iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118626

UUCD1 version

UUC-TaR-00586

Ensembl Protein ID

ENSTRUP00000027911.1

UniProt Accession

H2TTA3; H2TTA3_TAKRU

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000011055.1	ENSTRUT00000028021.1	ENSTRUP00000027911.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-118	397.6	2143	2611

Active Site

Position(s)	Description	Evidence
2580	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q+++lg++l++++  d+e++q++   glk+p                     
   Q: 2143 HADRKSVLEVEFQGEEGTGL-GPTLEFYALIAAEFQRTSLGIWLCDDDfpDDESRQVDLGGGLKPPgfyvqrscglfpapfpqdsee 2228
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlpls++f+kll                                                  
   Q: 2229 leRITKLFHFLGIFLAKCIQDNRLVDLPLSQPFFKLLcmgdiksnwskllyqscsftpgqdpershlqpflllseseasteesqety 2315
           *************************************99**********99999999999999999999999999999999988888 PP
   S: 101  .........................lgkklsledleevdpelykslkeikenaes................................ 130
                                     +  l+++d++ v+p+++ +lke+ke+a +                                
   Q: 2316 svgsfdedsksefimdppkpkppawYHGILTWDDFQLVNPHRASFLKELKELAMKrrqilsskslsedekntrlqdlmlrnplgsgp 2402
           88888887777777666666666655557***********************933444555566777778889999999999***** PP
   S: 131  ..dieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeele 215
             +ie+lgl+++f++s+++ g  + + Lkp+G+n++Vt+eN+eeYv+l++++++++gi++q+eafreGfn+v+p+e++s+F+++e++
   Q: 2403 plSIEDLGLNFQFCPSSKVHGFSALD-LKPNGDNEMVTMENAEEYVELMFDLCMHTGIQKQMEAFREGFNRVFPMEKMSSFSHKEVQ 2488
           ***************99988887777.************************************************************ PP
   S: 216  llicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlP 299
           +++cG+  ++++++d+ + t+ k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+++rk da+d+++P
   Q: 2489 MILCGNqsPSWTADDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTIVRKvDATDSSYP 2575
           ******6666777777777777***************************************************************** PP
   S: 300  ssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           s+nTC++yLkLPeY+s++i++e+Ll+A++e kgF+l+
   Q: 2576 SVNTCVHYLKLPEYTSEDIMRERLLAATME-KGFHLN 2611
           ******************************.****86 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGATG TGGACCCAGA CACTCTGCTG GAGTGGCTGC AGATGGGACA AGGCGATGAG 60
CGCGACATGC AGCTCATCGC CCTGGAACAG CTCTGCATGC TGTTGCTCAT GTCGGACAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	81.90	0.00e+00	3844.00
IUUC-Apl-003493	Anas platyrhynchos	82.23	0.00e+00	3865.00
IUUC-Aca-004521	Anolis carolinensis	86.47	0.00e+00	2542.00
IUUC-Ame-011258	Astyanax mexicanus	92.01	0.00e+00	2388.00
IUUC-Bta-012835	Bos taurus	81.68	0.00e+00	3848.00
IUUC-Cel-018153	Caenorhabditis elegans	51.93	4.00e-168	587.00
IUUC-Cja-019174	Callithrix jacchus	81.35	0.00e+00	3800.00
IUUC-Cfa-021115	Canis familiaris	81.60	0.00e+00	3794.00
IUUC-Cpo-022382	Cavia porcellus	78.22	0.00e+00	3628.00
IUUC-Csa-023230	Chlorocebus sabaeus	81.87	0.00e+00	3845.00
IUUC-Cho-024711	Choloepus hoffmanni	75.11	0.00e+00	1271.00
IUUC-Cin-025342	Ciona intestinalis	52.92	0.00e+00	1358.00
IUUC-Csv-026031	Ciona savignyi	51.76	0.00e+00	1385.00
IUUC-Dre-027435	Danio rerio	86.89	0.00e+00	4026.00
IUUC-Dno-029954	Dasypus novemcinctus	81.72	0.00e+00	3813.00
IUUC-Dor-030734	Dipodomys ordii	89.69	0.00e+00	1352.00
IUUC-Dme-031739	Drosophila melanogaster	59.60	0.00e+00	1602.00
IUUC-Ete-033192	Echinops telfairi	85.58	0.00e+00	1127.00
IUUC-Eca-033434	Equus caballus	81.68	0.00e+00	3837.00
IUUC-Eeu-035031	Erinaceus europaeus	77.98	0.00e+00	1016.00
IUUC-Fca-035998	Felis catus	80.25	0.00e+00	3737.00
IUUC-Fal-037468	Ficedula albicollis	85.54	0.00e+00	2547.00
IUUC-Gmo-038495	Gadus morhua	93.43	0.00e+00	1392.00
IUUC-Gga-040736	Gallus gallus	86.88	0.00e+00	2552.00
IUUC-Gac-041777	Gasterosteus aculeatus	96.45	0.00e+00	2469.00
IUUC-Ggo-044677	Gorilla gorilla	77.71	0.00e+00	3601.00
IUUC-Hsa-045879	Homo sapiens	81.87	0.00e+00	3845.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	81.80	0.00e+00	3845.00
IUUC-Lch-050444	Latimeria chalumnae	85.56	0.00e+00	2497.00
IUUC-Loc-051986	Lepisosteus oculatus	83.27	0.00e+00	3924.00
IUUC-Laf-054230	Loxodonta africana	81.64	0.00e+00	3798.00
IUUC-Mcc-054787	Macaca mulatta	81.87	0.00e+00	3845.00
IUUC-Meu-056502	Macropus eugenii	71.18	0.00e+00	1045.00
IUUC-Mga-059409	Meleagris gallopavo	92.83	0.00e+00	1855.00
IUUC-Mmr-061667	Microcebus murinus	81.31	0.00e+00	3831.00
IUUC-Mdo-061960	Monodelphis domestica	82.22	0.00e+00	3862.00
IUUC-Mmu-063941	Mus musculus	81.35	0.00e+00	3830.00
IUUC-Mpu-065939	Mustela putorius furo	81.95	0.00e+00	3847.00
IUUC-Mlu-068112	Myotis lucifugus	81.61	0.00e+00	3811.00
IUUC-Nle-069001	Nomascus leucogenys	81.91	0.00e+00	3846.00
IUUC-Opr-071222	Ochotona princeps	89.21	0.00e+00	2014.00
IUUC-Ont-072101	Oreochromis niloticus	91.65	0.00e+00	4259.00
IUUC-Oan-072814	Ornithorhynchus anatinus	82.09	0.00e+00	3828.00
IUUC-Ocu-074011	Oryctolagus cuniculus	82.02	0.00e+00	3851.00
IUUC-Ola-086412	Oryzias latipes	88.88	0.00e+00	4039.00
IUUC-Oar-089668	Ovis aries	81.68	0.00e+00	3841.00
IUUC-Ptr-090517	Pan troglodytes	81.80	0.00e+00	3827.00
IUUC-Pan-091849	Papio anubis	79.47	0.00e+00	3704.00
IUUC-Psi-093390	Pelodiscus sinensis	83.82	0.00e+00	2452.00
IUUC-Pma-094628	Petromyzon marinus	81.35	0.00e+00	1517.00
IUUC-Ppa-095264	Physcomitrella patens	31.94	8.00e-80	292.00
IUUC-Pfo-097075	Poecilia formosa	91.56	0.00e+00	2750.00
IUUC-Pab-098176	Pongo abelii	81.87	0.00e+00	3845.00
IUUC-Pca-101123	Procavia capensis	69.40	0.00e+00	1790.00
IUUC-Pva-103008	Pteropus vampyrus	94.41	0.00e+00	1526.00
IUUC-Rno-105885	Rattus norvegicus	81.87	0.00e+00	3842.00
IUUC-Sha-107048	Sarcophilus harrisii	81.92	0.00e+00	3860.00
IUUC-Sar-113071	Sorex araneus	88.73	0.00e+00	1217.00
IUUC-Ssc-115963	Sus scrofa	81.90	0.00e+00	3839.00
IUUC-Tgu-117167	Taeniopygia guttata	75.25	0.00e+00	2079.00
IUUC-Tsy-119504	Tarsius syrichta	82.12	0.00e+00	2019.00
IUUC-Tni-119877	Tetraodon nigroviridis	94.94	0.00e+00	4392.00
IUUC-Tbe-127602	Tupaia belangeri	86.17	0.00e+00	1001.00
IUUC-Ttr-128394	Tursiops truncatus	75.74	0.00e+00	2390.00
IUUC-Vpa-130280	Vicugna pacos	80.91	0.00e+00	3642.00
IUUC-Xtr-131787	Xenopus tropicalis	86.79	0.00e+00	2316.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence