iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-073960

UUCD1 version

UUC-OrC-00596

Ensembl Protein ID

ENSOCUP00000014044.2

UniProt Accession

G1TBF1; G1TBF1_RABIT

Protein Name

Uncharacterized protein

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000016326.3	ENSOCUT00000016334.3	ENSOCUP00000014044.2
ENSOCUG00000016326.3	ENSOCUT00000029043.2	ENSOCUP00000022001.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-124	415.9	405	739

Active Site

Position(s)	Description	Evidence
708	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll+ e+ np++glf+ys +++++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 405  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLC-EMLNPYYGLFQYSTDNSYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 491
           689****************************9.689************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g   ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 492  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRLLQHELKPNGRNVPVTEENKKEYVRLYVN 576
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gf+e+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 577  WRFMRGIEAQFLALQKGFSELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 664
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 665  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 739
           ******************************99999**************************************76 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

FSVLCAKNLA KKDFFRLPDP FAKIVVDGSG QCHSTDTVKN TLDPKWNQHY DLYVGKSDSI 60
TISVWNHKKI HKKQGAGFLG CVRLLSNAVS RLKDTGYQRL DLCKLNPSDT DAVRGQIVVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTCAGTGT TATGTGCCAA GAACCTTGCA AAGAAGGACT TCTTCCGTAA GTAAACACCG 60
ATTTTTGCCC TCTTACATTA TTCTTCATGT GTTTCTGAAA CTTTACACTT TTTAAAAACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	89.13	0.00e+00	1384.00
IUUC-Apl-004155	Anas platyrhynchos	93.69	0.00e+00	1419.00
IUUC-Aca-005238	Anolis carolinensis	91.26	0.00e+00	1382.00
IUUC-Ame-010901	Astyanax mexicanus	86.39	0.00e+00	1308.00
IUUC-Bta-013221	Bos taurus	88.63	0.00e+00	1308.00
IUUC-Cja-018985	Callithrix jacchus	97.84	0.00e+00	1500.00
IUUC-Cfa-020568	Canis familiaris	96.76	0.00e+00	1475.00
IUUC-Cpo-022531	Cavia porcellus	97.17	0.00e+00	1489.00
IUUC-Csa-024145	Chlorocebus sabaeus	93.79	0.00e+00	1418.00
IUUC-Cho-024963	Choloepus hoffmanni	79.71	0.00e+00	962.00
IUUC-Dre-028341	Danio rerio	86.81	0.00e+00	1319.00
IUUC-Dno-029705	Dasypus novemcinctus	97.29	0.00e+00	1481.00
IUUC-Dme-031740	Drosophila melanogaster	72.54	2.00e-174	606.00
IUUC-Eca-034125	Equus caballus	97.70	0.00e+00	1491.00
IUUC-Fca-035905	Felis catus	94.06	0.00e+00	1425.00
IUUC-Fal-037336	Ficedula albicollis	92.19	0.00e+00	1392.00
IUUC-Gmo-039486	Gadus morhua	75.81	0.00e+00	843.00
IUUC-Gga-040218	Gallus gallus	93.94	0.00e+00	1419.00
IUUC-Gac-041707	Gasterosteus aculeatus	80.64	0.00e+00	1211.00
IUUC-Ggo-045408	Gorilla gorilla	91.36	0.00e+00	1381.00
IUUC-Hsa-045878	Homo sapiens	97.44	0.00e+00	1494.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	97.29	0.00e+00	1474.00
IUUC-Loc-052628	Lepisosteus oculatus	81.58	0.00e+00	1293.00
IUUC-Laf-053644	Loxodonta africana	88.69	0.00e+00	1368.00
IUUC-Mcc-055479	Macaca mulatta	86.50	0.00e+00	1271.00
IUUC-Mga-059723	Meleagris gallopavo	88.77	0.00e+00	1366.00
IUUC-Mdo-063005	Monodelphis domestica	93.25	0.00e+00	1414.00
IUUC-Mmu-063634	Mus musculus	93.79	0.00e+00	1416.00
IUUC-Mpu-065898	Mustela putorius furo	93.93	0.00e+00	1426.00
IUUC-Mlu-067584	Myotis lucifugus	97.03	0.00e+00	1484.00
IUUC-Nle-069033	Nomascus leucogenys	97.70	0.00e+00	1491.00
IUUC-Ont-072265	Oreochromis niloticus	83.22	0.00e+00	1258.00
IUUC-Oan-073621	Ornithorhynchus anatinus	88.06	0.00e+00	1382.00
IUUC-Oga-088579	Otolemur garnettii	97.71	0.00e+00	1498.00
IUUC-Oar-090396	Ovis aries	95.68	0.00e+00	1381.00
IUUC-Ptr-091624	Pan troglodytes	97.44	0.00e+00	1494.00
IUUC-Pan-092479	Papio anubis	97.57	0.00e+00	1493.00
IUUC-Pfo-097203	Poecilia formosa	80.80	0.00e+00	1222.00
IUUC-Pab-097540	Pongo abelii	97.18	0.00e+00	1422.00
IUUC-Pca-100379	Procavia capensis	72.51	0.00e+00	635.00
IUUC-Rno-105396	Rattus norvegicus	93.93	0.00e+00	1419.00
IUUC-Sha-107216	Sarcophilus harrisii	93.93	0.00e+00	1430.00
IUUC-Sar-113250	Sorex araneus	95.64	0.00e+00	816.00
IUUC-Ssc-116413	Sus scrofa	94.06	0.00e+00	1379.00
IUUC-Tgu-116723	Taeniopygia guttata	92.99	0.00e+00	1406.00
IUUC-Tru-117843	Takifugu rubripes	78.80	0.00e+00	1204.00
IUUC-Tsy-119455	Tarsius syrichta	97.59	0.00e+00	1417.00
IUUC-Tni-120829	Tetraodon nigroviridis	76.02	0.00e+00	1168.00
IUUC-Tbe-127879	Tupaia belangeri	84.01	0.00e+00	1228.00
IUUC-Ttr-128423	Tursiops truncatus	96.34	0.00e+00	1426.00
IUUC-Xtr-132237	Xenopus tropicalis	87.77	0.00e+00	1335.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence