iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117664

UUCD1 version

UUC-TaR-01097

Ensembl Protein ID

ENSTRUP00000030279.1

UniProt Accession

H2U020; H2U020_TAKRU

Protein Name

Ubiquitin thioesterase

Gene Name

otub1b; otub1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000011966.1	ENSTRUT00000030396.1	ENSTRUP00000030279.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.00e-44	153.5	77	272

Active Site

Position(s)	Description	Evidence
84	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
87	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
266		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs...............................................................llgvfdd 27
           +i+kt++DGnC++rA++++                                                               l+ +f++
   Q: 77   YIRKTRPDGNCFYRAFGFAhlesllddskelqnlcldrfkavaakskldlvnegfteftiedfhntfmdlielcekepslekLIDSFNN 165
           89*************************************************************************************** PP
   S: 28   dslsdalveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfp 115
           + +sd++v++Lr+lts ylq+e+ ff++fie+++ +kefcq++vep++k +++ihi+aLaq+L+++i v+++d++e   gg++++++fp
   Q: 166  QNVSDYVVVYLRLLTSGYLQREHGFFQHFIEGGRSVKEFCQQEVEPMSKeSDHIHIIALAQALNVSILVEYMDRGE---GGTVNHHVFP 251
           ***************************************************************************9...9********* PP
   S: 116  eeklkkpivLlYrsgHYdaLva 137
           e+  +++i LlYr+gHYd+L++
   Q: 252  EDG-DPRIFLLYRPGHYDILYK 272
           ***.****************96 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

KMAEEQQEAS QGDMEGVNCL AYDEAIIAQQ DRIQQEIANS NPLVSDRQDL SVLQREYAEE 60
DTVYQLKIKD LYKKYSYIRK TRPDGNCFYR AFGFAHLESL LDDSKELQNL CLDRFKAVAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGATGGCGG AGGAGCAGCA GGAAGCATCA CAGGGAGATA TGGAGGGTGA GAGAAACAGT 60
TTTGCCACAA AAATCTAAAA AGGAGCCGTG TCATCCAATT AGCAAGCAAA ACCTATAACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	76.45	1.00e-122	432.00
IUUC-Apl-003233	Anas platyrhynchos	52.31	6.00e-15	71.60
IUUC-Aca-004648	Anolis carolinensis	74.63	1.00e-114	405.00
IUUC-Aly-005710	Arabidopsis lyrata	40.94	1.00e-50	192.00
IUUC-Ath-007112	Arabidopsis thaliana	41.51	1.00e-49	189.00
IUUC-Afl-008439	Aspergillus flavus	31.46	4.00e-07	48.10
IUUC-Ame-010662	Astyanax mexicanus	88.19	2.00e-143	501.00
IUUC-Bta-013533	Bos taurus	78.93	5.00e-121	426.00
IUUC-Bol-016100	Brassica oleracea	40.60	5.00e-49	187.00
IUUC-Bra-017705	Brassica rapa	37.15	1.00e-41	163.00
IUUC-Cel-018295	Caenorhabditis elegans	33.57	2.00e-37	149.00
IUUC-Cja-019190	Callithrix jacchus	79.23	1.00e-121	429.00
IUUC-Cfa-020430	Canis familiaris	78.76	2.00e-120	425.00
IUUC-Cpo-022355	Cavia porcellus	79.31	5.00e-122	430.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	37.00	1.00e-41	162.00
IUUC-Csa-023286	Chlorocebus sabaeus	76.30	2.00e-119	421.00
IUUC-Cho-024411	Choloepus hoffmanni	43.28	1.00e-28	119.00
IUUC-Cin-025507	Ciona intestinalis	42.70	2.00e-41	162.00
IUUC-Csv-026273	Ciona savignyi	46.67	1.00e-65	242.00
IUUC-Dre-028315	Danio rerio	85.99	3.00e-129	454.00
IUUC-Dno-029165	Dasypus novemcinctus	79.02	5.00e-96	342.00
IUUC-Dor-030943	Dipodomys ordii	79.31	5.00e-122	430.00
IUUC-Dme-031922	Drosophila melanogaster	52.55	8.00e-71	259.00
IUUC-Ete-032296	Echinops telfairi	76.88	6.00e-72	263.00
IUUC-Eca-033695	Equus caballus	78.38	5.00e-120	423.00
IUUC-Eeu-034775	Erinaceus europaeus	43.67	2.00e-54	205.00
IUUC-Fca-036441	Felis catus	78.76	2.00e-120	424.00
IUUC-Gmo-038908	Gadus morhua	88.24	2.00e-142	497.00
IUUC-Ggr-040020	Gaeumannomyces graminis	32.28	3.00e-30	126.00
IUUC-Gga-040460	Gallus gallus	69.85	5.00e-111	393.00
IUUC-Gac-042417	Gasterosteus aculeatus	90.07	2.00e-138	484.00
IUUC-Gma-043712	Glycine max	41.54	2.00e-49	189.00
IUUC-Ggo-044552	Gorilla gorilla	79.25	4.00e-74	270.00
IUUC-Hsa-046766	Homo sapiens	78.93	8.00e-122	429.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	79.31	5.00e-122	430.00
IUUC-Lch-050602	Latimeria chalumnae	71.98	1.00e-107	382.00
IUUC-Loc-052003	Lepisosteus oculatus	43.91	2.00e-48	185.00
IUUC-Laf-053705	Loxodonta africana	79.31	5.00e-122	430.00
IUUC-Mcc-055745	Macaca mulatta	73.84	2.00e-118	418.00
IUUC-Meu-056569	Macropus eugenii	68.77	7.00e-106	376.00
IUUC-Mtr-057712	Medicago truncatula	39.93	6.00e-45	174.00
IUUC-Mvi-060358	Microbotryum violaceum	33.53	1.00e-16	80.50
IUUC-Mmr-061123	Microcebus murinus	80.09	2.00e-101	361.00
IUUC-Mdo-062613	Monodelphis domestica	70.76	1.00e-97	348.00
IUUC-Mmu-063658	Mus musculus	79.31	5.00e-122	430.00
IUUC-Mac-065274	Musa acuminata	34.39	5.00e-34	137.00
IUUC-Mpu-066172	Mustela putorius furo	78.93	8.00e-122	429.00
IUUC-Mlu-066966	Myotis lucifugus	79.62	3.00e-122	431.00
IUUC-Nle-069519	Nomascus leucogenys	78.26	9.00e-75	273.00
IUUC-Opr-070761	Ochotona princeps	35.33	8.00e-25	106.00
IUUC-Ont-071901	Oreochromis niloticus	91.18	8.00e-139	486.00
IUUC-Oan-072922	Ornithorhynchus anatinus	44.54	5.00e-56	210.00
IUUC-Ocu-074643	Oryctolagus cuniculus	44.98	8.00e-56	209.00
IUUC-Oni-082026	Oryza nivara	28.71	1.00e-13	71.20
IUUC-Oru-084761	Oryza rufipogon	28.71	1.00e-13	71.20
IUUC-Ola-087331	Oryzias latipes	86.15	3.00e-96	344.00
IUUC-Oga-088064	Otolemur garnettii	78.93	8.00e-122	429.00
IUUC-Oar-089251	Ovis aries	79.07	3.00e-119	420.00
IUUC-Ptr-091430	Pan troglodytes	79.23	1.00e-121	428.00
IUUC-Pan-091969	Papio anubis	44.10	2.00e-55	208.00
IUUC-Psi-093823	Pelodiscus sinensis	74.81	2.00e-113	401.00
IUUC-Pma-094366	Petromyzon marinus	69.89	3.00e-99	354.00
IUUC-Pfo-096734	Poecilia formosa	89.06	3.00e-127	447.00
IUUC-Pab-097919	Pongo abelii	79.64	5.00e-100	357.00
IUUC-Pop-099401	Populus trichocarpa	39.04	7.00e-47	180.00
IUUC-Pca-100252	Procavia capensis	56.25	2.00e-17	82.00
IUUC-Ppe-101977	Prunus persica	40.07	2.00e-48	186.00
IUUC-Pva-102499	Pteropus vampyrus	79.30	5.00e-120	423.00
IUUC-Rno-105233	Rattus norvegicus	79.31	5.00e-122	430.00
IUUC-Sha-107081	Sarcophilus harrisii	78.99	7.00e-120	423.00
IUUC-Sly-111640	Solanum lycopersicum	39.78	6.00e-45	174.00
IUUC-Sar-113295	Sorex araneus	44.98	3.00e-55	208.00
IUUC-Ssc-116202	Sus scrofa	78.93	8.00e-122	429.00
IUUC-Tni-120440	Tetraodon nigroviridis	39.41	3.00e-32	131.00
IUUC-Tca-121467	Theobroma cacao	39.64	5.00e-48	184.00
IUUC-Tbe-128116	Tupaia belangeri	78.26	9.00e-75	273.00
IUUC-Ttr-128622	Tursiops truncatus	78.16	3.00e-119	420.00
IUUC-Uma-129443	Ustilago maydis	30.08	6.00e-24	104.00
IUUC-Vvi-131389	Vitis vinifera	40.73	4.00e-49	187.00
IUUC-Xtr-131951	Xenopus tropicalis	43.35	3.00e-52	197.00
IUUC-Xma-134191	Xiphophorus maculatus	89.84	3.00e-128	450.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence