolagus cuniculus	99.36	4.00e-171	593.00
IUUC-Oba-075690	Oryza barthii	42.25	7.00e-12	65.10
IUUC-Ogl-077513	Oryza glaberrima	42.25	8.00e-12	65.10
IUUC-Ogu-078755	Oryza glumaepatula	42.25	9.00e-12	65.10
IUUC-Oni-082398	Oryza nivara	42.25	8.00e-12	65.50
IUUC-Oru-084965	Oryza rufipogon	42.25	8.00e-12	65.50
IUUC-Osa-086282	Oryza sativa	42.25	5.00e-12	65.90
IUUC-Ola-087057	Oryzias latipes	85.19	4.00e-124	437.00
IUUC-Oga-088346	Otolemur garnettii	100.00	0.00e+00	630.00
IUUC-Oar-089843	Ovis aries	99.08	2.00e-171	595.00
IUUC-Ptr-090486	Pan troglodytes	100.00	0.00e+00	630.00
IUUC-Pan-092667	Papio anubis	94.58	0.00e+00	790.00
IUUC-Psi-093469	Pelodiscus sinensis	95.40	1.00e-173	602.00
IUUC-Pma-094481	Petromyzon marinus	74.04	4.00e-90	323.00
IUUC-Pfo-097156	Poecilia formosa	80.41	2.00e-133	468.00
IUUC-Pab-097670	Pongo abelii	100.00	0.00e+00	630.00
IUUC-Pop-098807	Populus trichocarpa	37.08	1.00e-12	67.80
IUUC-Pva-102800	Pteropus vampyrus	100.00	0.00e+00	630.00
IUUC-Rno-105128	Rattus norvegicus	94.59	1.00e-170	592.00
IUUC-Sha-106747	Sarcophilus harrisii	97.85	2.00e-163	568.00
IUUC-Sar-113416	Sorex araneus	99.36	0.00e+00	627.00
IUUC-Ssc-115864	Sus scrofa	99.68	0.00e+00	630.00
IUUC-Tgu-116851	Taeniopygia guttata	95.14	1.00e-136	479.00
IUUC-Tru-117698	Takifugu rubripes	86.18	1.00e-124	439.00
IUUC-Tsy-119590	Tarsius syrichta	99.36	0.00e+00	627.00
IUUC-Tni-120170	Tetraodon nigroviridis	83.85	6.00e-129	453.00
IUUC-Tae-123760	Triticum aestivum	37.21	7.00e-12	65.50
IUUC-Tur-126396	Triticum urartu	40.85	6.00e-12	65.50
IUUC-Tbe-127790	Tupaia belangeri	99.68	0.00e+00	629.00
IUUC-Ttr-129316	Tursiops truncatus	99.39	0.00e+00	627.00
IUUC-Vpa-130669	Vicugna pacos	99.69	3.00e-172	597.00
IUUC-Xtr-131912	Xenopus tropicalis	87.77	5.00e-148	516.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence