iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003752

Ensembl Protein ID

ENSAPLP00000013204.1

UniProt Accession

U3J127; U3J127_ANAPL

Genbank Protein ID

ENSAPLP00000013204

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

ADON01036035

Gene Name

ITCH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000013320.1	ENSAPLT00000013953.1	ENSAPLP00000013204.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.30e-137	456.7	533	865

Active Site

Position(s)	Description	Evidence
834	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            +dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 533  SQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 620
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle+vdpe+y+sl ++ken   diee+gl++ fsv++eilge+k+++Lkp+G+ni Vt+eNkeeY++lv+e
   Q: 621  GFSLPFYKRILNKPVGLKDLESVDPEFYNSLIWVKEN---DIEECGLEMFFSVDKEILGEIKSHDLKPNGSNILVTEENKEEYIRLVAE 706
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d++++t y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 707  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHTIYRH-YTRTSRQILWFWQFVKEIDNEKRMRLLQFV 794
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+++e+lkekLl+Aieet+gF++
   Q: 795  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKNYEQLKEKLLFAIEETEGFGQ 865
           *********************************************************************96 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

SSGFSMKSQL QVTVISAKLK EKNKWFGPSP YVEVLVDGQS KKTEKCNNTS SPKWKQHLTV 60
IVTPVSKLTF RVWSHQTLKS DVLLGSAALD IHETLKSNSM KLEQVVVTLH LLGDREPAEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGATTCAA GATCCAGCCC TTATTATGGC TGGCACTGGA TCCAAATCAG GATCATCTAG 60
TGGATTTTCC ATGAAATCAC AGCTTCAAGT CACTGGTAAG TCATTTGAAA TTATATATCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	84.86	0.00e+00	1435.00
IUUC-Aca-005338	Anolis carolinensis	86.49	0.00e+00	1468.00
IUUC-Ago-007742	Ashbya gossypii	49.05	3.00e-162	565.00
IUUC-Ame-010601	Astyanax mexicanus	86.27	0.00e+00	1108.00
IUUC-Bta-012782	Bos taurus	96.16	0.00e+00	1186.00
IUUC-Cja-018899	Callithrix jacchus	76.80	0.00e+00	1288.00
IUUC-Cfa-020648	Canis familiaris	83.76	0.00e+00	1400.00
IUUC-Cpo-022073	Cavia porcellus	83.85	0.00e+00	1443.00
IUUC-Csa-023252	Chlorocebus sabaeus	83.51	0.00e+00	1434.00
IUUC-Cho-024695	Choloepus hoffmanni	78.28	0.00e+00	1402.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	48.88	6.00e-157	547.00
IUUC-Cme-027267	Cyanidioschyzon merolae	43.57	4.00e-85	310.00
IUUC-Dre-028451	Danio rerio	74.83	0.00e+00	1291.00
IUUC-Dno-029884	Dasypus novemcinctus	83.97	0.00e+00	1447.00
IUUC-Eca-033793	Equus caballus	84.76	0.00e+00	1433.00
IUUC-Eeu-034716	Erinaceus europaeus	90.61	0.00e+00	875.00
IUUC-Fca-035605	Felis catus	85.09	0.00e+00	1454.00
IUUC-Fal-037126	Ficedula albicollis	94.47	0.00e+00	1579.00
IUUC-Fso-038393	Fusarium solani	47.38	6.00e-155	541.00
IUUC-Gmo-038596	Gadus morhua	80.20	0.00e+00	1000.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.95	9.00e-156	543.00
IUUC-Gga-040832	Gallus gallus	95.61	0.00e+00	1618.00
IUUC-Gac-041658	Gasterosteus aculeatus	86.22	0.00e+00	1115.00
IUUC-Ggo-044535	Gorilla gorilla	80.97	0.00e+00	1399.00
IUUC-Hsa-046564	Homo sapiens	79.85	0.00e+00	1419.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	93.91	0.00e+00	1191.00
IUUC-Kpa-049273	Komagataella pastoris	45.28	6.00e-166	577.00
IUUC-Lch-050454	Latimeria chalumnae	91.64	0.00e+00	1167.00
IUUC-Loc-052647	Lepisosteus oculatus	73.28	0.00e+00	1328.00
IUUC-Laf-054383	Loxodonta africana	84.20	0.00e+00	1444.00
IUUC-Mcc-055532	Macaca mulatta	83.28	0.00e+00	1432.00
IUUC-Mor-057097	Magnaporthe oryzae	49.15	4.00e-157	548.00
IUUC-Mla-058996	Melampsora laricipopulina	46.60	7.00e-153	534.00
IUUC-Mga-059661	Meleagris gallopavo	95.73	0.00e+00	1591.00
IUUC-Mmr-061135	Microcebus murinus	84.18	0.00e+00	1449.00
IUUC-Mdo-062505	Monodelphis domestica	86.59	0.00e+00	1477.00
IUUC-Mmu-063375	Mus musculus	95.09	0.00e+00	1206.00
IUUC-Mpu-066203	Mustela putorius furo	85.09	0.00e+00	1435.00
IUUC-Mlu-067837	Myotis lucifugus	84.87	0.00e+00	1438.00
IUUC-Nle-069244	Nomascus leucogenys	83.95	0.00e+00	1425.00
IUUC-Opr-070585	Ochotona princeps	79.82	0.00e+00	1400.00
IUUC-Ont-071798	Oreochromis niloticus	87.46	0.00e+00	1129.00
IUUC-Ocu-074298	Oryctolagus cuniculus	84.41	0.00e+00	1436.00
IUUC-Ola-086526	Oryzias latipes	85.86	0.00e+00	1111.00
IUUC-Oga-088167	Otolemur garnettii	78.11	0.00e+00	1320.00
IUUC-Oar-090316	Ovis aries	73.09	0.00e+00	834.00
IUUC-Ptr-090819	Pan troglodytes	79.05	0.00e+00	1380.00
IUUC-Pan-092454	Papio anubis	83.28	0.00e+00	1431.00
IUUC-Psi-093319	Pelodiscus sinensis	87.73	0.00e+00	1484.00
IUUC-Pfo-097346	Poecilia formosa	84.99	0.00e+00	1093.00
IUUC-Pab-097580	Pongo abelii	73.02	0.00e+00	1266.00
IUUC-Pop-099613	Populus trichocarpa	44.74	2.00e-93	338.00
IUUC-Pca-100923	Procavia capensis	73.73	0.00e+00	1193.00
IUUC-Pva-103209	Pteropus vampyrus	83.47	0.00e+00	1388.00
IUUC-Pgr-103620	Puccinia graminis	52.07	1.00e-146	513.00
IUUC-Rno-104924	Rattus norvegicus	94.92	0.00e+00	1205.00
IUUC-Sha-107175	Sarcophilus harrisii	86.13	0.00e+00	1466.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	47.21	2.00e-159	556.00
IUUC-Sar-113761	Sorex araneus	95.81	0.00e+00	1180.00
IUUC-Tgu-116632	Taeniopygia guttata	87.82	0.00e+00	1433.00
IUUC-Tru-118442	Takifugu rubripes	88.39	0.00e+00	1118.00
IUUC-Tsy-119198	Tarsius syrichta	77.34	0.00e+00	1308.00
IUUC-Tni-120168	Tetraodon nigroviridis	87.39	0.00e+00	1052.00
IUUC-Tbe-127756	Tupaia belangeri	65.93	0.00e+00	1100.00
IUUC-Ttr-128504	Tursiops truncatus	76.46	0.00e+00	993.00
IUUC-Vda-129753	Verticillium dahliae	47.61	4.00e-156	545.00
IUUC-Vpa-130103	Vicugna pacos	71.15	0.00e+00	1191.00
IUUC-Xtr-132885	Xenopus tropicalis	76.04	0.00e+00	1362.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence