iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089452

Ensembl Protein ID

ENSOARP00000015924.1

UniProt Accession

W5PZN8; W5PZN8_SHEEP

Genbank Protein ID

ENSOARP00000015924

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01055130

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000014836.1	ENSOART00000016157.1	ENSOARP00000015924.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-121	406.5	1239	1571

Active Site

Position(s)	Description	Evidence
1539	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1239 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1324
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1325 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1407
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1408 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1494
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1495 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1571
           **************************************************************************985 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQSSMTEN MTLQRANSDT DLVTSESRSS 60
LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCCGGCGG CCCCATCCCC ACCCGCAGCC GGCGGCGGTA GGCGCCGAGC TCCAGGTGAG 60
TGTGCGGCCC TCGCCCGGCC CTTGCTCCGC AAGCCGGACG ACGGGAGGTG GCTTTGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

KEGG

oas:101119960

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	96.82	0.00e+00	2999.00
IUUC-Apl-003935	Anas platyrhynchos	85.95	0.00e+00	2715.00
IUUC-Aca-004558	Anolis carolinensis	83.05	0.00e+00	2653.00
IUUC-Ame-010893	Astyanax mexicanus	88.31	0.00e+00	1305.00
IUUC-Bta-013093	Bos taurus	96.85	0.00e+00	1585.00
IUUC-Cja-019651	Callithrix jacchus	95.16	0.00e+00	2838.00
IUUC-Cfa-021232	Canis familiaris	99.24	0.00e+00	1629.00
IUUC-Cpo-021770	Cavia porcellus	89.64	0.00e+00	2814.00
IUUC-Csa-023970	Chlorocebus sabaeus	96.25	0.00e+00	2930.00
IUUC-Cho-024512	Choloepus hoffmanni	88.74	0.00e+00	2635.00
IUUC-Csv-026127	Ciona savignyi	72.27	3.00e-155	541.00
IUUC-Dre-028275	Danio rerio	85.48	0.00e+00	1488.00
IUUC-Dno-029963	Dasypus novemcinctus	95.03	0.00e+00	2804.00
IUUC-Dor-030282	Dipodomys ordii	89.74	0.00e+00	2001.00
IUUC-Dme-032217	Drosophila melanogaster	71.91	0.00e+00	659.00
IUUC-Ete-033132	Echinops telfairi	83.02	0.00e+00	1262.00
IUUC-Eca-033978	Equus caballus	97.01	0.00e+00	2967.00
IUUC-Eeu-035278	Erinaceus europaeus	64.32	0.00e+00	1214.00
IUUC-Fca-036157	Felis catus	96.44	0.00e+00	2950.00
IUUC-Fal-037110	Ficedula albicollis	83.61	0.00e+00	2393.00
IUUC-Gmo-039291	Gadus morhua	80.16	0.00e+00	1017.00
IUUC-Gga-040821	Gallus gallus	85.61	0.00e+00	2715.00
IUUC-Gac-042456	Gasterosteus aculeatus	64.20	0.00e+00	1899.00
IUUC-Ggo-044862	Gorilla gorilla	96.36	0.00e+00	2849.00
IUUC-Hsa-046219	Homo sapiens	96.44	0.00e+00	3001.00
IUUC-Lch-050526	Latimeria chalumnae	77.70	0.00e+00	2445.00
IUUC-Loc-052648	Lepisosteus oculatus	78.58	0.00e+00	1529.00
IUUC-Laf-054005	Loxodonta africana	95.80	0.00e+00	2981.00
IUUC-Mcc-055314	Macaca mulatta	96.37	0.00e+00	2922.00
IUUC-Meu-056356	Macropus eugenii	70.07	0.00e+00	1138.00
IUUC-Mga-060074	Meleagris gallopavo	85.84	0.00e+00	2608.00
IUUC-Mmr-061526	Microcebus murinus	96.37	0.00e+00	2924.00
IUUC-Mdo-063017	Monodelphis domestica	91.94	0.00e+00	2833.00
IUUC-Mmu-064165	Mus musculus	93.92	0.00e+00	2882.00
IUUC-Mpu-065835	Mustela putorius furo	82.99	0.00e+00	1575.00
IUUC-Mlu-067709	Myotis lucifugus	90.64	0.00e+00	2793.00
IUUC-Nle-069308	Nomascus leucogenys	96.18	0.00e+00	2961.00
IUUC-Opr-070330	Ochotona princeps	81.74	0.00e+00	2387.00
IUUC-Ont-071345	Oreochromis niloticus	78.46	0.00e+00	1462.00
IUUC-Ocu-074775	Oryctolagus cuniculus	94.86	0.00e+00	2644.00
IUUC-Ola-087225	Oryzias latipes	64.10	0.00e+00	1841.00
IUUC-Oga-088177	Otolemur garnettii	94.10	0.00e+00	2812.00
IUUC-Ptr-090806	Pan troglodytes	96.50	0.00e+00	2993.00
IUUC-Pan-091838	Papio anubis	96.09	0.00e+00	2809.00
IUUC-Psi-094090	Pelodiscus sinensis	85.61	0.00e+00	2706.00
IUUC-Pfo-096520	Poecilia formosa	68.42	0.00e+00	1524.00
IUUC-Pab-098405	Pongo abelii	96.44	0.00e+00	2968.00
IUUC-Pca-100441	Procavia capensis	90.37	0.00e+00	2294.00
IUUC-Pva-102324	Pteropus vampyrus	98.87	0.00e+00	1623.00
IUUC-Rno-105943	Rattus norvegicus	93.47	0.00e+00	2974.00
IUUC-Sha-106985	Sarcophilus harrisii	88.49	0.00e+00	2365.00
IUUC-Sar-113505	Sorex araneus	95.32	0.00e+00	1538.00
IUUC-Ssc-115439	Sus scrofa	96.32	0.00e+00	1994.00
IUUC-Tgu-117078	Taeniopygia guttata	91.23	0.00e+00	1764.00
IUUC-Tru-118671	Takifugu rubripes	81.95	0.00e+00	1450.00
IUUC-Tni-120619	Tetraodon nigroviridis	86.64	0.00e+00	1426.00
IUUC-Tbe-127975	Tupaia belangeri	93.35	0.00e+00	2447.00
IUUC-Ttr-128469	Tursiops truncatus	91.41	0.00e+00	2693.00
IUUC-Vpa-130498	Vicugna pacos	86.93	0.00e+00	2506.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence