iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007436

Ensembl Protein ID

AT4G38630.1

UniProt Accession

P55034; Q8L9G3; PSMD4_ARATH

Genbank Protein ID

AAA85583.1; CAB37519.1; CAB80527.1; AEE86956.1; AAK26029.1; AAM44937.1; AAM65985.1

Protein Name

26S proteasome non-ATPase regulatory subunit 4 homolog; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A homolog; Multiubiquitin chain-binding protein 1

Genbank Nucleotide ID

U33269; AL035540; AL035656; CP002687; AF360319; AY113889; AY088449

Gene Name

RPN10; MBP1; MCB1; At4g38630; F20M13.190; T9A14.7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G38630	AT4G38630.1	AT4G38630.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPPT	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	21764993

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UIM	9.70e-08	32.1	305	323
UBD/Alpha-Helix/UIM	4.4e-05	13.6	223	238

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           dEd++L+lAl++S++ ee+
   Q: 305  DEDQDLALALQMSMSGEES 323
           7***************997 PP

UBD/Alpha-Helix/UIM

   S: 3    deeLqlAlalSlqEee 18
           d+eL+lAl++S++Ee+
   Q: 223  DPELALALRVSMEEER 238
           89************97 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Plays a role in maintaining the structural integrity of the 19S regulatory particule (RP), subcomplex of the 26S proteasome. Plays a major role in both the direct and indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP). Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a potential docking subunit for both ubiquitin receptors RAD23s and DSK2s. Plays a role in the growth and development via the proteasome-dependent degradation of the ABA-signaling protein ABI5/DPBF1. Plays an important role for balancing cell expansion with cell proliferation rates during shoot development.

Protein Sequence
(Fasta)

MVLEATMICI DNSEWMRNGD YSPSRLQAQT EAVNLLCGAK TQSNPENTVG ILTMAGKGVR 60
VLTTPTSDLG KILACMHGLD VGGEINLTAA IQIAQLALKH RQNKNQRQRI IVFAGSPIKY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGAAAGTA AAAAAGTAAA GGGGATATTT AAAGAAGAAC AATGTTATTA TTATCGGTCT 60
AAACTAAAAT CTAAATCTTG CCTTCCTGAC TTTCTCTCTA CGACAGAATT TTTGAAGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR027040--Proteasome_su_Rpn10
IPR003903--UIM_dom
IPR002035--VWF_A

PROSITE

PS50330--UIM
PS50234--VWFA

Pfam

PF02809--UIM
PF13519--VWA_2

SMART

SM00726--UIM
SM00327--VWA

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0008540--C:proteasome regulatory particle, base subcomplex
GO:0001653--F:peptide receptor activity
GO:0031593--F:polyubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0048366--P:leaf development
GO:0010150--P:leaf senescence
GO:0009555--P:pollen development
GO:0048528--P:post-embryonic root development
GO:0043248--P:proteasome assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0030163--P:protein catabolic process
GO:0010029--P:regulation of seed germination
GO:0009737--P:response to abscisic acid
GO:0009733--P:response to auxin
GO:0009735--P:response to cytokinin
GO:0009408--P:response to heat
GO:0051788--P:response to misfolded protein
GO:0009651--P:response to salt stress
GO:0009744--P:response to sucrose
GO:0048767--P:root hair elongation
GO:0048455--P:stamen formation

KEGG

ath:AT4G38630

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001241	Ailuropoda melanoleuca	42.27	9.00e-68	249.00
IUUC-Atr-002938	Amborella trichopoda	69.49	3.00e-127	447.00
IUUC-Apl-003881	Anas platyrhynchos	49.32	2.00e-52	197.00
IUUC-Aca-004397	Anolis carolinensis	51.27	4.00e-61	227.00
IUUC-Aly-005564	Arabidopsis lyrata	98.64	1.00e-163	568.00
IUUC-Ago-007858	Ashbya gossypii	50.00	2.00e-58	218.00
IUUC-Acl-008094	Aspergillus clavatus	46.58	1.00e-44	172.00
IUUC-Afl-008689	Aspergillus flavus	45.73	9.00e-45	172.00
IUUC-Afu-008959	Aspergillus fumigatus	45.06	2.00e-44	171.00
IUUC-Ani-009344	Aspergillus nidulans	41.45	2.00e-29	122.00
IUUC-Ang-009602	Aspergillus niger	44.87	2.00e-42	165.00
IUUC-Aor-009906	Aspergillus oryzae	43.46	2.00e-30	124.00
IUUC-Ate-010267	Aspergillus terreus	44.13	2.00e-33	134.00
IUUC-Ame-011018	Astyanax mexicanus	42.01	5.00e-70	257.00
IUUC-Bgr-012200	Blumeria graminis	51.24	9.00e-59	219.00
IUUC-Bta-013066	Bos taurus	43.30	2.00e-67	248.00
IUUC-Bci-013904	Botrytis cinerea	50.83	2.00e-56	212.00
IUUC-Bdi-014537	Brachypodium distachyon	61.85	7.00e-105	373.00
IUUC-Bol-015474	Brassica oleracea	97.27	1.00e-151	528.00
IUUC-Bra-018039	Brassica rapa	96.99	3.00e-151	526.00
IUUC-Cel-018187	Caenorhabditis elegans	42.32	7.00e-44	170.00
IUUC-Cja-019738	Callithrix jacchus	42.78	8.00e-68	249.00
IUUC-Cfa-020362	Canis familiaris	42.27	1.00e-67	249.00
IUUC-Cpo-021297	Cavia porcellus	41.42	1.00e-61	231.00
IUUC-Cre-022783	Chlamydomonas reinhardtii	56.50	6.00e-65	239.00
IUUC-Cho-024800	Choloepus hoffmanni	53.85	1.00e-20	93.20
IUUC-Cin-025469	Ciona intestinalis	38.54	1.00e-52	199.00
IUUC-Csv-026297	Ciona savignyi	39.37	8.00e-59	220.00
IUUC-Cgl-026657	Colletotrichum gloeosporioides	47.46	2.00e-42	165.00
IUUC-Cne-027027	Cryptococcus neoformans	47.72	7.00e-60	223.00
IUUC-Cme-027212	Cyanidioschyzon merolae	44.44	2.00e-48	186.00
IUUC-Dre-027759	Danio rerio	42.97	1.00e-70	259.00
IUUC-Dno-029528	Dasypus novemcinctus	42.78	8.00e-68	249.00
IUUC-Dor-030255	Dipodomys ordii	41.69	8.00e-62	229.00
IUUC-Dse-031464	Dothistroma septosporum	52.97	2.00e-56	211.00
IUUC-Dme-032000	Drosophila melanogaster	41.43	9.00e-62	229.00
IUUC-Ete-032762	Echinops telfairi	42.53	2.00e-67	248.00
IUUC-Eca-034399	Equus caballus	40.93	2.00e-62	233.00
IUUC-Eeu-035072	Erinaceus europaeus	39.02	2.00e-42	165.00
IUUC-Fca-035993	Felis catus	41.95	1.00e-61	229.00
IUUC-Fal-037623	Ficedula albicollis	34.02	2.00e-42	165.00
IUUC-Fox-037746	Fusarium oxysporum	46.61	1.00e-52	199.00
IUUC-Fso-038431	Fusarium solani	45.34	2.00e-52	198.00
IUUC-Gmo-039290	Gadus morhua	41.34	2.00e-62	231.00
IUUC-Ggr-039821	Gaeumannomyces graminis	48.70	2.00e-46	178.00
IUUC-Gga-040288	Gallus gallus	42.53	8.00e-67	246.00
IUUC-Gac-042587	Gasterosteus aculeatus	40.79	2.00e-61	230.00
IUUC-Gma-043225	Glycine max	62.50	4.00e-122	430.00
IUUC-Ggo-044628	Gorilla gorilla	42.78	8.00e-68	249.00
IUUC-Hsa-045850	Homo sapiens	42.53	5.00e-68	250.00
IUUC-Hvu-047715	Hordeum vulgare	76.03	5.00e-96	343.00
IUUC-Itr-048388	Ictidomys tridecemlineatus	41.88	3.00e-64	238.00
IUUC-Kpa-049158	Komagataella pastoris	52.23	8.00e-59	219.00
IUUC-Lch-050472	Latimeria chalumnae	40.62	3.00e-61	229.00
IUUC-Lpe-051233	Leersia perrieri	77.02	2.00e-87	316.00
IUUC-Loc-052437	Lepisosteus oculatus	37.72	7.00e-35	142.00
IUUC-Lma-053295	Leptosphaeria maculans	47.28	1.00e-48	186.00
IUUC-Laf-053504	Loxodonta africana	42.53	1.00e-67	249.00
IUUC-Mcc-054877	Macaca mulatta	42.78	1.00e-67	249.00
IUUC-Meu-056114	Macropus eugenii	43.01	2.00e-67	248.00
IUUC-Mor-057212	Magnaporthe oryzae	49.37	2.00e-49	188.00
IUUC-Mpo-057587	Magnaporthe poae	48.19	4.00e-46	177.00
IUUC-Mtr-058520	Medicago truncatula	65.55	4.00e-119	420.00
IUUC-Mla-059105	Melampsora laricipopulina	43.98	2.00e-23	102.00
IUUC-Mga-059537	Meleagris gallopavo	41.49	6.00e-68	250.00
IUUC-Mvi-060277	Microbotryum violaceum	40.70	2.00e-49	188.00
IUUC-Mmr-061736	Microcebus murinus	43.04	2.00e-66	245.00
IUUC-Mdo-062403	Monodelphis domestica	41.42	2.00e-61	230.00
IUUC-Mmu-063937	Mus musculus	41.86	2.00e-66	245.00
IUUC-Mac-065367	Musa acuminata	59.86	4.00e-115	407.00
IUUC-Mpu-065901	Mustela putorius furo	42.27	7.00e-68	250.00
IUUC-Mlu-067994	Myotis lucifugus	42.27	1.00e-67	249.00
IUUC-Nfi-068540	Neosartorya fischeri	45.06	2.00e-44	171.00
IUUC-Ncr-068760	Neurospora crassa	49.79	9.00e-56	209.00
IUUC-Nle-069463	Nomascus leucogenys	42.78	1.00e-67	249.00
IUUC-Opr-070298	Ochotona princeps	42.78	2.00e-67	248.00
IUUC-Ont-072615	Oreochromis niloticus	42.89	4.00e-70	257.00
IUUC-Ocu-074141	Oryctolagus cuniculus	42.78	2.00e-67	248.00
IUUC-Oba-075955	Oryza barthii	77.02	2.00e-88	318.00
IUUC-Obr-076545	Oryza brachyantha	76.17	3.00e-86	311.00
IUUC-Ogl-077252	Oryza glaberrima	76.17	1.00e-85	309.00
IUUC-Ogu-078986	Oryza glumaepatula	77.02	3.00e-88	318.00
IUUC-Oin-080166	Oryza indica	76.29	3.00e-86	311.00
IUUC-Olo-080390	Oryza longistaminata	76.52	8.00e-85	308.00
IUUC-Ome-082015	Oryza meridionalis	77.02	1.00e-88	319.00
IUUC-Oni-082397	Oryza nivara	77.02	2.00e-88	318.00
IUUC-Opu-083674	Oryza punctata	76.60	3.00e-88	317.00
IUUC-Oru-085199	Oryza rufipogon	77.02	2.00e-88	318.00
IUUC-Osa-085911	Oryza sativa	77.02	2.00e-88	318.00
IUUC-Ola-086325	Oryzias latipes	41.38	2.00e-61	229.00
IUUC-Olu-087857	Ostreococcus lucimarinus	55.65	5.00e-60	223.00
IUUC-Oga-088882	Otolemur garnettii	41.42	9.00e-62	230.00
IUUC-Oar-089311	Ovis aries	42.78	2.00e-67	248.00
IUUC-Ptr-090931	Pan troglodytes	42.53	5.00e-68	250.00
IUUC-Pan-092286	Papio anubis	42.53	5.00e-68	250.00
IUUC-Psi-093908	Pelodiscus sinensis	40.91	2.00e-60	225.00
IUUC-Pma-094737	Petromyzon marinus	41.46	3.00e-61	228.00
IUUC-Pno-094807	Phaeosphaeria nodorum	48.77	1.00e-57	216.00
IUUC-Ppa-095749	Physcomitrella patens	55.93	1.00e-98	352.00
IUUC-Pfo-097212	Poecilia formosa	42.30	1.00e-70	259.00
IUUC-Pab-097708	Pongo abelii	41.69	1.00e-62	233.00
IUUC-Pop-099138	Populus trichocarpa	69.25	1.00e-123	436.00
IUUC-Pca-100722	Procavia capensis	47.86	5.00e-26	111.00
IUUC-Ppe-101877	Prunus persica	66.42	1.00e-130	458.00
IUUC-Pva-103185	Pteropus vampyrus	42.53	3.00e-67	248.00
IUUC-Pgr-103361	Puccinia graminis	38.75	2.00e-34	139.00
IUUC-Ptt-103848	Puccinia triticina	36.10	7.00e-16	76.60
IUUC-Pte-104114	Pyrenophora teres	44.16	8.00e-49	186.00
IUUC-Pyt-104662	Pyrenophora triticirepentis	45.80	9.00e-53	199.00
IUUC-Rno-104906	Rattus norvegicus	42.53	6.00e-67	247.00
IUUC-Sce-106427	Saccharomyces cerevisiae	44.54	1.00e-52	198.00
IUUC-Sha-106574	Sarcophilus harrisii	42.56	2.00e-65	241.00
IUUC-Sja-107706	Schizosaccharomyces japonicus	48.21	5.00e-51	193.00
IUUC-Spo-108378	Schizosaccharomyces pombe	44.84	3.00e-51	194.00
IUUC-Smo-109639	Selaginella moellendorffii	61.30	2.00e-102	365.00
IUUC-Sit-110284	Setaria italica	77.27	2.00e-94	338.00
IUUC-Sly-111246	Solanum lycopersicum	66.58	4.00e-119	420.00
IUUC-Stu-112695	Solanum tuberosum	67.18	4.00e-119	420.00
IUUC-Sar-113015	Sorex araneus	51.18	1.00e-45	176.00
IUUC-Sbi-114495	Sorghum bicolor	77.27	2.00e-94	338.00
IUUC-Sre-114891	Sporisorium reilianum	51.71	1.00e-62	233.00
IUUC-Ssc-116142	Sus scrofa	42.53	7.00e-68	250.00
IUUC-Tgu-116946	Taeniopygia guttata	38.92	2.00e-40	158.00
IUUC-Tru-118485	Takifugu rubripes	42.29	2.00e-64	240.00
IUUC-Tsy-119004	Tarsius syrichta	38.37	6.00e-44	170.00
IUUC-Tni-120074	Tetraodon nigroviridis	43.12	5.00e-69	253.00
IUUC-Tca-121251	Theobroma cacao	68.08	2.00e-124	437.00
IUUC-Tre-122168	Trichoderma reesei	49.17	3.00e-60	224.00
IUUC-Tvi-122655	Trichoderma virens	48.73	4.00e-53	200.00
IUUC-Tae-125631	Triticum aestivum	75.62	2.00e-95	342.00
IUUC-Tur-126420	Triticum urartu	75.62	2.00e-95	341.00
IUUC-Tme-126937	Tuber melanosporum	52.89	2.00e-63	234.00
IUUC-Tbe-128080	Tupaia belangeri	41.49	4.00e-64	237.00
IUUC-Ttr-128811	Tursiops truncatus	42.78	8.00e-68	249.00
IUUC-Uma-129436	Ustilago maydis	51.71	2.00e-64	239.00
IUUC-Vda-129920	Verticillium dahliae	48.33	1.00e-48	186.00
IUUC-Vpa-130762	Vicugna pacos	56.76	5.00e-35	141.00
IUUC-Vvi-130840	Vitis vinifera	66.42	2.00e-117	414.00
IUUC-Xtr-131967	Xenopus tropicalis	39.73	1.00e-34	139.00
IUUC-Xma-134224	Xiphophorus maculatus	42.45	3.00e-70	258.00
IUUC-Yli-134643	Yarrowia lipolytica	52.05	1.00e-62	232.00
IUUC-Zma-135870	Zea mays	62.99	3.00e-108	384.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence