iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	20133640; 19805280

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	7.50e-79	264.0	1126	1481

Active Site

Position(s)	Description	Evidence
1450	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysen.dketlqpnpdsglknp..............ehlklFeflGrllgkalqdgrlldlp 91
            +le+e+++E+g++l G+t+ef++ +sk + +++l+++++++   ++++ ++ +  + ++              ++++lF +lG++++ +l d+r+ld +
   Q: 1126 DVLEIEYQEEAGTGL-GPTLEFYSVVSKYFARKSLNMWRCNSYsYRSEMDVDTTDDYITTllfpeplnpfsnneKVIELFGYLGTFVARSLLDNRILDFR 1224
           689************.**********************6666533333333333332233566677777777789************************* PP
   S: 92   lsksfyklllgk............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           +sk+f++ll +             +  l  +e vdp l+kslk+i +n++++++ ++l ltf+     ++  ++ eL+pgG n + + +N eeY++ v++
   Q: 1225 FSKVFFELLHRMstpnvttvpsdvETCLLMIELVDPLLAKSLKYIVANKDDNMTLESLSLTFT-----VPGNDDIELIPGGCNKSLNSSNVEEYIHGVID 1319
           *********666555555565555788899********************************9.....89999*************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgG 278
            +l +gi++q++af eGf++v++ e + ++ + el  +     e++++ +l  + + ++gyt ds+ i+ F++++++f ++er+ fLqF+Tgs++lP+gG
   Q: 1320 QILGKGIEKQLKAFIEGFSKVFSYERMLILFPDELVDIFGRVeEDWSMATLYTNLNAEHGYTMDSSIIHDFISIISAFGKHERRLFLQFLTGSPKLPIGG 1419
           ************************97666666666554443359******************************************************** PP
   S: 279  faelkprlfvirk.....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFe 334
           f++l+p+++v+ k      ++d+ lPs++TC+nyLkLP+Y+sk+i++++L  Aiee+  +F 
   Q: 1420 FKSLNPKFTVVLKhaedgLTADEYLPSVMTCANYLKLPKYTSKDIMRSRLCQAIEEGaGAFL 1481
           *************999888899**********************************977775 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MSENNSHNLD EHESHSENSD YMMDTQVEDD YDEDGHVQGE YSYYPDEDED EHMLSSVGSF 60
EADDGEDDDN DYHHEDDSGL LYGYHRTQNG SDEDRNEEED GLERSHDNNE FGSNPLHLPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTGAAA ATAATTCGCA CAACCTTGAT GAACATGAGT CCCATAGCGA AAACAGTGAT 60
TATATGATGG ATACGCAGGT AGAAGATGAC TATGATGAGG ATGGCCATGT ACAGGGTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0010994--P:free ubiquitin chain polymerization
GO:0051974--P:negative regulation of telomerase activity
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

KEGG

sce:YKL010C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	36.89	2.00e-85	309.00
IUUC-Aml-001502	Ailuropoda melanoleuca	35.00	2.00e-83	303.00
IUUC-Atr-002515	Amborella trichopoda	37.94	7.00e-79	287.00
IUUC-Apl-003531	Anas platyrhynchos	32.96	8.00e-74	271.00
IUUC-Aca-004521	Anolis carolinensis	35.92	6.00e-30	125.00
IUUC-Aly-006493	Arabidopsis lyrata	37.09	4.00e-86	311.00
IUUC-Ath-006679	Arabidopsis thaliana	36.89	4.00e-84	304.00
IUUC-Ago-007875	Ashbya gossypii	44.92	0.00e+00	1120.00
IUUC-Acl-008242	Aspergillus clavatus	40.78	6.00e-125	441.00
IUUC-Afl-008736	Aspergillus flavus	40.61	4.00e-124	438.00
IUUC-Afu-008812	Aspergillus fumigatus	40.62	1.00e-124	439.00
IUUC-Ani-009407	Aspergillus nidulans	40.80	3.00e-124	438.00
IUUC-Ang-009763	Aspergillus niger	40.10	2.00e-118	419.00
IUUC-Aor-009941	Aspergillus oryzae	37.89	2.00e-130	459.00
IUUC-Ate-010459	Aspergillus terreus	38.27	3.00e-102	365.00
IUUC-Ame-011761	Astyanax mexicanus	34.26	2.00e-83	302.00
IUUC-Bgr-012265	Blumeria graminis	43.91	1.00e-122	433.00
IUUC-Bta-013070	Bos taurus	35.00	1.00e-83	303.00
IUUC-Bci-013890	Botrytis cinerea	46.73	2.00e-123	436.00
IUUC-Bdi-014961	Brachypodium distachyon	34.84	5.00e-83	301.00
IUUC-Bol-015440	Brassica oleracea	36.05	9.00e-85	306.00
IUUC-Bra-016849	Brassica rapa	36.74	6.00e-85	308.00
IUUC-Cel-018153	Caenorhabditis elegans	32.09	1.00e-65	244.00
IUUC-Cja-019046	Callithrix jacchus	35.00	3.00e-83	302.00
IUUC-Cfa-020521	Canis familiaris	35.19	5.00e-84	305.00
IUUC-Cpo-021639	Cavia porcellus	35.19	2.00e-83	303.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	36.03	1.00e-79	288.00
IUUC-Csa-023231	Chlorocebus sabaeus	35.00	2.00e-83	303.00
IUUC-Cho-024380	Choloepus hoffmanni	35.68	3.00e-65	242.00
IUUC-Cin-025482	Ciona intestinalis	32.47	9.00e-79	285.00
IUUC-Csv-026121	Ciona savignyi	33.46	3.00e-78	285.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	41.15	7.00e-131	460.00
IUUC-Cne-026857	Cryptococcus neoformans	38.57	1.00e-106	380.00
IUUC-Cme-027226	Cyanidioschyzon merolae	32.57	1.00e-67	250.00
IUUC-Dre-028174	Danio rerio	33.70	2.00e-81	296.00
IUUC-Dno-029954	Dasypus novemcinctus	34.95	5.00e-29	122.00
IUUC-Dor-030939	Dipodomys ordii	31.30	4.00e-67	248.00
IUUC-Dse-031444	Dothistroma septosporum	40.26	2.00e-122	432.00
IUUC-Dme-031739	Drosophila melanogaster	30.65	9.00e-66	244.00
IUUC-Ete-032345	Echinops telfairi	29.44	3.00e-57	216.00
IUUC-Eca-033229	Equus caballus	35.00	2.00e-83	303.00
IUUC-Eeu-035205	Erinaceus europaeus	35.00	2.00e-81	296.00
IUUC-Fca-036444	Felis catus	35.00	2.00e-83	303.00
IUUC-Fal-037131	Ficedula albicollis	34.26	1.00e-83	303.00
IUUC-Fox-038035	Fusarium oxysporum	41.37	5.00e-127	446.00
IUUC-Fso-038320	Fusarium solani	41.53	1.00e-128	453.00
IUUC-Gmo-039497	Gadus morhua	34.71	1.00e-82	300.00
IUUC-Ggr-040057	Gaeumannomyces graminis	41.21	8.00e-131	460.00
IUUC-Gga-041021	Gallus gallus	34.26	2.00e-83	303.00
IUUC-Gac-042474	Gasterosteus aculeatus	34.90	2.00e-82	300.00
IUUC-Gma-043952	Glycine max	30.45	1.00e-82	300.00
IUUC-Ggo-044855	Gorilla gorilla	35.00	3.00e-83	302.00
IUUC-Hsa-046147	Homo sapiens	34.44	2.00e-83	303.00
IUUC-Hvu-047811	Hordeum vulgare	37.32	5.00e-84	304.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	34.44	3.00e-83	302.00
IUUC-Kpa-049098	Komagataella pastoris	37.52	2.00e-128	452.00
IUUC-Lch-049818	Latimeria chalumnae	34.53	9.00e-81	294.00
IUUC-Lpe-051017	Leersia perrieri	34.91	3.00e-82	298.00
IUUC-Loc-051777	Lepisosteus oculatus	34.44	2.00e-84	306.00
IUUC-Lma-052990	Leptosphaeria maculans	41.60	9.00e-126	443.00
IUUC-Laf-053727	Loxodonta africana	35.19	2.00e-83	303.00
IUUC-Mcc-055799	Macaca mulatta	35.00	2.00e-83	303.00
IUUC-Meu-056065	Macropus eugenii	32.00	2.00e-61	229.00
IUUC-Mor-057054	Magnaporthe oryzae	40.38	4.00e-130	457.00
IUUC-Mpo-057417	Magnaporthe poae	40.64	7.00e-130	457.00
IUUC-Mtr-058626	Medicago truncatula	35.52	3.00e-82	298.00
IUUC-Mla-058870	Melampsora laricipopulina	44.51	9.00e-104	370.00
IUUC-Mga-059409	Meleagris gallopavo	35.92	1.00e-30	127.00
IUUC-Mvi-060507	Microbotryum violaceum	38.47	4.00e-110	391.00
IUUC-Mmr-060816	Microcebus murinus	34.26	4.00e-82	298.00
IUUC-Mdo-062866	Monodelphis domestica	32.14	3.00e-62	232.00
IUUC-Mmu-063906	Mus musculus	34.63	6.00e-83	301.00
IUUC-Mac-065046	Musa acuminata	37.19	4.00e-83	301.00
IUUC-Mpu-066199	Mustela putorius furo	35.00	2.00e-83	303.00
IUUC-Mlu-067110	Myotis lucifugus	33.89	2.00e-81	296.00
IUUC-Nfi-068482	Neosartorya fischeri	40.46	4.00e-124	437.00
IUUC-Ncr-068906	Neurospora crassa	46.52	1.00e-124	439.00
IUUC-Nle-069410	Nomascus leucogenys	35.00	3.00e-83	302.00
IUUC-Opr-070401	Ochotona princeps	37.39	1.00e-34	140.00
IUUC-Ont-072100	Oreochromis niloticus	34.07	1.00e-82	300.00
IUUC-Oan-073121	Ornithorhynchus anatinus	34.81	7.00e-83	301.00
IUUC-Ocu-074623	Oryctolagus cuniculus	34.44	8.00e-84	304.00
IUUC-Oba-075380	Oryza barthii	35.98	3.00e-81	295.00
IUUC-Obr-076904	Oryza brachyantha	35.38	7.00e-82	297.00
IUUC-Ogl-076926	Oryza glaberrima	35.98	7.00e-81	294.00
IUUC-Ogu-078892	Oryza glumaepatula	36.11	5.00e-81	294.00
IUUC-Oin-079256	Oryza indica	34.62	2.00e-80	293.00
IUUC-Olo-080343	Oryza longistaminata	34.69	2.00e-81	296.00
IUUC-Ome-081422	Oryza meridionalis	34.69	2.00e-81	296.00
IUUC-Oni-083047	Oryza nivara	36.18	1.00e-81	296.00
IUUC-Opu-083641	Oryza punctata	34.96	1.00e-78	286.00
IUUC-Oru-084439	Oryza rufipogon	35.77	6.00e-81	294.00
IUUC-Osa-085617	Oryza sativa	35.77	1.00e-80	291.00
IUUC-Ola-087173	Oryzias latipes	34.26	3.00e-83	302.00
IUUC-Olu-087871	Ostreococcus lucimarinus	33.33	4.00e-76	276.00
IUUC-Oga-087908	Otolemur garnettii	34.81	2.00e-82	300.00
IUUC-Oar-090277	Ovis aries	35.00	8.00e-84	304.00
IUUC-Ptr-091543	Pan troglodytes	35.00	2.00e-83	303.00
IUUC-Pan-092243	Papio anubis	35.00	2.00e-83	303.00
IUUC-Psi-093150	Pelodiscus sinensis	34.44	8.00e-83	301.00
IUUC-Pno-094891	Phaeosphaeria nodorum	40.96	1.00e-124	439.00
IUUC-Ppa-095181	Physcomitrella patens	35.73	9.00e-79	286.00
IUUC-Pfo-096267	Poecilia formosa	35.04	5.00e-83	301.00
IUUC-Pab-098072	Pongo abelii	35.00	3.00e-83	302.00
IUUC-Pop-099190	Populus trichocarpa	35.44	9.00e-88	317.00
IUUC-Pca-100311	Procavia capensis	34.63	2.00e-83	303.00
IUUC-Ppe-101284	Prunus persica	37.55	1.00e-88	320.00
IUUC-Pva-102215	Pteropus vampyrus	32.34	1.00e-69	257.00
IUUC-Pgr-103694	Puccinia graminis	38.54	1.00e-106	379.00
IUUC-Ptt-103916	Puccinia triticina	37.42	4.00e-98	351.00
IUUC-Pte-104346	Pyrenophora teres	42.08	5.00e-127	447.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	41.76	2.00e-126	445.00
IUUC-Rno-105315	Rattus norvegicus	34.44	4.00e-83	301.00
IUUC-Sha-106835	Sarcophilus harrisii	34.81	2.00e-82	299.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	35.28	4.00e-116	411.00
IUUC-Spo-108081	Schizosaccharomyces pombe	44.10	7.00e-109	387.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	46.72	3.00e-123	434.00
IUUC-Smo-108776	Selaginella moellendorffii	35.71	5.00e-83	301.00
IUUC-Sit-110332	Setaria italica	36.38	6.00e-85	307.00
IUUC-Sly-111557	Solanum lycopersicum	37.15	1.00e-89	323.00
IUUC-Stu-112896	Solanum tuberosum	36.65	2.00e-78	284.00
IUUC-Sar-113224	Sorex araneus	36.32	3.00e-60	226.00
IUUC-Sbi-114106	Sorghum bicolor	37.12	3.00e-89	322.00
IUUC-Sre-114993	Sporisorium reilianum	44.14	1.00e-112	400.00
IUUC-Ssc-115535	Sus scrofa	33.84	2.00e-72	266.00
IUUC-Tgu-117167	Taeniopygia guttata	35.92	1.00e-30	127.00
IUUC-Tru-118669	Takifugu rubripes	34.07	4.00e-82	298.00
IUUC-Tsy-119373	Tarsius syrichta	29.75	1.00e-49	190.00
IUUC-Tni-120049	Tetraodon nigroviridis	30.77	8.00e-66	242.00
IUUC-Tca-121779	Theobroma cacao	37.05	9.00e-87	313.00
IUUC-Tre-122195	Trichoderma reesei	41.68	2.00e-130	459.00
IUUC-Tvi-122650	Trichoderma virens	41.50	1.00e-130	459.00
IUUC-Tae-123580	Triticum aestivum	36.40	2.00e-84	305.00
IUUC-Tur-126295	Triticum urartu	36.56	2.00e-85	309.00
IUUC-Tme-126964	Tuber melanosporum	48.01	4.00e-126	444.00
IUUC-Tbe-128149	Tupaia belangeri	32.30	7.00e-47	181.00
IUUC-Ttr-128165	Tursiops truncatus	35.00	1.00e-83	304.00
IUUC-Uma-129365	Ustilago maydis	42.72	1.00e-101	363.00
IUUC-Vda-129725	Verticillium dahliae	47.90	1.00e-129	456.00
IUUC-Vpa-130678	Vicugna pacos	35.00	1.00e-83	303.00
IUUC-Vvi-131147	Vitis vinifera	36.36	5.00e-89	321.00
IUUC-Xtr-132636	Xenopus tropicalis	34.32	2.00e-81	296.00
IUUC-Xma-133458	Xiphophorus maculatus	35.04	6.00e-83	301.00
IUUC-Yli-134481	Yarrowia lipolytica	40.44	3.00e-117	414.00
IUUC-Zma-135769	Zea mays	36.31	5.00e-84	304.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence