iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090396

Ensembl Protein ID

ENSOARP00000000094.1

UniProt Accession

W5NPK4; W5NPK4_SHEEP

Genbank Protein ID

ENSOARP00000000094

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01069519

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000000110.1	ENSOART00000000119.1	ENSOARP00000000094.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-127	425.0	422	757

Active Site

Position(s)	Description	Evidence
726	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 422  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 509
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 510  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 594
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds++++wFw+++e f++e r+++LqFv
   Q: 595  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLDDWKSNTRLKH-CGADSNVVRWFWQAVETFDEERRARLLQFV 682
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+P+ Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 683  TGSTRVPPPGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 757
           ******************************99999**************************************76 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

LKENTFSSYL SVFCLILFSV LCAKNLAKKD FFRLPDPFAK IVVDGSGQCH STDTVKSTLD 60
PKWNQHYDLY VGKTDSITIS VWNHKKVHKK QGAGFLGCVR LLSNAVSRLK DTGYQRLDLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAAGGAGA ACACATTTTC TAGTTACTTG TCAGTTTTTT GTTTAATGTA ACACTTAATT 60
TGAGATACAA TCAATGGCAA AGATAATTTT GAGGTTTTTT TTTTTTCTTC CCCGTTGCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	88.26	0.00e+00	1356.00
IUUC-Apl-004155	Anas platyrhynchos	91.37	0.00e+00	1382.00
IUUC-Aca-005238	Anolis carolinensis	89.68	0.00e+00	1351.00
IUUC-Ame-010901	Astyanax mexicanus	85.75	0.00e+00	1300.00
IUUC-Bta-013221	Bos taurus	89.55	0.00e+00	1320.00
IUUC-Cja-018985	Callithrix jacchus	95.96	0.00e+00	1453.00
IUUC-Cfa-020568	Canis familiaris	94.80	0.00e+00	1439.00
IUUC-Cpo-022531	Cavia porcellus	95.42	0.00e+00	1444.00
IUUC-Csa-024145	Chlorocebus sabaeus	92.73	0.00e+00	1389.00
IUUC-Cho-024963	Choloepus hoffmanni	79.05	0.00e+00	931.00
IUUC-Dre-028341	Danio rerio	86.31	0.00e+00	1311.00
IUUC-Dno-029705	Dasypus novemcinctus	95.03	0.00e+00	1434.00
IUUC-Dor-030314	Dipodomys ordii	98.17	9.00e-129	454.00
IUUC-Dme-031740	Drosophila melanogaster	71.50	2.00e-172	600.00
IUUC-Eca-034125	Equus caballus	95.94	0.00e+00	1442.00
IUUC-Fca-035905	Felis catus	92.90	0.00e+00	1396.00
IUUC-Fal-037336	Ficedula albicollis	90.52	0.00e+00	1365.00
IUUC-Gmo-039486	Gadus morhua	76.71	0.00e+00	843.00
IUUC-Gga-040218	Gallus gallus	92.21	0.00e+00	1385.00
IUUC-Gac-041707	Gasterosteus aculeatus	80.83	0.00e+00	1214.00
IUUC-Ggo-045408	Gorilla gorilla	89.26	0.00e+00	1345.00
IUUC-Hsa-045878	Homo sapiens	95.56	0.00e+00	1447.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	95.81	0.00e+00	1431.00
IUUC-Loc-052628	Lepisosteus oculatus	80.62	0.00e+00	1285.00
IUUC-Laf-053644	Loxodonta africana	88.17	0.00e+00	1341.00
IUUC-Mcc-055479	Macaca mulatta	85.60	0.00e+00	1242.00
IUUC-Meu-055995	Macropus eugenii	81.69	0.00e+00	661.00
IUUC-Mga-059723	Meleagris gallopavo	87.60	0.00e+00	1335.00
IUUC-Mdo-063005	Monodelphis domestica	92.19	0.00e+00	1393.00
IUUC-Mmu-063634	Mus musculus	92.73	0.00e+00	1389.00
IUUC-Mpu-065898	Mustela putorius furo	93.14	0.00e+00	1402.00
IUUC-Mlu-067584	Myotis lucifugus	94.06	0.00e+00	1449.00
IUUC-Nle-069033	Nomascus leucogenys	95.94	0.00e+00	1444.00
IUUC-Ont-072265	Oreochromis niloticus	83.13	0.00e+00	1256.00
IUUC-Oan-073621	Ornithorhynchus anatinus	87.16	0.00e+00	1359.00
IUUC-Ocu-073960	Oryctolagus cuniculus	95.68	0.00e+00	1437.00
IUUC-Oga-088579	Otolemur garnettii	95.83	0.00e+00	1451.00
IUUC-Ptr-091624	Pan troglodytes	95.56	0.00e+00	1447.00
IUUC-Pan-092479	Papio anubis	94.83	0.00e+00	1452.00
IUUC-Pfo-097203	Poecilia formosa	80.98	0.00e+00	1219.00
IUUC-Pab-097540	Pongo abelii	95.21	0.00e+00	1375.00
IUUC-Pca-100379	Procavia capensis	71.86	2.00e-177	615.00
IUUC-Pva-102456	Pteropus vampyrus	86.34	0.00e+00	1239.00
IUUC-Rno-105396	Rattus norvegicus	92.87	0.00e+00	1391.00
IUUC-Sha-107216	Sarcophilus harrisii	92.36	0.00e+00	1402.00
IUUC-Ssc-116413	Sus scrofa	93.79	0.00e+00	1362.00
IUUC-Tgu-116723	Taeniopygia guttata	92.18	0.00e+00	1384.00
IUUC-Tru-117843	Takifugu rubripes	78.99	0.00e+00	1202.00
IUUC-Tsy-119455	Tarsius syrichta	95.75	0.00e+00	1371.00
IUUC-Tni-120037	Tetraodon nigroviridis	80.35	0.00e+00	1172.00
IUUC-Tbe-127879	Tupaia belangeri	81.98	0.00e+00	1176.00
IUUC-Ttr-128423	Tursiops truncatus	95.53	0.00e+00	1392.00
IUUC-Xtr-132237	Xenopus tropicalis	86.69	0.00e+00	1319.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence