iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004873

UUCD1 version

UUC-AnC-00728

Ensembl Protein ID

ENSACAP00000011883.3

UniProt Accession

G1KLV9; G1KLV9_ANOCA

Protein Name

Uncharacterized protein

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000012036.3	ENSACAT00000012127.3	ENSACAP00000011883.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.10e-107	358.8	556	882

Active Site

Position(s)	Description	Evidence
851	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e  k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 556  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEATKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 639
           689******************************************998888776.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfs.vseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+sl  ++++ e ++e+  + +tf+  +++++g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 640  HFPMVVYRKLMGKKGTFRDLADSHPVLYQSLRDLLQY-EGSVEDD-MMITFQiSHTDLFGNPMMHDLKENGDTIPITNENRKEFVNLYS 726
           *************************************.6677775.999999445566******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 727  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSLIIREFWEIVHAFTDEQKRLFLQ 815
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 816  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 882
           *****************...8888866666**************************************97 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MATACKRSPG EPHSETIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE FCASCPTFLR 60
MDNNAAAIKA LELYKINAKL CDPHPSKKGT SSAYLENNSK GAHNNSCTDR KMNKKEIQGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACAG CTTGTAAGAG GTAAATGCCA AGATAATTGT TGATTTTTTA AAAGTATCTC 60
AGTGAACATA ATGTTTGGGA ACGCGTTTTT TTGGGGGGGG GGGTTGCTTT GTAATTGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

acs:100566357

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	94.08	0.00e+00	1570.00
IUUC-Atr-003144	Amborella trichopoda	45.58	2.00e-96	345.00
IUUC-Apl-003742	Anas platyrhynchos	96.94	0.00e+00	1668.00
IUUC-Ame-011166	Astyanax mexicanus	85.65	0.00e+00	1456.00
IUUC-Bta-013286	Bos taurus	92.75	0.00e+00	1553.00
IUUC-Cja-019707	Callithrix jacchus	93.39	0.00e+00	1587.00
IUUC-Cfa-020154	Canis familiaris	93.96	0.00e+00	1583.00
IUUC-Cpo-021292	Cavia porcellus	92.92	0.00e+00	1550.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.37	9.00e-82	296.00
IUUC-Csa-023378	Chlorocebus sabaeus	93.20	0.00e+00	1594.00
IUUC-Cho-025059	Choloepus hoffmanni	90.37	0.00e+00	1490.00
IUUC-Cin-025643	Ciona intestinalis	43.99	0.00e+00	705.00
IUUC-Csv-026282	Ciona savignyi	44.75	0.00e+00	666.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.02	4.00e-101	362.00
IUUC-Dre-027901	Danio rerio	84.95	0.00e+00	1433.00
IUUC-Dno-029320	Dasypus novemcinctus	93.66	0.00e+00	1610.00
IUUC-Dor-030756	Dipodomys ordii	89.19	0.00e+00	714.00
IUUC-Dme-032035	Drosophila melanogaster	42.98	3.00e-166	578.00
IUUC-Eca-033843	Equus caballus	93.15	0.00e+00	1528.00
IUUC-Eeu-035109	Erinaceus europaeus	91.87	0.00e+00	1511.00
IUUC-Fca-036344	Felis catus	93.54	0.00e+00	1595.00
IUUC-Fal-036747	Ficedula albicollis	96.83	0.00e+00	1667.00
IUUC-Gmo-038840	Gadus morhua	62.74	0.00e+00	1101.00
IUUC-Gga-040399	Gallus gallus	96.83	0.00e+00	1667.00
IUUC-Gac-041933	Gasterosteus aculeatus	84.77	0.00e+00	1404.00
IUUC-Ggo-044804	Gorilla gorilla	92.95	0.00e+00	1583.00
IUUC-Hsa-045727	Homo sapiens	92.95	0.00e+00	1583.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	89.78	0.00e+00	1466.00
IUUC-Lch-050197	Latimeria chalumnae	90.54	0.00e+00	1569.00
IUUC-Loc-052743	Lepisosteus oculatus	90.43	0.00e+00	1559.00
IUUC-Lma-053245	Leptosphaeria maculans	35.28	4.00e-57	217.00
IUUC-Laf-053615	Loxodonta africana	92.91	0.00e+00	1588.00
IUUC-Mcc-054934	Macaca mulatta	93.25	0.00e+00	1580.00
IUUC-Meu-056061	Macropus eugenii	95.65	0.00e+00	1360.00
IUUC-Mga-059271	Meleagris gallopavo	95.02	0.00e+00	1623.00
IUUC-Mmr-061288	Microcebus murinus	93.25	0.00e+00	1583.00
IUUC-Mdo-062975	Monodelphis domestica	96.04	0.00e+00	1657.00
IUUC-Mmu-063674	Mus musculus	91.85	0.00e+00	1552.00
IUUC-Mpu-066568	Mustela putorius furo	93.88	0.00e+00	1614.00
IUUC-Mlu-067522	Myotis lucifugus	86.61	0.00e+00	1472.00
IUUC-Nle-069505	Nomascus leucogenys	92.95	0.00e+00	1583.00
IUUC-Opr-070570	Ochotona princeps	87.59	0.00e+00	1423.00
IUUC-Ont-071527	Oreochromis niloticus	86.26	0.00e+00	1481.00
IUUC-Oan-073446	Ornithorhynchus anatinus	90.98	0.00e+00	1068.00
IUUC-Ocu-074922	Oryctolagus cuniculus	93.33	0.00e+00	1597.00
IUUC-Ola-086996	Oryzias latipes	84.44	0.00e+00	1467.00
IUUC-Oga-088261	Otolemur garnettii	93.38	0.00e+00	1561.00
IUUC-Oar-090024	Ovis aries	92.75	0.00e+00	1553.00
IUUC-Ptr-090455	Pan troglodytes	92.95	0.00e+00	1583.00
IUUC-Pan-092509	Papio anubis	90.90	0.00e+00	1414.00
IUUC-Psi-092974	Pelodiscus sinensis	96.49	0.00e+00	1637.00
IUUC-Pma-094643	Petromyzon marinus	70.10	0.00e+00	1253.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.58	2.00e-58	221.00
IUUC-Pfo-096905	Poecilia formosa	84.50	0.00e+00	1464.00
IUUC-Pab-097840	Pongo abelii	91.65	0.00e+00	1523.00
IUUC-Pca-100869	Procavia capensis	93.62	0.00e+00	1574.00
IUUC-Pva-103040	Pteropus vampyrus	94.94	0.00e+00	656.00
IUUC-Rno-105453	Rattus norvegicus	91.39	0.00e+00	1546.00
IUUC-Sha-107651	Sarcophilus harrisii	96.04	0.00e+00	1657.00
IUUC-Smo-108858	Selaginella moellendorffii	49.65	3.00e-115	409.00
IUUC-Sar-113293	Sorex araneus	93.62	0.00e+00	1561.00
IUUC-Ssc-115979	Sus scrofa	93.50	0.00e+00	1557.00
IUUC-Tgu-116901	Taeniopygia guttata	96.83	0.00e+00	1666.00
IUUC-Tru-118368	Takifugu rubripes	84.99	0.00e+00	1468.00
IUUC-Tsy-119516	Tarsius syrichta	89.90	0.00e+00	1457.00
IUUC-Tni-120143	Tetraodon nigroviridis	84.88	0.00e+00	1463.00
IUUC-Tbe-127484	Tupaia belangeri	87.69	0.00e+00	1066.00
IUUC-Ttr-129078	Tursiops truncatus	92.92	0.00e+00	1532.00
IUUC-Vpa-130312	Vicugna pacos	85.14	0.00e+00	1307.00
IUUC-Xtr-132881	Xenopus tropicalis	91.56	0.00e+00	1590.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence