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Tag Content
iUUCD ID IUUC-Yli-134517
Ensembl Protein ID CAG78834
UniProt Accession Q6BZZ1; ATG12_YARLI
Genbank Protein ID CAG78834.1
Protein Name Ubiquitin-like protein ATG12; Autophagy-related protein 12
Genbank Nucleotide ID CR382132
Gene Name ATG12; YALI0F29689g
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YALI0_F29689g CAG78834 CAG78834
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UBL/ATG12 36.25 5.00e-09 58.50 IUUC-Hsa-046903
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Yarrowia lipolytica
Functional Description
(View)

Functional Description


     Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
 Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
Protein Sequence
(Fasta)
MIESDSDTSD DAPQEYVSAS ANIPAQFELA TAHMKATPEP QPTQQPDAEA LHDDDPLTTT 60
QDHPTGPSAT ASDTIDSTPQ PMAPATLSAS AVLPSLPSDT AALLETFSQQ LQQSNVKCQL 120
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Protein Fasta Sequence


>IUUC-Yli-134517|ULD,ATG12|Yarrowia lipolytica
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Nucleotide Sequence
(Fasta)
ATGATCGAAA GTGACTCAGA CACCAGCGAC GACGCTCCCC AGGAGTACGT CTCGGCGTCT 60
GCTAACATTC CTGCGCAATT TGAACTCGCC ACAGCACATA TGAAGGCTAC TCCAGAGCCC 120
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Nucleotide Fasta Sequence


>IUUC-Yli-134517|ULD,ATG12|Yarrowia lipolytica
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Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom
Pfam

PF04110--APG12
Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport
KEGG yli:YALI0F29689g
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001177 Aegilops tauschii 41.25 3.00e-13 64.30
IUUC-Aml-002116 Ailuropoda melanoleuca 36.25 5.00e-11 58.20
IUUC-Atr-002615 Amborella trichopoda 37.50 4.00e-12 60.50
IUUC-Apl-003753 Anas platyrhynchos 45.00 2.00e-05 37.70
IUUC-Aca-005231 Anolis carolinensis 45.45 4.00e-07 45.10
IUUC-Aly-006172 Arabidopsis lyrata 41.11 3.00e-14 67.40
IUUC-Ath-006953 Arabidopsis thaliana 38.89 6.00e-14 66.60
IUUC-Ago-007970 Ashbya gossypii 37.78 6.00e-09 51.60
IUUC-Acl-008072 Aspergillus clavatus 43.33 1.00e-20 89.40
IUUC-Afl-008725 Aspergillus flavus 43.90 2.00e-22 96.70
IUUC-Afu-008967 Aspergillus fumigatus 43.90 5.00e-22 94.70
IUUC-Ani-009248 Aspergillus nidulans 39.84 2.00e-19 86.30
IUUC-Ang-009684 Aspergillus niger 42.86 5.00e-21 91.70
IUUC-Aor-009947 Aspergillus oryzae 43.90 2.00e-22 96.70
IUUC-Ame-011656 Astyanax mexicanus 31.25 5.00e-08 47.80
IUUC-Bgr-012174 Blumeria graminis 41.76 2.00e-13 65.90
IUUC-Bta-012483 Bos taurus 36.25 8.00e-11 57.00
IUUC-Bci-013755 Botrytis cinerea 34.13 2.00e-14 68.90
IUUC-Bdi-014156 Brachypodium distachyon 42.50 7.00e-14 66.20
IUUC-Bol-015683 Brassica oleracea 40.00 2.00e-14 68.20
IUUC-Bra-016802 Brassica rapa 40.00 1.00e-13 65.10
IUUC-Cja-019514 Callithrix jacchus 36.25 1.00e-10 57.40
IUUC-Cfa-020748 Canis familiaris 36.25 6.00e-11 58.20
IUUC-Cpo-021965 Cavia porcellus 36.25 9.00e-11 57.80
IUUC-Cre-023009 Chlamydomonas reinhardtii 40.00 2.00e-11 57.80
IUUC-Csa-023494 Chlorocebus sabaeus 36.25 8.00e-11 57.40
IUUC-Cho-024631 Choloepus hoffmanni 36.25 1.00e-10 57.00
IUUC-Cin-025609 Ciona intestinalis 36.67 2.00e-10 55.10
IUUC-Cgl-026722 Colletotrichum gloeosporioides 40.91 2.00e-25 105.00
IUUC-Dre-027479 Danio rerio 32.50 2.00e-09 52.00
IUUC-Dno-029693 Dasypus novemcinctus 45.00 1.00e-05 40.40
IUUC-Dse-031440 Dothistroma septosporum 40.65 1.00e-22 96.30
IUUC-Dme-031892 Drosophila melanogaster 33.75 1.00e-10 55.80
IUUC-Ete-032550 Echinops telfairi 36.25 7.00e-11 57.00
IUUC-Eca-033553 Equus caballus 36.25 6.00e-11 57.80
IUUC-Fca-036524 Felis catus 33.75 2.00e-09 53.10
IUUC-Fal-036942 Ficedula albicollis 36.25 1.00e-10 55.50
IUUC-Fox-037753 Fusarium oxysporum 43.31 1.00e-20 90.10
IUUC-Gmo-039498 Gadus morhua 31.25 4.00e-08 47.80
IUUC-Ggr-039852 Gaeumannomyces graminis 37.10 2.00e-18 83.60
IUUC-Gga-041263 Gallus gallus 36.25 6.00e-11 57.80
IUUC-Gac-042346 Gasterosteus aculeatus 31.25 3.00e-08 48.50
IUUC-Gma-042896 Glycine max 38.38 4.00e-13 63.90
IUUC-Ggo-045601 Gorilla gorilla 36.25 1.00e-10 57.40
IUUC-Hsa-046903 Homo sapiens 36.25 8.00e-11 57.40
IUUC-Hvu-047239 Hordeum vulgare 41.11 2.00e-13 64.30
IUUC-Itr-048445 Ictidomys tridecemlineatus 36.25 8.00e-11 57.80
IUUC-Kpa-049355 Komagataella pastoris 36.62 2.00e-18 82.40
IUUC-Lch-050619 Latimeria chalumnae 32.22 2.00e-10 55.80
IUUC-Lma-053299 Leptosphaeria maculans 39.45 2.00e-16 75.50
IUUC-Laf-054205 Loxodonta africana 36.25 3.00e-11 58.90
IUUC-Meu-056804 Macropus eugenii 30.91 6.00e-11 57.80
IUUC-Mor-057052 Magnaporthe oryzae 40.50 4.00e-20 88.60
IUUC-Mtr-057961 Medicago truncatula 40.00 3.00e-13 64.30
IUUC-Mla-059045 Melampsora laricipopulina 40.00 2.00e-13 65.50
IUUC-Mga-060198 Meleagris gallopavo 30.77 5.00e-03 35.00
IUUC-Mvi-060360 Microbotryum violaceum 38.89 7.00e-13 63.90
IUUC-Mmr-061654 Microcebus murinus 36.25 5.00e-11 57.40
IUUC-Mdo-062649 Monodelphis domestica 36.25 3.00e-11 58.50
IUUC-Mmu-064105 Mus musculus 36.25 7.00e-11 57.40
IUUC-Mac-065532 Musa acuminata 37.78 2.00e-12 61.60
IUUC-Mpu-066269 Mustela putorius furo 36.25 1.00e-11 59.70
IUUC-Mlu-067631 Myotis lucifugus 36.25 2.00e-11 59.30
IUUC-Nfi-068468 Neosartorya fischeri 43.33 4.00e-20 87.80
IUUC-Ncr-068750 Neurospora crassa 38.12 5.00e-21 91.30
IUUC-Nle-069483 Nomascus leucogenys 36.25 7.00e-11 58.20
IUUC-Opr-070936 Ochotona princeps 36.25 1.00e-10 57.40
IUUC-Obr-076322 Oryza brachyantha 36.67 5.00e-13 63.20
IUUC-Ogl-077226 Oryza glaberrima 37.65 3.00e-12 61.20
IUUC-Oin-079220 Oryza indica 31.88 1.00e-07 46.20
IUUC-Olo-080688 Oryza longistaminata 37.65 3.00e-12 61.20
IUUC-Ome-081265 Oryza meridionalis 37.65 3.00e-12 61.20
IUUC-Oni-082451 Oryza nivara 32.31 1.20e+00 27.70
IUUC-Oru-084342 Oryza rufipogon 36.67 3.00e-12 63.20
IUUC-Osa-086212 Oryza sativa 37.65 3.00e-12 61.20
IUUC-Ola-087277 Oryzias latipes 32.50 2.00e-09 52.40
IUUC-Oga-088175 Otolemur garnettii 36.25 9.00e-11 57.00
IUUC-Oar-089477 Ovis aries 36.25 1.00e-10 57.00
IUUC-Ptr-091129 Pan troglodytes 36.25 1.00e-10 57.40
IUUC-Psi-093351 Pelodiscus sinensis 36.25 8.00e-11 57.40
IUUC-Pno-094948 Phaeosphaeria nodorum 45.71 3.00e-20 88.20
IUUC-Ppa-095788 Physcomitrella patens 38.89 4.00e-13 63.90
IUUC-Pfo-096993 Poecilia formosa 31.25 1.00e-08 49.70
IUUC-Pab-098502 Pongo abelii 36.25 9.00e-11 57.80
IUUC-Pop-098819 Populus trichocarpa 36.36 8.00e-11 56.20
IUUC-Ppe-101560 Prunus persica 38.75 3.00e-12 60.50
IUUC-Pva-102810 Pteropus vampyrus 36.07 1.00e-06 43.50
IUUC-Pgr-103531 Puccinia graminis 36.89 6.00e-13 63.90
IUUC-Ptt-103753 Puccinia triticina 36.94 3.00e-13 64.70
IUUC-Pyt-104733 Pyrenophora triticirepentis 40.16 1.00e-21 93.60
IUUC-Rno-106072 Rattus norvegicus 36.25 2.00e-11 59.70
IUUC-Sce-106275 Saccharomyces cerevisiae 41.11 4.00e-15 72.40
IUUC-Sha-107554 Sarcophilus harrisii 36.25 2.00e-11 59.30
IUUC-Sja-107682 Schizosaccharomyces japonicus 39.83 2.00e-20 89.40
IUUC-Spo-108275 Schizosaccharomyces pombe 42.11 1.00e-17 79.30
IUUC-Smo-109151 Selaginella moellendorffii 38.20 4.00e-12 60.50
IUUC-Sit-110270 Setaria italica 42.50 3.00e-13 64.30
IUUC-Sly-111862 Solanum lycopersicum 40.00 2.00e-12 61.20
IUUC-Stu-112663 Solanum tuberosum 30.91 3.00e-05 38.10
IUUC-Sbi-114148 Sorghum bicolor 42.50 3.00e-13 64.30
IUUC-Sre-115216 Sporisorium reilianum 33.98 2.00e-12 62.80
IUUC-Ssc-116051 Sus scrofa 36.25 5.00e-11 57.80
IUUC-Tgu-117008 Taeniopygia guttata 27.78 1.60e+00 22.30
IUUC-Tru-118466 Takifugu rubripes 32.50 1.00e-08 48.50
IUUC-Tsy-119334 Tarsius syrichta 33.75 4.00e-07 45.40
IUUC-Tni-119792 Tetraodon nigroviridis 33.75 2.00e-09 51.20
IUUC-Tca-121861 Theobroma cacao 37.78 5.00e-12 60.80
IUUC-Tvi-122499 Trichoderma virens 39.10 1.00e-17 79.30
IUUC-Tae-123431 Triticum aestivum 41.25 3.00e-13 64.30
IUUC-Tme-126934 Tuber melanosporum 46.67 2.00e-19 86.30
IUUC-Ttr-129001 Tursiops truncatus 34.18 2.00e-08 49.70
IUUC-Uma-129324 Ustilago maydis 35.92 2.00e-13 65.50
IUUC-Vda-129846 Verticillium dahliae 43.08 7.00e-21 90.90
IUUC-Vpa-130202 Vicugna pacos 45.00 6.00e-06 42.00
IUUC-Vvi-131474 Vitis vinifera 41.27 6.00e-08 47.80
IUUC-Xtr-132782 Xenopus tropicalis 37.50 2.00e-11 59.30
IUUC-Xma-134140 Xiphophorus maculatus 31.25 3.00e-08 48.50
IUUC-Zma-134764 Zea mays 42.50 2.00e-13 64.30
Created Date 25-Jun-2017

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