iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108171

UUCD1 version

UUC-ScP-00046

Ensembl Protein ID

SPAC11G7.02.1:pep

UniProt Accession

Q92462; O14454; PUB1_SCHPO

Genbank Protein ID

CAA68867.1; AAB07514.1; CAB16207.1; AAB63350.1

Protein Name

E3 ubiquitin-protein ligase pub1; HECT-type E3 ubiquitin transferase pub1

Genbank Nucleotide ID

Y07592; U66716; CU329670; U62795

Gene Name

pub1; SPAC11G7.02

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC11G7.02	SPAC11G7.02.1	SPAC11G7.02.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	18852296

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	9.70e-129	427.6	435	766

Active Site

Position(s)	Description	Evidence
735	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
           + dlkkrl+++f gE+gld+gG++re+++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+a++++r++d+++ 
   Q: 435  ATDLKKRLMIKFDGEDGLDYGGLSREYFFLLSHEMFNPFYCLFEYSSVDNYTLQINPHSGI-NPEHLNYFKFIGRVIGLAIFHRRFVDAFFV 525
           579*********************************************************9.89**************************** PP
   S: 94   ksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkeg 185
            sfyk++l+kk++l+d+e++d+e+y+sl +i++n   di+   ldltfsv+++ +ge+ + +Lkp+G+ni+Vt+eNk+eYv+lv+ +r++++
   Q: 526  VSFYKMILQKKVTLQDMESMDAEYYRSLVWILDN---DITGV-LDLTFSVEDNCFGEVVTIDLKPNGRNIEVTEENKREYVDLVTVWRIQKR 613
           ********************************99...9***8.************************************************* PP
   S: 186  ikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlg 277
           i+eq++af+eGf+e+ip+el+++F+e+elelli G +eid+ed+kk+t y++ y+e+++ i+wFwe + e+s+e+++++LqF+Tg+sr+P++
   Q: 614  IEEQFNAFHEGFSELIPQELINVFDERELELLIGGISEIDMEDWKKHTDYRS-YSENDQIIKWFWELMDEWSNEKKSRLLQFTTGTSRIPVN 704
           **************************************************99.*************************************** PP
   S: 278  Gfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Gf++l+    pr+f+i+k++++++lP+++TCfn+L+LP+Y+sk+ l +kL +A+eet gF++
   Q: 705  GFKDLQgsdgPRKFTIEKAGEPNKLPKAHTCFNRLDLPPYTSKKDLDHKLSIAVEETIGFGQ 766
           ************************************************************86 PP

Organism

Schizosaccharomyces pombe

Protein Sequence
(Fasta)

MSNSAQSRRI RVTIVAADGL YKRDVFRFPD PFAVLTVDGE QTHTTTAIKK TLNPYWNETF 60
EVNVTDNSTI AIQVFDQKKF KKKGQGFLGV INLRVGDVLD LAIGGDEMLT RDLKKSNENT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCTTTCAG CCAACACCAC GCGAAATCCG ACGGATTTCA AAATTGTGCG CTGAAAGCAC 60
GAATTTGATT AAGGATTCCT TTTGTAGTTC TTTTTTATTT ATTTCGTTCC CGAAAAAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0071944--C:cell periphery
GO:0005737--C:cytoplasm
GO:0005794--C:Golgi apparatus
GO:0016020--C:membrane
GO:0005543--F:phospholipid binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0060360--P:negative regulation of leucine import in response to ammonium ion
GO:0034067--P:protein localization to Golgi apparatus
GO:0051453--P:regulation of intracellular pH
GO:0034762--P:regulation of transmembrane transport
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0015857--P:uracil transport

KEGG

spo:SPAC11G7.02

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	50.53	1.00e-166	578.00
IUUC-Apl-003513	Anas platyrhynchos	41.13	2.00e-166	577.00
IUUC-Aca-005358	Anolis carolinensis	39.83	8.00e-166	575.00
IUUC-Ago-007742	Ashbya gossypii	72.00	0.00e+00	908.00
IUUC-Acl-008273	Aspergillus clavatus	67.45	0.00e+00	1033.00
IUUC-Afl-008713	Aspergillus flavus	66.75	0.00e+00	1046.00
IUUC-Afu-009103	Aspergillus fumigatus	65.34	0.00e+00	1004.00
IUUC-Ani-009259	Aspergillus nidulans	65.33	0.00e+00	1043.00
IUUC-Ang-009738	Aspergillus niger	66.63	0.00e+00	1046.00
IUUC-Aor-010053	Aspergillus oryzae	73.58	1.00e-138	483.00
IUUC-Ate-010529	Aspergillus terreus	68.81	0.00e+00	1058.00
IUUC-Ame-011081	Astyanax mexicanus	50.35	2.00e-163	567.00
IUUC-Bgr-012148	Blumeria graminis	65.49	0.00e+00	997.00
IUUC-Bta-012782	Bos taurus	50.71	3.00e-167	580.00
IUUC-Bci-013785	Botrytis cinerea	65.73	0.00e+00	1034.00
IUUC-Cel-018299	Caenorhabditis elegans	45.79	3.00e-147	513.00
IUUC-Cja-019355	Callithrix jacchus	40.30	1.00e-165	574.00
IUUC-Cfa-020258	Canis familiaris	49.91	1.00e-162	565.00
IUUC-Cpo-022073	Cavia porcellus	51.06	2.00e-167	580.00
IUUC-Csa-023252	Chlorocebus sabaeus	50.44	1.00e-166	578.00
IUUC-Cho-024695	Choloepus hoffmanni	50.80	7.00e-166	575.00
IUUC-Cin-025126	Ciona intestinalis	40.57	6.00e-152	529.00
IUUC-Csv-026339	Ciona savignyi	40.12	3.00e-162	563.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	66.75	0.00e+00	1020.00
IUUC-Cne-026849	Cryptococcus neoformans	60.48	0.00e+00	1003.00
IUUC-Dre-027650	Danio rerio	39.30	1.00e-165	574.00
IUUC-Dno-029534	Dasypus novemcinctus	40.00	3.00e-166	576.00
IUUC-Dor-030138	Dipodomys ordii	46.02	2.00e-153	534.00
IUUC-Dse-031241	Dothistroma septosporum	67.25	0.00e+00	1060.00
IUUC-Dme-032041	Drosophila melanogaster	45.93	2.00e-150	524.00
IUUC-Ete-032779	Echinops telfairi	48.14	1.00e-142	498.00
IUUC-Eca-033580	Equus caballus	40.38	2.00e-165	573.00
IUUC-Eeu-035247	Erinaceus europaeus	46.18	2.00e-157	548.00
IUUC-Fca-035605	Felis catus	50.53	2.00e-166	577.00
IUUC-Fal-037126	Ficedula albicollis	50.71	4.00e-166	576.00
IUUC-Fox-037774	Fusarium oxysporum	65.72	0.00e+00	1012.00
IUUC-Fso-038393	Fusarium solani	66.13	0.00e+00	1001.00
IUUC-Gmo-039674	Gadus morhua	45.84	4.00e-152	530.00
IUUC-Ggr-040107	Gaeumannomyces graminis	65.03	0.00e+00	1031.00
IUUC-Gga-040832	Gallus gallus	50.89	5.00e-167	579.00
IUUC-Gac-041295	Gasterosteus aculeatus	39.60	2.00e-165	574.00
IUUC-Ggo-045332	Gorilla gorilla	48.41	4.00e-158	550.00
IUUC-Hsa-046726	Homo sapiens	40.25	2.00e-166	577.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	50.53	8.00e-167	578.00
IUUC-Kpa-049273	Komagataella pastoris	67.13	0.00e+00	1046.00
IUUC-Lch-050454	Latimeria chalumnae	50.71	2.00e-164	570.00
IUUC-Loc-052647	Lepisosteus oculatus	50.18	1.00e-162	565.00
IUUC-Lma-052980	Leptosphaeria maculans	61.20	4.00e-173	598.00
IUUC-Laf-054383	Loxodonta africana	50.53	7.00e-167	578.00
IUUC-Mcc-054815	Macaca mulatta	40.12	6.00e-166	575.00
IUUC-Meu-055953	Macropus eugenii	42.23	8.00e-124	436.00
IUUC-Mor-057097	Magnaporthe oryzae	67.04	0.00e+00	1056.00
IUUC-Mpo-057442	Magnaporthe poae	63.19	0.00e+00	918.00
IUUC-Mla-058996	Melampsora laricipopulina	67.61	0.00e+00	895.00
IUUC-Mga-059661	Meleagris gallopavo	50.89	7.00e-167	579.00
IUUC-Mvi-060395	Microbotryum violaceum	78.17	0.00e+00	820.00
IUUC-Mmr-061135	Microcebus murinus	50.71	4.00e-167	579.00
IUUC-Mdo-062805	Monodelphis domestica	40.17	7.00e-167	578.00
IUUC-Mmu-064034	Mus musculus	40.25	8.00e-167	578.00
IUUC-Mpu-066762	Mustela putorius furo	40.27	2.00e-165	574.00
IUUC-Mlu-067837	Myotis lucifugus	51.06	5.00e-168	583.00
IUUC-Nfi-068427	Neosartorya fischeri	66.75	0.00e+00	1043.00
IUUC-Ncr-068918	Neurospora crassa	65.60	0.00e+00	1000.00
IUUC-Nle-069804	Nomascus leucogenys	40.35	4.00e-166	576.00
IUUC-Opr-071044	Ochotona princeps	48.07	5.00e-157	546.00
IUUC-Ont-072243	Oreochromis niloticus	39.00	8.00e-166	575.00
IUUC-Oan-072699	Ornithorhynchus anatinus	39.31	9.00e-165	571.00
IUUC-Ocu-074913	Oryctolagus cuniculus	40.25	6.00e-167	578.00
IUUC-Ola-086526	Oryzias latipes	49.04	2.00e-163	567.00
IUUC-Oga-088460	Otolemur garnettii	48.41	1.00e-158	551.00
IUUC-Oar-089366	Ovis aries	40.23	3.00e-164	570.00
IUUC-Ptr-091382	Pan troglodytes	40.25	2.00e-166	577.00
IUUC-Pan-092454	Papio anubis	50.44	1.00e-166	578.00
IUUC-Psi-093298	Pelodiscus sinensis	40.18	3.00e-165	573.00
IUUC-Pma-094364	Petromyzon marinus	52.97	1.00e-145	507.00
IUUC-Pno-095118	Phaeosphaeria nodorum	65.79	0.00e+00	1037.00
IUUC-Pfo-096142	Poecilia formosa	39.90	6.00e-163	565.00
IUUC-Pab-098088	Pongo abelii	48.41	2.00e-158	551.00
IUUC-Pca-100568	Procavia capensis	46.91	3.00e-141	494.00
IUUC-Pva-102354	Pteropus vampyrus	46.79	4.00e-159	553.00
IUUC-Pgr-103620	Puccinia graminis	77.55	0.00e+00	824.00
IUUC-Ptt-103806	Puccinia triticina	79.56	0.00e+00	710.00
IUUC-Pte-104016	Pyrenophora teres	72.80	0.00e+00	894.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	72.80	0.00e+00	894.00
IUUC-Rno-104924	Rattus norvegicus	50.53	1.00e-166	578.00
IUUC-Sce-106289	Saccharomyces cerevisiae	64.14	0.00e+00	996.00
IUUC-Sha-107175	Sarcophilus harrisii	50.35	2.00e-166	577.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	80.57	0.00e+00	1273.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	66.42	0.00e+00	1033.00
IUUC-Sar-113761	Sorex araneus	50.53	4.00e-166	576.00
IUUC-Sre-114929	Sporisorium reilianum	71.14	0.00e+00	872.00
IUUC-Ssc-115368	Sus scrofa	47.39	9.00e-154	535.00
IUUC-Tgu-117112	Taeniopygia guttata	40.00	5.00e-165	572.00
IUUC-Tru-118442	Takifugu rubripes	50.35	8.00e-166	575.00
IUUC-Tsy-119492	Tarsius syrichta	47.93	3.00e-156	543.00
IUUC-Tni-119993	Tetraodon nigroviridis	48.62	7.00e-152	529.00
IUUC-Tre-122203	Trichoderma reesei	64.66	0.00e+00	994.00
IUUC-Tvi-122595	Trichoderma virens	64.14	0.00e+00	997.00
IUUC-Tme-126897	Tuber melanosporum	68.85	0.00e+00	1029.00
IUUC-Tbe-127793	Tupaia belangeri	49.79	2.00e-136	478.00
IUUC-Ttr-128275	Tursiops truncatus	49.56	4.00e-157	546.00
IUUC-Uma-129332	Ustilago maydis	70.97	0.00e+00	840.00
IUUC-Vda-129753	Verticillium dahliae	64.74	0.00e+00	982.00
IUUC-Vpa-130503	Vicugna pacos	49.11	5.00e-151	526.00
IUUC-Xtr-132885	Xenopus tropicalis	51.24	4.00e-167	579.00
IUUC-Xma-133797	Xiphophorus maculatus	44.69	6.00e-158	549.00
IUUC-Yli-134668	Yarrowia lipolytica	69.44	0.00e+00	891.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence