iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013461

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

F-box/LRR-repeat protein 15

Genbank Nucleotide ID

AAFC03082941

Gene Name

FBXL15

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000002500.4	ENSBTAT00000003249.4	ENSBTAP00000003249.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	95.00	2.00e-158	555.00	IUUC-Hsa-046910

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity).

Protein Sequence
(Fasta)

MEPPMDPSGG EQEPGAVRLL DLPWEDVLLP HVLSRVPLRQ LLWLQRVSRA FRALVQLHLA 60
RLRRFDAAQV GPQIPRAALA WLLRDAEGLQ ELALAPCHEW LSDEDLVPVL ARNPQLRSVA 120

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Nucleotide Sequence
(Fasta)

ACTGCGCACG CGCAGTAGGC AGCCGATGGA GCCACCGATG GACCCGTCCG GAGGGGAGCA 60
AGAGCCCGGA GCCGTCAGGT ACCTAGCACC GGAGGGGCCG AGAGAGGGAA GAAGGGCCTG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

Pfam

PF00646--F-box
PF13516--LRR_6

SMART

SM00367--LRR_CC

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030282--P:bone mineralization
GO:0009953--P:dorsal/ventral pattern formation
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002259	Ailuropoda melanoleuca	94.67	2.00e-145	508.00
IUUC-Apl-003471	Anas platyrhynchos	65.30	4.00e-79	287.00
IUUC-Aca-005211	Anolis carolinensis	62.75	2.00e-100	358.00
IUUC-Ame-011477	Astyanax mexicanus	56.81	3.00e-94	337.00
IUUC-Cja-019278	Callithrix jacchus	96.99	2.00e-147	514.00
IUUC-Cfa-020248	Canis familiaris	96.67	2.00e-153	534.00
IUUC-Cpo-021313	Cavia porcellus	92.00	3.00e-130	457.00
IUUC-Csa-023633	Chlorocebus sabaeus	95.67	5.00e-160	556.00
IUUC-Cin-025760	Ciona intestinalis	30.86	3.00e-36	145.00
IUUC-Csv-025866	Ciona savignyi	31.18	7.00e-40	157.00
IUUC-Dre-027366	Danio rerio	59.41	2.00e-100	358.00
IUUC-Dno-029700	Dasypus novemcinctus	95.00	4.00e-149	520.00
IUUC-Dor-031069	Dipodomys ordii	91.61	1.00e-150	526.00
IUUC-Dme-031701	Drosophila melanogaster	31.52	3.00e-26	112.00
IUUC-Ete-032998	Echinops telfairi	85.95	1.00e-130	459.00
IUUC-Eca-034140	Equus caballus	97.00	2.00e-148	517.00
IUUC-Fca-035431	Felis catus	97.33	2.00e-153	534.00
IUUC-Fal-036960	Ficedula albicollis	65.25	4.00e-101	360.00
IUUC-Gmo-039411	Gadus morhua	57.45	8.00e-95	339.00
IUUC-Gga-040351	Gallus gallus	65.25	4.00e-99	353.00
IUUC-Gac-041972	Gasterosteus aculeatus	57.80	2.00e-86	312.00
IUUC-Ggo-044538	Gorilla gorilla	95.00	3.00e-145	507.00
IUUC-Hsa-046910	Homo sapiens	95.00	2.00e-145	508.00
IUUC-Itr-048011	Ictidomys tridecemlineatus	94.65	2.00e-148	518.00
IUUC-Lch-049710	Latimeria chalumnae	55.96	1.00e-98	352.00
IUUC-Loc-052288	Lepisosteus oculatus	59.04	2.00e-97	348.00
IUUC-Laf-053590	Loxodonta africana	88.10	1.00e-133	469.00
IUUC-Meu-056548	Macropus eugenii	79.86	3.00e-122	431.00
IUUC-Mga-059794	Meleagris gallopavo	64.18	1.00e-97	348.00
IUUC-Mmr-060829	Microcebus murinus	94.33	9.00e-149	519.00
IUUC-Mdo-062207	Monodelphis domestica	81.42	1.00e-133	469.00
IUUC-Mmu-063353	Mus musculus	96.33	6.00e-152	529.00
IUUC-Mpu-065841	Mustela putorius furo	97.00	8.00e-153	532.00
IUUC-Mlu-068035	Myotis lucifugus	92.04	2.00e-139	488.00
IUUC-Nle-069269	Nomascus leucogenys	96.33	8.00e-147	512.00
IUUC-Opr-070289	Ochotona princeps	88.56	7.00e-109	386.00
IUUC-Ont-072581	Oreochromis niloticus	55.52	3.00e-93	334.00
IUUC-Oan-073529	Ornithorhynchus anatinus	67.41	2.00e-78	285.00
IUUC-Ocu-074827	Oryctolagus cuniculus	94.00	4.00e-152	530.00
IUUC-Ola-087306	Oryzias latipes	55.03	1.00e-94	339.00
IUUC-Oga-088596	Otolemur garnettii	94.54	2.00e-136	478.00
IUUC-Oar-089473	Ovis aries	77.00	5.00e-85	306.00
IUUC-Ptr-091197	Pan troglodytes	95.33	6.00e-146	509.00
IUUC-Pan-092908	Papio anubis	95.67	9.00e-155	538.00
IUUC-Psi-093318	Pelodiscus sinensis	60.28	2.00e-68	252.00
IUUC-Pfo-097479	Poecilia formosa	57.09	4.00e-96	344.00
IUUC-Pab-097744	Pongo abelii	95.33	2.00e-145	508.00
IUUC-Pca-100930	Procavia capensis	92.33	5.00e-140	490.00
IUUC-Pva-102763	Pteropus vampyrus	89.29	4.00e-59	221.00
IUUC-Rno-105651	Rattus norvegicus	95.33	7.00e-155	539.00
IUUC-Tgu-117097	Taeniopygia guttata	65.96	6.00e-103	366.00
IUUC-Tru-118057	Takifugu rubripes	56.55	7.00e-94	337.00
IUUC-Tni-120693	Tetraodon nigroviridis	56.55	7.00e-93	333.00
IUUC-Tbe-127992	Tupaia belangeri	95.29	2.00e-102	365.00
IUUC-Xtr-132283	Xenopus tropicalis	56.51	4.00e-99	353.00
IUUC-Xma-134238	Xiphophorus maculatus	56.42	6.00e-95	340.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence