iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000008604.11	ENSMUST00000008748.7	ENSMUSP00000008748.6
ENSMUSG00000008604.11	ENSMUST00000192962.1	ENSMUSP00000142145.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	11162551; 18079109; 20940304
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	11162551; 18079109; 20940304; 24674348

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	2.90e-10	41.1	554	591
ULD/UDP/UBQ/UBQ_PIM	6.10e-23	81.7	13	86

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGF.dreealqaLraannnleaAveyLl 39
           ++++leql +MGF +re++lqaL a++++++aA+e+Ll
   Q: 554  FQQQLEQLNSMGFiNREANLQALIATGGDINAAIERLL 591
           799**********************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           +++tvkt+k+ke e+ +  + +v+e+Ke+i+++++ +++q+ LI+aGkiLkD +tLs++gikdg +vhlv+k+++
   Q: 13   IRVTVKTPKDKE-EIVICDQASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLSQHGIKDGLTVHLVIKTPQ 86
           68**********.***********************************************************987 PP

Organism

Mus musculus

Functional Description
(View)

Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (By similarity). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (PubMed:18079109, PubMed:20940304). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (By similarity).

Protein Sequence
(Fasta)

MAEPSGAETR PQIRVTVKTP KDKEEIVICD QASVKEFKEE ISRRFKAQQD QLVLIFAGKI 60
LKDGDTLSQH GIKDGLTVHL VIKTPQKAQD PVTAAASPPS TPDSASAPST TPASPAAAPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGAGGAGG AGGAGCCGGA CGGGCTGGCG GGCGGCCGGG CGGCGGCATG GCGGAGCCGA 60
GTGGGGCTGA GACGAGGCCC CAGATTCGGG TCACCGTCAA GACCCCCAAG GACAAGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0256--Endoplasmic reticulum
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR015496--Ubiquilin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0031597--C:cytosolic proteasome complex
GO:0005789--C:endoplasmic reticulum membrane
GO:0031595--C:nuclear proteasome complex
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0042802--F:identical protein binding
GO:0031593--F:polyubiquitin binding
GO:0006914--P:autophagy
GO:1901097--P:negative regulation of autophagosome maturation
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process

KEGG

mmu:94232

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001730	Ailuropoda melanoleuca	86.28	5.00e-154	538.00
IUUC-Apl-004150	Anas platyrhynchos	85.14	3.00e-155	541.00
IUUC-Ago-007963	Ashbya gossypii	36.23	1.00e-08	53.90
IUUC-Ani-009418	Aspergillus nidulans	38.10	2.00e-08	53.50
IUUC-Ame-011329	Astyanax mexicanus	70.38	1.00e-167	582.00
IUUC-Bta-012938	Bos taurus	92.72	5.00e-161	561.00
IUUC-Cja-018858	Callithrix jacchus	94.84	3.00e-166	578.00
IUUC-Cfa-020455	Canis familiaris	93.43	6.00e-165	574.00
IUUC-Cpo-021410	Cavia porcellus	91.78	4.00e-160	558.00
IUUC-Cgl-026590	Colletotrichum gloeosporioides	27.38	6.00e-05	42.00
IUUC-Dre-028009	Danio rerio	71.36	6.00e-147	514.00
IUUC-Dno-029892	Dasypus novemcinctus	94.60	1.00e-160	560.00
IUUC-Dor-030154	Dipodomys ordii	84.75	3.00e-109	389.00
IUUC-Eca-034284	Equus caballus	95.07	1.00e-164	573.00
IUUC-Fca-036145	Felis catus	78.09	3.00e-119	422.00
IUUC-Fal-037180	Ficedula albicollis	85.14	3.00e-153	535.00
IUUC-Fox-037726	Fusarium oxysporum	50.00	8.00e-07	48.50
IUUC-Gga-041050	Gallus gallus	85.38	5.00e-146	511.00
IUUC-Gac-041826	Gasterosteus aculeatus	72.09	5.00e-149	521.00
IUUC-Ggo-044680	Gorilla gorilla	94.84	3.00e-164	571.00
IUUC-Hsa-046554	Homo sapiens	94.84	1.00e-164	573.00
IUUC-Hvu-047094	Hordeum vulgare	52.27	8.00e-09	52.40
IUUC-Itr-048781	Ictidomys tridecemlineatus	93.90	1.00e-164	573.00
IUUC-Lch-049480	Latimeria chalumnae	78.33	8.00e-118	417.00
IUUC-Loc-051845	Lepisosteus oculatus	68.91	1.00e-133	470.00
IUUC-Laf-054476	Loxodonta africana	94.13	1.00e-165	576.00
IUUC-Mcc-054765	Macaca mulatta	94.84	1.00e-164	573.00
IUUC-Meu-056843	Macropus eugenii	88.29	2.00e-162	565.00
IUUC-Mpo-057467	Magnaporthe poae	50.00	3.00e-07	47.00
IUUC-Mla-058987	Melampsora laricipopulina	53.49	4.00e-07	49.30
IUUC-Mga-059730	Meleagris gallopavo	85.38	6.00e-153	534.00
IUUC-Mvi-060466	Microbotryum violaceum	55.32	2.00e-08	53.50
IUUC-Mmr-061256	Microcebus murinus	94.84	9.00e-173	600.00
IUUC-Mdo-061917	Monodelphis domestica	85.78	9.00e-163	566.00
IUUC-Mpu-066300	Mustela putorius furo	92.47	3.00e-167	582.00
IUUC-Mlu-067197	Myotis lucifugus	90.85	6.00e-159	554.00
IUUC-Opr-070323	Ochotona princeps	91.57	9.00e-165	573.00
IUUC-Ont-072038	Oreochromis niloticus	73.52	3.00e-149	521.00
IUUC-Ocu-074759	Oryctolagus cuniculus	93.90	4.00e-159	554.00
IUUC-Ola-086802	Oryzias latipes	67.95	2.00e-146	512.00
IUUC-Oga-088466	Otolemur garnettii	92.96	1.00e-160	559.00
IUUC-Oar-090375	Ovis aries	93.19	5.00e-161	561.00
IUUC-Ptr-091312	Pan troglodytes	94.84	1.00e-164	573.00
IUUC-Pan-092351	Papio anubis	94.84	1.00e-164	573.00
IUUC-Psi-093262	Pelodiscus sinensis	85.14	8.00e-159	553.00
IUUC-Pfo-096638	Poecilia formosa	65.59	5.00e-179	620.00
IUUC-Pab-097627	Pongo abelii	92.72	2.00e-163	569.00
IUUC-Pop-099549	Populus trichocarpa	33.26	5.00e-48	185.00
IUUC-Pca-100181	Procavia capensis	88.04	8.00e-98	350.00
IUUC-Pva-102687	Pteropus vampyrus	80.28	1.00e-130	460.00
IUUC-Rno-105804	Rattus norvegicus	97.32	0.00e+00	822.00
IUUC-Sha-107346	Sarcophilus harrisii	88.02	5.00e-160	557.00
IUUC-Ssl-108425	Sclerotinia sclerotiorum	50.00	7.00e-07	47.80
IUUC-Ssc-116185	Sus scrofa	94.60	6.00e-161	560.00
IUUC-Tgu-116930	Taeniopygia guttata	85.14	5.00e-152	531.00
IUUC-Tru-118652	Takifugu rubripes	71.20	1.00e-146	513.00
IUUC-Tni-119780	Tetraodon nigroviridis	66.16	0.00e+00	637.00
IUUC-Tre-122085	Trichoderma reesei	48.84	4.00e-07	48.90
IUUC-Tvi-122381	Trichoderma virens	48.84	7.00e-07	48.50
IUUC-Ttr-128771	Tursiops truncatus	94.13	1.00e-164	573.00
IUUC-Vpa-130633	Vicugna pacos	74.49	4.00e-100	358.00
IUUC-Xtr-132978	Xenopus tropicalis	67.84	7.00e-137	481.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence