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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046507
UUCD1 version UUC-HoS-00253
Ensembl Protein ID ENSP00000309186.6
UniProt Accession Q8TEJ3; A0SDZ7; A8MPR1; Q8NDU1; SH3R3_HUMAN
Genbank Protein ID ABC25188.1; BAB84957.1; CAD38539.1
Protein Name SH3 domain-containing RING finger protein 3; Plenty of SH3s 2; SH3 multiple domains protein 4
Genbank Nucleotide ID AC010906; AK074131; AL831825
Gene Name SH3RF3; POSH2; SH3MD4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000172985.10 ENST00000309415.7 ENSP00000309186.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsitecircBasecircRNADbCircNet
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
GWAS Central
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20696164
Classification
Family E-value Score Start End
E3 activity/RING/RING 3.00e-05 26.1 57 98
UBD/SH3 4.30e-45 153.1 469 524
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle++++  +vlpC+H+f++ Cl+ +      s+ e rCP Cr
   Q: 57   CSVCLERLDTTAKVLPCQHTFCRRCLESI----VCSRHELRCPECR 98
           **********9***************888....99**********8 PP
   

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
             +ly y++q++deL+l+kG++ +v+ + +   gW kg +  +g +G+fP n+v+ ++
   Q: 469  YLALYAYKPQKSDELELHKGEMYRVL-E-KCQDGWFKGASLRTGVSGVFPGNYVTPVS 524
           569***********************.5.55569********************9986 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MLLGASWLCA SKAAAAAAQS EGDEDRPGER RRRRAAATAA GAGEDMDESS LLDLLECSVC 60
LERLDTTAKV LPCQHTFCRR CLESIVCSRH ELRCPECRIL VGCGVDELPA NILLVRLLDG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046507|E3,RING;UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGGTCCCCG CCACGCAGGC CGGTCGGTGA GCCACTTCGC ACCGCCACAG CCCTAGCATC 60
GGGCCACCAG CCGGGGTGAA GAAAGTCACG GCGGAGCCCG GCTCCCCAGT CCTGATGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046507|E3,RING;UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001452--SH3_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50002--SH3
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00018--SH3_1
PF14604--SH3_9
SMART

SM00184--RING
SM00326--SH3
Gene Ontology

GO:0008270--F:zinc ion binding
KEGG hsa:344558
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003620 Anas platyrhynchos 53.75 4.00e-126 445.00
IUUC-Aca-004827 Anolis carolinensis 74.27 0.00e+00 909.00
IUUC-Afu-009122 Aspergillus fumigatus 34.12 2.00e-10 62.00
IUUC-Bta-012957 Bos taurus 77.20 0.00e+00 1099.00
IUUC-Cja-019143 Callithrix jacchus 97.17 0.00e+00 1145.00
IUUC-Cfa-020487 Canis familiaris 83.99 0.00e+00 1049.00
IUUC-Cpo-021310 Cavia porcellus 76.67 0.00e+00 962.00
IUUC-Csa-023558 Chlorocebus sabaeus 98.70 0.00e+00 1076.00
IUUC-Cho-024580 Choloepus hoffmanni 76.04 2.00e-81 295.00
IUUC-Csv-026136 Ciona savignyi 40.37 4.00e-75 275.00
IUUC-Dre-027362 Danio rerio 64.82 4.00e-85 309.00
IUUC-Dno-029743 Dasypus novemcinctus 83.45 0.00e+00 715.00
IUUC-Dme-032207 Drosophila melanogaster 45.04 4.00e-67 249.00
IUUC-Ete-032535 Echinops telfairi 73.40 7.00e-102 363.00
IUUC-Eca-033662 Equus caballus 82.27 0.00e+00 986.00
IUUC-Eeu-034918 Erinaceus europaeus 74.49 2.00e-75 275.00
IUUC-Fca-036300 Felis catus 84.50 0.00e+00 1151.00
IUUC-Fal-036788 Ficedula albicollis 68.07 7.00e-179 620.00
IUUC-Gga-040469 Gallus gallus 70.31 4.00e-154 538.00
IUUC-Gac-042360 Gasterosteus aculeatus 55.00 4.00e-107 383.00
IUUC-Ggo-045079 Gorilla gorilla 92.96 0.00e+00 1129.00
IUUC-Itr-048409 Ictidomys tridecemlineatus 87.43 0.00e+00 1040.00
IUUC-Loc-052248 Lepisosteus oculatus 50.65 6.00e-77 282.00
IUUC-Laf-054149 Loxodonta africana 87.32 0.00e+00 1054.00
IUUC-Mcc-054608 Macaca mulatta 97.96 0.00e+00 1438.00
IUUC-Meu-055916 Macropus eugenii 58.77 4.00e-93 334.00
IUUC-Mpo-057576 Magnaporthe poae 27.56 1.00e-06 49.70
IUUC-Mmr-061655 Microcebus murinus 90.01 0.00e+00 1146.00
IUUC-Mdo-061928 Monodelphis domestica 73.85 1.00e-149 523.00
IUUC-Mmu-063697 Mus musculus 80.14 0.00e+00 1226.00
IUUC-Mpu-065720 Mustela putorius furo 85.86 0.00e+00 1053.00
IUUC-Nle-069458 Nomascus leucogenys 96.34 0.00e+00 1186.00
IUUC-Opr-070532 Ochotona princeps 83.42 4.00e-177 614.00
IUUC-Ont-072057 Oreochromis niloticus 64.36 3.00e-162 565.00
IUUC-Ocu-074663 Oryctolagus cuniculus 75.22 2.00e-160 559.00
IUUC-Oga-088327 Otolemur garnettii 85.39 1.00e-163 570.00
IUUC-Oar-090424 Ovis aries 68.71 0.00e+00 816.00
IUUC-Ptr-091455 Pan troglodytes 98.99 0.00e+00 1225.00
IUUC-Pan-092267 Papio anubis 98.70 0.00e+00 1246.00
IUUC-Psi-093991 Pelodiscus sinensis 64.32 0.00e+00 875.00
IUUC-Pfo-097283 Poecilia formosa 55.87 0.00e+00 730.00
IUUC-Pab-098571 Pongo abelii 86.00 0.00e+00 1055.00
IUUC-Pca-100786 Procavia capensis 84.27 2.00e-137 482.00
IUUC-Rno-105896 Rattus norvegicus 83.33 0.00e+00 1082.00
IUUC-Sha-106870 Sarcophilus harrisii 78.61 0.00e+00 774.00
IUUC-Sar-113194 Sorex araneus 74.07 1.00e-142 499.00
IUUC-Tru-118702 Takifugu rubripes 48.67 4.00e-121 429.00
IUUC-Tbe-127901 Tupaia belangeri 84.51 2.00e-160 558.00
IUUC-Ttr-128349 Tursiops truncatus 71.43 9.00e-129 453.00
IUUC-Vda-129879 Verticillium dahliae 30.00 2.00e-08 55.80
IUUC-Xtr-131833 Xenopus tropicalis 60.84 0.00e+00 779.00
Created Date 25-Jun-2017

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