iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000003591.1	ENSONIT00000004519.1	ENSONIP00000004517.1
ENSONIG00000003591.1	ENSONIT00000004520.1	ENSONIP00000004518.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.80e-135	451.4	628	960

Active Site

Position(s)	Description	Evidence
929	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 628  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASAI-NPDHLSYFCFIGRFIAMALFHGKFIDT 715
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl l+dle++dpe+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lkp+G+ni+Vt+eNkeeY++l++e
   Q: 716  GFSLPFYKRMLNKKLILKDLESIDPEFYNSLIWIRDN---NIEECGLEMFFSVDMEILGKITSHDLKPNGANIQVTEENKEEYISLMAE 801
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++ q++af +Gfnev+pl++l++F+e+ele+++cG++e+d++d++++t y++ yt++s++i+wFw+ ++e+++e r +++qFv
   Q: 802  WRFSRGVEGQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRH-YTRNSKQIIWFWQLVKEVDNEVRLRLMQFV 889
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 890  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 960
           *********************************************************************96 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MATASSRAET SHNHRGTSQL YAIVSCAKLK RKKSSLFGTA IYVEVTAEGE TRRTAKSHSS 60
SNPKWDERLT LNVTPHTQVD FKVWSHHTLK ADALLGKATL DLTRALEDHD RKLENVKEVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCTAGTTG GGACGCACAC CCCCCTACAT CATTTTTCTG GTAAAATTGG TTAAGTAAAC 60
GGGAAACGGG ACTTTCAGTC AACATTGCCT ACAACGTTCA GTAACGTGAA ATGTAAAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	91.20	0.00e+00	1120.00
IUUC-Apl-003310	Anas platyrhynchos	90.41	0.00e+00	1154.00
IUUC-Aca-005388	Anolis carolinensis	70.44	0.00e+00	1293.00
IUUC-Ago-007742	Ashbya gossypii	47.36	3.00e-160	559.00
IUUC-Cel-018299	Caenorhabditis elegans	67.59	0.00e+00	841.00
IUUC-Cja-019448	Callithrix jacchus	91.97	0.00e+00	1138.00
IUUC-Cpo-021635	Cavia porcellus	89.95	0.00e+00	1130.00
IUUC-Csa-023805	Chlorocebus sabaeus	92.32	0.00e+00	1124.00
IUUC-Cin-025212	Ciona intestinalis	73.58	0.00e+00	912.00
IUUC-Csv-026256	Ciona savignyi	72.84	0.00e+00	907.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.16	1.00e-153	537.00
IUUC-Dre-028245	Danio rerio	96.08	0.00e+00	1209.00
IUUC-Dno-029618	Dasypus novemcinctus	92.29	0.00e+00	1135.00
IUUC-Dme-032041	Drosophila melanogaster	71.57	0.00e+00	901.00
IUUC-Ete-032779	Echinops telfairi	89.44	0.00e+00	1059.00
IUUC-Eca-033313	Equus caballus	91.36	0.00e+00	1130.00
IUUC-Eeu-035259	Erinaceus europaeus	81.34	0.00e+00	974.00
IUUC-Fca-035420	Felis catus	91.53	0.00e+00	1139.00
IUUC-Fal-037335	Ficedula albicollis	90.58	0.00e+00	1157.00
IUUC-Gmo-039172	Gadus morhua	90.48	0.00e+00	1093.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.07	7.00e-153	534.00
IUUC-Gga-040246	Gallus gallus	93.48	0.00e+00	1155.00
IUUC-Gac-042211	Gasterosteus aculeatus	97.78	0.00e+00	1234.00
IUUC-Hsa-046544	Homo sapiens	91.62	0.00e+00	1135.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	92.29	0.00e+00	1136.00
IUUC-Lch-050398	Latimeria chalumnae	92.49	0.00e+00	1164.00
IUUC-Loc-052116	Lepisosteus oculatus	95.60	0.00e+00	1207.00
IUUC-Laf-053551	Loxodonta africana	91.71	0.00e+00	1140.00
IUUC-Mor-057097	Magnaporthe oryzae	47.10	6.00e-153	535.00
IUUC-Mga-059986	Meleagris gallopavo	71.85	0.00e+00	1344.00
IUUC-Mmr-060945	Microcebus murinus	87.12	0.00e+00	1067.00
IUUC-Mdo-063024	Monodelphis domestica	90.32	0.00e+00	1084.00
IUUC-Mmu-063202	Mus musculus	65.58	0.00e+00	1213.00
IUUC-Mpu-065773	Mustela putorius furo	91.22	0.00e+00	1134.00
IUUC-Nle-069188	Nomascus leucogenys	91.97	0.00e+00	1137.00
IUUC-Opr-070965	Ochotona princeps	91.61	0.00e+00	1114.00
IUUC-Oan-073497	Ornithorhynchus anatinus	92.01	0.00e+00	1156.00
IUUC-Ocu-073891	Oryctolagus cuniculus	87.01	0.00e+00	1043.00
IUUC-Ola-087438	Oryzias latipes	97.64	0.00e+00	1246.00
IUUC-Oar-089317	Ovis aries	91.37	0.00e+00	1130.00
IUUC-Ptr-090484	Pan troglodytes	91.62	0.00e+00	1135.00
IUUC-Pan-092117	Papio anubis	92.64	0.00e+00	1139.00
IUUC-Psi-093338	Pelodiscus sinensis	91.30	0.00e+00	1157.00
IUUC-Pma-094279	Petromyzon marinus	71.21	0.00e+00	837.00
IUUC-Pfo-096171	Poecilia formosa	98.30	0.00e+00	1245.00
IUUC-Pab-098654	Pongo abelii	89.23	0.00e+00	1086.00
IUUC-Pva-102811	Pteropus vampyrus	92.18	0.00e+00	1133.00
IUUC-Rno-106125	Rattus norvegicus	92.29	0.00e+00	1128.00
IUUC-Sce-106289	Saccharomyces cerevisiae	47.08	1.00e-158	553.00
IUUC-Sha-107243	Sarcophilus harrisii	90.53	0.00e+00	1139.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	49.38	3.00e-158	552.00
IUUC-Ssc-115368	Sus scrofa	91.22	0.00e+00	1130.00
IUUC-Tgu-117079	Taeniopygia guttata	90.41	0.00e+00	1155.00
IUUC-Tru-118062	Takifugu rubripes	97.96	0.00e+00	1244.00
IUUC-Tsy-119507	Tarsius syrichta	84.24	0.00e+00	1022.00
IUUC-Tni-120151	Tetraodon nigroviridis	97.79	0.00e+00	1228.00
IUUC-Xtr-132877	Xenopus tropicalis	80.43	0.00e+00	970.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence