iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000017399.3	ENSOCUT00000033476.1	ENSOCUP00000026523.1
ENSOCUG00000017399.3	ENSOCUT00000017398.2	ENSOCUP00000014950.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.40e-08	35.2	548	586

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ +f +  +++pC+H fha Cl kw       + +++CP C
   Q: 548  CAICYHEFTTSARITPCNHYFHALCLRKW------LYIQDTCPMC 586
           ********999******************......********** PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MAAVGPPQLQ VRMAHQQVCA ALEVALRVPC LYIIDAIFNS YYDSSQSGLC IVLQIFLRLL 60
GIFVSSIVLI LSQRSLFKFY MYSSTFLLVT SAVLVNYYAA LHIDFYEGAY NTSAFEIELL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCATTAAC TTCATAATTT TATAATTATG TACATGTATA AATTATGAGT ACAGTGTGTA 60
TATTTAAAAT ACACAAACAA AATTTAAAAT AAGTAACAAA TAGAAAAAGC ACTTTAATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N
PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0036503--P:ERAD pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0017148--P:negative regulation of translation
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0070613--P:regulation of protein processing

KEGG

ocu:100357210

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002401	Ailuropoda melanoleuca	94.28	0.00e+00	1202.00
IUUC-Apl-004214	Anas platyrhynchos	84.22	0.00e+00	942.00
IUUC-Aca-005326	Anolis carolinensis	75.93	0.00e+00	947.00
IUUC-Ame-011687	Astyanax mexicanus	74.12	0.00e+00	860.00
IUUC-Bta-013394	Bos taurus	94.01	0.00e+00	1237.00
IUUC-Bci-013813	Botrytis cinerea	41.38	9.00e-08	51.20
IUUC-Cja-019499	Callithrix jacchus	93.10	0.00e+00	1251.00
IUUC-Cfa-020357	Canis familiaris	94.30	0.00e+00	1212.00
IUUC-Cpo-021924	Cavia porcellus	93.47	0.00e+00	1173.00
IUUC-Csa-023513	Chlorocebus sabaeus	94.30	0.00e+00	1243.00
IUUC-Cho-024285	Choloepus hoffmanni	87.72	0.00e+00	1076.00
IUUC-Cin-025223	Ciona intestinalis	53.93	2.00e-74	271.00
IUUC-Csv-026018	Ciona savignyi	47.32	3.00e-64	238.00
IUUC-Dre-028660	Danio rerio	67.78	0.00e+00	786.00
IUUC-Dno-029463	Dasypus novemcinctus	91.96	2.00e-157	549.00
IUUC-Dor-030728	Dipodomys ordii	93.14	0.00e+00	1101.00
IUUC-Dse-031284	Dothistroma septosporum	43.40	7.00e-09	54.30
IUUC-Dme-032186	Drosophila melanogaster	48.57	2.00e-98	353.00
IUUC-Ete-032368	Echinops telfairi	88.02	0.00e+00	1164.00
IUUC-Eca-034325	Equus caballus	93.41	0.00e+00	1179.00
IUUC-Fca-035537	Felis catus	93.60	0.00e+00	1170.00
IUUC-Fal-037459	Ficedula albicollis	84.17	0.00e+00	921.00
IUUC-Gmo-039442	Gadus morhua	79.03	7.00e-99	354.00
IUUC-Ggr-039921	Gaeumannomyces graminis	31.91	9.00e-08	52.80
IUUC-Gga-041071	Gallus gallus	81.04	0.00e+00	974.00
IUUC-Gac-042483	Gasterosteus aculeatus	66.87	0.00e+00	894.00
IUUC-Ggo-044672	Gorilla gorilla	94.00	0.00e+00	1241.00
IUUC-Hsa-045836	Homo sapiens	93.25	0.00e+00	1209.00
IUUC-Itr-048588	Ictidomys tridecemlineatus	94.68	0.00e+00	1243.00
IUUC-Lch-050073	Latimeria chalumnae	74.10	0.00e+00	966.00
IUUC-Loc-052908	Lepisosteus oculatus	69.61	0.00e+00	932.00
IUUC-Lma-053202	Leptosphaeria maculans	42.59	3.00e-08	52.00
IUUC-Laf-053519	Loxodonta africana	91.17	0.00e+00	1230.00
IUUC-Mcc-054674	Macaca mulatta	88.50	3.00e-95	340.00
IUUC-Mor-057262	Magnaporthe oryzae	32.93	3.00e-08	53.90
IUUC-Mga-059922	Meleagris gallopavo	83.96	0.00e+00	937.00
IUUC-Mmr-061452	Microcebus murinus	93.71	0.00e+00	1181.00
IUUC-Mdo-062412	Monodelphis domestica	87.67	0.00e+00	1164.00
IUUC-Mmu-063147	Mus musculus	91.93	0.00e+00	1216.00
IUUC-Mpu-065929	Mustela putorius furo	94.15	0.00e+00	1212.00
IUUC-Mlu-067899	Myotis lucifugus	90.70	0.00e+00	1197.00
IUUC-Nle-070083	Nomascus leucogenys	94.00	0.00e+00	1239.00
IUUC-Opr-070461	Ochotona princeps	95.05	0.00e+00	1294.00
IUUC-Ont-072256	Oreochromis niloticus	69.72	0.00e+00	900.00
IUUC-Oan-073150	Ornithorhynchus anatinus	82.50	0.00e+00	918.00
IUUC-Oga-088565	Otolemur garnettii	93.78	0.00e+00	1217.00
IUUC-Oar-089432	Ovis aries	94.23	0.00e+00	1154.00
IUUC-Ptr-091422	Pan troglodytes	93.85	0.00e+00	1239.00
IUUC-Pan-092331	Papio anubis	94.15	0.00e+00	1241.00
IUUC-Psi-092933	Pelodiscus sinensis	81.90	0.00e+00	914.00
IUUC-Pfo-097466	Poecilia formosa	63.80	0.00e+00	903.00
IUUC-Pab-098702	Pongo abelii	93.85	0.00e+00	1239.00
IUUC-Pca-100125	Procavia capensis	88.38	0.00e+00	1176.00
IUUC-Pva-102628	Pteropus vampyrus	93.84	0.00e+00	1203.00
IUUC-Rno-104886	Rattus norvegicus	92.39	0.00e+00	1224.00
IUUC-Sha-106702	Sarcophilus harrisii	84.65	0.00e+00	1137.00
IUUC-Ssc-116164	Sus scrofa	92.81	0.00e+00	1238.00
IUUC-Tgu-116829	Taeniopygia guttata	82.02	0.00e+00	952.00
IUUC-Tru-118557	Takifugu rubripes	65.07	0.00e+00	866.00
IUUC-Tsy-119399	Tarsius syrichta	88.59	0.00e+00	655.00
IUUC-Tni-120006	Tetraodon nigroviridis	60.99	0.00e+00	755.00
IUUC-Tbe-127664	Tupaia belangeri	92.19	0.00e+00	1182.00
IUUC-Ttr-129144	Tursiops truncatus	92.37	0.00e+00	1228.00
IUUC-Vpa-130226	Vicugna pacos	93.71	0.00e+00	1237.00
IUUC-Vvi-131278	Vitis vinifera	41.07	1.00e-10	58.90
IUUC-Xtr-132461	Xenopus tropicalis	70.14	0.00e+00	895.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence