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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045714
UUCD1 version UUC-HoS-01109
Ensembl Protein ID ENSP00000356051.1
UniProt Accession Q5VVQ6; B2RNX3; Q5VVQ5; Q6ZRS6; Q86T63; Q9P1L8; OTU1_HUMAN
Genbank Protein ID BAC87233.1; CAH70775.1; CAH70776.1; EAW93509.1; EAW93510.1; AAI37167.1; AAI37168.1; CAD89975.1; AAF71033.1
Protein Name Ubiquitin thioesterase OTU1; DUBA-8; HIV-1-induced protease 7; OTU domain-containing protein 2
Genbank Nucleotide ID AK128014; AL445493; AL445493; CH471100; CH471100; BC137166; BC137167; AL833081; AF116608
Gene Name YOD1; DUBA8; HIN7; OTUD2; PRO0907
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000180667.10 ENST00000315927.8 ENSP00000326813.4
ENSG00000180667.10 ENST00000367084.1 ENSP00000356051.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/OTU OTU 19818707; 21103003
UBD/ZnF/Other UBD/ZnF/Other 23827681
Reviewed
Classification
Family Identity E-value Score Source Orthology
DUB/OTU 32.62 2.00e-35 144.00 IUUC-Sce-106323
ULD/UDP/UFD/UBX 32.62 2.00e-35 144.00 IUUC-Sce-106323
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin.
 Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin.
Protein Sequence
(Fasta)
METLHIIYSE AKSFTVEGLS SRTRVRELQG QIAAITGIAP GGQRILVGYP PECLDLSNGD 60
TILEDLPIQS GDMLIIEEDQ TRPRSSPAFT KRGASSYVRE TLPVLTRTVV PADNSCLFTS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045714|DUB,OTU;UBD,UBD/ZnF/Other;ULD,UBX|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGACTATTCG GTAGGCGTCT TGAGAGCGGG TGTGCCGGGT GACGAGAAAA TGCTGCAAAG 60
ATTAACGCTC TCATTCCTGA ATCCCAGCAG AACCTCATTA GATCCATAAA TGGGAACGTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045714|DUB,OTU;UBD,UBD/ZnF/Other;ULD,UBX|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003323--OTU_dom
IPR029071--Ubiquitin-rel_dom
IPR013087--Znf_C2H2_type
PROSITE

PS50802--OTU
PS00028--ZINC_FINGER_C2H2_1
Pfam

PF02338--OTU
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031625--F:ubiquitin protein ligase binding
GO:1904265--F:ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:1990167--P:protein K27-linked deubiquitination
GO:0035523--P:protein K29-linked deubiquitination
GO:1990168--P:protein K33-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:55432
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000271 Aegilops tauschii 48.15 3.00e-45 174.00
IUUC-Aml-001860 Ailuropoda melanoleuca 91.15 2.00e-163 568.00
IUUC-Atr-002548 Amborella trichopoda 50.97 2.00e-51 195.00
IUUC-Apl-004025 Anas platyrhynchos 79.58 2.00e-106 378.00
IUUC-Aca-004505 Anolis carolinensis 74.41 3.00e-134 471.00
IUUC-Aly-005999 Arabidopsis lyrata 45.45 5.00e-48 184.00
IUUC-Ath-006774 Arabidopsis thaliana 46.41 1.00e-48 186.00
IUUC-Ago-007741 Ashbya gossypii 38.89 8.00e-38 150.00
IUUC-Acl-008278 Aspergillus clavatus 33.33 1.00e-42 167.00
IUUC-Afl-008710 Aspergillus flavus 34.73 3.00e-43 168.00
IUUC-Afu-009009 Aspergillus fumigatus 33.76 4.00e-45 175.00
IUUC-Ani-009430 Aspergillus nidulans 33.75 1.00e-41 163.00
IUUC-Ang-009508 Aspergillus niger 40.64 6.00e-37 147.00
IUUC-Aor-009992 Aspergillus oryzae 35.05 4.00e-44 171.00
IUUC-Ate-010440 Aspergillus terreus 33.44 4.00e-44 171.00
IUUC-Ame-011038 Astyanax mexicanus 69.76 1.00e-119 422.00
IUUC-Bgr-012262 Blumeria graminis 33.78 4.00e-35 142.00
IUUC-Bta-012864 Bos taurus 90.20 4.00e-160 557.00
IUUC-Bci-013986 Botrytis cinerea 34.84 2.00e-35 143.00
IUUC-Bdi-014194 Brachypodium distachyon 49.27 1.00e-51 195.00
IUUC-Bol-016166 Brassica oleracea 47.09 2.00e-49 188.00
IUUC-Bra-017783 Brassica rapa 47.57 1.00e-49 189.00
IUUC-Cja-019488 Callithrix jacchus 92.79 2.00e-167 581.00
IUUC-Cpo-021728 Cavia porcellus 89.51 2.00e-162 564.00
IUUC-Cre-022819 Chlamydomonas reinhardtii 47.06 4.00e-43 167.00
IUUC-Csa-024237 Chlorocebus sabaeus 97.26 1.00e-167 581.00
IUUC-Cho-024544 Choloepus hoffmanni 89.51 1.00e-161 562.00
IUUC-Cin-025549 Ciona intestinalis 44.48 2.00e-68 252.00
IUUC-Cgl-026552 Colletotrichum gloeosporioides 31.99 7.00e-34 137.00
IUUC-Cne-027022 Cryptococcus neoformans 45.05 9.00e-45 174.00
IUUC-Cme-027196 Cyanidioschyzon merolae 38.61 4.00e-45 175.00
IUUC-Dre-027799 Danio rerio 69.20 7.00e-113 400.00
IUUC-Dno-029863 Dasypus novemcinctus 88.52 2.00e-159 555.00
IUUC-Dor-030804 Dipodomys ordii 85.47 9.00e-145 506.00
IUUC-Dse-031494 Dothistroma septosporum 40.19 4.00e-41 162.00
IUUC-Dme-032065 Drosophila melanogaster 42.48 1.00e-66 246.00
IUUC-Ete-033193 Echinops telfairi 88.20 1.00e-160 558.00
IUUC-Eca-033993 Equus caballus 90.49 3.00e-163 567.00
IUUC-Fca-035949 Felis catus 91.15 1.00e-163 568.00
IUUC-Fal-037473 Ficedula albicollis 77.54 4.00e-103 367.00
IUUC-Fox-037779 Fusarium oxysporum 31.65 6.00e-29 121.00
IUUC-Fso-038370 Fusarium solani 36.11 2.00e-28 119.00
IUUC-Gmo-038778 Gadus morhua 57.68 2.00e-85 309.00
IUUC-Ggr-039940 Gaeumannomyces graminis 33.57 2.00e-34 139.00
IUUC-Gga-041102 Gallus gallus 73.96 2.00e-120 424.00
IUUC-Gac-041954 Gasterosteus aculeatus 68.69 8.00e-119 419.00
IUUC-Gma-043608 Glycine max 48.54 7.00e-50 189.00
IUUC-Ggo-044753 Gorilla gorilla 95.08 7.00e-168 583.00
IUUC-Hvu-047600 Hordeum vulgare 49.27 3.00e-52 197.00
IUUC-Itr-048026 Ictidomys tridecemlineatus 90.16 5.00e-163 566.00
IUUC-Kpa-049360 Komagataella pastoris 30.99 4.00e-38 151.00
IUUC-Lch-049900 Latimeria chalumnae 73.45 3.00e-119 421.00
IUUC-Lpe-050984 Leersia perrieri 40.69 7.00e-33 133.00
IUUC-Loc-052567 Lepisosteus oculatus 70.79 4.00e-124 437.00
IUUC-Lma-053247 Leptosphaeria maculans 33.22 1.00e-39 157.00
IUUC-Laf-053361 Loxodonta africana 90.16 2.00e-162 565.00
IUUC-Meu-056137 Macropus eugenii 79.86 3.00e-135 474.00
IUUC-Mor-057191 Magnaporthe oryzae 36.50 1.00e-24 107.00
IUUC-Mpo-057565 Magnaporthe poae 37.50 3.00e-31 129.00
IUUC-Mtr-058196 Medicago truncatula 47.57 3.00e-50 191.00
IUUC-Mla-059096 Melampsora laricipopulina 41.92 4.00e-39 155.00
IUUC-Mga-059489 Meleagris gallopavo 80.08 3.00e-113 400.00
IUUC-Mvi-060300 Microbotryum violaceum 37.12 4.00e-42 165.00
IUUC-Mmr-061618 Microcebus murinus 93.84 5.00e-164 570.00
IUUC-Mdo-061909 Monodelphis domestica 84.69 6.00e-154 537.00
IUUC-Mmu-063434 Mus musculus 87.54 3.00e-159 554.00
IUUC-Mac-064676 Musa acuminata 50.00 8.00e-52 196.00
IUUC-Mpu-066733 Mustela putorius furo 91.48 2.00e-164 571.00
IUUC-Mlu-066990 Myotis lucifugus 90.10 7.00e-159 553.00
IUUC-Nfi-068249 Neosartorya fischeri 41.67 2.00e-43 169.00
IUUC-Ncr-068764 Neurospora crassa 35.61 1.00e-35 143.00
IUUC-Nle-069094 Nomascus leucogenys 94.75 1.00e-167 582.00
IUUC-Oan-073585 Ornithorhynchus anatinus 83.28 1.00e-146 512.00
IUUC-Oba-075949 Oryza barthii 49.51 8.00e-50 189.00
IUUC-Obr-076096 Oryza brachyantha 49.51 1.00e-50 192.00
IUUC-Ogl-077106 Oryza glaberrima 49.03 3.00e-49 188.00
IUUC-Ogu-078024 Oryza glumaepatula 49.51 1.00e-49 189.00
IUUC-Oin-079635 Oryza indica 48.54 1.00e-49 189.00
IUUC-Olo-080299 Oryza longistaminata 49.51 2.00e-49 188.00
IUUC-Ome-081359 Oryza meridionalis 49.51 1.00e-49 189.00
IUUC-Oni-082459 Oryza nivara 49.03 2.00e-49 188.00
IUUC-Opu-083167 Oryza punctata 50.49 3.00e-51 194.00
IUUC-Oru-084577 Oryza rufipogon 48.54 1.00e-49 189.00
IUUC-Osa-085746 Oryza sativa 54.90 7.00e-13 65.10
IUUC-Ola-086890 Oryzias latipes 69.18 8.00e-121 426.00
IUUC-Olu-087585 Ostreococcus lucimarinus 43.28 7.00e-44 170.00
IUUC-Oga-088190 Otolemur garnettii 88.85 3.00e-158 550.00
IUUC-Oar-089631 Ovis aries 90.54 1.00e-160 558.00
IUUC-Pan-091892 Papio anubis 94.43 3.00e-167 580.00
IUUC-Pma-094491 Petromyzon marinus 55.05 1.00e-82 300.00
IUUC-Pno-094993 Phaeosphaeria nodorum 36.92 4.00e-42 165.00
IUUC-Ppa-095791 Physcomitrella patens 53.40 1.00e-54 205.00
IUUC-Pfo-096301 Poecilia formosa 69.86 4.00e-121 427.00
IUUC-Pab-097873 Pongo abelii 94.75 3.00e-168 583.00
IUUC-Pop-099482 Populus trichocarpa 49.03 8.00e-52 196.00
IUUC-Pca-100817 Procavia capensis 86.23 5.00e-152 530.00
IUUC-Ppe-101624 Prunus persica 49.76 6.00e-52 196.00
IUUC-Pva-102120 Pteropus vampyrus 89.51 3.00e-161 561.00
IUUC-Pgr-103368 Puccinia graminis 31.10 2.00e-41 162.00
IUUC-Ptt-103923 Puccinia triticina 37.90 3.00e-41 162.00
IUUC-Pte-104199 Pyrenophora teres 37.18 3.00e-42 165.00
IUUC-Pyt-104502 Pyrenophora triticirepentis 36.48 2.00e-42 166.00
IUUC-Rno-105605 Rattus norvegicus 88.20 2.00e-160 558.00
IUUC-Sce-106323 Saccharomyces cerevisiae 32.37 3.00e-32 132.00
IUUC-Sha-107176 Sarcophilus harrisii 88.59 6.00e-140 489.00
IUUC-Sja-107812 Schizosaccharomyces japonicus 37.26 2.00e-36 146.00
IUUC-Spo-108085 Schizosaccharomyces pombe 29.76 2.00e-39 156.00
IUUC-Smo-109050 Selaginella moellendorffii 48.06 1.00e-50 192.00
IUUC-Sit-110056 Setaria italica 48.06 3.00e-50 191.00
IUUC-Sly-111869 Solanum lycopersicum 50.86 4.00e-45 174.00
IUUC-Stu-112452 Solanum tuberosum 49.76 8.00e-52 196.00
IUUC-Sar-113629 Sorex araneus 83.61 1.00e-56 213.00
IUUC-Sbi-114422 Sorghum bicolor 49.03 2.00e-51 195.00
IUUC-Sre-115105 Sporisorium reilianum 43.28 9.00e-34 137.00
IUUC-Ssc-115553 Sus scrofa 90.49 3.00e-162 564.00
IUUC-Tgu-116921 Taeniopygia guttata 78.06 2.00e-102 365.00
IUUC-Tru-117830 Takifugu rubripes 67.58 5.00e-118 417.00
IUUC-Tsy-119320 Tarsius syrichta 90.82 5.00e-162 563.00
IUUC-Tni-119706 Tetraodon nigroviridis 67.12 4.00e-113 400.00
IUUC-Tca-121238 Theobroma cacao 49.51 4.00e-51 194.00
IUUC-Tae-124711 Triticum aestivum 49.51 2.00e-51 196.00
IUUC-Tme-126966 Tuber melanosporum 36.02 1.00e-50 193.00
IUUC-Tbe-127712 Tupaia belangeri 96.97 3.00e-112 397.00
IUUC-Ttr-129168 Tursiops truncatus 88.85 2.00e-161 561.00
IUUC-Uma-129461 Ustilago maydis 41.46 5.00e-39 155.00
IUUC-Vda-129890 Verticillium dahliae 36.67 6.00e-27 114.00
IUUC-Vpa-130616 Vicugna pacos 88.20 6.00e-159 553.00
IUUC-Vvi-131250 Vitis vinifera 49.03 2.00e-50 191.00
IUUC-Xtr-132126 Xenopus tropicalis 69.31 1.00e-123 436.00
IUUC-Xma-133596 Xiphophorus maculatus 69.73 1.00e-120 425.00
IUUC-Yli-134562 Yarrowia lipolytica 32.64 2.00e-35 143.00
IUUC-Zma-135205 Zea mays 48.54 1.00e-50 192.00
Created Date 25-Jun-2017

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