iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059481

UUCD1 version

UUC-MeG-00361

Ensembl Protein ID

ENSMGAP00000007755.2

UniProt Accession

G1N6M5; G1N6M5_MELGA

Protein Name

Uncharacterized protein

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000007618.2	ENSMGAT00000008537.2	ENSMGAP00000007755.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-131	437.5	410	742

Active Site

Position(s)	Description	Evidence
711	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 410  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 497
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt+eNk+eYv+l+v+
   Q: 498  GFTLPFYKQLLGKPITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVN 582
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k++t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 583  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKANTRLKH-CTPDSNIVKWFWKAVEFFDEERRARLLQFV 670
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P+Y+s+++l+ekLl+Aieet gF +
   Q: 671  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPPYESYDKLYEKLLTAIEETCGFAV 742
           **********************************************************************76 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

TVLCAKNLVK KDFFRLPDPF AKVVVDGSGQ CHSTDTVKNT LDPKWNQHYD LYIGKSDSIT 60
ISVWNHKKIH KKQGAGFLGC VRLLSNAINR LKDTGYQRLD LCKLGPNDND TVRGQIVVCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGTACTGT GTGCAAAGAA CTTGGTGAAA AAGGACTTTT TCCGTAAGTA GCCGTTCAAG 60
TTTTAAACAT TTATAGTTGG GATAAATATT ATGCAAGTTC TGTAAATCCC TGTTTGCATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom

PROSITE

PS50004--C2
PS50237--HECT

Pfam

PF00168--C2
PF00632--HECT

SMART

SM00239--C2
SM00119--HECTc

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006083	Arabidopsis lyrata	45.36	3.00e-92	335.00
IUUC-Ath-007472	Arabidopsis thaliana	45.36	3.00e-92	335.00
IUUC-Cho-024804	Choloepus hoffmanni	98.38	0.00e+00	641.00
IUUC-Dme-031740	Drosophila melanogaster	72.42	3.00e-174	605.00
IUUC-Gga-041060	Gallus gallus	77.04	0.00e+00	1091.00
IUUC-Pop-099520	Populus trichocarpa	45.32	2.00e-93	338.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence