iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004410

UUCD1 version

UUC-AnC-00247

Ensembl Protein ID

ENSACAP00000011272.3

UniProt Accession

H9GHQ5; H9GHQ5_ANOCA

Protein Name

Uncharacterized protein

Gene Name

BTRC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000011203.3	ENSACAT00000011508.3	ENSACAP00000011272.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.50e-58	190.9	527	562
UBD/Beta-Prp	1.80e-69	234.1	441	606

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvll 36
           gH++ v+c++f d +++vsG++Dg+ikvWDl    ++
   Q: 527  GHEELVRCIRF-DsKRIVSGAYDGKIKVWDLVAALDP 562
           8**********.55****************9876665 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++ +    +vsGs+d+tir+wd+e g cl+ +
   Q: 441  LRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRE--RLVVSGSSDNTIRLWDIECGACLR-V 524
           445579*************9..8**************************************..************************.* PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlq 210
           l+gh+++v+c+++++  + +vsG++D+++++Wdl         +   +lrtl + h ++v  l+fd+  +++vs s+d t+ +wd+ 
   Q: 525  LEGHEELVRCIRFDS--KRIVSGAYDGKIKVWDLvaaldprapAGTLCLRTLVE-HSGRVFRLQFDE--FQIVSSSHDDTILIWDFL 606
           ***************..*************************877889****98.************..99**************85 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MDPAEAVVQE KALKFMPRIH MPKDGFQLTS SGYQAWLKQC SMPRSLWLGC SSLADSMPSL 60
RCLYNPGTGS LTAFQNSSDR EDCNNDEPPR KIIPEKNALR QTYNSCARLC LNQEAVCLGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGGCAGATA TACCCACAAG GCATATAACC CACAATATCA AGGCAGAAAG TGACAGAGCT 60
TACAAGGCCC TATTAGATGT CGAGCCTCAG TCGGGACAAC TACAGCTCCC ATCAGCCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0071407--P:cellular response to organic cyclic compound
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0051726--P:regulation of cell cycle
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001961	Ailuropoda melanoleuca	92.52	0.00e+00	1205.00
IUUC-Apl-003437	Anas platyrhynchos	96.99	0.00e+00	1006.00
IUUC-Acl-008355	Aspergillus clavatus	29.26	1.00e-49	191.00
IUUC-Afl-008580	Aspergillus flavus	28.33	3.00e-45	176.00
IUUC-Afu-008790	Aspergillus fumigatus	29.37	3.00e-47	183.00
IUUC-Ani-009324	Aspergillus nidulans	29.53	2.00e-47	183.00
IUUC-Aor-009916	Aspergillus oryzae	29.31	2.00e-48	186.00
IUUC-Ate-010492	Aspergillus terreus	29.31	4.00e-49	189.00
IUUC-Ame-011174	Astyanax mexicanus	74.24	0.00e+00	891.00
IUUC-Bgr-012194	Blumeria graminis	32.08	2.00e-54	207.00
IUUC-Bta-013453	Bos taurus	95.86	0.00e+00	1116.00
IUUC-Bci-013685	Botrytis cinerea	32.83	5.00e-56	212.00
IUUC-Cel-018392	Caenorhabditis elegans	65.07	0.00e+00	636.00
IUUC-Cja-019121	Callithrix jacchus	88.85	0.00e+00	1140.00
IUUC-Cfa-020553	Canis familiaris	92.68	0.00e+00	1206.00
IUUC-Cpo-022126	Cavia porcellus	94.58	0.00e+00	1132.00
IUUC-Csa-023688	Chlorocebus sabaeus	92.83	0.00e+00	1209.00
IUUC-Cho-024658	Choloepus hoffmanni	63.87	1.00e-108	386.00
IUUC-Cin-025188	Ciona intestinalis	79.25	0.00e+00	812.00
IUUC-Csv-026020	Ciona savignyi	75.94	0.00e+00	780.00
IUUC-Cgl-026429	Colletotrichum gloeosporioides	33.19	2.00e-61	230.00
IUUC-Dno-029484	Dasypus novemcinctus	91.24	0.00e+00	1142.00
IUUC-Dor-031010	Dipodomys ordii	87.46	0.00e+00	1068.00
IUUC-Dme-031885	Drosophila melanogaster	79.59	0.00e+00	813.00
IUUC-Ete-032978	Echinops telfairi	80.57	0.00e+00	1007.00
IUUC-Eca-033374	Equus caballus	95.76	0.00e+00	1184.00
IUUC-Eeu-034760	Erinaceus europaeus	72.77	0.00e+00	900.00
IUUC-Fca-035427	Felis catus	89.01	0.00e+00	1143.00
IUUC-Fal-037530	Ficedula albicollis	96.71	0.00e+00	1234.00
IUUC-Fox-037978	Fusarium oxysporum	34.43	9.00e-64	238.00
IUUC-Fso-038077	Fusarium solani	32.89	2.00e-58	219.00
IUUC-Ggr-039974	Gaeumannomyces graminis	32.74	3.00e-58	219.00
IUUC-Gga-041087	Gallus gallus	96.66	0.00e+00	1276.00
IUUC-Gac-041305	Gasterosteus aculeatus	74.07	0.00e+00	863.00
IUUC-Ggo-045369	Gorilla gorilla	96.21	0.00e+00	1114.00
IUUC-Hsa-045962	Homo sapiens	92.83	0.00e+00	1209.00
IUUC-Itr-047872	Ictidomys tridecemlineatus	97.79	0.00e+00	926.00
IUUC-Lch-050285	Latimeria chalumnae	87.31	0.00e+00	937.00
IUUC-Loc-052686	Lepisosteus oculatus	87.90	0.00e+00	1145.00
IUUC-Lma-053289	Leptosphaeria maculans	38.43	8.00e-48	185.00
IUUC-Laf-054022	Loxodonta africana	95.93	0.00e+00	1187.00
IUUC-Mcc-055782	Macaca mulatta	96.42	0.00e+00	1185.00
IUUC-Meu-056078	Macropus eugenii	83.27	0.00e+00	892.00
IUUC-Mor-057283	Magnaporthe oryzae	33.48	1.00e-59	224.00
IUUC-Mpo-057540	Magnaporthe poae	32.74	9.00e-59	221.00
IUUC-Mla-058989	Melampsora laricipopulina	41.19	2.00e-61	229.00
IUUC-Mga-059388	Meleagris gallopavo	96.77	0.00e+00	1195.00
IUUC-Mvi-060284	Microbotryum violaceum	43.84	1.00e-68	254.00
IUUC-Mmr-060969	Microcebus murinus	92.68	0.00e+00	1206.00
IUUC-Mdo-063041	Monodelphis domestica	92.68	0.00e+00	1195.00
IUUC-Mmu-064096	Mus musculus	91.72	0.00e+00	1195.00
IUUC-Mpu-066875	Mustela putorius furo	92.88	0.00e+00	1110.00
IUUC-Mlu-067621	Myotis lucifugus	96.22	0.00e+00	1006.00
IUUC-Nfi-068263	Neosartorya fischeri	28.85	1.00e-48	187.00
IUUC-Ncr-068639	Neurospora crassa	34.82	5.00e-45	176.00
IUUC-Nle-069548	Nomascus leucogenys	92.83	0.00e+00	1208.00
IUUC-Opr-071194	Ochotona princeps	87.10	0.00e+00	1115.00
IUUC-Ont-071792	Oreochromis niloticus	74.92	0.00e+00	885.00
IUUC-Oan-072867	Ornithorhynchus anatinus	89.78	0.00e+00	1195.00
IUUC-Ocu-074246	Oryctolagus cuniculus	92.68	0.00e+00	1206.00
IUUC-Ola-086985	Oryzias latipes	75.76	0.00e+00	902.00
IUUC-Oga-088244	Otolemur garnettii	93.99	0.00e+00	1009.00
IUUC-Oar-089199	Ovis aries	96.26	0.00e+00	1016.00
IUUC-Ptr-090475	Pan troglodytes	76.59	0.00e+00	933.00
IUUC-Pan-092826	Papio anubis	92.83	0.00e+00	1209.00
IUUC-Psi-093485	Pelodiscus sinensis	93.90	0.00e+00	1152.00
IUUC-Pma-094315	Petromyzon marinus	78.99	0.00e+00	877.00
IUUC-Pfo-096783	Poecilia formosa	74.92	0.00e+00	896.00
IUUC-Pab-097680	Pongo abelii	92.36	0.00e+00	1203.00
IUUC-Pca-100843	Procavia capensis	85.99	0.00e+00	1083.00
IUUC-Pva-102793	Pteropus vampyrus	83.44	0.00e+00	1051.00
IUUC-Pgr-103358	Puccinia graminis	37.72	1.00e-53	204.00
IUUC-Ptt-103853	Puccinia triticina	32.15	3.00e-61	229.00
IUUC-Pte-104392	Pyrenophora teres	37.37	1.00e-47	184.00
IUUC-Pyt-104678	Pyrenophora triticirepentis	37.72	6.00e-48	186.00
IUUC-Rno-105304	Rattus norvegicus	95.40	0.00e+00	1174.00
IUUC-Sha-107454	Sarcophilus harrisii	88.58	0.00e+00	1178.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.71	5.00e-75	275.00
IUUC-Spo-108200	Schizosaccharomyces pombe	32.49	9.00e-67	247.00
IUUC-Sar-113471	Sorex araneus	72.77	0.00e+00	880.00
IUUC-Sre-114916	Sporisorium reilianum	34.08	1.00e-45	178.00
IUUC-Ssc-115490	Sus scrofa	96.84	0.00e+00	1023.00
IUUC-Tgu-117445	Taeniopygia guttata	92.99	0.00e+00	1213.00
IUUC-Tru-117671	Takifugu rubripes	73.78	0.00e+00	890.00
IUUC-Tsy-118983	Tarsius syrichta	91.85	0.00e+00	1126.00
IUUC-Tni-120359	Tetraodon nigroviridis	80.85	0.00e+00	871.00
IUUC-Tre-122207	Trichoderma reesei	34.15	4.00e-57	216.00
IUUC-Tvi-122344	Trichoderma virens	34.15	1.00e-57	217.00
IUUC-Tme-127141	Tuber melanosporum	35.47	4.00e-64	238.00
IUUC-Tbe-128146	Tupaia belangeri	83.28	0.00e+00	1021.00
IUUC-Ttr-128946	Tursiops truncatus	92.52	0.00e+00	1204.00
IUUC-Uma-129491	Ustilago maydis	33.97	9.00e-47	182.00
IUUC-Vda-129941	Verticillium dahliae	32.23	8.00e-58	218.00
IUUC-Vpa-130709	Vicugna pacos	90.92	0.00e+00	1177.00
IUUC-Xtr-132861	Xenopus tropicalis	91.69	0.00e+00	1145.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence