iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-051986

Ensembl Protein ID

ENSLOCP00000011731.1

UniProt Accession

W5MTM2; W5MTM2_LEPOC

Genbank Protein ID

ENSLOCP00000011731

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01003854

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000009590.1	ENSLOCT00000011749.1	ENSLOCP00000011731.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-120	402.6	2103	2561

Active Site

Position(s)	Description	Evidence
2530	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q+++lg +l++++  d+e++q++   glk+p                     
   Q: 2103 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRKSLGVWLCDDDfpDDESRQVDLGGGLKPPgyyvqrscglfpapfpqdsde 2188
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             +  klF flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2189 ldRISKLFLFLGVFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskllyesrgdadlhfseiqseasteeghdtysvgsfdedsk 2275
           *************************************99999999999999999999999999999988888888888888777777 PP
   S: 101  ...............lgkklsledleevdpelykslkeikena.........es.........................dieelgld 138
                           +  l++ed+e v+p+++k+lke+ke+a         +s                         +ie+lgl+
   Q: 2276 sefildppkpkppawYHGILTWEDFELVNPHRAKFLKEVKELAvmrrqiltnKSltedekntrlqdlmlknpsgsgpalSIEDLGLN 2362
           7777666666666555557***********************9887777665115556677788888889999999999******** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe..ee 223
           ++f++s+++ g t+++ Lkp+Ge+++Vt++N+eeYv+l++++++++gi++q+e+fr+Gfn+v+p+e+ls+F++ee+++++cG+  ++
   Q: 2363 FQFCPSSKVHGFTAVD-LKPNGEDEMVTIDNAEEYVELMFDFCMHTGIQKQMESFRDGFNRVFPMEKLSSFSHEEVQMILCGNqsPS 2448
           *******999999888.******************************************************************5555 PP
   S: 224  idvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLk 309
           +++ed+ + t+ k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+++rk da+d+++Ps+nTC++yLk
   Q: 2449 WTAEDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTIVRKvDATDASYPSVNTCVHYLK 2535
           666666666666*************************************************************************** PP
   S: 310  LPeYsskeilkekLlyAieetkgFels 336
           LPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2536 LPEYSSEEIMRERLLAATME-KGFHLN 2561
           ********************.****86 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGATG TGGACCCCGA CACATTGCTG GAGTGGCTCC AGATGGGGCA GGGGGACGAA 60
AGGGACATGC AGCTGATCGC TCTGGAGCAG CTGTGCATGC TCCTCTTGAT GTCGGACAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	88.52	0.00e+00	4115.00
IUUC-Apl-003493	Anas platyrhynchos	88.80	0.00e+00	4150.00
IUUC-Aca-004521	Anolis carolinensis	90.32	0.00e+00	2572.00
IUUC-Ame-011258	Astyanax mexicanus	97.36	0.00e+00	2447.00
IUUC-Bta-012835	Bos taurus	88.40	0.00e+00	4124.00
IUUC-Cel-018153	Caenorhabditis elegans	52.09	9.00e-169	588.00
IUUC-Cja-019174	Callithrix jacchus	87.59	0.00e+00	4046.00
IUUC-Cfa-021115	Canis familiaris	88.40	0.00e+00	4081.00
IUUC-Cpo-022382	Cavia porcellus	84.55	0.00e+00	3877.00
IUUC-Csa-023230	Chlorocebus sabaeus	88.52	0.00e+00	4125.00
IUUC-Cho-024711	Choloepus hoffmanni	86.74	0.00e+00	1511.00
IUUC-Cin-025342	Ciona intestinalis	52.96	0.00e+00	1369.00
IUUC-Csv-026031	Ciona savignyi	50.93	0.00e+00	1341.00
IUUC-Dre-027435	Danio rerio	89.79	0.00e+00	4187.00
IUUC-Dno-029954	Dasypus novemcinctus	88.52	0.00e+00	4095.00
IUUC-Dor-030734	Dipodomys ordii	91.94	0.00e+00	1377.00
IUUC-Dme-031739	Drosophila melanogaster	59.67	0.00e+00	1565.00
IUUC-Ete-033192	Echinops telfairi	87.81	0.00e+00	1140.00
IUUC-Eca-033434	Equus caballus	88.12	0.00e+00	4093.00
IUUC-Eeu-035031	Erinaceus europaeus	80.34	0.00e+00	1032.00
IUUC-Fca-035998	Felis catus	90.34	0.00e+00	4152.00
IUUC-Fal-037468	Ficedula albicollis	89.05	0.00e+00	2551.00
IUUC-Gmo-038495	Gadus morhua	91.33	0.00e+00	1358.00
IUUC-Gga-040736	Gallus gallus	90.62	0.00e+00	2561.00
IUUC-Gac-041777	Gasterosteus aculeatus	91.29	0.00e+00	2348.00
IUUC-Ggo-044677	Gorilla gorilla	84.35	0.00e+00	3855.00
IUUC-Hsa-045879	Homo sapiens	88.52	0.00e+00	4125.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	88.37	0.00e+00	4122.00
IUUC-Lch-050444	Latimeria chalumnae	89.30	0.00e+00	4049.00
IUUC-Laf-054230	Loxodonta africana	88.05	0.00e+00	4053.00
IUUC-Mcc-054787	Macaca mulatta	88.52	0.00e+00	4125.00
IUUC-Meu-056502	Macropus eugenii	84.11	0.00e+00	1255.00
IUUC-Mga-059409	Meleagris gallopavo	96.13	0.00e+00	1891.00
IUUC-Mmr-061667	Microcebus murinus	87.95	0.00e+00	4096.00
IUUC-Mdo-061960	Monodelphis domestica	88.83	0.00e+00	4123.00
IUUC-Mmu-063941	Mus musculus	87.83	0.00e+00	4080.00
IUUC-Mpu-065939	Mustela putorius furo	88.56	0.00e+00	4123.00
IUUC-Mlu-068112	Myotis lucifugus	88.40	0.00e+00	4091.00
IUUC-Nle-069001	Nomascus leucogenys	88.48	0.00e+00	4122.00
IUUC-Opr-071222	Ochotona princeps	91.37	0.00e+00	2038.00
IUUC-Ont-072101	Oreochromis niloticus	83.61	0.00e+00	3981.00
IUUC-Oan-072814	Ornithorhynchus anatinus	88.98	0.00e+00	4118.00
IUUC-Ocu-074011	Oryctolagus cuniculus	88.48	0.00e+00	4120.00
IUUC-Ola-086412	Oryzias latipes	95.04	0.00e+00	2351.00
IUUC-Oar-089668	Ovis aries	88.40	0.00e+00	4118.00
IUUC-Ptr-090517	Pan troglodytes	88.23	0.00e+00	4084.00
IUUC-Pan-091849	Papio anubis	85.99	0.00e+00	3954.00
IUUC-Psi-093390	Pelodiscus sinensis	92.75	0.00e+00	2603.00
IUUC-Pma-094628	Petromyzon marinus	82.78	0.00e+00	1553.00
IUUC-Ppa-095264	Physcomitrella patens	32.10	3.00e-81	297.00
IUUC-Pfo-097075	Poecilia formosa	94.88	0.00e+00	2399.00
IUUC-Pab-098176	Pongo abelii	88.52	0.00e+00	4125.00
IUUC-Pca-101123	Procavia capensis	78.29	0.00e+00	2035.00
IUUC-Pva-103008	Pteropus vampyrus	96.81	0.00e+00	1543.00
IUUC-Rno-105885	Rattus norvegicus	88.40	0.00e+00	4114.00
IUUC-Sha-107048	Sarcophilus harrisii	88.37	0.00e+00	4119.00
IUUC-Sar-113071	Sorex araneus	91.09	0.00e+00	1231.00
IUUC-Ssc-115963	Sus scrofa	87.98	0.00e+00	4121.00
IUUC-Tgu-117167	Taeniopygia guttata	83.35	0.00e+00	2333.00
IUUC-Tru-118626	Takifugu rubripes	91.64	0.00e+00	2395.00
IUUC-Tsy-119504	Tarsius syrichta	86.37	0.00e+00	2021.00
IUUC-Tni-119877	Tetraodon nigroviridis	94.97	0.00e+00	2358.00
IUUC-Tbe-127602	Tupaia belangeri	87.92	0.00e+00	1012.00
IUUC-Ttr-128394	Tursiops truncatus	83.32	0.00e+00	2647.00
IUUC-Vpa-130280	Vicugna pacos	87.46	0.00e+00	3899.00
IUUC-Xtr-131787	Xenopus tropicalis	87.32	0.00e+00	2563.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence