iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.10e-06	27.5	68	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +D  ++vgg++++ahk vLaa+S+  +   l   +   s+ + +++d  pev  ++l+ +Yt++l+
   Q: 68   SDLKIKVGGRHISAHKFVLAARSDSWSLANL---S---STAELDLSDANPEVTMTMLRWIYTDELE 127
           5889*******************97664443...3...367889*******************997 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAEEEVAKLE KHLMLLRQEY VKLQKKLAET EKRCTLLAAQ ANKENSSESF ISRLLAIVAG 60
LYEQEQYSDL KIKVGGRHIS AHKFVLAARS DSWSLANLSS TAELDLSDAN PEVTMTMLRW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGTAGGCAG GGCCGGGCCC GACATGGCGG AAGGTAGGTT TTTTTGTGGG GCGGCGCGGG 60
AAAATGCGGA CCTGTAGGAG CGACACTGAC GGGGCACAGA AGCCCCAGGA AGGGTTGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50097--BTB
PS50178--ZF_FYVE

Pfam

PF00023--Ank
PF12796--Ank_2
PF00651--BTB
PF01363--FYVE

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00225--BTB
SM00064--FYVE

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0005765--C:lysosomal membrane
GO:0044354--C:macropinosome
GO:0030904--C:retromer complex
GO:0046872--F:metal ion binding
GO:1901981--F:phosphatidylinositol phosphate binding
GO:0034058--P:endosomal vesicle fusion
GO:0032439--P:endosome localization
GO:0090160--P:Golgi to lysosome transport
GO:0048549--P:positive regulation of pinocytosis
GO:0042147--P:retrograde transport, endosome to Golgi

KEGG

rno:303292

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001682	Ailuropoda melanoleuca	93.40	0.00e+00	2138.00
IUUC-Apl-003732	Anas platyrhynchos	90.08	0.00e+00	2100.00
IUUC-Aca-004355	Anolis carolinensis	86.67	0.00e+00	1966.00
IUUC-Ame-010634	Astyanax mexicanus	71.00	0.00e+00	1540.00
IUUC-Cel-018263	Caenorhabditis elegans	28.13	7.00e-101	362.00
IUUC-Cja-019470	Callithrix jacchus	94.46	0.00e+00	2127.00
IUUC-Cfa-020532	Canis familiaris	94.09	0.00e+00	2142.00
IUUC-Cpo-021895	Cavia porcellus	94.85	0.00e+00	2067.00
IUUC-Csa-023282	Chlorocebus sabaeus	95.12	0.00e+00	2201.00
IUUC-Dme-031775	Drosophila melanogaster	25.61	2.00e-40	161.00
IUUC-Ete-032462	Echinops telfairi	92.05	0.00e+00	886.00
IUUC-Eca-033586	Equus caballus	95.04	0.00e+00	2161.00
IUUC-Eeu-034587	Erinaceus europaeus	89.18	0.00e+00	978.00
IUUC-Fca-036266	Felis catus	92.39	0.00e+00	2070.00
IUUC-Fal-037151	Ficedula albicollis	89.54	0.00e+00	2093.00
IUUC-Gga-041225	Gallus gallus	90.57	0.00e+00	2115.00
IUUC-Ggo-045343	Gorilla gorilla	95.01	0.00e+00	2037.00
IUUC-Loc-052515	Lepisosteus oculatus	30.75	8.00e-32	132.00
IUUC-Laf-053959	Loxodonta africana	85.07	0.00e+00	1820.00
IUUC-Mcc-055564	Macaca mulatta	94.94	0.00e+00	2189.00
IUUC-Mga-059747	Meleagris gallopavo	90.41	0.00e+00	2105.00
IUUC-Mmr-061103	Microcebus murinus	96.40	0.00e+00	2189.00
IUUC-Mmu-063791	Mus musculus	98.20	0.00e+00	2268.00
IUUC-Mpu-066395	Mustela putorius furo	91.78	0.00e+00	2084.00
IUUC-Mlu-067251	Myotis lucifugus	94.34	0.00e+00	2174.00
IUUC-Nfi-068574	Neosartorya fischeri	26.29	3.00e-10	60.10
IUUC-Nle-069993	Nomascus leucogenys	94.87	0.00e+00	2196.00
IUUC-Opr-071215	Ochotona princeps	90.15	0.00e+00	1259.00
IUUC-Ont-071407	Oreochromis niloticus	83.93	0.00e+00	1927.00
IUUC-Oan-072736	Ornithorhynchus anatinus	49.75	6.00e-84	304.00
IUUC-Oga-088772	Otolemur garnettii	96.05	0.00e+00	2113.00
IUUC-Oar-089385	Ovis aries	24.91	1.00e-30	129.00
IUUC-Ptr-091429	Pan troglodytes	94.70	0.00e+00	2160.00
IUUC-Pan-092110	Papio anubis	94.86	0.00e+00	2186.00
IUUC-Psi-093787	Pelodiscus sinensis	91.01	0.00e+00	2127.00
IUUC-Pma-094245	Petromyzon marinus	70.62	0.00e+00	1646.00
IUUC-Pab-097869	Pongo abelii	94.79	0.00e+00	2149.00
IUUC-Pca-100672	Procavia capensis	23.07	1.00e-26	115.00
IUUC-Pva-103200	Pteropus vampyrus	94.02	0.00e+00	2110.00
IUUC-Ssc-115682	Sus scrofa	94.74	0.00e+00	1973.00
IUUC-Tgu-117165	Taeniopygia guttata	90.14	0.00e+00	2108.00
IUUC-Tsy-119348	Tarsius syrichta	84.40	0.00e+00	1882.00
IUUC-Vpa-130622	Vicugna pacos	94.86	0.00e+00	913.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence