iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-116776

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Histone deacetylase

Genbank Nucleotide ID

ABQF01047823

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000003197.1	ENSTGUT00000003371.1	ENSTGUP00000003338.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	90.18	0.00e+00	1675.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
807	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Taeniopygia guttata

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

FSPLFPDGLS GRDQPVELLN PPRVNHMPSS VDVSTALPLQ VAPSSVPMDL RLDHQFSMPV 60
TEPTLREQQL QQELLALKQK QQIQRQILIA EFQRQHEQLS RQHEAQLHEH IKQQQEMLAM 120

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Nucleotide Sequence
(Fasta)

TTTTCCCCCC TCTTTCCAGA TGGGCTTTCT GGCAGAGATC AGCCAGTTGA GCTGTTGAAT 60
CCACCTCGAG TGAACCACAT GCCCAGCTCT GGTAAGGAAA AAACCTCCTA TTAAACCTCA 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0004407--F:histone deacetylase activity
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	89.46	0.00e+00	1687.00
IUUC-Apl-003250	Anas platyrhynchos	94.84	0.00e+00	1745.00
IUUC-Aca-004668	Anolis carolinensis	85.50	0.00e+00	1685.00
IUUC-Ath-007355	Arabidopsis thaliana	40.99	2.00e-74	273.00
IUUC-Ang-009522	Aspergillus niger	29.08	2.00e-34	140.00
IUUC-Bta-013215	Bos taurus	89.32	0.00e+00	1679.00
IUUC-Bol-015468	Brassica oleracea	41.22	9.00e-75	274.00
IUUC-Bra-016680	Brassica rapa	41.48	5.00e-75	275.00
IUUC-Cja-019816	Callithrix jacchus	89.52	0.00e+00	1719.00
IUUC-Cfa-020861	Canis familiaris	90.12	0.00e+00	1686.00
IUUC-Cpo-021562	Cavia porcellus	88.75	0.00e+00	1704.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	49.55	1.00e-52	198.00
IUUC-Csa-023612	Chlorocebus sabaeus	90.02	0.00e+00	1712.00
IUUC-Csv-026359	Ciona savignyi	52.70	1.00e-89	322.00
IUUC-Cgl-026709	Colletotrichum gloeosporioides	36.36	1.00e-66	247.00
IUUC-Cne-026978	Cryptococcus neoformans	38.31	1.00e-72	267.00
IUUC-Dre-028284	Danio rerio	86.41	0.00e+00	864.00
IUUC-Dno-029951	Dasypus novemcinctus	86.74	0.00e+00	1552.00
IUUC-Dor-030362	Dipodomys ordii	79.23	0.00e+00	1408.00
IUUC-Dme-031766	Drosophila melanogaster	58.45	6.00e-159	555.00
IUUC-Fca-036187	Felis catus	90.66	0.00e+00	1662.00
IUUC-Fox-038067	Fusarium oxysporum	39.31	3.00e-68	252.00
IUUC-Fso-038263	Fusarium solani	38.57	3.00e-68	252.00
IUUC-Gmo-038473	Gadus morhua	77.33	0.00e+00	746.00
IUUC-Gga-040501	Gallus gallus	97.85	0.00e+00	1830.00
IUUC-Gac-042335	Gasterosteus aculeatus	69.53	0.00e+00	1275.00
IUUC-Ggo-045380	Gorilla gorilla	89.80	0.00e+00	1693.00
IUUC-Hsa-046925	Homo sapiens	90.18	0.00e+00	1697.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	89.10	0.00e+00	1627.00
IUUC-Lch-050325	Latimeria chalumnae	86.02	0.00e+00	1558.00
IUUC-Loc-052231	Lepisosteus oculatus	82.72	0.00e+00	1490.00
IUUC-Laf-054490	Loxodonta africana	83.10	0.00e+00	1571.00
IUUC-Mcc-055265	Macaca mulatta	90.05	0.00e+00	1721.00
IUUC-Meu-056676	Macropus eugenii	88.54	0.00e+00	779.00
IUUC-Mmr-061633	Microcebus murinus	82.14	0.00e+00	1499.00
IUUC-Mmu-063089	Mus musculus	89.93	0.00e+00	1653.00
IUUC-Mpu-065887	Mustela putorius furo	90.36	0.00e+00	1698.00
IUUC-Mlu-067470	Myotis lucifugus	89.85	0.00e+00	1681.00
IUUC-Ncr-068672	Neurospora crassa	37.84	5.00e-68	251.00
IUUC-Nle-069099	Nomascus leucogenys	86.79	0.00e+00	1117.00
IUUC-Ont-071613	Oreochromis niloticus	72.81	0.00e+00	1290.00
IUUC-Oan-073275	Ornithorhynchus anatinus	92.83	0.00e+00	1706.00
IUUC-Ola-087031	Oryzias latipes	67.92	0.00e+00	1209.00
IUUC-Oga-088201	Otolemur garnettii	83.23	0.00e+00	1466.00
IUUC-Oar-089997	Ovis aries	81.89	0.00e+00	1358.00
IUUC-Ptr-091116	Pan troglodytes	90.08	0.00e+00	1729.00
IUUC-Pan-092132	Papio anubis	89.79	0.00e+00	1112.00
IUUC-Psi-093734	Pelodiscus sinensis	93.03	0.00e+00	1665.00
IUUC-Pma-094347	Petromyzon marinus	72.39	0.00e+00	718.00
IUUC-Pfo-096293	Poecilia formosa	70.44	0.00e+00	1206.00
IUUC-Pab-098491	Pongo abelii	87.09	0.00e+00	1630.00
IUUC-Pop-099174	Populus trichocarpa	40.29	2.00e-70	260.00
IUUC-Pca-101004	Procavia capensis	79.11	0.00e+00	864.00
IUUC-Pva-102961	Pteropus vampyrus	66.46	0.00e+00	833.00
IUUC-Rno-105005	Rattus norvegicus	89.83	0.00e+00	1624.00
IUUC-Sha-107646	Sarcophilus harrisii	66.59	0.00e+00	1011.00
IUUC-Smo-109615	Selaginella moellendorffii	42.38	7.00e-77	281.00
IUUC-Sit-110160	Setaria italica	41.09	1.00e-69	257.00
IUUC-Sly-111164	Solanum lycopersicum	39.90	1.00e-77	283.00
IUUC-Sre-115013	Sporisorium reilianum	40.56	9.00e-70	258.00
IUUC-Ssc-115428	Sus scrofa	89.46	0.00e+00	1606.00
IUUC-Tru-118180	Takifugu rubripes	70.80	0.00e+00	1294.00
IUUC-Tsy-119468	Tarsius syrichta	72.24	0.00e+00	1013.00
IUUC-Tni-120196	Tetraodon nigroviridis	69.32	0.00e+00	1259.00
IUUC-Tca-121312	Theobroma cacao	42.61	3.00e-75	275.00
IUUC-Tre-121930	Trichoderma reesei	38.88	4.00e-72	265.00
IUUC-Tvi-122373	Trichoderma virens	39.36	5.00e-70	258.00
IUUC-Ttr-128360	Tursiops truncatus	82.03	0.00e+00	965.00
IUUC-Uma-129408	Ustilago maydis	43.53	1.00e-68	253.00
IUUC-Vda-129994	Verticillium dahliae	41.39	3.00e-61	229.00
IUUC-Vvi-131038	Vitis vinifera	39.61	4.00e-74	272.00
IUUC-Xtr-132956	Xenopus tropicalis	78.78	0.00e+00	1462.00
IUUC-Xma-134265	Xiphophorus maculatus	69.74	0.00e+00	1218.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence