iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000061397.6	ENSDART00000145863.2	ENSDARP00000112916.1
ENSDARG00000061397.6	ENSDART00000087566.5	ENSDARP00000082000.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-96	324.4	1732	2111

Active Site

Position(s)	Description	Evidence
2078	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.......................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ + + ++g+  +                       +   
   Q: 1732 RAMLEIQYENEVGTGL-GPTQEFYALVSQELQRADLGLWRGEEVTLSNPKGS-QEGT--KymfssrglfavpfgrttkpahiaKIKM 1814
           56899***********.**********************4444422222211.1111..233555677777799********99999 PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgk..klsledleevdpelykslkeikenaes........................ 130
            F+flG+l++ka++d rlldlpl  +fyk +l++  ++s +dl ++dp ++ks++ +++   +                        
   Q: 1815 KFRFLGKLMAKAIMDFRLLDLPLGLPFYKWMLRHesSISSHDLVNIDPGVAKSIQHLEDIIRQkkrieqdrshtretlqqaleslnm 1901
           9*********************************444666******************99833445555666667777544444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG+++pVt+ N+e+Y +lvv ++l+eg+ +q+e+freGf++v+pl++l++F
   Q: 1902 ngcSVED------------LgldftLPGFPNIELKKGGKDVPVTIHNLEDYLRLVVYWTLNEGVLRQFESFREGFESVFPLHHLQYF 1976
           4444444............34455588999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  e++dv++l + ++ ++gyt+ds+a+++++evl++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1977 YPEELDQLLCGSksESWDVKTLMECCRPDHGYTHDSRAVRFLFEVLSSFDAEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 2063
           ***********98889*********************************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 2064 stENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGqQSFHLS 2111
           988888***************************************985 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MSNRPNSNPG GSLRRSQRNT AAAQPIDHTL AGRLQPEQVN QKANSPPENR RSNSKASKAP 60
PSSAVGYARG HTSRRNSLSL SVGSLSIPDP DLEAAGTSGQ QGRREGSSTR ALKRSSVSEP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGCAGGTCG CTCAGCTGAT GAAGGTAAAG CTGCTACTGC TGCACTGTGT CTAACAGCAA 60
CTACAACACT GGAACAAATA GGTAATTACA ACAACACCAA GAAATATACA CGTATATGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.08	3.00e-126	447.00
IUUC-Aml-001502	Ailuropoda melanoleuca	80.30	0.00e+00	3052.00
IUUC-Atr-002821	Amborella trichopoda	37.02	3.00e-118	421.00
IUUC-Apl-003531	Anas platyrhynchos	78.88	0.00e+00	2950.00
IUUC-Aly-005962	Arabidopsis lyrata	38.74	4.00e-116	413.00
IUUC-Ath-006636	Arabidopsis thaliana	38.45	2.00e-116	414.00
IUUC-Ago-007875	Ashbya gossypii	36.26	2.00e-81	298.00
IUUC-Acl-008242	Aspergillus clavatus	36.57	4.00e-118	420.00
IUUC-Afl-008736	Aspergillus flavus	40.81	7.00e-117	416.00
IUUC-Afu-008812	Aspergillus fumigatus	37.18	5.00e-121	429.00
IUUC-Ani-009407	Aspergillus nidulans	37.89	6.00e-115	409.00
IUUC-Ang-009763	Aspergillus niger	41.28	3.00e-112	400.00
IUUC-Aor-009941	Aspergillus oryzae	31.85	2.00e-121	431.00
IUUC-Ate-010459	Aspergillus terreus	39.13	5.00e-93	337.00
IUUC-Ame-011761	Astyanax mexicanus	95.04	0.00e+00	3212.00
IUUC-Bgr-012265	Blumeria graminis	35.41	7.00e-105	376.00
IUUC-Bta-013070	Bos taurus	78.31	0.00e+00	3019.00
IUUC-Bci-013890	Botrytis cinerea	40.28	7.00e-104	373.00
IUUC-Bdi-014046	Brachypodium distachyon	37.82	2.00e-121	431.00
IUUC-Bol-015942	Brassica oleracea	43.65	3.00e-115	410.00
IUUC-Bra-016849	Brassica rapa	43.65	7.00e-115	409.00
IUUC-Cja-019046	Callithrix jacchus	85.57	0.00e+00	2977.00
IUUC-Cfa-020521	Canis familiaris	78.89	0.00e+00	2949.00
IUUC-Cpo-021639	Cavia porcellus	77.13	0.00e+00	2956.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.69	1.00e-90	327.00
IUUC-Csa-023231	Chlorocebus sabaeus	88.12	0.00e+00	3049.00
IUUC-Cho-024380	Choloepus hoffmanni	80.07	0.00e+00	1904.00
IUUC-Cin-025482	Ciona intestinalis	50.47	5.00e-159	554.00
IUUC-Csv-026121	Ciona savignyi	47.74	0.00e+00	1536.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	35.37	5.00e-110	393.00
IUUC-Cne-026857	Cryptococcus neoformans	39.54	9.00e-94	339.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.32	1.00e-74	276.00
IUUC-Dor-030939	Dipodomys ordii	76.00	0.00e+00	1271.00
IUUC-Dse-031444	Dothistroma septosporum	40.12	3.00e-109	391.00
IUUC-Dme-032162	Drosophila melanogaster	59.97	0.00e+00	721.00
IUUC-Ete-032345	Echinops telfairi	78.91	0.00e+00	2044.00
IUUC-Eca-033229	Equus caballus	79.87	0.00e+00	3006.00
IUUC-Eeu-035205	Erinaceus europaeus	86.61	0.00e+00	1533.00
IUUC-Fca-036444	Felis catus	86.22	0.00e+00	2949.00
IUUC-Fal-037131	Ficedula albicollis	88.48	0.00e+00	3041.00
IUUC-Fox-038035	Fusarium oxysporum	36.52	3.00e-110	392.00
IUUC-Fso-038320	Fusarium solani	36.27	3.00e-110	394.00
IUUC-Gmo-039497	Gadus morhua	90.28	0.00e+00	3135.00
IUUC-Ggr-040057	Gaeumannomyces graminis	39.43	1.00e-106	382.00
IUUC-Gga-041021	Gallus gallus	88.86	0.00e+00	3068.00
IUUC-Gac-042474	Gasterosteus aculeatus	84.05	0.00e+00	3178.00
IUUC-Gma-043060	Glycine max	39.26	1.00e-121	432.00
IUUC-Ggo-044855	Gorilla gorilla	85.62	0.00e+00	2979.00
IUUC-Hsa-046147	Homo sapiens	85.39	0.00e+00	2981.00
IUUC-Hvu-047775	Hordeum vulgare	38.08	4.00e-124	440.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	87.75	0.00e+00	3032.00
IUUC-Kpa-049098	Komagataella pastoris	37.70	4.00e-85	310.00
IUUC-Lch-049818	Latimeria chalumnae	86.97	0.00e+00	2945.00
IUUC-Lpe-051017	Leersia perrieri	37.30	2.00e-117	418.00
IUUC-Loc-051777	Lepisosteus oculatus	86.65	0.00e+00	3340.00
IUUC-Lma-052990	Leptosphaeria maculans	40.30	5.00e-115	410.00
IUUC-Laf-053727	Loxodonta africana	80.02	0.00e+00	3029.00
IUUC-Mcc-055799	Macaca mulatta	88.38	0.00e+00	2977.00
IUUC-Meu-056065	Macropus eugenii	82.05	0.00e+00	1899.00
IUUC-Mor-057054	Magnaporthe oryzae	38.56	3.00e-105	377.00
IUUC-Mpo-057417	Magnaporthe poae	39.13	4.00e-107	384.00
IUUC-Mtr-057849	Medicago truncatula	37.29	1.00e-113	405.00
IUUC-Mla-058870	Melampsora laricipopulina	41.70	9.00e-109	389.00
IUUC-Mga-059580	Meleagris gallopavo	87.07	0.00e+00	2552.00
IUUC-Mvi-060507	Microbotryum violaceum	40.55	5.00e-117	417.00
IUUC-Mmr-060816	Microcebus murinus	87.81	0.00e+00	3038.00
IUUC-Mdo-062866	Monodelphis domestica	88.18	0.00e+00	2873.00
IUUC-Mmu-063906	Mus musculus	80.28	0.00e+00	3082.00
IUUC-Mac-064675	Musa acuminata	37.72	1.00e-109	391.00
IUUC-Mpu-066199	Mustela putorius furo	88.10	0.00e+00	2929.00
IUUC-Mlu-067110	Myotis lucifugus	80.52	0.00e+00	3044.00
IUUC-Nfi-068482	Neosartorya fischeri	37.03	6.00e-120	426.00
IUUC-Ncr-068906	Neurospora crassa	37.73	1.00e-106	382.00
IUUC-Nle-069410	Nomascus leucogenys	86.48	0.00e+00	2971.00
IUUC-Opr-070401	Ochotona princeps	75.25	0.00e+00	1728.00
IUUC-Ont-072100	Oreochromis niloticus	88.49	0.00e+00	3331.00
IUUC-Oan-073121	Ornithorhynchus anatinus	81.92	0.00e+00	3184.00
IUUC-Ocu-074623	Oryctolagus cuniculus	88.15	0.00e+00	2978.00
IUUC-Oba-075380	Oryza barthii	32.06	1.00e-118	421.00
IUUC-Obr-076915	Oryza brachyantha	36.47	2.00e-117	418.00
IUUC-Ogl-077055	Oryza glaberrima	37.61	1.00e-117	419.00
IUUC-Ogu-078892	Oryza glumaepatula	31.85	8.00e-118	419.00
IUUC-Oin-079256	Oryza indica	37.43	2.00e-116	414.00
IUUC-Olo-080343	Oryza longistaminata	37.43	2.00e-116	414.00
IUUC-Ome-081422	Oryza meridionalis	37.43	2.00e-116	415.00
IUUC-Oni-083047	Oryza nivara	32.06	2.00e-119	424.00
IUUC-Opu-083641	Oryza punctata	40.04	5.00e-109	389.00
IUUC-Oru-084439	Oryza rufipogon	31.95	2.00e-118	420.00
IUUC-Osa-085972	Oryza sativa	37.61	8.00e-116	411.00
IUUC-Ola-087173	Oryzias latipes	84.98	0.00e+00	3216.00
IUUC-Olu-087871	Ostreococcus lucimarinus	37.26	1.00e-88	320.00
IUUC-Oga-087908	Otolemur garnettii	79.17	0.00e+00	3057.00
IUUC-Oar-090277	Ovis aries	80.07	0.00e+00	3087.00
IUUC-Ptr-091543	Pan troglodytes	85.44	0.00e+00	2983.00
IUUC-Pan-092243	Papio anubis	88.38	0.00e+00	2977.00
IUUC-Psi-093150	Pelodiscus sinensis	80.67	0.00e+00	3109.00
IUUC-Pno-094891	Phaeosphaeria nodorum	41.84	4.00e-116	413.00
IUUC-Ppa-095181	Physcomitrella patens	41.94	1.00e-105	377.00
IUUC-Pfo-096267	Poecilia formosa	93.36	0.00e+00	3225.00
IUUC-Pab-098072	Pongo abelii	86.75	0.00e+00	2980.00
IUUC-Pop-099190	Populus trichocarpa	37.29	4.00e-116	413.00
IUUC-Pca-100311	Procavia capensis	84.87	0.00e+00	1571.00
IUUC-Ppe-101284	Prunus persica	37.14	8.00e-116	412.00
IUUC-Pva-102215	Pteropus vampyrus	80.84	0.00e+00	1026.00
IUUC-Pgr-103694	Puccinia graminis	40.76	1.00e-106	382.00
IUUC-Ptt-103916	Puccinia triticina	40.16	1.00e-102	369.00
IUUC-Pte-104346	Pyrenophora teres	40.97	4.00e-115	410.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	40.97	2.00e-114	408.00
IUUC-Rno-105315	Rattus norvegicus	88.21	0.00e+00	2959.00
IUUC-Sce-106273	Saccharomyces cerevisiae	33.70	2.00e-69	258.00
IUUC-Sha-106835	Sarcophilus harrisii	87.92	0.00e+00	3086.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	39.80	5.00e-98	353.00
IUUC-Spo-108081	Schizosaccharomyces pombe	40.04	1.00e-96	349.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	40.32	2.00e-108	388.00
IUUC-Smo-108776	Selaginella moellendorffii	42.54	6.00e-111	396.00
IUUC-Sit-109757	Setaria italica	37.59	2.00e-121	431.00
IUUC-Sly-111469	Solanum lycopersicum	38.31	5.00e-120	426.00
IUUC-Stu-112896	Solanum tuberosum	37.52	3.00e-105	376.00
IUUC-Sar-113224	Sorex araneus	82.94	0.00e+00	1206.00
IUUC-Sbi-114313	Sorghum bicolor	37.29	2.00e-122	434.00
IUUC-Sre-114993	Sporisorium reilianum	34.14	1.00e-102	369.00
IUUC-Ssc-115535	Sus scrofa	77.06	0.00e+00	2948.00
IUUC-Tgu-117493	Taeniopygia guttata	87.23	0.00e+00	2279.00
IUUC-Tru-118669	Takifugu rubripes	84.59	0.00e+00	3185.00
IUUC-Tsy-119373	Tarsius syrichta	80.64	0.00e+00	1637.00
IUUC-Tni-120049	Tetraodon nigroviridis	83.67	0.00e+00	921.00
IUUC-Tca-121779	Theobroma cacao	38.63	4.00e-115	410.00
IUUC-Tre-122195	Trichoderma reesei	35.76	2.00e-105	378.00
IUUC-Tvi-122650	Trichoderma virens	35.63	4.00e-107	384.00
IUUC-Tae-123580	Triticum aestivum	38.15	2.00e-124	440.00
IUUC-Tur-126295	Triticum urartu	38.08	1.00e-125	445.00
IUUC-Tme-126964	Tuber melanosporum	41.27	2.00e-109	391.00
IUUC-Tbe-128149	Tupaia belangeri	74.97	0.00e+00	1135.00
IUUC-Ttr-128165	Tursiops truncatus	84.32	0.00e+00	2773.00
IUUC-Uma-129365	Ustilago maydis	35.64	2.00e-88	322.00
IUUC-Vda-129725	Verticillium dahliae	41.32	6.00e-109	389.00
IUUC-Vpa-130678	Vicugna pacos	84.52	0.00e+00	2402.00
IUUC-Vvi-131147	Vitis vinifera	38.37	9.00e-121	429.00
IUUC-Xtr-132636	Xenopus tropicalis	77.99	0.00e+00	2949.00
IUUC-Xma-133458	Xiphophorus maculatus	87.77	0.00e+00	3315.00
IUUC-Yli-134481	Yarrowia lipolytica	39.32	3.00e-97	350.00
IUUC-Zma-135782	Zea mays	42.94	1.00e-116	415.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence