iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074218

UUCD1 version

UUC-OrC-00716

Ensembl Protein ID

ENSOCUP00000018281.1

UniProt Accession

G1TMR9; G1TMR9_RABIT

Protein Name

Nitric oxide synthase-interacting protein

Gene Name

NOSIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000027829.2	ENSOCUT00000022167.1	ENSOCUP00000018281.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.00e-15	56.6	40	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ +++k
   Q: 40   VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKK 79
           567789*****************************99887 PP

Organism

Oryctolagus cuniculus

Functional Description
(View)

Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGAQREEQR QLRRAAAQDQ VRGFLEKEAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGCGCC ACGGCAAGAA CTGCACCGCA GGGGCCCGTG TACACGTACC ACGAGAAGAA 60
GAAGGACACA GGTACGGGCG CTGGGCGCAC GTGCAGGCCC AGGGCTCGAC ACGAGAGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0050999--P:regulation of nitric-oxide synthase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	46.51	1.00e-16	80.90
IUUC-Aml-002069	Ailuropoda melanoleuca	86.35	5.00e-145	506.00
IUUC-Atr-002661	Amborella trichopoda	31.07	6.00e-26	110.00
IUUC-Aca-004630	Anolis carolinensis	72.24	6.00e-121	426.00
IUUC-Aly-006316	Arabidopsis lyrata	29.97	8.00e-25	107.00
IUUC-Ath-007000	Arabidopsis thaliana	28.17	2.00e-24	106.00
IUUC-Acl-008175	Aspergillus clavatus	34.51	9.00e-06	44.70
IUUC-Afl-008440	Aspergillus flavus	33.88	7.00e-06	44.70
IUUC-Afu-009012	Aspergillus fumigatus	34.68	2.00e-06	46.60
IUUC-Ani-009153	Aspergillus nidulans	28.80	2.20e-02	33.10
IUUC-Ang-009556	Aspergillus niger	34.75	1.00e-05	44.30
IUUC-Aor-009892	Aspergillus oryzae	33.88	7.00e-06	44.70
IUUC-Ate-010473	Aspergillus terreus	35.37	1.00e-04	42.00
IUUC-Ame-011874	Astyanax mexicanus	63.76	4.00e-101	360.00
IUUC-Bgr-012090	Blumeria graminis	28.23	2.00e-06	46.60
IUUC-Bta-012956	Bos taurus	90.75	2.00e-150	524.00
IUUC-Bci-013897	Botrytis cinerea	42.50	8.00e-10	57.80
IUUC-Bdi-014968	Brachypodium distachyon	30.11	2.00e-30	126.00
IUUC-Bol-015578	Brassica oleracea	29.23	2.00e-29	122.00
IUUC-Bra-017234	Brassica rapa	29.23	2.00e-29	122.00
IUUC-Cel-018637	Caenorhabditis elegans	45.51	1.00e-53	203.00
IUUC-Cja-019632	Callithrix jacchus	88.57	1.00e-149	521.00
IUUC-Cfa-020192	Canis familiaris	90.00	1.00e-150	526.00
IUUC-Cpo-021939	Cavia porcellus	89.29	2.00e-143	501.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	33.22	6.00e-38	150.00
IUUC-Csa-023802	Chlorocebus sabaeus	88.93	1.00e-149	522.00
IUUC-Cho-024637	Choloepus hoffmanni	85.44	4.00e-74	270.00
IUUC-Cin-025180	Ciona intestinalis	50.18	1.00e-77	282.00
IUUC-Csv-026206	Ciona savignyi	44.91	2.00e-36	144.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	27.71	9.00e-14	70.90
IUUC-Cne-026827	Cryptococcus neoformans	27.71	8.00e-09	54.30
IUUC-Dre-028092	Danio rerio	63.96	2.00e-107	381.00
IUUC-Dno-029501	Dasypus novemcinctus	83.63	1.00e-124	439.00
IUUC-Dor-030542	Dipodomys ordii	90.43	3.00e-151	527.00
IUUC-Dse-031188	Dothistroma septosporum	26.04	1.00e-12	67.00
IUUC-Dme-031734	Drosophila melanogaster	48.60	2.00e-73	269.00
IUUC-Eca-033577	Equus caballus	91.43	5.00e-153	533.00
IUUC-Fca-035761	Felis catus	90.71	5.00e-151	526.00
IUUC-Fox-037703	Fusarium oxysporum	37.04	2.00e-07	49.70
IUUC-Fso-038208	Fusarium solani	27.87	1.00e-12	67.00
IUUC-Gmo-038523	Gadus morhua	58.97	2.00e-61	228.00
IUUC-Ggr-040087	Gaeumannomyces graminis	41.03	8.00e-10	57.80
IUUC-Gac-042621	Gasterosteus aculeatus	59.08	1.00e-99	355.00
IUUC-Gma-042698	Glycine max	29.75	3.00e-28	119.00
IUUC-Ggo-045357	Gorilla gorilla	88.93	6.00e-150	523.00
IUUC-Hsa-046195	Homo sapiens	88.93	6.00e-150	523.00
IUUC-Hvu-047174	Hordeum vulgare	30.11	3.00e-31	128.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	92.14	6.00e-150	523.00
IUUC-Lch-050569	Latimeria chalumnae	65.97	2.00e-103	369.00
IUUC-Lpe-050992	Leersia perrieri	35.64	8.00e-24	104.00
IUUC-Loc-052522	Lepisosteus oculatus	70.00	7.00e-106	376.00
IUUC-Lma-053254	Leptosphaeria maculans	39.24	2.00e-09	57.00
IUUC-Laf-053397	Loxodonta africana	90.43	3.00e-151	527.00
IUUC-Mcc-054681	Macaca mulatta	89.64	6.00e-151	526.00
IUUC-Meu-056723	Macropus eugenii	83.69	1.00e-137	481.00
IUUC-Mor-056961	Magnaporthe oryzae	25.48	4.00e-12	65.90
IUUC-Mpo-057359	Magnaporthe poae	28.80	2.00e-06	45.80
IUUC-Mtr-058063	Medicago truncatula	30.47	4.00e-29	121.00
IUUC-Mla-059004	Melampsora laricipopulina	32.16	1.00e-22	100.00
IUUC-Mvi-060460	Microbotryum violaceum	30.56	3.00e-24	105.00
IUUC-Mmr-060847	Microcebus murinus	91.07	6.00e-153	533.00
IUUC-Mdo-062480	Monodelphis domestica	83.33	1.00e-137	482.00
IUUC-Mmu-063809	Mus musculus	91.43	1.00e-151	528.00
IUUC-Mac-064870	Musa acuminata	30.00	6.00e-28	117.00
IUUC-Mpu-066322	Mustela putorius furo	89.72	5.00e-149	520.00
IUUC-Mlu-067556	Myotis lucifugus	88.34	8.00e-141	492.00
IUUC-Nfi-068440	Neosartorya fischeri	35.65	3.00e-06	46.20
IUUC-Ncr-068898	Neurospora crassa	38.46	1.00e-07	50.80
IUUC-Nle-070049	Nomascus leucogenys	89.29	3.00e-150	523.00
IUUC-Opr-070972	Ochotona princeps	89.79	3.00e-146	510.00
IUUC-Ont-071682	Oreochromis niloticus	66.43	3.00e-109	387.00
IUUC-Oan-073296	Ornithorhynchus anatinus	98.31	1.00e-32	131.00
IUUC-Oba-075284	Oryza barthii	31.54	5.00e-31	127.00
IUUC-Obr-076651	Oryza brachyantha	31.18	6.00e-33	134.00
IUUC-Ogl-077899	Oryza glaberrima	31.54	5.00e-31	127.00
IUUC-Ogu-078477	Oryza glumaepatula	31.90	4.00e-31	128.00
IUUC-Oin-080011	Oryza indica	31.54	6.00e-31	127.00
IUUC-Olo-080545	Oryza longistaminata	31.91	2.00e-28	120.00
IUUC-Ome-081543	Oryza meridionalis	31.54	6.00e-31	127.00
IUUC-Oni-082955	Oryza nivara	31.54	6.00e-31	127.00
IUUC-Opu-083565	Oryza punctata	31.54	3.00e-31	128.00
IUUC-Oru-084474	Oryza rufipogon	31.54	6.00e-31	127.00
IUUC-Osa-085913	Oryza sativa	31.54	6.00e-31	127.00
IUUC-Ola-086851	Oryzias latipes	64.64	4.00e-108	384.00
IUUC-Olu-087724	Ostreococcus lucimarinus	40.79	1.00e-09	57.40
IUUC-Oga-087970	Otolemur garnettii	90.04	1.00e-150	525.00
IUUC-Oar-089756	Ovis aries	87.23	2.00e-139	488.00
IUUC-Ptr-091485	Pan troglodytes	89.09	1.00e-147	515.00
IUUC-Pan-091832	Papio anubis	89.29	2.00e-150	524.00
IUUC-Pma-094551	Petromyzon marinus	61.54	9.00e-98	349.00
IUUC-Pno-094830	Phaeosphaeria nodorum	27.27	6.00e-09	54.70
IUUC-Ppa-095255	Physcomitrella patens	27.96	2.00e-26	112.00
IUUC-Pfo-096373	Poecilia formosa	63.86	2.00e-105	375.00
IUUC-Pab-098247	Pongo abelii	88.93	8.00e-150	522.00
IUUC-Pop-099186	Populus trichocarpa	29.75	7.00e-28	117.00
IUUC-Pca-100677	Procavia capensis	87.40	2.00e-122	431.00
IUUC-Ppe-101403	Prunus persica	29.39	2.00e-27	116.00
IUUC-Pva-103000	Pteropus vampyrus	90.00	3.00e-151	527.00
IUUC-Pgr-103663	Puccinia graminis	31.01	8.00e-29	121.00
IUUC-Ptt-103712	Puccinia triticina	40.00	5.00e-09	54.70
IUUC-Pte-104287	Pyrenophora teres	27.11	1.00e-17	84.00
IUUC-Pyt-104579	Pyrenophora triticirepentis	27.40	3.00e-13	69.30
IUUC-Rno-106069	Rattus norvegicus	91.07	2.00e-151	527.00
IUUC-Sha-106553	Sarcophilus harrisii	82.62	2.00e-137	481.00
IUUC-Smo-108874	Selaginella moellendorffii	30.36	3.00e-32	132.00
IUUC-Sit-110307	Setaria italica	31.18	3.00e-29	122.00
IUUC-Sly-111094	Solanum lycopersicum	31.07	3.00e-28	118.00
IUUC-Stu-112363	Solanum tuberosum	30.11	3.00e-28	118.00
IUUC-Sar-113480	Sorex araneus	89.64	9.00e-142	495.00
IUUC-Sbi-113939	Sorghum bicolor	31.18	2.00e-30	125.00
IUUC-Ssc-115644	Sus scrofa	91.43	6.00e-153	533.00
IUUC-Tru-118781	Takifugu rubripes	63.99	2.00e-108	385.00
IUUC-Tni-119985	Tetraodon nigroviridis	91.53	4.00e-30	122.00
IUUC-Tca-121795	Theobroma cacao	30.47	8.00e-31	127.00
IUUC-Tre-122037	Trichoderma reesei	36.36	3.00e-08	52.40
IUUC-Tvi-122524	Trichoderma virens	28.72	8.00e-19	87.80
IUUC-Tae-122828	Triticum aestivum	30.47	2.00e-31	129.00
IUUC-Tur-126387	Triticum urartu	30.74	8.00e-29	121.00
IUUC-Tme-127111	Tuber melanosporum	40.00	2.00e-09	56.60
IUUC-Ttr-128227	Tursiops truncatus	90.36	9.00e-150	522.00
IUUC-Vda-129924	Verticillium dahliae	27.18	3.00e-15	75.50
IUUC-Vpa-130802	Vicugna pacos	98.39	8.00e-34	137.00
IUUC-Vvi-131105	Vitis vinifera	30.11	4.00e-28	118.00
IUUC-Xtr-132830	Xenopus tropicalis	64.55	2.00e-112	399.00
IUUC-Xma-133618	Xiphophorus maculatus	64.31	1.00e-99	355.00
IUUC-Zma-135389	Zea mays	30.47	2.00e-29	122.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence