iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000008515.1	ENSONIT00000010714.1	ENSONIP00000010705.1
ENSONIG00000008515.1	ENSONIT00000010715.1	ENSONIP00000010706.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.40e-127	424.9	414	749

Active Site

Position(s)	Description	Evidence
718	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ +tlq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 414  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI-NPDHLSYFHFVGRVMGLAVFHGHYING 501
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle++dpel+ksl +i+en   di+   ld tf+v+++ +g+ +++eLkp+G+nipVt+eNk+eYv+l+v+
   Q: 502  SFTLPFYKQLLGKPIQLNDLETTDPELHKSLVWILEN---DITSV-LDHTFCVEHNAFGKFSQHELKPNGRNIPVTEENKKEYVRLYVN 586
           ***********************************99...99998.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gf+e+ip++ll+ F+++elel+i G  +id+ d+k +t+ k+ +t++s++++wFw+++e+fs+e r ++LqFv
   Q: 587  WRFMRGIEAQFLALQKGFSELIPQHLLKPFDHKELELIIGGLGKIDLADWKTNTRLKH-CTSESNVVRWFWQAVEAFSEERRGRLLQFV 674
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++++lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 675  TGSTRVPLQGFKALQgstgsagPRLFTIHLiDANTENLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 749
           ******************************99999**************************************76 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MSNPGSRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKV VVDGSGQCHS TDTVKSTLDP 60
KWNQHYDLYI GKTDSITISI WNHKKIHKRQ GAGFLGCIRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAAAAGCCA CTTGTTTTGT CTGAATAATA ATAAACGGAG CAATTCCAAT AGGGTCTTCG 60
TACTTTTAGT GCCCGGGCCC TAATTACTGA AGTAAAAACC AAAACAGAAT GTCTAAAGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	78.10	0.00e+00	1217.00
IUUC-Apl-004155	Anas platyrhynchos	82.96	0.00e+00	1289.00
IUUC-Aca-005238	Anolis carolinensis	82.04	0.00e+00	1262.00
IUUC-Ame-010901	Astyanax mexicanus	87.78	0.00e+00	1356.00
IUUC-Bta-013221	Bos taurus	76.43	0.00e+00	1175.00
IUUC-Cja-018985	Callithrix jacchus	84.76	0.00e+00	1326.00
IUUC-Cfa-020568	Canis familiaris	82.45	0.00e+00	1272.00
IUUC-Cpo-022531	Cavia porcellus	84.36	0.00e+00	1321.00
IUUC-Csa-024145	Chlorocebus sabaeus	83.31	0.00e+00	1293.00
IUUC-Cho-024963	Choloepus hoffmanni	67.64	0.00e+00	798.00
IUUC-Dre-028341	Danio rerio	87.91	0.00e+00	1362.00
IUUC-Dno-029705	Dasypus novemcinctus	82.65	0.00e+00	1260.00
IUUC-Dme-031740	Drosophila melanogaster	72.28	2.00e-174	606.00
IUUC-Eca-034125	Equus caballus	83.98	0.00e+00	1285.00
IUUC-Fca-035905	Felis catus	81.83	0.00e+00	1247.00
IUUC-Fal-037336	Ficedula albicollis	82.57	0.00e+00	1246.00
IUUC-Gmo-039486	Gadus morhua	78.38	0.00e+00	1158.00
IUUC-Gga-040218	Gallus gallus	84.25	0.00e+00	1319.00
IUUC-Gac-041707	Gasterosteus aculeatus	92.89	0.00e+00	1400.00
IUUC-Ggo-045408	Gorilla gorilla	79.81	0.00e+00	1196.00
IUUC-Hsa-045878	Homo sapiens	84.89	0.00e+00	1330.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	84.12	0.00e+00	1280.00
IUUC-Loc-052628	Lepisosteus oculatus	81.03	0.00e+00	1315.00
IUUC-Laf-053644	Loxodonta africana	78.40	0.00e+00	1198.00
IUUC-Mcc-055479	Macaca mulatta	76.35	0.00e+00	1145.00
IUUC-Mga-059723	Meleagris gallopavo	79.82	0.00e+00	1234.00
IUUC-Mdo-063005	Monodelphis domestica	83.42	0.00e+00	1304.00
IUUC-Mmu-063634	Mus musculus	83.05	0.00e+00	1280.00
IUUC-Mpu-065898	Mustela putorius furo	82.22	0.00e+00	1251.00
IUUC-Mlu-067584	Myotis lucifugus	83.47	0.00e+00	1286.00
IUUC-Nle-069033	Nomascus leucogenys	84.66	0.00e+00	1294.00
IUUC-Oan-073621	Ornithorhynchus anatinus	78.26	0.00e+00	1257.00
IUUC-Ocu-073960	Oryctolagus cuniculus	83.22	0.00e+00	1258.00
IUUC-Ola-086960	Oryzias latipes	83.07	0.00e+00	1250.00
IUUC-Oga-088579	Otolemur garnettii	84.76	0.00e+00	1327.00
IUUC-Oar-090396	Ovis aries	83.27	0.00e+00	1236.00
IUUC-Ptr-091624	Pan troglodytes	84.89	0.00e+00	1330.00
IUUC-Pan-092479	Papio anubis	84.66	0.00e+00	1293.00
IUUC-Pfo-097203	Poecilia formosa	92.37	0.00e+00	1409.00
IUUC-Pab-097540	Pongo abelii	84.34	0.00e+00	1259.00
IUUC-Pca-100516	Procavia capensis	55.11	0.00e+00	810.00
IUUC-Rno-105396	Rattus norvegicus	83.05	0.00e+00	1281.00
IUUC-Sha-107216	Sarcophilus harrisii	83.18	0.00e+00	1289.00
IUUC-Ssc-116413	Sus scrofa	81.29	0.00e+00	1232.00
IUUC-Tgu-116723	Taeniopygia guttata	83.60	0.00e+00	1268.00
IUUC-Tru-117843	Takifugu rubripes	87.93	0.00e+00	1379.00
IUUC-Tsy-119455	Tarsius syrichta	83.52	0.00e+00	1198.00
IUUC-Tni-120037	Tetraodon nigroviridis	89.61	0.00e+00	1332.00
IUUC-Tbe-127879	Tupaia belangeri	70.89	0.00e+00	1027.00
IUUC-Ttr-128423	Tursiops truncatus	83.29	0.00e+00	1220.00
IUUC-Xtr-132237	Xenopus tropicalis	81.47	0.00e+00	1274.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence