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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046932
UUCD1 version UUC-HoS-00200
Ensembl Protein ID ENSP00000351052.4
UniProt Accession Q86WB0; A6NH66; Q75MF3; Q75MF4; Q8N330; Q96F75; Q9HA34; Q9NVX4; Q9P0R0; NIPA_HUMAN
Genbank Protein ID CAD61161.1; AAF36136.1; BAA91619.1; BAB14024.1; AAS07546.1; AAS07547.1; AAH11551.1; AAH28917.1
Protein Name Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; Zinc finger C3HC-type protein 1
Genbank Nucleotide ID AJ537494; AF151050; AK001317; AK022373; AC073320; AC073320; AC087071; BC028917
Gene Name ZC3HC1; NIPA; HSPC216
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000091732.15 ENST00000358303.8 ENSP00000351052.4
ENSG00000091732.15 ENST00000360708.9 ENSP00000353933.5
ENSG00000091732.15 ENST00000467642.5 ENSP00000419509.1
ENSG00000091732.15 ENST00000481503.5 ENSP00000418533.1
ENSG00000091732.15 ENST00000470651.1 ENSP00000420068.1
ENSG00000091732.15 ENST00000484432.1 ENSP00000417217.1
ENSG00000091732.15 ENST00000311873.9 ENSP00000309301.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 16009132
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
 Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
Protein Sequence
(Fasta)
MAAPCEGQAF AVGVEKNWGA VVRSPEGTPQ KIRQLIDEGI APEEGGVDAK DTSATSQSVN 60
GSPQAEQPSL ESTSKEAFFS RVETFSSLKW AGKPFELSPL VCAKYGWVTV ECDMLKCSSC 120
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Protein Fasta Sequence


>IUUC-Hsa-046932|E3,F-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCCTCAAGAG GCGGATATTA ACCTCCCAGG ACGGAAGTTC CGGAGCCTTC AAACTCTCGG 60
GGAAGCAACT CGGCAGCGGA CCAAGATGGC GGCGCCCTGT GAGGGACAAG CGTTTGCCGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046932|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR013909--NIPA/Rsm1
IPR012935--Znf_C3HC-like
Pfam

PF08600--Rsm1
PF07967--zf-C3HC
Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005634--C:nucleus
GO:0019901--F:protein kinase binding
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:2001240--P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0016567--P:protein ubiquitination
KEGG hsa:51530
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002290 Ailuropoda melanoleuca 91.25 0.00e+00 833.00
IUUC-Atr-003126 Amborella trichopoda 25.93 1.00e-11 65.50
IUUC-Aca-004720 Anolis carolinensis 61.36 1.00e-145 509.00
IUUC-Ath-006863 Arabidopsis thaliana 28.46 1.00e-11 65.10
IUUC-Bgr-012247 Blumeria graminis 20.34 9.20e-02 33.10
IUUC-Bta-012342 Bos taurus 91.22 0.00e+00 838.00
IUUC-Bra-016709 Brassica rapa 31.71 2.00e-10 62.00
IUUC-Cja-019724 Callithrix jacchus 94.84 0.00e+00 870.00
IUUC-Cfa-020918 Canis familiaris 93.01 0.00e+00 866.00
IUUC-Cpo-022028 Cavia porcellus 84.82 0.00e+00 804.00
IUUC-Csa-023238 Chlorocebus sabaeus 98.90 0.00e+00 629.00
IUUC-Cho-024962 Choloepus hoffmanni 91.13 0.00e+00 762.00
IUUC-Dre-027658 Danio rerio 45.79 3.00e-104 372.00
IUUC-Dno-028891 Dasypus novemcinctus 89.82 0.00e+00 826.00
IUUC-Dse-031338 Dothistroma septosporum 22.13 4.00e-06 46.60
IUUC-Eca-033965 Equus caballus 91.05 0.00e+00 791.00
IUUC-Eeu-034997 Erinaceus europaeus 69.38 3.00e-85 309.00
IUUC-Fca-036112 Felis catus 91.82 0.00e+00 822.00
IUUC-Gmo-039188 Gadus morhua 41.79 7.00e-93 334.00
IUUC-Ggr-039778 Gaeumannomyces graminis 24.03 5.00e-08 52.80
IUUC-Gga-040879 Gallus gallus 63.21 1.00e-149 523.00
IUUC-Gac-041886 Gasterosteus aculeatus 43.80 3.00e-92 332.00
IUUC-Gma-043122 Glycine max 28.67 8.00e-12 65.90
IUUC-Ggo-045489 Gorilla gorilla 99.01 0.00e+00 912.00
IUUC-Itr-048776 Ictidomys tridecemlineatus 89.82 0.00e+00 850.00
IUUC-Lch-050627 Latimeria chalumnae 55.50 7.00e-115 407.00
IUUC-Loc-052294 Lepisosteus oculatus 51.23 2.00e-113 402.00
IUUC-Laf-053461 Loxodonta africana 90.10 0.00e+00 849.00
IUUC-Mcc-055411 Macaca mulatta 97.81 0.00e+00 864.00
IUUC-Meu-056049 Macropus eugenii 79.92 0.00e+00 756.00
IUUC-Mga-059941 Meleagris gallopavo 62.24 1.00e-136 479.00
IUUC-Mmr-061230 Microcebus murinus 92.83 0.00e+00 850.00
IUUC-Mdo-062254 Monodelphis domestica 64.55 2.00e-166 578.00
IUUC-Mmu-063183 Mus musculus 85.54 0.00e+00 809.00
IUUC-Mpu-066430 Mustela putorius furo 91.02 0.00e+00 803.00
IUUC-Mlu-067318 Myotis lucifugus 89.68 0.00e+00 776.00
IUUC-Nle-069871 Nomascus leucogenys 97.21 0.00e+00 891.00
IUUC-Opr-071023 Ochotona princeps 81.40 3.00e-103 368.00
IUUC-Ont-071854 Oreochromis niloticus 42.83 9.00e-89 320.00
IUUC-Ocu-074725 Oryctolagus cuniculus 86.31 0.00e+00 804.00
IUUC-Ogl-076943 Oryza glaberrima 27.69 5.00e-13 70.10
IUUC-Ogu-078596 Oryza glumaepatula 28.46 3.00e-13 70.90
IUUC-Ome-081625 Oryza meridionalis 28.46 6.00e-13 70.10
IUUC-Oru-084191 Oryza rufipogon 28.46 3.00e-13 71.20
IUUC-Osa-085482 Oryza sativa 28.46 2.00e-13 71.20
IUUC-Ola-086385 Oryzias latipes 40.64 9.00e-90 324.00
IUUC-Oga-089112 Otolemur garnettii 87.23 0.00e+00 783.00
IUUC-Oar-089630 Ovis aries 91.47 0.00e+00 840.00
IUUC-Ptr-091222 Pan troglodytes 99.40 0.00e+00 917.00
IUUC-Pan-092930 Papio anubis 98.21 0.00e+00 878.00
IUUC-Psi-093330 Pelodiscus sinensis 63.45 1.00e-137 483.00
IUUC-Ppa-095707 Physcomitrella patens 28.70 7.00e-14 73.20
IUUC-Pfo-096184 Poecilia formosa 39.88 9.00e-85 307.00
IUUC-Pab-097781 Pongo abelii 90.08 0.00e+00 804.00
IUUC-Pop-099933 Populus trichocarpa 22.31 9.00e-07 49.30
IUUC-Pca-101038 Procavia capensis 86.49 0.00e+00 741.00
IUUC-Pva-102707 Pteropus vampyrus 86.07 0.00e+00 729.00
IUUC-Rno-105631 Rattus norvegicus 85.46 0.00e+00 816.00
IUUC-Sha-106923 Sarcophilus harrisii 78.66 0.00e+00 670.00
IUUC-Smo-109192 Selaginella moellendorffii 24.79 6.00e-13 69.30
IUUC-Sly-111755 Solanum lycopersicum 30.33 1.00e-10 62.40
IUUC-Sar-113436 Sorex araneus 78.80 0.00e+00 712.00
IUUC-Ssc-115977 Sus scrofa 89.59 7.00e-161 560.00
IUUC-Tni-120167 Tetraodon nigroviridis 41.68 2.00e-86 312.00
IUUC-Tbe-127998 Tupaia belangeri 83.03 0.00e+00 725.00
IUUC-Ttr-128617 Tursiops truncatus 91.02 0.00e+00 808.00
IUUC-Vda-129867 Verticillium dahliae 22.69 3.00e-05 43.50
IUUC-Xtr-132321 Xenopus tropicalis 52.36 2.00e-108 386.00
Created Date 25-Jun-2017

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