iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074922

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02050362

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000017465.3	ENSOCUT00000026447.2	ENSOCUP00000017548.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.40e-108	362.0	554	880

Active Site

Position(s)	Description	Evidence
849	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 554  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 637
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 638  HFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 724
           *************************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 725  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 813
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 814  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 880
           *****************...8888866666**************************************97 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MATACKRSPG EPQSDDIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE FCASCPTFHR 60
MDNNAAAIKA LELYKINAKL CDPHPSKKGA SSAYLENSKG APNNSEIKMN KKEGKGPRID 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGGACGCG GGGGGCGACG ACAGGTCAGT GTTGCTGCGG ACGCGGCCAA GGCCGGGCGG 60
CGCTTCCTGC CCTCGGCTGC CTGTGCCCCT CGCCATCCTC AGGGCCTGCT CTGGCAAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ocu:100342825

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	96.98	0.00e+00	1598.00
IUUC-Atr-003144	Amborella trichopoda	45.80	4.00e-96	345.00
IUUC-Apl-003742	Anas platyrhynchos	93.44	0.00e+00	1602.00
IUUC-Aca-004873	Anolis carolinensis	93.04	0.00e+00	1604.00
IUUC-Ame-011166	Astyanax mexicanus	85.53	0.00e+00	1436.00
IUUC-Bta-013286	Bos taurus	94.90	0.00e+00	1595.00
IUUC-Cja-019707	Callithrix jacchus	95.55	0.00e+00	1625.00
IUUC-Cfa-020154	Canis familiaris	95.55	0.00e+00	1617.00
IUUC-Cpo-021292	Cavia porcellus	96.74	0.00e+00	1599.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.06	3.00e-82	298.00
IUUC-Csa-023378	Chlorocebus sabaeus	95.81	0.00e+00	1635.00
IUUC-Cho-025059	Choloepus hoffmanni	92.81	0.00e+00	1506.00
IUUC-Cin-025643	Ciona intestinalis	43.76	0.00e+00	714.00
IUUC-Csv-026282	Ciona savignyi	45.29	0.00e+00	673.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.02	3.00e-101	363.00
IUUC-Dre-027901	Danio rerio	85.07	0.00e+00	1420.00
IUUC-Dno-029320	Dasypus novemcinctus	96.83	0.00e+00	1638.00
IUUC-Dor-030756	Dipodomys ordii	94.57	0.00e+00	752.00
IUUC-Dme-032035	Drosophila melanogaster	43.35	2.00e-164	573.00
IUUC-Eca-033843	Equus caballus	95.01	0.00e+00	1558.00
IUUC-Eeu-035109	Erinaceus europaeus	94.77	0.00e+00	1540.00
IUUC-Fca-036344	Felis catus	96.04	0.00e+00	1631.00
IUUC-Fal-036747	Ficedula albicollis	93.44	0.00e+00	1601.00
IUUC-Gmo-038840	Gadus morhua	63.00	0.00e+00	1100.00
IUUC-Gga-040399	Gallus gallus	93.33	0.00e+00	1599.00
IUUC-Gac-041933	Gasterosteus aculeatus	82.84	0.00e+00	1369.00
IUUC-Ggo-044804	Gorilla gorilla	95.56	0.00e+00	1625.00
IUUC-Hsa-045727	Homo sapiens	95.56	0.00e+00	1625.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	93.83	0.00e+00	1523.00
IUUC-Lch-050197	Latimeria chalumnae	89.29	0.00e+00	1536.00
IUUC-Loc-052743	Lepisosteus oculatus	89.31	0.00e+00	1524.00
IUUC-Lma-053245	Leptosphaeria maculans	33.87	5.00e-57	216.00
IUUC-Laf-053615	Loxodonta africana	95.09	0.00e+00	1585.00
IUUC-Mcc-054934	Macaca mulatta	95.88	0.00e+00	1622.00
IUUC-Meu-056061	Macropus eugenii	88.95	0.00e+00	1406.00
IUUC-Mga-059271	Meleagris gallopavo	91.74	0.00e+00	1559.00
IUUC-Mmr-061288	Microcebus murinus	97.14	0.00e+00	1625.00
IUUC-Mdo-062975	Monodelphis domestica	94.92	0.00e+00	1607.00
IUUC-Mmu-063674	Mus musculus	93.87	0.00e+00	1592.00
IUUC-Mpu-066568	Mustela putorius furo	97.28	0.00e+00	1652.00
IUUC-Mlu-067522	Myotis lucifugus	89.19	0.00e+00	1506.00
IUUC-Nle-069505	Nomascus leucogenys	95.56	0.00e+00	1625.00
IUUC-Opr-070570	Ochotona princeps	92.09	0.00e+00	1497.00
IUUC-Ont-071527	Oreochromis niloticus	84.84	0.00e+00	1456.00
IUUC-Oan-073446	Ornithorhynchus anatinus	89.93	0.00e+00	1052.00
IUUC-Ola-086996	Oryzias latipes	83.94	0.00e+00	1451.00
IUUC-Oga-088261	Otolemur garnettii	97.10	0.00e+00	1600.00
IUUC-Oar-090024	Ovis aries	94.90	0.00e+00	1595.00
IUUC-Ptr-090455	Pan troglodytes	95.56	0.00e+00	1625.00
IUUC-Pan-092509	Papio anubis	93.64	0.00e+00	1456.00
IUUC-Psi-092974	Pelodiscus sinensis	91.40	0.00e+00	1575.00
IUUC-Pma-094643	Petromyzon marinus	71.67	0.00e+00	1253.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.32	8.00e-58	219.00
IUUC-Pfo-096905	Poecilia formosa	82.43	0.00e+00	1436.00
IUUC-Pab-097840	Pongo abelii	95.24	0.00e+00	1558.00
IUUC-Pca-100869	Procavia capensis	95.48	0.00e+00	1565.00
IUUC-Pva-103040	Pteropus vampyrus	97.02	0.00e+00	666.00
IUUC-Rno-105453	Rattus norvegicus	93.64	0.00e+00	1588.00
IUUC-Sha-107651	Sarcophilus harrisii	94.92	0.00e+00	1607.00
IUUC-Smo-108858	Selaginella moellendorffii	49.88	2.00e-116	412.00
IUUC-Sar-113293	Sorex araneus	95.93	0.00e+00	1583.00
IUUC-Ssc-115979	Sus scrofa	96.40	0.00e+00	1591.00
IUUC-Tgu-116901	Taeniopygia guttata	93.44	0.00e+00	1602.00
IUUC-Tru-118368	Takifugu rubripes	85.07	0.00e+00	1453.00
IUUC-Tsy-119516	Tarsius syrichta	93.03	0.00e+00	1488.00
IUUC-Tni-120143	Tetraodon nigroviridis	83.70	0.00e+00	1450.00
IUUC-Tbe-127484	Tupaia belangeri	90.97	0.00e+00	1093.00
IUUC-Ttr-129078	Tursiops truncatus	94.77	0.00e+00	1569.00
IUUC-Vpa-130312	Vicugna pacos	87.07	0.00e+00	1342.00
IUUC-Xtr-132881	Xenopus tropicalis	89.29	0.00e+00	1541.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence